P43175 (MPA5B_AMBPS) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Pollen allergen Amb p 5b Alternative name(s): Allergen Amb p Vb Allergen=Amb p 5b
Organism	Ambrosia psilostachya (Western ragweed) (Ambrosia coronopifolia)
Taxonomic identifier	29715 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Heliantheae alliance › Heliantheae › Ambrosia

Protein attributes

Sequence length	77 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted.
Allergenic properties	Causes an allergic reaction in human.

Ontologies

Keywords
Cellular component	Secreted
Disease	Allergen
Domain	Signal
PTM	Disulfide bond
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Potential
	Chain	23 – 77	55	Pollen allergen Amb p 5b		PRO_0000021744
Amino acid modifications
	Disulfide bond	26 ↔ 61		By similarity
	Disulfide bond	33 ↔ 48		By similarity
	Disulfide bond	40 ↔ 54		By similarity
Natural variations
	Natural variant	40	1	C → S in clone B2.
	Natural variant	41 – 43	3	SSD → CTN in clone B3.

Sequences

	Sequence		Length	Mass (Da)
	P43175 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 5FB321DB46AB4560	FASTA	77	8,641
	10 20 30 40 50 60 MNNEKNVSFE FIGSTNEVDE IKVMACYAAG SICGEKRGYC SSDPGRYCPW QVVCYESRKI 70 CAKNAAKMRM NVTKNTI

References

[1]

"Immunologic and molecular characterization of Amb p V allergens from Ambrosia psilostachya (western Ragweed) pollen." Ghosh B., Rafnar T., Perry M.P., Bassolino-Klimas D., Metzler W.J., Klapper D.G., Marsh D.G. J. Immunol. 152:2882-2889(1994) [PubMed: 7511632] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Pollen.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L24467 Unassigned DNA. Translation: AAA20064.1. L24468 Unassigned DNA. Translation: AAA20066.1. L24469 Unassigned DNA. Translation: AAA20068.1.
3D structure databases
ModBase	Search...
Protein family/group databases
Allergome	3073. Amb p 5.0201. 31. Amb p 5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR005611. Amb_V_allergen. [Graphical view]
Gene3D	G3DSA:3.30.160.80. Amb_V_allergen. 1 hit.
Pfam	PF03913. Amb_V_allergen. 1 hit. [Graphical view]
PIRSF	PIRSF002697. Amb_V_allergen. 1 hit.
ProDom	PD018950. Amb_V_allergen. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00816. Amb_V_allergen. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MPA5B_AMBPS

Accession

Primary (citable) accession number: P43175

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	January 11, 2011
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program