Reviewed, UniProtKB/Swiss-Prot P43174 (MPA5A_AMBPS)

Names and origin

Protein names	Recommended name:     Pollen allergen Amb p 5a Alternative name(s):     Allergen Amb p Va     Allergen=Amb p 5a
Organism	Ambrosia psilostachya (Western ragweed)
Taxonomic identifier	29715 [NCBI]
Taxonomic lineage	Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › campanulids › Asterales › Asteraceae › Asteroideae › Heliantheae › Ambrosia

Protein attributes

Sequence length	77 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Allergenic properties

Causes an allergic reaction in human.

Ontologies

Keywords
Disease	Allergen
Domain	Signal
PTM	Disulfide bond
Technical term	Direct protein sequencing
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 22	22	Ref.1
	Chain	23 – 77	55	Pollen allergen Amb p 5a		PRO_0000021742
Amino acid modifications
	Disulfide bond	26 ↔ 61		By similarity
	Disulfide bond	33 ↔ 48		By similarity
	Disulfide bond	40 ↔ 54		By similarity
	Disulfide bond	41 ↔ 65		By similarity
Natural variations
	Natural variant	59	1	E → K in clone A3.

Sequences

	Sequence		Length	Mass (Da)
	P43174-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 2D8976EB65D9A00F	FASTA	77	8,710
	10 20 30 40 50 60 MNNEKNVSFE FIGSTDEVDE IKLLPCAWAG NVCGEKRAYC CSDPGRYCPW QVVCYESSEI 70 CSQKCGKMRM NVTKNTI

References

[1]

"Immunologic and molecular characterization of Amb p V allergens from Ambrosia psilostachya (western Ragweed) pollen." Ghosh B., Rafnar T., Perry M.P., Bassolino-Klimas D., Metzler W.J., Klapper D.G., Marsh D.G. J. Immunol. 152:2882-2889(1994) [PubMed: 7511632] [Abstract] Cited for: NUCLEOTIDE SEQUENCE, PROTEIN SEQUENCE OF 23-63. Tissue: Pollen.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L24465 Unassigned DNA. Translation: AAA20065.1. L24466 Unassigned DNA. Translation: AAA20067.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR005611. Amb_V_allergen. [Graphical view]
Pfam	PF03913. Amb_V_allergen. 1 hit. [Graphical view]
PIRSF	PIRSF002697. Amb_V_allergen. 1 hit.
ProDom	PD018950. Amb_V_allergen. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00816. Amb_V_allergen. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MPA5A_AMBPS

Accession

Primary (citable) accession number: P43174

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 24, 2009
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)