Reviewed, UniProtKB/Swiss-Prot P43166 (CAH7_HUMAN)

Names and origin

Protein names

Recommended name:
    Carbonic anhydrase 7
    EC=4.2.1.1
Alternative name(s):
    Carbonic anhydrase VII
      Short name=CA-VII
    Carbonate dehydratase VII

Gene names

Name:

CA7

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	264 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O.
Cofactor	Zinc By similarity.
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon compound metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	carbonate dehydratase activity Ref.1 Traceable author statement. Source: ProtInc zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 264	264	Carbonic anhydrase 7		PRO_0000077431
Sites
	Metal binding	96	1	Zinc; catalytic By similarity
	Metal binding	98	1	Zinc; catalytic By similarity
	Metal binding	121	1	Zinc; catalytic By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43166-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 7AD559FC6E07EF96	FASTA	264	29,658
	10 20 30 40 50 60 MTGHHGWGYG QDDGPSHWHK LYPIAQGDRQ SPINIISSQA VYSPSLQPLE LSYEACMSLS 70 80 90 100 110 120 ITNNGHSVQV DFNDSDDRTV VTGGPLEGPY RLKQFHFHWG KKHDVGSEHT VDGKSFPSEL 130 140 150 160 170 180 HLVHWNAKKY STFGEAASAP DGLAVVGVFL ETGDEHPSMN RLTDALYMVR FKGTKAQFSC 190 200 210 220 230 240 FNPKCLLPAS RHYWTYPGSL TTPPLSESVT WIVLREPICI SERQMGKFRS LLFTSEDDER 250 260 IHMVNNFRPP QPLKGRVVKA SFRA

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the human gene for a newly discovered carbonic anhydrase, CA VII, and its localization to chromosome 16." Montgomery J.C., Venta P.J., Eddy R.L., Fukushima Y.S., Shows T.B., Tashian R.E. Genomics 11:835-848(1991) [PubMed: 1783392] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Molecular identification of carbonic anhydrases (CA) and CA-related (CAR) genes." Chen Y., Huang C.-H. Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q." Loftus B.J., Kim U.-J., Sneddon V.P., Kalush F., Brandon R., Fuhrmann J., Mason T., Crosby M.L., Barnstead M., Cronin L., Mays A.D., Cao Y., Xu R.X., Kang H.-L., Mitchell S., Eichler E.E., Harris P.C., Venter J.C., Adams M.D. Genomics 60:295-308(1999) [PubMed: 10493829] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Colon, Kidney and Stomach.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M76423 , M76420, M76421, M76422 Genomic DNA. Translation: AAA51923.1. AY075019 mRNA. Translation: AAL78167.1. AC004638 Genomic DNA. Translation: AAC23785.1. BC033865 mRNA. Translation: AAH33865.1.
IPI	IPI00016493.
PIR	CRHU7. A55272.
RefSeq	NP_005173.1.
UniGene	Hs.37014
3D structure databases
HSSP	HSSP built from PDB template 1BV3 based on UniProtKB P00918.
ModBase	Search...
Proteomic databases
PRIDE	P43166.
Genome annotation databases
Ensembl	ENSG00000168748. Homo sapiens. [Contig view]
GeneID	766.
UCSC	uc002eqi.1. human.
Organism-specific databases
GeneCards	GC16P065435.
H-InvDB	HIX0013122.
HGNC	HGNC:1381. CA7.
MIM	114770. gene.
PharmGKB	PA24382.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	P43166.
HOVERGEN	P43166.
OMA	P43166. IANNGHS.
Enzyme and pathway databases
BRENDA	4.2.1.1. 247.
Gene expression databases
ArrayExpress	P43166.
Bgee	P43166.
CleanEx	HS_CA7.
GermOnline	ENSG00000168748. Homo sapiens.
Family and domain databases
InterPro	IPR001148. Carbonic_anhydrase_a-class_cat. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018438. Carbonic_anhydrase_CA7. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
PANTHER	PTHR18952:SF26. Carbonic_anhydrase_CA7. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
ProDom	PD000865. Euk_COanhd. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
BindingDB	P43166.
NextBio	3096.
SOURCE	Search...

Entry information

Entry name

CAH7_HUMAN

Accession

Primary (citable) accession number: P43166
Secondary accession number(s): Q541F0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	July 7, 2009
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)