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Protein

Carbonic anhydrase 7

Gene

CA7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Reversible hydration of carbon dioxide.

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+1 Publication

Enzyme regulationi

Activated by histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. Inhibited by coumarins, sulfonamide derivatives such as acetazolamide (AZA), by saccharin and Foscarnet (phosphonoformate trisodium salt).7 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei66Proton acceptorBy similarity1
Metal bindingi96Zinc; catalytic1 Publication1
Metal bindingi98Zinc; catalytic1 Publication1
Metal bindingi121Zinc; catalytic1 Publication1
Active sitei130By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:HS09814-MONOMER.
BRENDAi4.2.1.1. 2681.
ReactomeiR-HSA-1475029. Reversible hydration of carbon dioxide.
SABIO-RKP43166.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 7 (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase VII
Carbonic anhydrase VII
Short name:
CA-VII
Gene namesi
Name:CA7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:1381. CA7.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi766.
OpenTargetsiENSG00000168748.
PharmGKBiPA25996.

Chemistry databases

ChEMBLiCHEMBL2326.
DrugBankiDB00819. Acetazolamide.
DB01144. Diclofenamide.
DB00703. Methazolamide.
DB00909. Zonisamide.
GuidetoPHARMACOLOGYi2749.

Polymorphism and mutation databases

BioMutaiCA7.
DMDMi1168744.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000774311 – 264Carbonic anhydrase 7Add BLAST264

Proteomic databases

PaxDbiP43166.
PeptideAtlasiP43166.
PRIDEiP43166.

PTM databases

iPTMnetiP43166.
PhosphoSitePlusiP43166.

Expressioni

Gene expression databases

BgeeiENSG00000168748.
CleanExiHS_CA7.
ExpressionAtlasiP43166. baseline and differential.
GenevisibleiP43166. HS.

Organism-specific databases

HPAiHPA047237.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000345659.

Chemistry databases

BindingDBiP43166.

Structurei

Secondary structure

1264
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni11 – 13Combined sources3
Helixi15 – 17Combined sources3
Helixi18 – 21Combined sources4
Helixi23 – 26Combined sources4
Beta strandi27 – 29Combined sources3
Helixi37 – 39Combined sources3
Beta strandi40 – 42Combined sources3
Beta strandi46 – 52Combined sources7
Beta strandi58 – 63Combined sources6
Beta strandi68 – 72Combined sources5
Beta strandi75 – 84Combined sources10
Beta strandi90 – 99Combined sources10
Beta strandi108 – 111Combined sources4
Beta strandi117 – 125Combined sources9
Turni127 – 129Combined sources3
Helixi133 – 136Combined sources4
Beta strandi142 – 154Combined sources13
Helixi157 – 164Combined sources8
Turni165 – 169Combined sources5
Beta strandi174 – 177Combined sources4
Helixi183 – 186Combined sources4
Beta strandi193 – 198Combined sources6
Beta strandi209 – 216Combined sources8
Beta strandi218 – 220Combined sources3
Helixi222 – 229Combined sources8
Beta strandi232 – 234Combined sources3
Beta strandi259 – 262Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MDZX-ray2.32A5-262[»]
3ML5X-ray2.05A1-264[»]
ProteinModelPortaliP43166.
SMRiP43166.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 262Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST258

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni201 – 202Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated
Contains 1 alpha-carbonic anhydrase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
GeneTreeiENSGT00760000118915.
HOGENOMiHOG000112637.
HOVERGENiHBG002837.
InParanoidiP43166.
KOiK01672.
OMAiLVHWNAR.
OrthoDBiEOG091G0XFM.
PhylomeDBiP43166.
TreeFamiTF316425.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
IPR018438. Carbonic_anhydrase_CA7.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF124. PTHR18952:SF124. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P43166-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTGHHGWGYG QDDGPSHWHK LYPIAQGDRQ SPINIISSQA VYSPSLQPLE
60 70 80 90 100
LSYEACMSLS ITNNGHSVQV DFNDSDDRTV VTGGPLEGPY RLKQFHFHWG
110 120 130 140 150
KKHDVGSEHT VDGKSFPSEL HLVHWNAKKY STFGEAASAP DGLAVVGVFL
160 170 180 190 200
ETGDEHPSMN RLTDALYMVR FKGTKAQFSC FNPKCLLPAS RHYWTYPGSL
210 220 230 240 250
TTPPLSESVT WIVLREPICI SERQMGKFRS LLFTSEDDER IHMVNNFRPP
260
QPLKGRVVKA SFRA
Length:264
Mass (Da):29,658
Last modified:November 1, 1995 - v1
Checksum:i7AD559FC6E07EF96
GO
Isoform 2 (identifier: P43166-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Show »
Length:208
Mass (Da):23,452
Checksum:iAF3D016A27182D18
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0442541 – 56Missing in isoform 2. 1 PublicationAdd BLAST56

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76423
, M76420, M76421, M76422 Genomic DNA. Translation: AAA51923.1.
AY075019 mRNA. Translation: AAL78167.1.
AY075020 mRNA. Translation: AAL78168.1.
AC004638 Genomic DNA. Translation: AAC23785.1.
AC044802 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83047.1.
BC033865 mRNA. Translation: AAH33865.1.
CCDSiCCDS10821.1. [P43166-1]
CCDS42173.1. [P43166-2]
PIRiA55272. CRHU7.
RefSeqiNP_001014435.1. NM_001014435.1. [P43166-2]
NP_005173.1. NM_005182.2. [P43166-1]
XP_005256193.1. XM_005256136.3. [P43166-2]
XP_011521614.1. XM_011523312.1. [P43166-2]
UniGeneiHs.37014.

Genome annotation databases

EnsembliENST00000338437; ENSP00000345659; ENSG00000168748. [P43166-1]
ENST00000394069; ENSP00000377632; ENSG00000168748. [P43166-2]
GeneIDi766.
KEGGihsa:766.
UCSCiuc002eqi.4. human. [P43166-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M76423
, M76420, M76421, M76422 Genomic DNA. Translation: AAA51923.1.
AY075019 mRNA. Translation: AAL78167.1.
AY075020 mRNA. Translation: AAL78168.1.
AC004638 Genomic DNA. Translation: AAC23785.1.
AC044802 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83047.1.
BC033865 mRNA. Translation: AAH33865.1.
CCDSiCCDS10821.1. [P43166-1]
CCDS42173.1. [P43166-2]
PIRiA55272. CRHU7.
RefSeqiNP_001014435.1. NM_001014435.1. [P43166-2]
NP_005173.1. NM_005182.2. [P43166-1]
XP_005256193.1. XM_005256136.3. [P43166-2]
XP_011521614.1. XM_011523312.1. [P43166-2]
UniGeneiHs.37014.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3MDZX-ray2.32A5-262[»]
3ML5X-ray2.05A1-264[»]
ProteinModelPortaliP43166.
SMRiP43166.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000345659.

Chemistry databases

BindingDBiP43166.
ChEMBLiCHEMBL2326.
DrugBankiDB00819. Acetazolamide.
DB01144. Diclofenamide.
DB00703. Methazolamide.
DB00909. Zonisamide.
GuidetoPHARMACOLOGYi2749.

PTM databases

iPTMnetiP43166.
PhosphoSitePlusiP43166.

Polymorphism and mutation databases

BioMutaiCA7.
DMDMi1168744.

Proteomic databases

PaxDbiP43166.
PeptideAtlasiP43166.
PRIDEiP43166.

Protocols and materials databases

DNASUi766.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338437; ENSP00000345659; ENSG00000168748. [P43166-1]
ENST00000394069; ENSP00000377632; ENSG00000168748. [P43166-2]
GeneIDi766.
KEGGihsa:766.
UCSCiuc002eqi.4. human. [P43166-1]

Organism-specific databases

CTDi766.
DisGeNETi766.
GeneCardsiCA7.
HGNCiHGNC:1381. CA7.
HPAiHPA047237.
MIMi114770. gene.
neXtProtiNX_P43166.
OpenTargetsiENSG00000168748.
PharmGKBiPA25996.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
GeneTreeiENSGT00760000118915.
HOGENOMiHOG000112637.
HOVERGENiHBG002837.
InParanoidiP43166.
KOiK01672.
OMAiLVHWNAR.
OrthoDBiEOG091G0XFM.
PhylomeDBiP43166.
TreeFamiTF316425.

Enzyme and pathway databases

BioCyciZFISH:HS09814-MONOMER.
BRENDAi4.2.1.1. 2681.
ReactomeiR-HSA-1475029. Reversible hydration of carbon dioxide.
SABIO-RKP43166.

Miscellaneous databases

GeneWikiiCarbonic_anhydrase_7.
GenomeRNAii766.
PROiP43166.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168748.
CleanExiHS_CA7.
ExpressionAtlasiP43166. baseline and differential.
GenevisibleiP43166. HS.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
IPR018438. Carbonic_anhydrase_CA7.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF124. PTHR18952:SF124. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAH7_HUMAN
AccessioniPrimary (citable) accession number: P43166
Secondary accession number(s): Q541F0, Q86YU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.