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Protein

Carbonic anhydrase 5A, mitochondrial

Gene

Ca5a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Reversible hydration of carbon dioxide. Low activity.

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+By similarity

Enzyme regulationi

Inhibited by acetazolamide.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi129Zinc; catalyticBy similarity1
Metal bindingi131Zinc; catalyticBy similarity1
Metal bindingi154Zinc; catalyticBy similarity1
Active sitei163By similarity1

GO - Molecular functioni

  • carbonate dehydratase activity Source: RGD
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-1475029. Reversible hydration of carbon dioxide.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 5A, mitochondrial (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase VA
Carbonic anhydrase VA
Short name:
CA-VA
Gene namesi
Name:Ca5a
Synonyms:Ca5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi2243. Ca5a.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34Mitochondrion1 PublicationAdd BLAST34
ChainiPRO_000000423635 – 304Carbonic anhydrase 5A, mitochondrialAdd BLAST270

Proteomic databases

PaxDbiP43165.
PRIDEiP43165.

Expressioni

Tissue specificityi

High in liver, also detected in heart, lung, kidney, spleen and intestine.

Gene expression databases

BgeeiENSRNOG00000019098.
GenevisibleiP43165. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025848.

Structurei

3D structure databases

ProteinModelPortaliP43165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 295Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST261

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni234 – 235Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated
Contains 1 alpha-carbonic anhydrase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
GeneTreeiENSGT00760000118915.
HOGENOMiHOG000112637.
HOVERGENiHBG002837.
InParanoidiP43165.
KOiK01672.
OMAiPFQPSCL.
OrthoDBiEOG091G0XFM.
PhylomeDBiP43165.
TreeFamiTF316425.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43165-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRAKMLGRG PYKPLAILRH MGPLCATRPQ HWRFQHSYAE KHSNCARHPL
60 70 80 90 100
WTGPVSSPGG TQQSPINIQW TDSVYDPKLA PLRVSYDAAS CRYLWNTGYF
110 120 130 140 150
FQVEFDDSCE ESGISGGPLG NHYRLKQFHF HWGATDEWGS EHMVDGHAYP
160 170 180 190 200
AELHLVHWNS MKYENYKKAT TGENGLAVIG VFLKLGAHHE ALQRLVDILP
210 220 230 240 250
EVRHKDTQVT MGPFDPSCLL PACRDYWTYP GSLTTPPLAE SVTWIVHKMP
260 270 280 290 300
IEVSPSQLST FRTLLFSGRG EDEEVMVNNF RPLQPLRGRN VRSSFQVPRV

GTKS
Length:304
Mass (Da):34,499
Last modified:November 1, 1995 - v1
Checksum:iC997805D690F95D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12268 mRNA. Translation: AAA50832.1.
BC088147 mRNA. Translation: AAH88147.1.
PIRiI59261.
RefSeqiNP_062166.1. NM_019293.3.
UniGeneiRn.9988.

Genome annotation databases

EnsembliENSRNOT00000025848; ENSRNOP00000025848; ENSRNOG00000019098.
GeneIDi54233.
KEGGirno:54233.
UCSCiRGD:2243. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12268 mRNA. Translation: AAA50832.1.
BC088147 mRNA. Translation: AAH88147.1.
PIRiI59261.
RefSeqiNP_062166.1. NM_019293.3.
UniGeneiRn.9988.

3D structure databases

ProteinModelPortaliP43165.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025848.

Proteomic databases

PaxDbiP43165.
PRIDEiP43165.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025848; ENSRNOP00000025848; ENSRNOG00000019098.
GeneIDi54233.
KEGGirno:54233.
UCSCiRGD:2243. rat.

Organism-specific databases

CTDi763.
RGDi2243. Ca5a.

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
GeneTreeiENSGT00760000118915.
HOGENOMiHOG000112637.
HOVERGENiHBG002837.
InParanoidiP43165.
KOiK01672.
OMAiPFQPSCL.
OrthoDBiEOG091G0XFM.
PhylomeDBiP43165.
TreeFamiTF316425.

Enzyme and pathway databases

ReactomeiR-RNO-1475029. Reversible hydration of carbon dioxide.

Miscellaneous databases

PROiP43165.

Gene expression databases

BgeeiENSRNOG00000019098.
GenevisibleiP43165. RN.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCAH5A_RAT
AccessioniPrimary (citable) accession number: P43165
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 5, 2016
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.