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Protein

Carbonic anhydrase 5A, mitochondrial

Gene

Ca5a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Reversible hydration of carbon dioxide. Low activity.

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+By similarity

Enzyme regulationi

Inhibited by acetazolamide.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi129Zinc; catalyticBy similarity1
Metal bindingi131Zinc; catalyticBy similarity1
Metal bindingi154Zinc; catalyticBy similarity1
Active sitei163By similarity1

GO - Molecular functioni

  • carbonate dehydratase activity Source: RGD
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-1475029 Reversible hydration of carbon dioxide

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 5A, mitochondrial (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase VA
Carbonic anhydrase VA
Short name:
CA-VA
Gene namesi
Name:Ca5a
Synonyms:Ca5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi2243 Ca5a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34Mitochondrion1 PublicationAdd BLAST34
ChainiPRO_000000423635 – 304Carbonic anhydrase 5A, mitochondrialAdd BLAST270

Proteomic databases

PaxDbiP43165
PRIDEiP43165

Expressioni

Tissue specificityi

High in liver, also detected in heart, lung, kidney, spleen and intestine.

Gene expression databases

BgeeiENSRNOG00000019098
GenevisibleiP43165 RN

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025848

Structurei

3D structure databases

ProteinModelPortaliP43165
SMRiP43165
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 295Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST261

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni234 – 235Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0382 Eukaryota
COG3338 LUCA
GeneTreeiENSGT00760000118915
HOGENOMiHOG000112637
HOVERGENiHBG002837
InParanoidiP43165
KOiK01672
OMAiNNFRPPM
OrthoDBiEOG091G0XFM
PhylomeDBiP43165
TreeFamiTF316425

Family and domain databases

Gene3Di3.10.200.10, 1 hit
InterProiView protein in InterPro
IPR001148 CA_dom
IPR036398 CA_dom_sf
IPR023561 Carbonic_anhydrase_a-class
IPR018338 Carbonic_anhydrase_a-class_CS
PANTHERiPTHR18952 PTHR18952, 1 hit
PfamiView protein in Pfam
PF00194 Carb_anhydrase, 1 hit
SMARTiView protein in SMART
SM01057 Carb_anhydrase, 1 hit
SUPFAMiSSF51069 SSF51069, 1 hit
PROSITEiView protein in PROSITE
PS00162 ALPHA_CA_1, 1 hit
PS51144 ALPHA_CA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43165-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRAKMLGRG PYKPLAILRH MGPLCATRPQ HWRFQHSYAE KHSNCARHPL
60 70 80 90 100
WTGPVSSPGG TQQSPINIQW TDSVYDPKLA PLRVSYDAAS CRYLWNTGYF
110 120 130 140 150
FQVEFDDSCE ESGISGGPLG NHYRLKQFHF HWGATDEWGS EHMVDGHAYP
160 170 180 190 200
AELHLVHWNS MKYENYKKAT TGENGLAVIG VFLKLGAHHE ALQRLVDILP
210 220 230 240 250
EVRHKDTQVT MGPFDPSCLL PACRDYWTYP GSLTTPPLAE SVTWIVHKMP
260 270 280 290 300
IEVSPSQLST FRTLLFSGRG EDEEVMVNNF RPLQPLRGRN VRSSFQVPRV

GTKS
Length:304
Mass (Da):34,499
Last modified:November 1, 1995 - v1
Checksum:iC997805D690F95D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12268 mRNA Translation: AAA50832.1
BC088147 mRNA Translation: AAH88147.1
PIRiI59261
RefSeqiNP_062166.1, NM_019293.3
UniGeneiRn.9988

Genome annotation databases

EnsembliENSRNOT00000025848; ENSRNOP00000025848; ENSRNOG00000019098
GeneIDi54233
KEGGirno:54233
UCSCiRGD:2243 rat

Similar proteinsi

Entry informationi

Entry nameiCAH5A_RAT
AccessioniPrimary (citable) accession number: P43165
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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