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Protein

Carbonic anhydrase 5A, mitochondrial

Gene

Ca5a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Reversible hydration of carbon dioxide. Low activity.

Catalytic activityi

H2CO3 = CO2 + H2O.

Cofactori

Zn2+By similarity

Enzyme regulationi

Inhibited by acetazolamide.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi129 – 1291Zinc; catalyticBy similarity
Metal bindingi131 – 1311Zinc; catalyticBy similarity
Metal bindingi154 – 1541Zinc; catalyticBy similarity
Active sitei163 – 1631By similarity

GO - Molecular functioni

  • carbonate dehydratase activity Source: RGD
  • zinc ion binding Source: InterPro

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-1475029. Reversible hydration of carbon dioxide.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 5A, mitochondrial (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase VA
Carbonic anhydrase VA
Short name:
CA-VA
Gene namesi
Name:Ca5a
Synonyms:Ca5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi2243. Ca5a.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3434Mitochondrion1 PublicationAdd
BLAST
Chaini35 – 304270Carbonic anhydrase 5A, mitochondrialPRO_0000004236Add
BLAST

Proteomic databases

PaxDbiP43165.
PRIDEiP43165.

Expressioni

Tissue specificityi

High in liver, also detected in heart, lung, kidney, spleen and intestine.

Gene expression databases

GenevisibleiP43165. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025848.

Structurei

3D structure databases

ProteinModelPortaliP43165.
SMRiP43165. Positions 60-295.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 295261Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni234 – 2352Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Curated
Contains 1 alpha-carbonic anhydrase domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
GeneTreeiENSGT00760000118915.
HOGENOMiHOG000112637.
HOVERGENiHBG002837.
InParanoidiP43165.
KOiK01672.
OMAiCLLPACR.
OrthoDBiEOG7WMCK7.
PhylomeDBiP43165.
TreeFamiTF316425.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43165-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRAKMLGRG PYKPLAILRH MGPLCATRPQ HWRFQHSYAE KHSNCARHPL
60 70 80 90 100
WTGPVSSPGG TQQSPINIQW TDSVYDPKLA PLRVSYDAAS CRYLWNTGYF
110 120 130 140 150
FQVEFDDSCE ESGISGGPLG NHYRLKQFHF HWGATDEWGS EHMVDGHAYP
160 170 180 190 200
AELHLVHWNS MKYENYKKAT TGENGLAVIG VFLKLGAHHE ALQRLVDILP
210 220 230 240 250
EVRHKDTQVT MGPFDPSCLL PACRDYWTYP GSLTTPPLAE SVTWIVHKMP
260 270 280 290 300
IEVSPSQLST FRTLLFSGRG EDEEVMVNNF RPLQPLRGRN VRSSFQVPRV

GTKS
Length:304
Mass (Da):34,499
Last modified:November 1, 1995 - v1
Checksum:iC997805D690F95D0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12268 mRNA. Translation: AAA50832.1.
BC088147 mRNA. Translation: AAH88147.1.
PIRiI59261.
RefSeqiNP_062166.1. NM_019293.3.
UniGeneiRn.9988.

Genome annotation databases

EnsembliENSRNOT00000025848; ENSRNOP00000025848; ENSRNOG00000019098.
GeneIDi54233.
KEGGirno:54233.
UCSCiRGD:2243. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12268 mRNA. Translation: AAA50832.1.
BC088147 mRNA. Translation: AAH88147.1.
PIRiI59261.
RefSeqiNP_062166.1. NM_019293.3.
UniGeneiRn.9988.

3D structure databases

ProteinModelPortaliP43165.
SMRiP43165. Positions 60-295.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025848.

Proteomic databases

PaxDbiP43165.
PRIDEiP43165.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025848; ENSRNOP00000025848; ENSRNOG00000019098.
GeneIDi54233.
KEGGirno:54233.
UCSCiRGD:2243. rat.

Organism-specific databases

CTDi12352.
RGDi2243. Ca5a.

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
GeneTreeiENSGT00760000118915.
HOGENOMiHOG000112637.
HOVERGENiHBG002837.
InParanoidiP43165.
KOiK01672.
OMAiCLLPACR.
OrthoDBiEOG7WMCK7.
PhylomeDBiP43165.
TreeFamiTF316425.

Enzyme and pathway databases

ReactomeiR-RNO-1475029. Reversible hydration of carbon dioxide.

Miscellaneous databases

PROiP43165.

Gene expression databases

GenevisibleiP43165. RN.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiIPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
[Graphical view]
PANTHERiPTHR18952. PTHR18952. 1 hit.
PfamiPF00194. Carb_anhydrase. 1 hit.
[Graphical view]
SMARTiSM01057. Carb_anhydrase. 1 hit.
[Graphical view]
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiPS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mitochondrial carbonic anhydrase (isozyme V) in mouse and rat: cDNA cloning, expression, subcellular localization, processing, and tissue distribution."
    Nagao Y., Srinivasan M., Platero J.S., Svendrowski M., Waheed A., Sly W.S.
    Proc. Natl. Acad. Sci. U.S.A. 91:10330-10334(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 35-46.
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiCAH5A_RAT
AccessioniPrimary (citable) accession number: P43165
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 8, 2016
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.