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Protein

Cathepsin E

Gene

CTSE

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain (By similarity).By similarity

Catalytic activityi

Similar to cathepsin D, but slightly broader specificity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96PROSITE-ProRule annotation1
Active sitei281PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.010.

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin E (EC:3.4.23.34)
Gene namesi
Name:CTSE
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

  • Endosome By similarity

  • Note: The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000002597820 – 53Activation peptideBy similarityAdd BLAST34
ChainiPRO_000002597954 – 396Cathepsin EAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi60InterchainCurated
Glycosylationi90N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi109 ↔ 114By similarity
Disulfide bondi272 ↔ 276By similarity
Disulfide bondi314 ↔ 351By similarity

Post-translational modificationi

Glycosylated. The nature of the carbohydrate chain varies between cell types (By similarity).By similarity

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, Zymogen

Miscellaneous databases

PMAP-CutDBP43159.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001598.

Structurei

3D structure databases

ProteinModelPortaliP43159.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 392Peptidase A1PROSITE-ProRule annotationAdd BLAST315

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated
Contains 1 peptidase A1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiP43159.
KOiK01382.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033145. Cathepsin_E.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF81. PTHR13683:SF81. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 1 hit.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43159-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLPLLLLL LLDLGQAQGT LDRVPLRRQP SLRKKLRAQG QLSEFWKAHK
60 70 80 90 100
VDMVQYTETC TMEQSANEPL INYLDMEYFG TISIGSPPQN FTVIFDTVSS
110 120 130 140 150
NLWVPSVYCT SPACQMHPQF RPSQSNTYSE VGTPFSIAYG TGSLTGIIGA
160 170 180 190 200
DQVSVQGLTV VGQQFGESVK EPGQTFVNAE FDGILGLGYP SLAAGGVTPV
210 220 230 240 250
FDNMMAQNLV SLPMFSVYMS SNPEGGSGSE LTFGGYDSSH FSGSLNWVPV
260 270 280 290 300
TKQGYWQIAL DEIQVGGSPM FCPEGCQAIV DTGTSLITGP SDKIIQLQAA
310 320 330 340 350
IGATPMDGEY AVECENLNIM PDVTFVINGV PYTLSATAYT LPDFVDGMQF
360 370 380 390
CGSGFQGLDI QPPAGPLWIL GDVFIRQFYS VFDRGSNRVG LAPAVP
Length:396
Mass (Da):42,679
Last modified:November 1, 1995 - v1
Checksum:iE5D84FE48DC760A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08418 mRNA. Translation: AAC37308.1.
PIRiS36865.
RefSeqiNP_001075713.1. NM_001082244.1.
UniGeneiOcu.2222.

Genome annotation databases

GeneIDi100009063.
KEGGiocu:100009063.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08418 mRNA. Translation: AAC37308.1.
PIRiS36865.
RefSeqiNP_001075713.1. NM_001082244.1.
UniGeneiOcu.2222.

3D structure databases

ProteinModelPortaliP43159.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001598.

Protein family/group databases

MEROPSiA01.010.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100009063.
KEGGiocu:100009063.

Organism-specific databases

CTDi1510.

Phylogenomic databases

eggNOGiKOG1339. Eukaryota.
ENOG410XNV7. LUCA.
HOGENOMiHOG000197681.
HOVERGENiHBG000482.
InParanoidiP43159.
KOiK01382.

Miscellaneous databases

PMAP-CutDBP43159.

Family and domain databases

Gene3Di2.40.70.10. 2 hits.
InterProiIPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR012848. Aspartic_peptidase_N.
IPR033145. Cathepsin_E.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
[Graphical view]
PANTHERiPTHR13683. PTHR13683. 1 hit.
PTHR13683:SF81. PTHR13683:SF81. 1 hit.
PfamiPF07966. A1_Propeptide. 1 hit.
PF00026. Asp. 1 hit.
[Graphical view]
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiPS00141. ASP_PROTEASE. 1 hit.
PS51767. PEPTIDASE_A1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCATE_RABIT
AccessioniPrimary (citable) accession number: P43159
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 5, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.