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Protein

Cathepsin E

Gene

CTSE

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain (By similarity).By similarity

Catalytic activityi

Similar to cathepsin D, but slightly broader specificity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei96PROSITE-ProRule annotation1
Active sitei281PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Protein family/group databases

MEROPSiA01.010

Names & Taxonomyi

Protein namesi
Recommended name:
Cathepsin E (EC:3.4.23.34)
Gene namesi
Name:CTSE
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
PropeptideiPRO_000002597820 – 53Activation peptideBy similarityAdd BLAST34
ChainiPRO_000002597954 – 396Cathepsin EAdd BLAST343

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi60InterchainCurated
Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi109 ↔ 114By similarity
Disulfide bondi272 ↔ 276By similarity
Disulfide bondi314 ↔ 351By similarity

Post-translational modificationi

Glycosylated. The nature of the carbohydrate chain varies between cell types (By similarity).By similarity

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PRIDEiP43159

Miscellaneous databases

PMAP-CutDBiP43159

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000001598

Structurei

3D structure databases

ProteinModelPortaliP43159
SMRiP43159
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini78 – 392Peptidase A1PROSITE-ProRule annotationAdd BLAST315

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1339 Eukaryota
ENOG410XNV7 LUCA
HOGENOMiHOG000197681
HOVERGENiHBG000482
InParanoidiP43159
KOiK01382

Family and domain databases

Gene3Di2.40.70.10, 2 hits
InterProiView protein in InterPro
IPR001461 Aspartic_peptidase_A1
IPR001969 Aspartic_peptidase_AS
IPR012848 Aspartic_peptidase_N
IPR033145 Cathepsin_E
IPR033121 PEPTIDASE_A1
IPR021109 Peptidase_aspartic_dom_sf
PANTHERiPTHR13683 PTHR13683, 1 hit
PTHR13683:SF81 PTHR13683:SF81, 1 hit
PfamiView protein in Pfam
PF07966 A1_Propeptide, 1 hit
PF00026 Asp, 1 hit
PRINTSiPR00792 PEPSIN
SUPFAMiSSF50630 SSF50630, 1 hit
PROSITEiView protein in PROSITE
PS00141 ASP_PROTEASE, 1 hit
PS51767 PEPTIDASE_A1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43159-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTLPLLLLL LLDLGQAQGT LDRVPLRRQP SLRKKLRAQG QLSEFWKAHK
60 70 80 90 100
VDMVQYTETC TMEQSANEPL INYLDMEYFG TISIGSPPQN FTVIFDTVSS
110 120 130 140 150
NLWVPSVYCT SPACQMHPQF RPSQSNTYSE VGTPFSIAYG TGSLTGIIGA
160 170 180 190 200
DQVSVQGLTV VGQQFGESVK EPGQTFVNAE FDGILGLGYP SLAAGGVTPV
210 220 230 240 250
FDNMMAQNLV SLPMFSVYMS SNPEGGSGSE LTFGGYDSSH FSGSLNWVPV
260 270 280 290 300
TKQGYWQIAL DEIQVGGSPM FCPEGCQAIV DTGTSLITGP SDKIIQLQAA
310 320 330 340 350
IGATPMDGEY AVECENLNIM PDVTFVINGV PYTLSATAYT LPDFVDGMQF
360 370 380 390
CGSGFQGLDI QPPAGPLWIL GDVFIRQFYS VFDRGSNRVG LAPAVP
Length:396
Mass (Da):42,679
Last modified:November 1, 1995 - v1
Checksum:iE5D84FE48DC760A4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08418 mRNA Translation: AAC37308.1
PIRiS36865
RefSeqiNP_001075713.1, NM_001082244.1
UniGeneiOcu.2222

Genome annotation databases

GeneIDi100009063
KEGGiocu:100009063

Similar proteinsi

Entry informationi

Entry nameiCATE_RABIT
AccessioniPrimary (citable) accession number: P43159
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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