Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Netrin receptor DCC

Gene

DCC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.2 Publications

GO - Molecular functioni

  • netrin receptor activity Source: InterPro
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • anterior/posterior axon guidance Source: Ensembl
  • apoptotic process Source: ProtInc
  • axon guidance Source: Reactome
  • axonogenesis Source: ProtInc
  • dorsal/ventral axon guidance Source: Ensembl
  • extrinsic apoptotic signaling pathway in absence of ligand Source: Reactome
  • negative regulation of collateral sprouting Source: BHF-UCL
  • negative regulation of dendrite development Source: BHF-UCL
  • negative regulation of neuron projection development Source: BHF-UCL
  • neuron migration Source: Ensembl
  • regulation of neuron death Source: UniProtKB
  • spinal cord ventral commissure morphogenesis Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172155-MONOMER.
ReactomeiR-HSA-373752. Netrin-1 signaling.
R-HSA-376172. DSCAM interactions.
R-HSA-418885. DCC mediated attractive signaling.
R-HSA-418886. Netrin mediated repulsion signals.
R-HSA-418889. Ligand-independent caspase activation via DCC.
R-HSA-418890. Role of second messengers in netrin-1 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Netrin receptor DCC
Alternative name(s):
Colorectal cancer suppressor
Immunoglobulin superfamily DCC subclass member 1
Tumor suppressor protein DCC
Gene namesi
Name:DCC
Synonyms:IGDCC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 18

Organism-specific databases

HGNCiHGNC:2701. DCC.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini26 – 1097ExtracellularSequence analysisAdd BLAST1072
Transmembranei1098 – 1122HelicalSequence analysisAdd BLAST25
Topological domaini1123 – 1447CytoplasmicSequence analysisAdd BLAST325

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Involvement in diseasei

Mirror movements 1 (MRMV1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.
See also OMIM:157600

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi1432L → S: Abolishes interaction with MYO10. 1 Publication1
Mutagenesisi1435 – 1436LM → SS: Abolishes interaction with MYO10. 1 Publication2
Mutagenesisi1439L → S: Abolishes interaction with MYO10. 1 Publication1

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi1630.
MalaCardsiDCC.
MIMi157600. phenotype.
OpenTargetsiENSG00000187323.
Orphaneti238722. Familial congenital mirror movements.
PharmGKBiPA27170.

Polymorphism and mutation databases

BioMutaiDCC.
DMDMi296434474.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000001474426 – 1447Netrin receptor DCCAdd BLAST1422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi61 ↔ 117PROSITE-ProRule annotation
Glycosylationi94N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi161 ↔ 212PROSITE-ProRule annotation
Disulfide bondi261 ↔ 310PROSITE-ProRule annotation
Glycosylationi299N-linked (GlcNAc...)Sequence analysis1
Glycosylationi318N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi352 ↔ 400PROSITE-ProRule annotation
Glycosylationi478N-linked (GlcNAc...)Sequence analysis1
Glycosylationi628N-linked (GlcNAc...)Sequence analysis1
Glycosylationi702N-linked (GlcNAc...)Sequence analysis1
Modified residuei1178Phosphoserine; by MAPK1By similarity1
Modified residuei1187Phosphothreonine; by MAPK1By similarity1
Modified residuei1267Phosphoserine; by MAPK1By similarity1

Post-translational modificationi

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.Curated

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiP43146.
PaxDbiP43146.
PeptideAtlasiP43146.
PRIDEiP43146.

PTM databases

iPTMnetiP43146.
PhosphoSitePlusiP43146.
SwissPalmiP43146.

Expressioni

Tissue specificityi

Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.1 Publication

Gene expression databases

BgeeiENSG00000187323.
CleanExiHS_DCC.
ExpressionAtlasiP43146. baseline and differential.
GenevisibleiP43146. HS.

Organism-specific databases

HPAiHPA069552.

Interactioni

Subunit structurei

Interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D. Interacts with DSCAM. Interacts with PTK2/FAK1 and MAPK1. Interacts with NTN1 (By similarity). Interacts with MYO10. Interacts with CBLN4; this interaction can be competed by NTN1 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MAZP562704EBI-1222919,EBI-1809742
MYO10Q9HD677EBI-1222919,EBI-307061
NTN1O956313EBI-1222919,EBI-2678626
RPL28P467793EBI-1222919,EBI-366357
RPL5P467777EBI-1222919,EBI-358018
RPS23P622662EBI-1222919,EBI-353072

Protein-protein interaction databases

BioGridi107998. 39 interactors.
DIPiDIP-38423N.
IntActiP43146. 42 interactors.
STRINGi9606.ENSP00000389140.

Structurei

Secondary structure

11447
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi425 – 428Combined sources4
Beta strandi436 – 440Combined sources5
Beta strandi445 – 448Combined sources4
Beta strandi459 – 470Combined sources12
Beta strandi475 – 478Combined sources4
Beta strandi486 – 489Combined sources4
Beta strandi494 – 500Combined sources7
Beta strandi503 – 508Combined sources6
Beta strandi517 – 520Combined sources4
Beta strandi532 – 537Combined sources6
Beta strandi543 – 549Combined sources7
Beta strandi560 – 567Combined sources8
Turni568 – 570Combined sources3
Beta strandi573 – 578Combined sources6
Beta strandi583 – 587Combined sources5
Beta strandi593 – 601Combined sources9
Beta strandi606 – 609Combined sources4
Beta strandi613 – 616Combined sources4
Beta strandi631 – 635Combined sources5
Beta strandi638 – 642Combined sources5
Turni648 – 650Combined sources3
Beta strandi657 – 668Combined sources12
Beta strandi671 – 674Combined sources4
Beta strandi679 – 684Combined sources6
Beta strandi691 – 694Combined sources4
Beta strandi696 – 699Combined sources4
Beta strandi711 – 714Combined sources4
Beta strandi716 – 719Combined sources4
Beta strandi732 – 736Combined sources5
Beta strandi741 – 745Combined sources5
Beta strandi757 – 766Combined sources10
Beta strandi769 – 775Combined sources7
Beta strandi780 – 783Combined sources4
Beta strandi788 – 800Combined sources13
Beta strandi808 – 810Combined sources3
Beta strandi848 – 854Combined sources7
Beta strandi856 – 858Combined sources3
Beta strandi860 – 865Combined sources6
Beta strandi867 – 869Combined sources3
Beta strandi880 – 889Combined sources10
Beta strandi899 – 907Combined sources9
Beta strandi915 – 924Combined sources10
Beta strandi925 – 927Combined sources3
Beta strandi935 – 938Combined sources4
Beta strandi949 – 955Combined sources7
Beta strandi963 – 968Combined sources6
Beta strandi979 – 986Combined sources8
Beta strandi988 – 990Combined sources3
Beta strandi992 – 995Combined sources4
Beta strandi998 – 1000Combined sources3
Beta strandi1005 – 1009Combined sources5
Beta strandi1017 – 1026Combined sources10
Beta strandi1037 – 1040Combined sources4
Helixi1415 – 1421Combined sources7
Helixi1425 – 1443Combined sources19

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ED7NMR-A419-524[»]
2ED8NMR-A528-620[»]
2ED9NMR-A602-718[»]
2EDBNMR-A716-818[»]
2EDDNMR-A833-942[»]
2EDENMR-A944-1044[»]
3AU4X-ray1.90B1390-1447[»]
4URTX-ray3.10B844-1043[»]
ProteinModelPortaliP43146.
SMRiP43146.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP43146.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 135Ig-like C2-type 1Add BLAST110
Domaini139 – 229Ig-like C2-type 2Add BLAST91
Domaini234 – 326Ig-like C2-type 3Add BLAST93
Domaini331 – 416Ig-like C2-type 4Add BLAST86
Domaini431 – 524Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST94
Domaini530 – 620Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST91
Domaini625 – 718Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST94
Domaini728 – 821Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST94
Domaini846 – 942Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST97
Domaini947 – 1044Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1432 – 1439Interaction with MYO101 Publication8

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. DCC family.Curated
Contains 6 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4221. Eukaryota.
ENOG410Z913. LUCA.
GeneTreeiENSGT00840000129688.
HOGENOMiHOG000230686.
HOVERGENiHBG005455.
InParanoidiP43146.
KOiK06765.
OMAiWGPGESS.
OrthoDBiEOG091G098C.
PhylomeDBiP43146.
TreeFamiTF321506.

Family and domain databases

CDDicd00063. FN3. 6 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR033012. DCC.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR010560. Neogenin_C.
[Graphical view]
PANTHERiPTHR10489:SF68. PTHR10489:SF68. 1 hit.
PfamiPF00041. fn3. 6 hits.
PF07679. I-set. 3 hits.
PF06583. Neogenin_C. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 6 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 6 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43146-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MENSLRCVWV PKLAFVLFGA SLFSAHLQVT GFQIKAFTAL RFLSEPSDAV
60 70 80 90 100
TMRGGNVLLD CSAESDRGVP VIKWKKDGIH LALGMDERKQ QLSNGSLLIQ
110 120 130 140 150
NILHSRHHKP DEGLYQCEAS LGDSGSIISR TAKVAVAGPL RFLSQTESVT
160 170 180 190 200
AFMGDTVLLK CEVIGEPMPT IHWQKNQQDL TPIPGDSRVV VLPSGALQIS
210 220 230 240 250
RLQPGDIGIY RCSARNPASS RTGNEAEVRI LSDPGLHRQL YFLQRPSNVV
260 270 280 290 300
AIEGKDAVLE CCVSGYPPPS FTWLRGEEVI QLRSKKYSLL GGSNLLISNV
310 320 330 340 350
TDDDSGMYTC VVTYKNENIS ASAELTVLVP PWFLNHPSNL YAYESMDIEF
360 370 380 390 400
ECTVSGKPVP TVNWMKNGDV VIPSDYFQIV GGSNLRILGV VKSDEGFYQC
410 420 430 440 450
VAENEAGNAQ TSAQLIVPKP AIPSSSVLPS APRDVVPVLV SSRFVRLSWR
460 470 480 490 500
PPAEAKGNIQ TFTVFFSREG DNRERALNTT QPGSLQLTVG NLKPEAMYTF
510 520 530 540 550
RVVAYNEWGP GESSQPIKVA TQPELQVPGP VENLQAVSTS PTSILITWEP
560 570 580 590 600
PAYANGPVQG YRLFCTEVST GKEQNIEVDG LSYKLEGLKK FTEYSLRFLA
610 620 630 640 650
YNRYGPGVST DDITVVTLSD VPSAPPQNVS LEVVNSRSIK VSWLPPPSGT
660 670 680 690 700
QNGFITGYKI RHRKTTRRGE METLEPNNLW YLFTGLEKGS QYSFQVSAMT
710 720 730 740 750
VNGTGPPSNW YTAETPENDL DESQVPDQPS SLHVRPQTNC IIMSWTPPLN
760 770 780 790 800
PNIVVRGYII GYGVGSPYAE TVRVDSKQRY YSIERLESSS HYVISLKAFN
810 820 830 840 850
NAGEGVPLYE SATTRSITDP TDPVDYYPLL DDFPTSVPDL STPMLPPVGV
860 870 880 890 900
QAVALTHDAV RVSWADNSVP KNQKTSEVRL YTVRWRTSFS ASAKYKSEDT
910 920 930 940 950
TSLSYTATGL KPNTMYEFSV MVTKNRRSST WSMTAHATTY EAAPTSAPKD
960 970 980 990 1000
LTVITREGKP RAVIVSWQPP LEANGKITAY ILFYTLDKNI PIDDWIMETI
1010 1020 1030 1040 1050
SGDRLTHQIM DLNLDTMYYF RIQARNSKGV GPLSDPILFR TLKVEHPDKM
1060 1070 1080 1090 1100
ANDQGRHGDG GYWPVDTNLI DRSTLNEPPI GQMHPPHGSV TPQKNSNLLV
1110 1120 1130 1140 1150
IIVVTVGVIT VLVVVIVAVI CTRRSSAQQR KKRATHSAGK RKGSQKDLRP
1160 1170 1180 1190 1200
PDLWIHHEEM EMKNIEKPSG TDPAGRDSPI QSCQDLTPVS HSQSETQLGS
1210 1220 1230 1240 1250
KSTSHSGQDT EEAGSSMSTL ERSLAARRAP RAKLMIPMDA QSNNPAVVSA
1260 1270 1280 1290 1300
IPVPTLESAQ YPGILPSPTC GYPHPQFTLR PVPFPTLSVD RGFGAGRSQS
1310 1320 1330 1340 1350
VSEGPTTQQP PMLPPSQPEH SSSEEAPSRT IPTACVRPTH PLRSFANPLL
1360 1370 1380 1390 1400
PPPMSAIEPK VPYTPLLSQP GPTLPKTHVK TASLGLAGKA RSPLLPVSVP
1410 1420 1430 1440
TAPEVSEESH KPTEDSANVY EQDDLSEQMA SLEGLMKQLN AITGSAF
Length:1,447
Mass (Da):158,457
Last modified:May 18, 2010 - v2
Checksum:iBC17EA0E93DE8768
GO

Sequence cautioni

The sequence AAA52175 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence AAA52177 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA52179 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAA52180 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti951L → F in CAA53735 (PubMed:7926722).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06025723F → L.2 PublicationsCorresponds to variant rs9951523dbSNPEnsembl.1
Natural variantiVAR_003909168M → T in a esophageal carcinoma. 1 PublicationCorresponds to variant rs121912967dbSNPEnsembl.1
Natural variantiVAR_003910201R → G.1 PublicationCorresponds to variant rs2229080dbSNPEnsembl.1
Natural variantiVAR_060258679L → R.Corresponds to variant rs2271042dbSNPEnsembl.1
Natural variantiVAR_056043759I → M.Corresponds to variant rs2278339dbSNPEnsembl.1
Natural variantiVAR_0244951017M → V.Corresponds to variant rs984274dbSNPEnsembl.1
Natural variantiVAR_0355111039F → S in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0602591191H → L.Corresponds to variant rs2270950dbSNPEnsembl.1
Natural variantiVAR_0039111375P → H in a colorectal carcinoma. 1 PublicationCorresponds to variant rs387906555dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76132 mRNA. Translation: CAA53735.1.
AC011155 Genomic DNA. No translation available.
AC016383 Genomic DNA. No translation available.
AC019239 Genomic DNA. No translation available.
AC021486 Genomic DNA. No translation available.
AC027248 Genomic DNA. No translation available.
AC078999 Genomic DNA. No translation available.
AC090660 Genomic DNA. No translation available.
AC100777 Genomic DNA. No translation available.
AC103949 Genomic DNA. No translation available.
AC110591 Genomic DNA. No translation available.
AC116002 Genomic DNA. No translation available.
M32292 mRNA. Translation: AAA35751.1.
M32286 Genomic DNA. Translation: AAA52174.1.
M32288 Genomic DNA. Translation: AAA52175.1. Sequence problems.
M32290 Genomic DNA. Translation: AAA52176.1.
M63696 Genomic DNA. Translation: AAA52177.1. Different initiation.
M63700 Genomic DNA. Translation: AAA52178.1.
M63702 Genomic DNA. Translation: AAA52179.1. Different initiation.
M63718 Genomic DNA. Translation: AAA52180.1. Different initiation.
M63698 Genomic DNA. Translation: AAA52181.1.
CCDSiCCDS11952.1.
PIRiA54100.
RefSeqiNP_005206.2. NM_005215.3.
UniGeneiHs.162025.

Genome annotation databases

EnsembliENST00000442544; ENSP00000389140; ENSG00000187323.
GeneIDi1630.
KEGGihsa:1630.
UCSCiuc002lfe.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76132 mRNA. Translation: CAA53735.1.
AC011155 Genomic DNA. No translation available.
AC016383 Genomic DNA. No translation available.
AC019239 Genomic DNA. No translation available.
AC021486 Genomic DNA. No translation available.
AC027248 Genomic DNA. No translation available.
AC078999 Genomic DNA. No translation available.
AC090660 Genomic DNA. No translation available.
AC100777 Genomic DNA. No translation available.
AC103949 Genomic DNA. No translation available.
AC110591 Genomic DNA. No translation available.
AC116002 Genomic DNA. No translation available.
M32292 mRNA. Translation: AAA35751.1.
M32286 Genomic DNA. Translation: AAA52174.1.
M32288 Genomic DNA. Translation: AAA52175.1. Sequence problems.
M32290 Genomic DNA. Translation: AAA52176.1.
M63696 Genomic DNA. Translation: AAA52177.1. Different initiation.
M63700 Genomic DNA. Translation: AAA52178.1.
M63702 Genomic DNA. Translation: AAA52179.1. Different initiation.
M63718 Genomic DNA. Translation: AAA52180.1. Different initiation.
M63698 Genomic DNA. Translation: AAA52181.1.
CCDSiCCDS11952.1.
PIRiA54100.
RefSeqiNP_005206.2. NM_005215.3.
UniGeneiHs.162025.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2ED7NMR-A419-524[»]
2ED8NMR-A528-620[»]
2ED9NMR-A602-718[»]
2EDBNMR-A716-818[»]
2EDDNMR-A833-942[»]
2EDENMR-A944-1044[»]
3AU4X-ray1.90B1390-1447[»]
4URTX-ray3.10B844-1043[»]
ProteinModelPortaliP43146.
SMRiP43146.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107998. 39 interactors.
DIPiDIP-38423N.
IntActiP43146. 42 interactors.
STRINGi9606.ENSP00000389140.

PTM databases

iPTMnetiP43146.
PhosphoSitePlusiP43146.
SwissPalmiP43146.

Polymorphism and mutation databases

BioMutaiDCC.
DMDMi296434474.

Proteomic databases

MaxQBiP43146.
PaxDbiP43146.
PeptideAtlasiP43146.
PRIDEiP43146.

Protocols and materials databases

DNASUi1630.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000442544; ENSP00000389140; ENSG00000187323.
GeneIDi1630.
KEGGihsa:1630.
UCSCiuc002lfe.3. human.

Organism-specific databases

CTDi1630.
DisGeNETi1630.
GeneCardsiDCC.
H-InvDBHIX0039754.
HGNCiHGNC:2701. DCC.
HPAiHPA069552.
MalaCardsiDCC.
MIMi120470. gene.
157600. phenotype.
neXtProtiNX_P43146.
OpenTargetsiENSG00000187323.
Orphaneti238722. Familial congenital mirror movements.
PharmGKBiPA27170.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4221. Eukaryota.
ENOG410Z913. LUCA.
GeneTreeiENSGT00840000129688.
HOGENOMiHOG000230686.
HOVERGENiHBG005455.
InParanoidiP43146.
KOiK06765.
OMAiWGPGESS.
OrthoDBiEOG091G098C.
PhylomeDBiP43146.
TreeFamiTF321506.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172155-MONOMER.
ReactomeiR-HSA-373752. Netrin-1 signaling.
R-HSA-376172. DSCAM interactions.
R-HSA-418885. DCC mediated attractive signaling.
R-HSA-418886. Netrin mediated repulsion signals.
R-HSA-418889. Ligand-independent caspase activation via DCC.
R-HSA-418890. Role of second messengers in netrin-1 signaling.

Miscellaneous databases

ChiTaRSiDCC. human.
EvolutionaryTraceiP43146.
GeneWikiiDeleted_in_Colorectal_Cancer.
GenomeRNAii1630.
PROiP43146.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187323.
CleanExiHS_DCC.
ExpressionAtlasiP43146. baseline and differential.
GenevisibleiP43146. HS.

Family and domain databases

CDDicd00063. FN3. 6 hits.
Gene3Di2.60.40.10. 10 hits.
InterProiIPR033012. DCC.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR010560. Neogenin_C.
[Graphical view]
PANTHERiPTHR10489:SF68. PTHR10489:SF68. 1 hit.
PfamiPF00041. fn3. 6 hits.
PF07679. I-set. 3 hits.
PF06583. Neogenin_C. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 6 hits.
SM00409. IG. 5 hits.
SM00408. IGc2. 4 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 4 hits.
SSF49265. SSF49265. 4 hits.
PROSITEiPS50853. FN3. 6 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDCC_HUMAN
AccessioniPrimary (citable) accession number: P43146
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 170 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Inactivation of DCC due to allelic deletion and/or point mutations is related to lymphatic and hematogenous metastatic tumor dissemination.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.