P43146 (DCC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Netrin receptor DCC

Alternative name(s):
Colorectal cancer suppressor
Immunoglobulin superfamily DCC subclass member 1
Tumor suppressor protein DCC

Gene names

Name:	DCC
Synonyms:	IGDCC1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1447 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene. Ref.6 Ref.12
Subunit structure	Interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D. Interacts with DSCAM. Interacts with PTK2/FAK1 By similarity. Ref.7
Subcellular location	Membrane; Single-pass type I membrane protein.
Tissue specificity	Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells. Ref.1
Post-translational modification	Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation Probable. Ref.7
Involvement in disease	Defects in DCC are the cause of congenital mirror movements (MIMOC) [MIM:157600]. Mirror movements are contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. Ref.10
Miscellaneous	Inactivation of DCC due to allelic deletion and/or point mutations is related to lymphatic and hematogenous metastatic tumor dissemination.
Sequence similarities	Belongs to the immunoglobulin superfamily. DCC family. Contains 6 fibronectin type-III domains. Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
Sequence caution	The sequence AAA52175.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAA52177.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAA52179.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence AAA52180.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Apoptosis
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Disease	Tumor suppressor
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Developmental protein Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein Ubl conjugation
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	apoptotic process Traceable author statement. Source: Reactome axon guidance Traceable author statement. Source: Reactome induction of apoptosis Traceable author statement. Source: ProtInc negative regulation of collateral sprouting Traceable author statement. Source: BHF-UCL negative regulation of dendrite development Traceable author statement. Source: BHF-UCL
Cellular component	cytosol Traceable author statement. Source: Reactome integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
MAZ	P56270	4	EBI-1222919,EBI-1809742
RPL28	P46779	3	EBI-1222919,EBI-366357
RPL5	P46777	7	EBI-1222919,EBI-358018
RPS23	P62266	2	EBI-1222919,EBI-353072

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 25

25

Potential

Chain

26 – 1447

1422

Netrin receptor DCC

PRO_0000014744

Regions

Topological domain

26 – 1097

1072

Extracellular Potential

Transmembrane

1098 – 1122

25

Helical; Potential

Topological domain

1123 – 1447

325

Cytoplasmic Potential

Domain

26 – 135

110

Ig-like C2-type 1

Domain

139 – 229

91

Ig-like C2-type 2

Domain

234 – 326

93

Ig-like C2-type 3

Domain

331 – 416

86

Ig-like C2-type 4

Domain

429 – 520

92

Fibronectin type-III 1

Domain

528 – 616

89

Fibronectin type-III 2

Domain

622 – 714

93

Fibronectin type-III 3

Domain

726 – 814

89

Fibronectin type-III 4

Domain

843 – 939

97

Fibronectin type-III 5

Domain

944 – 1041

98

Fibronectin type-III 6

Amino acid modifications

Modified residue

868

1

Phosphoserine Ref.9

Modified residue

1073

1

Phosphoserine Ref.8

Modified residue

1074

1

Phosphothreonine Ref.8

Glycosylation

94

1

N-linked (GlcNAc...) Potential

Glycosylation

299

1

N-linked (GlcNAc...) Potential

Glycosylation

318

1

N-linked (GlcNAc...) Potential

Glycosylation

478

1

N-linked (GlcNAc...) Potential

Glycosylation

628

1

N-linked (GlcNAc...) Potential

Glycosylation

702

1

N-linked (GlcNAc...) Potential

Disulfide bond

61 ↔ 117

By similarity

Disulfide bond

161 ↔ 212

By similarity

Disulfide bond

261 ↔ 310

By similarity

Disulfide bond

352 ↔ 400

By similarity

Natural variations

Natural variant

23

1

F → L. Ref.1 Ref.3
Corresponds to variant rs9951523 [ dbSNP | Ensembl ].

VAR_060257

Natural variant

168

1

M → T in a esophageal carcinoma. Ref.12

VAR_003909

Natural variant

201

1

R → G. Ref.12
Corresponds to variant rs2229080 [ dbSNP | Ensembl ].

VAR_003910

Natural variant

679

1

L → R.
Corresponds to variant rs2271042 [ dbSNP | Ensembl ].

VAR_060258

Natural variant

759

1

I → M.
Corresponds to variant rs2278339 [ dbSNP | Ensembl ].

VAR_056043

Natural variant

1017

1

M → V.
Corresponds to variant rs984274 [ dbSNP | Ensembl ].

VAR_024495

Natural variant

1039

1

F → S in a colorectal cancer sample; somatic mutation. Ref.13

VAR_035511

Natural variant

1191

1

H → L.
Corresponds to variant rs2270950 [ dbSNP | Ensembl ].

VAR_060259

Natural variant

1375

1

P → H in a colorectal carcinoma. Ref.5

VAR_003911

Experimental info

Sequence conflict

951

1

L → F in CAA53735. Ref.1

Secondary structure

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1447

Helix Strand Turn

Details...

Beta strand

425 – 428

4

Beta strand

436 – 440

5

Beta strand

445 – 448

4

Beta strand

459 – 470

12

Beta strand

475 – 478

4

Beta strand

486 – 489

4

Beta strand

494 – 500

7

Beta strand

503 – 508

6

Beta strand

517 – 520

4

Beta strand

532 – 537

6

Beta strand

543 – 549

7

Beta strand

560 – 567

8

Turn

568 – 570

3

Beta strand

573 – 578

6

Beta strand

583 – 587

5

Beta strand

593 – 601

9

Beta strand

606 – 609

4

Beta strand

613 – 616

4

Beta strand

631 – 635

5

Beta strand

638 – 642

5

Turn

648 – 650

3

Beta strand

657 – 668

12

Beta strand

671 – 674

4

Beta strand

679 – 684

6

Beta strand

691 – 694

4

Beta strand

696 – 699

4

Beta strand

711 – 714

4

Beta strand

732 – 736

5

Beta strand

741 – 745

5

Beta strand

757 – 766

10

Beta strand

769 – 775

7

Beta strand

780 – 783

4

Beta strand

788 – 800

13

Beta strand

808 – 810

3

Beta strand

848 – 856

9

Beta strand

859 – 865

7

Beta strand

867 – 869

3

Beta strand

881 – 887

7

Beta strand

898 – 909

12

Beta strand

915 – 922

8

Beta strand

925 – 927

3

Beta strand

935 – 938

4

Beta strand

949 – 955

7

Beta strand

963 – 968

6

Beta strand

978 – 986

9

Beta strand

988 – 990

3

Turn

992 – 994

3

Beta strand

995 – 1001

7

Beta strand

1006 – 1009

4

Beta strand

1017 – 1025

9

Beta strand

1037 – 1040

4

Sequences

	Sequence		Length	Mass (Da)
	P43146 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: BC17EA0E93DE8768	FASTA	1,447	158,457
	10 20 30 40 50 60 MENSLRCVWV PKLAFVLFGA SLFSAHLQVT GFQIKAFTAL RFLSEPSDAV TMRGGNVLLD 70 80 90 100 110 120 CSAESDRGVP VIKWKKDGIH LALGMDERKQ QLSNGSLLIQ NILHSRHHKP DEGLYQCEAS 130 140 150 160 170 180 LGDSGSIISR TAKVAVAGPL RFLSQTESVT AFMGDTVLLK CEVIGEPMPT IHWQKNQQDL 190 200 210 220 230 240 TPIPGDSRVV VLPSGALQIS RLQPGDIGIY RCSARNPASS RTGNEAEVRI LSDPGLHRQL 250 260 270 280 290 300 YFLQRPSNVV AIEGKDAVLE CCVSGYPPPS FTWLRGEEVI QLRSKKYSLL GGSNLLISNV 310 320 330 340 350 360 TDDDSGMYTC VVTYKNENIS ASAELTVLVP PWFLNHPSNL YAYESMDIEF ECTVSGKPVP 370 380 390 400 410 420 TVNWMKNGDV VIPSDYFQIV GGSNLRILGV VKSDEGFYQC VAENEAGNAQ TSAQLIVPKP 430 440 450 460 470 480 AIPSSSVLPS APRDVVPVLV SSRFVRLSWR PPAEAKGNIQ TFTVFFSREG DNRERALNTT 490 500 510 520 530 540 QPGSLQLTVG NLKPEAMYTF RVVAYNEWGP GESSQPIKVA TQPELQVPGP VENLQAVSTS 550 560 570 580 590 600 PTSILITWEP PAYANGPVQG YRLFCTEVST GKEQNIEVDG LSYKLEGLKK FTEYSLRFLA 610 620 630 640 650 660 YNRYGPGVST DDITVVTLSD VPSAPPQNVS LEVVNSRSIK VSWLPPPSGT QNGFITGYKI 670 680 690 700 710 720 RHRKTTRRGE METLEPNNLW YLFTGLEKGS QYSFQVSAMT VNGTGPPSNW YTAETPENDL 730 740 750 760 770 780 DESQVPDQPS SLHVRPQTNC IIMSWTPPLN PNIVVRGYII GYGVGSPYAE TVRVDSKQRY 790 800 810 820 830 840 YSIERLESSS HYVISLKAFN NAGEGVPLYE SATTRSITDP TDPVDYYPLL DDFPTSVPDL 850 860 870 880 890 900 STPMLPPVGV QAVALTHDAV RVSWADNSVP KNQKTSEVRL YTVRWRTSFS ASAKYKSEDT 910 920 930 940 950 960 TSLSYTATGL KPNTMYEFSV MVTKNRRSST WSMTAHATTY EAAPTSAPKD LTVITREGKP 970 980 990 1000 1010 1020 RAVIVSWQPP LEANGKITAY ILFYTLDKNI PIDDWIMETI SGDRLTHQIM DLNLDTMYYF 1030 1040 1050 1060 1070 1080 RIQARNSKGV GPLSDPILFR TLKVEHPDKM ANDQGRHGDG GYWPVDTNLI DRSTLNEPPI 1090 1100 1110 1120 1130 1140 GQMHPPHGSV TPQKNSNLLV IIVVTVGVIT VLVVVIVAVI CTRRSSAQQR KKRATHSAGK 1150 1160 1170 1180 1190 1200 RKGSQKDLRP PDLWIHHEEM EMKNIEKPSG TDPAGRDSPI QSCQDLTPVS HSQSETQLGS 1210 1220 1230 1240 1250 1260 KSTSHSGQDT EEAGSSMSTL ERSLAARRAP RAKLMIPMDA QSNNPAVVSA IPVPTLESAQ 1270 1280 1290 1300 1310 1320 YPGILPSPTC GYPHPQFTLR PVPFPTLSVD RGFGAGRSQS VSEGPTTQQP PMLPPSQPEH 1330 1340 1350 1360 1370 1380 SSSEEAPSRT IPTACVRPTH PLRSFANPLL PPPMSAIEPK VPYTPLLSQP GPTLPKTHVK 1390 1400 1410 1420 1430 1440 TASLGLAGKA RSPLLPVSVP TAPEVSEESH KPTEDSANVY EQDDLSEQMA SLEGLMKQLN AITGSAF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DCC gene product in cellular differentiation and colorectal tumorigenesis." Hedrick L., Cho K.R., Fearon E.R., Wu T.-C., Kinzler K.W., Vogelstein B. Genes Dev. 8:1174-1183(1994) [PubMed: 7926722] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT LEU-23.
[2]	"DNA sequence and analysis of human chromosome 18." Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J. , Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L., Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A., Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C., Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K., Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R., Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S. Nature 437:551-555(2005) [PubMed: 16177791] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"Identification of a chromosome 18q gene that is altered in colorectal cancers." Fearon E.R., Cho K.R., Nigro J.M., Kern S.E., Simons J.W., Ruppert J.M., Hamilton S.R., Preisinger A.C., Thomas G., Kinzler K.W., Vogelstein B. Science 247:49-56(1990) [PubMed: 2294591] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-750, VARIANT LEU-23.
[4]	"Scrambled exons." Nigro J.M., Cho K.R., Fearon E.R., Kern S.E., Ruppert J.M., Oliner J.D., Kinzler K.W., Vogelstein B. Cell 64:607-613(1991) [PubMed: 1991322] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 107-472.
[5]	"The DCC gene: structural analysis and mutations in colorectal carcinomas." Cho K.R., Oliner J.D., Simons J.W., Hedrick L., Fearon E.R., Preisinger A.C., Hedge P., Silverman G.A., Vogelstein B. Genomics 19:525-531(1994) [PubMed: 8188295] [Abstract] Cited for: GENE STRUCTURE, VARIANT HIS-1375.
[6]	"Deleted in Colorectal Cancer (DCC) encodes a netrin receptor." Keino-Masu K., Masu M., Hinck L., Leonardo E.D., Chan S.S.-Y., Culotti J.G., Tessier-Lavigne M. Cell 87:175-185(1996) [PubMed: 8861902] [Abstract] Cited for: FUNCTION.
[7]	"Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway." Hu G., Zhang S., Vidal M., Baer J.L., Xu T., Fearon E.R. Genes Dev. 11:2701-2714(1997) [PubMed: 9334332] [Abstract] Cited for: INTERACTION WITH SIAH1 AND SIAH2, DEGRADATION.
[8]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1073 AND THR-1074, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[9]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-868, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[10]	"Mutations in DCC cause congenital mirror movements." Srour M., Riviere J.B., Pham J.M., Dube M.P., Girard S., Morin S., Dion P.A., Asselin G., Rochefort D., Hince P., Diab S., Sharafaddinzadeh N., Chouinard S., Theoret H., Charron F., Rouleau G.A. Science 328:592-592(2010) [PubMed: 20431009] [Abstract] Cited for: INVOLVEMENT IN MIMOC.
[11]	"Solution structure of the fibronectin type III domains of human netrin receptor DCC." RIKEN structural genomics initiative (RSGI) Submitted (MAR-2008) to the PDB data bank Cited for: STRUCTURE BY NMR OF 419-1047.
[12]	"Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis." Miyake S., Nagai K., Yoshino K., Oto M., Endo M., Yuasa Y. Cancer Res. 54:3007-3010(1994) [PubMed: 8187090] [Abstract] Cited for: VARIANTS THR-168 AND GLY-201, ROLE IN METASTATIC TUMOR DISSEMINATION.
[13]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-1039.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X76132 mRNA. Translation: CAA53735.1.
AC011155 Genomic DNA. No translation available.
AC016383 Genomic DNA. No translation available.
AC019239 Genomic DNA. No translation available.
AC021486 Genomic DNA. No translation available.
AC027248 Genomic DNA. No translation available.
AC078999 Genomic DNA. No translation available.
AC090660 Genomic DNA. No translation available.
AC100777 Genomic DNA. No translation available.
AC103949 Genomic DNA. No translation available.
AC110591 Genomic DNA. No translation available.
AC116002 Genomic DNA. No translation available.
M32292 mRNA. Translation: AAA35751.1.
M32286 Genomic DNA. Translation: AAA52174.1.
M32288 Genomic DNA. Translation: AAA52175.1. Sequence problems.
M32290 Genomic DNA. Translation: AAA52176.1.
M63696 Genomic DNA. Translation: AAA52177.1. Different initiation.
M63700 Genomic DNA. Translation: AAA52178.1.
M63702 Genomic DNA. Translation: AAA52179.1. Different initiation.
M63718 Genomic DNA. Translation: AAA52180.1. Different initiation.
M63698 Genomic DNA. Translation: AAA52181.1.

IPI

IPI00016422.

PIR

A54100.

RefSeq

NP_005206.2. NM_005215.3.

UniGene

Hs.162025.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2ED7	NMR	-	A	419-524	[»]
2ED8	NMR	-	A	528-620	[»]
2ED9	NMR	-	A	602-718	[»]
2EDB	NMR	-	A	716-818	[»]
2EDD	NMR	-	A	833-942	[»]
2EDE	NMR	-	A	944-1044	[»]
3AU4	X-ray	1.90	B	1390-1447	[»]

ProteinModelPortal

P43146.

SMR

P43146. Positions 7-1047, 1414-1445.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-38423N.

IntAct

P43146. 26 interactions.

STRING

P43146.

PTM databases

PhosphoSite

P43146.

Polymorphism databases

DMDM

296434474.

Proteomic databases

PRIDE

P43146.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000442544; ENSP00000389140; ENSG00000187323.

GeneID

1630.

KEGG

hsa:1630.

UCSC

uc002lfe.1. human.

Organism-specific databases

CTD

1630.

GeneCards

GC18P049802.

H-InvDB

HIX0039754.

HGNC

HGNC:2701. DCC.

HPA

CAB002311.

MIM

120470. gene.
157600. phenotype.

neXtProt

NX_P43146.

Orphanet

238722. Familial congenital mirror movements.

PharmGKB

PA27170.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG16468.

HOGENOM

HBG358293.

HOVERGEN

HBG005455.

InParanoid

P43146.

OMA

LVPPWFL.

OrthoDB

EOG4WM4SV.

PhylomeDB

P43146.

Enzyme and pathway databases

Reactome

REACT_111045. Developmental Biology.
REACT_111155. Cell-Cell communication.
REACT_578. Apoptosis.

Gene expression databases

ArrayExpress

P43146.

Bgee

P43146.

CleanEx

HS_DCC.

Genevestigator

P43146.

GermOnline

ENSG00000187323. Homo sapiens.

Family and domain databases

InterPro

IPR003961. Fibronectin_type3.
IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR010560. Neogenin_C.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 10 hits.

KO

K06765.

Pfam

PF00041. fn3. 6 hits.
PF07679. I-set. 3 hits.
PF06583. Neogenin_C. 1 hit.
[Graphical view]

SMART

SM00060. FN3. 6 hits.
SM00409. IG. 1 hit.
SM00408. IGc2. 3 hits.
[Graphical view]

SUPFAM

SSF49265. FN_III-like. 6 hits.

PROSITE

PS50853. FN3. 6 hits.
PS50835. IG_LIKE. 4 hits.
[Graphical view]

ProtoNet

Search...

Other

NextBio

6688.

SOURCE

Search...

Entry information

Entry name

DCC_HUMAN

Accession

Primary (citable) accession number: P43146

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	May 18, 2010
Last modified:	January 25, 2012
This is version 122 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.