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P43146

- DCC_HUMAN

UniProt

P43146 - DCC_HUMAN

Protein

Netrin receptor DCC

Gene

DCC

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 147 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.2 Publications

    GO - Molecular functioni

    1. netrin receptor activity Source: Ensembl
    2. protein binding Source: UniProtKB
    3. transcription coactivator activity Source: Ensembl
    4. transmembrane signaling receptor activity Source: ProtInc

    GO - Biological processi

    1. anterior/posterior axon guidance Source: Ensembl
    2. apoptotic process Source: Reactome
    3. axon guidance Source: Reactome
    4. axonogenesis Source: ProtInc
    5. dorsal/ventral axon guidance Source: Ensembl
    6. negative regulation of collateral sprouting Source: BHF-UCL
    7. negative regulation of dendrite development Source: BHF-UCL
    8. negative regulation of neuron projection development Source: BHF-UCL
    9. neuron migration Source: Ensembl
    10. positive regulation of apoptotic process Source: Reactome
    11. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    12. positive regulation of neuron projection development Source: Ensembl
    13. regulation of apoptotic process Source: Reactome
    14. response to amphetamine Source: Ensembl
    15. spinal cord ventral commissure morphogenesis Source: Ensembl

    Keywords - Molecular functioni

    Developmental protein, Receptor

    Keywords - Biological processi

    Apoptosis

    Enzyme and pathway databases

    ReactomeiREACT_22128. Role of DCC in regulating apoptosis.
    REACT_22228. Role of second messengers in netrin-1 signaling.
    REACT_22237. Netrin-1 signaling.
    REACT_22351. DCC mediated attractive signaling.
    REACT_22384. Netrin mediated repulsion signals.
    REACT_25299. DSCAM interactions.

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Netrin receptor DCC
    Alternative name(s):
    Colorectal cancer suppressor
    Immunoglobulin superfamily DCC subclass member 1
    Tumor suppressor protein DCC
    Gene namesi
    Name:DCC
    Synonyms:IGDCC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 18

    Organism-specific databases

    HGNCiHGNC:2701. DCC.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cytosol Source: Reactome
    3. growth cone membrane Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW
    5. membrane raft Source: Ensembl
    6. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Mirror movements 1 (MRMV1) [MIM:157600]: A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi1432 – 14321L → S: Abolishes interaction with MYO10. 1 Publication
    Mutagenesisi1435 – 14362LM → SS: Abolishes interaction with MYO10.
    Mutagenesisi1439 – 14391L → S: Abolishes interaction with MYO10. 1 Publication

    Keywords - Diseasei

    Tumor suppressor

    Organism-specific databases

    MIMi157600. phenotype.
    Orphaneti238722. Familial congenital mirror movements.
    PharmGKBiPA27170.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 14471422Netrin receptor DCCPRO_0000014744Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi61 ↔ 117PROSITE-ProRule annotation
    Glycosylationi94 – 941N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi161 ↔ 212PROSITE-ProRule annotation
    Disulfide bondi261 ↔ 310PROSITE-ProRule annotation
    Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi318 – 3181N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi352 ↔ 400PROSITE-ProRule annotation
    Glycosylationi478 – 4781N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi628 – 6281N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi702 – 7021N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1178 – 11781Phosphoserine; by MAPK1By similarity
    Modified residuei1187 – 11871Phosphothreonine; by MAPK1By similarity
    Modified residuei1267 – 12671Phosphoserine; by MAPK1By similarity

    Post-translational modificationi

    Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.Curated

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiP43146.
    PRIDEiP43146.

    PTM databases

    PhosphoSiteiP43146.

    Expressioni

    Tissue specificityi

    Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.1 Publication

    Gene expression databases

    ArrayExpressiP43146.
    BgeeiP43146.
    CleanExiHS_DCC.
    GenevestigatoriP43146.

    Organism-specific databases

    HPAiCAB002311.

    Interactioni

    Subunit structurei

    Interacts with the cytoplasmic part of UNC5A, UNC5B, UNC5C and probably UNC5D. Interacts with DSCAM. Interacts with PTK2/FAK1 and MAPK1. Interacts with NTN1 By similarity. Interacts with MYO10. Interacts with CBLN4; this interaction can be competed by NTN1 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MAZP562704EBI-1222919,EBI-1809742
    MYO10Q9HD677EBI-1222919,EBI-307061
    RPL28P467793EBI-1222919,EBI-366357
    RPL5P467777EBI-1222919,EBI-358018
    RPS23P622662EBI-1222919,EBI-353072

    Protein-protein interaction databases

    BioGridi107998. 41 interactions.
    DIPiDIP-38423N.
    IntActiP43146. 28 interactions.
    STRINGi9606.ENSP00000389140.

    Structurei

    Secondary structure

    1
    1447
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi425 – 4284
    Beta strandi436 – 4405
    Beta strandi445 – 4484
    Beta strandi459 – 47012
    Beta strandi475 – 4784
    Beta strandi486 – 4894
    Beta strandi494 – 5007
    Beta strandi503 – 5086
    Beta strandi517 – 5204
    Beta strandi532 – 5376
    Beta strandi543 – 5497
    Beta strandi560 – 5678
    Turni568 – 5703
    Beta strandi573 – 5786
    Beta strandi583 – 5875
    Beta strandi593 – 6019
    Beta strandi606 – 6094
    Beta strandi613 – 6164
    Beta strandi631 – 6355
    Beta strandi638 – 6425
    Turni648 – 6503
    Beta strandi657 – 66812
    Beta strandi671 – 6744
    Beta strandi679 – 6846
    Beta strandi691 – 6944
    Beta strandi696 – 6994
    Beta strandi711 – 7144
    Beta strandi716 – 7194
    Beta strandi732 – 7365
    Beta strandi741 – 7455
    Beta strandi757 – 76610
    Beta strandi769 – 7757
    Beta strandi780 – 7834
    Beta strandi788 – 80013
    Beta strandi808 – 8103
    Beta strandi848 – 8569
    Beta strandi859 – 8657
    Beta strandi867 – 8693
    Beta strandi881 – 8877
    Beta strandi898 – 90912
    Beta strandi915 – 9228
    Beta strandi925 – 9273
    Beta strandi935 – 9384
    Beta strandi949 – 9557
    Beta strandi963 – 9686
    Beta strandi978 – 9869
    Beta strandi988 – 9903
    Turni992 – 9943
    Beta strandi995 – 10017
    Beta strandi1006 – 10094
    Beta strandi1017 – 10259
    Beta strandi1037 – 10404
    Helixi1415 – 14217
    Helixi1425 – 144319

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2ED7NMR-A419-524[»]
    2ED8NMR-A528-620[»]
    2ED9NMR-A602-718[»]
    2EDBNMR-A716-818[»]
    2EDDNMR-A833-942[»]
    2EDENMR-A944-1044[»]
    3AU4X-ray1.90B1390-1447[»]
    ProteinModelPortaliP43146.
    SMRiP43146. Positions 39-818, 833-1047, 1414-1445.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP43146.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini26 – 10971072ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1123 – 1447325CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1098 – 112225HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 135110Ig-like C2-type 1Add
    BLAST
    Domaini139 – 22991Ig-like C2-type 2Add
    BLAST
    Domaini234 – 32693Ig-like C2-type 3Add
    BLAST
    Domaini331 – 41686Ig-like C2-type 4Add
    BLAST
    Domaini431 – 52494Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini530 – 62091Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini625 – 71894Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini728 – 82194Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini846 – 94297Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini947 – 104498Fibronectin type-III 6PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1432 – 14398Interaction with MYO10

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily. DCC family.Curated
    Contains 6 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249790.
    HOGENOMiHOG000230686.
    HOVERGENiHBG005455.
    InParanoidiP43146.
    KOiK06765.
    OMAiWGPGESS.
    OrthoDBiEOG7RRF65.
    PhylomeDBiP43146.
    TreeFamiTF321506.

    Family and domain databases

    Gene3Di2.60.40.10. 10 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR010560. Neogenin_C.
    [Graphical view]
    PfamiPF00041. fn3. 6 hits.
    PF07679. I-set. 3 hits.
    PF06583. Neogenin_C. 1 hit.
    [Graphical view]
    SMARTiSM00060. FN3. 6 hits.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 3 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 4 hits.
    PROSITEiPS50853. FN3. 6 hits.
    PS50835. IG_LIKE. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P43146-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENSLRCVWV PKLAFVLFGA SLFSAHLQVT GFQIKAFTAL RFLSEPSDAV     50
    TMRGGNVLLD CSAESDRGVP VIKWKKDGIH LALGMDERKQ QLSNGSLLIQ 100
    NILHSRHHKP DEGLYQCEAS LGDSGSIISR TAKVAVAGPL RFLSQTESVT 150
    AFMGDTVLLK CEVIGEPMPT IHWQKNQQDL TPIPGDSRVV VLPSGALQIS 200
    RLQPGDIGIY RCSARNPASS RTGNEAEVRI LSDPGLHRQL YFLQRPSNVV 250
    AIEGKDAVLE CCVSGYPPPS FTWLRGEEVI QLRSKKYSLL GGSNLLISNV 300
    TDDDSGMYTC VVTYKNENIS ASAELTVLVP PWFLNHPSNL YAYESMDIEF 350
    ECTVSGKPVP TVNWMKNGDV VIPSDYFQIV GGSNLRILGV VKSDEGFYQC 400
    VAENEAGNAQ TSAQLIVPKP AIPSSSVLPS APRDVVPVLV SSRFVRLSWR 450
    PPAEAKGNIQ TFTVFFSREG DNRERALNTT QPGSLQLTVG NLKPEAMYTF 500
    RVVAYNEWGP GESSQPIKVA TQPELQVPGP VENLQAVSTS PTSILITWEP 550
    PAYANGPVQG YRLFCTEVST GKEQNIEVDG LSYKLEGLKK FTEYSLRFLA 600
    YNRYGPGVST DDITVVTLSD VPSAPPQNVS LEVVNSRSIK VSWLPPPSGT 650
    QNGFITGYKI RHRKTTRRGE METLEPNNLW YLFTGLEKGS QYSFQVSAMT 700
    VNGTGPPSNW YTAETPENDL DESQVPDQPS SLHVRPQTNC IIMSWTPPLN 750
    PNIVVRGYII GYGVGSPYAE TVRVDSKQRY YSIERLESSS HYVISLKAFN 800
    NAGEGVPLYE SATTRSITDP TDPVDYYPLL DDFPTSVPDL STPMLPPVGV 850
    QAVALTHDAV RVSWADNSVP KNQKTSEVRL YTVRWRTSFS ASAKYKSEDT 900
    TSLSYTATGL KPNTMYEFSV MVTKNRRSST WSMTAHATTY EAAPTSAPKD 950
    LTVITREGKP RAVIVSWQPP LEANGKITAY ILFYTLDKNI PIDDWIMETI 1000
    SGDRLTHQIM DLNLDTMYYF RIQARNSKGV GPLSDPILFR TLKVEHPDKM 1050
    ANDQGRHGDG GYWPVDTNLI DRSTLNEPPI GQMHPPHGSV TPQKNSNLLV 1100
    IIVVTVGVIT VLVVVIVAVI CTRRSSAQQR KKRATHSAGK RKGSQKDLRP 1150
    PDLWIHHEEM EMKNIEKPSG TDPAGRDSPI QSCQDLTPVS HSQSETQLGS 1200
    KSTSHSGQDT EEAGSSMSTL ERSLAARRAP RAKLMIPMDA QSNNPAVVSA 1250
    IPVPTLESAQ YPGILPSPTC GYPHPQFTLR PVPFPTLSVD RGFGAGRSQS 1300
    VSEGPTTQQP PMLPPSQPEH SSSEEAPSRT IPTACVRPTH PLRSFANPLL 1350
    PPPMSAIEPK VPYTPLLSQP GPTLPKTHVK TASLGLAGKA RSPLLPVSVP 1400
    TAPEVSEESH KPTEDSANVY EQDDLSEQMA SLEGLMKQLN AITGSAF 1447
    Length:1,447
    Mass (Da):158,457
    Last modified:May 18, 2010 - v2
    Checksum:iBC17EA0E93DE8768
    GO

    Sequence cautioni

    The sequence AAA52177.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAA52179.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAA52180.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence AAA52175.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti951 – 9511L → F in CAA53735. (PubMed:7926722)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti23 – 231F → L.2 Publications
    Corresponds to variant rs9951523 [ dbSNP | Ensembl ].
    VAR_060257
    Natural varianti168 – 1681M → T in a esophageal carcinoma. 1 Publication
    VAR_003909
    Natural varianti201 – 2011R → G.1 Publication
    Corresponds to variant rs2229080 [ dbSNP | Ensembl ].
    VAR_003910
    Natural varianti679 – 6791L → R.
    Corresponds to variant rs2271042 [ dbSNP | Ensembl ].
    VAR_060258
    Natural varianti759 – 7591I → M.
    Corresponds to variant rs2278339 [ dbSNP | Ensembl ].
    VAR_056043
    Natural varianti1017 – 10171M → V.
    Corresponds to variant rs984274 [ dbSNP | Ensembl ].
    VAR_024495
    Natural varianti1039 – 10391F → S in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035511
    Natural varianti1191 – 11911H → L.
    Corresponds to variant rs2270950 [ dbSNP | Ensembl ].
    VAR_060259
    Natural varianti1375 – 13751P → H in a colorectal carcinoma. 1 Publication
    VAR_003911

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76132 mRNA. Translation: CAA53735.1.
    AC011155 Genomic DNA. No translation available.
    AC016383 Genomic DNA. No translation available.
    AC019239 Genomic DNA. No translation available.
    AC021486 Genomic DNA. No translation available.
    AC027248 Genomic DNA. No translation available.
    AC078999 Genomic DNA. No translation available.
    AC090660 Genomic DNA. No translation available.
    AC100777 Genomic DNA. No translation available.
    AC103949 Genomic DNA. No translation available.
    AC110591 Genomic DNA. No translation available.
    AC116002 Genomic DNA. No translation available.
    M32292 mRNA. Translation: AAA35751.1.
    M32286 Genomic DNA. Translation: AAA52174.1.
    M32288 Genomic DNA. Translation: AAA52175.1. Sequence problems.
    M32290 Genomic DNA. Translation: AAA52176.1.
    M63696 Genomic DNA. Translation: AAA52177.1. Different initiation.
    M63700 Genomic DNA. Translation: AAA52178.1.
    M63702 Genomic DNA. Translation: AAA52179.1. Different initiation.
    M63718 Genomic DNA. Translation: AAA52180.1. Different initiation.
    M63698 Genomic DNA. Translation: AAA52181.1.
    CCDSiCCDS11952.1.
    PIRiA54100.
    RefSeqiNP_005206.2. NM_005215.3.
    XP_005258261.1. XM_005258204.1.
    UniGeneiHs.162025.

    Genome annotation databases

    EnsembliENST00000442544; ENSP00000389140; ENSG00000187323.
    GeneIDi1630.
    KEGGihsa:1630.
    UCSCiuc002lfe.2. human.

    Polymorphism databases

    DMDMi296434474.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76132 mRNA. Translation: CAA53735.1 .
    AC011155 Genomic DNA. No translation available.
    AC016383 Genomic DNA. No translation available.
    AC019239 Genomic DNA. No translation available.
    AC021486 Genomic DNA. No translation available.
    AC027248 Genomic DNA. No translation available.
    AC078999 Genomic DNA. No translation available.
    AC090660 Genomic DNA. No translation available.
    AC100777 Genomic DNA. No translation available.
    AC103949 Genomic DNA. No translation available.
    AC110591 Genomic DNA. No translation available.
    AC116002 Genomic DNA. No translation available.
    M32292 mRNA. Translation: AAA35751.1 .
    M32286 Genomic DNA. Translation: AAA52174.1 .
    M32288 Genomic DNA. Translation: AAA52175.1 . Sequence problems.
    M32290 Genomic DNA. Translation: AAA52176.1 .
    M63696 Genomic DNA. Translation: AAA52177.1 . Different initiation.
    M63700 Genomic DNA. Translation: AAA52178.1 .
    M63702 Genomic DNA. Translation: AAA52179.1 . Different initiation.
    M63718 Genomic DNA. Translation: AAA52180.1 . Different initiation.
    M63698 Genomic DNA. Translation: AAA52181.1 .
    CCDSi CCDS11952.1.
    PIRi A54100.
    RefSeqi NP_005206.2. NM_005215.3.
    XP_005258261.1. XM_005258204.1.
    UniGenei Hs.162025.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2ED7 NMR - A 419-524 [» ]
    2ED8 NMR - A 528-620 [» ]
    2ED9 NMR - A 602-718 [» ]
    2EDB NMR - A 716-818 [» ]
    2EDD NMR - A 833-942 [» ]
    2EDE NMR - A 944-1044 [» ]
    3AU4 X-ray 1.90 B 1390-1447 [» ]
    ProteinModelPortali P43146.
    SMRi P43146. Positions 39-818, 833-1047, 1414-1445.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107998. 41 interactions.
    DIPi DIP-38423N.
    IntActi P43146. 28 interactions.
    STRINGi 9606.ENSP00000389140.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei P43146.

    Polymorphism databases

    DMDMi 296434474.

    Proteomic databases

    PaxDbi P43146.
    PRIDEi P43146.

    Protocols and materials databases

    DNASUi 1630.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000442544 ; ENSP00000389140 ; ENSG00000187323 .
    GeneIDi 1630.
    KEGGi hsa:1630.
    UCSCi uc002lfe.2. human.

    Organism-specific databases

    CTDi 1630.
    GeneCardsi GC18P049802.
    H-InvDB HIX0039754.
    HGNCi HGNC:2701. DCC.
    HPAi CAB002311.
    MIMi 120470. gene.
    157600. phenotype.
    neXtProti NX_P43146.
    Orphaneti 238722. Familial congenital mirror movements.
    PharmGKBi PA27170.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG249790.
    HOGENOMi HOG000230686.
    HOVERGENi HBG005455.
    InParanoidi P43146.
    KOi K06765.
    OMAi WGPGESS.
    OrthoDBi EOG7RRF65.
    PhylomeDBi P43146.
    TreeFami TF321506.

    Enzyme and pathway databases

    Reactomei REACT_22128. Role of DCC in regulating apoptosis.
    REACT_22228. Role of second messengers in netrin-1 signaling.
    REACT_22237. Netrin-1 signaling.
    REACT_22351. DCC mediated attractive signaling.
    REACT_22384. Netrin mediated repulsion signals.
    REACT_25299. DSCAM interactions.

    Miscellaneous databases

    EvolutionaryTracei P43146.
    GeneWikii Deleted_in_Colorectal_Cancer.
    GenomeRNAii 1630.
    NextBioi 6688.
    PROi P43146.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P43146.
    Bgeei P43146.
    CleanExi HS_DCC.
    Genevestigatori P43146.

    Family and domain databases

    Gene3Di 2.60.40.10. 10 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR010560. Neogenin_C.
    [Graphical view ]
    Pfami PF00041. fn3. 6 hits.
    PF07679. I-set. 3 hits.
    PF06583. Neogenin_C. 1 hit.
    [Graphical view ]
    SMARTi SM00060. FN3. 6 hits.
    SM00409. IG. 1 hit.
    SM00408. IGc2. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 4 hits.
    PROSITEi PS50853. FN3. 6 hits.
    PS50835. IG_LIKE. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The DCC gene product in cellular differentiation and colorectal tumorigenesis."
      Hedrick L., Cho K.R., Fearon E.R., Wu T.-C., Kinzler K.W., Vogelstein B.
      Genes Dev. 8:1174-1183(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, VARIANT LEU-23.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-750, VARIANT LEU-23.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 107-472.
    5. "The DCC gene: structural analysis and mutations in colorectal carcinomas."
      Cho K.R., Oliner J.D., Simons J.W., Hedrick L., Fearon E.R., Preisinger A.C., Hedge P., Silverman G.A., Vogelstein B.
      Genomics 19:525-531(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE STRUCTURE, VARIANT HIS-1375.
    6. Cited for: FUNCTION.
    7. "Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway."
      Hu G., Zhang S., Vidal M., Baer J.L., Xu T., Fearon E.R.
      Genes Dev. 11:2701-2714(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SIAH1 AND SIAH2, DEGRADATION.
    8. Cited for: INVOLVEMENT IN MRMV1.
    9. "Solution structure of the fibronectin type III domains of human netrin receptor DCC."
      RIKEN structural genomics initiative (RSGI)
      Submitted (MAR-2008) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 419-1047.
    10. "Structural basis of cargo recognition by the myosin-X MyTH4-FERM domain."
      Hirano Y., Hatano T., Takahashi A., Toriyama M., Inagaki N., Hakoshima T.
      EMBO J. 30:2734-2747(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 1390-1447 IN COMPLEX WITH MYO10, INTERACTION WITH MYO10, MUTAGENESIS OF LEU-1432; 1435-LEU-MET-1436 AND LEU-1439.
    11. "Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis."
      Miyake S., Nagai K., Yoshino K., Oto M., Endo M., Yuasa Y.
      Cancer Res. 54:3007-3010(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS THR-168 AND GLY-201, ROLE IN METASTATIC TUMOR DISSEMINATION.
    12. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-1039.

    Entry informationi

    Entry nameiDCC_HUMAN
    AccessioniPrimary (citable) accession number: P43146
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 147 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Inactivation of DCC due to allelic deletion and/or point mutations is related to lymphatic and hematogenous metastatic tumor dissemination.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 18
      Human chromosome 18: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3