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Protein

ADM

Gene

Adm

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

AM and PAMP are potent hypotensive and vasodilatator agents.

GO - Molecular functioni

  • adrenomedullin receptor binding Source: RGD
  • hormone activity Source: UniProtKB-KW

GO - Biological processi

  • aging Source: RGD
  • amylin receptor signaling pathway Source: Ensembl
  • androgen metabolic process Source: RGD
  • animal organ regeneration Source: RGD
  • branching involved in labyrinthine layer morphogenesis Source: Ensembl
  • calcium ion homeostasis Source: RGD
  • cAMP biosynthetic process Source: Ensembl
  • cAMP-mediated signaling Source: RGD
  • developmental growth Source: Ensembl
  • female pregnancy Source: RGD
  • G-protein coupled receptor internalization Source: Ensembl
  • heart development Source: Ensembl
  • hormone secretion Source: RGD
  • negative regulation of cell proliferation Source: RGD
  • negative regulation of vascular permeability Source: Ensembl
  • negative regulation of vasoconstriction Source: Ensembl
  • neural tube closure Source: Ensembl
  • neuron projection regeneration Source: RGD
  • odontogenesis of dentin-containing tooth Source: RGD
  • positive regulation of angiogenesis Source: Ensembl
  • positive regulation of apoptotic process Source: RGD
  • positive regulation of blood vessel diameter Source: RGD
  • positive regulation of cAMP biosynthetic process Source: Ensembl
  • positive regulation of cell proliferation Source: Ensembl
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of heart rate Source: RGD
  • positive regulation of vasculogenesis Source: Ensembl
  • regulation of systemic arterial blood pressure Source: Ensembl
  • regulation of the force of heart contraction Source: RGD
  • regulation of urine volume Source: Ensembl
  • response to cold Source: RGD
  • response to glucocorticoid Source: RGD
  • response to hypoxia Source: RGD
  • response to insulin Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to organic substance Source: RGD
  • response to starvation Source: RGD
  • response to wounding Source: RGD
  • spongiotrophoblast layer development Source: Ensembl
  • vascular smooth muscle cell development Source: Ensembl
  • vasculogenesis Source: Ensembl

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-RNO-418555. G alpha (s) signalling events.
R-RNO-419812. Calcitonin-like ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
ADM
Cleaved into the following 2 chains:
Adrenomedullin
Short name:
AM
Alternative name(s):
ProAM N-terminal 20 peptide
Short name:
PAMP
Short name:
ProAM-N20
Gene namesi
Name:Adm
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi2047. Adm.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
PeptideiPRO_000000097322 – 41Proadrenomedullin N-20 terminal peptide1 PublicationAdd BLAST20
PropeptideiPRO_000000097445 – 911 PublicationAdd BLAST47
PeptideiPRO_000000097594 – 143Adrenomedullin1 PublicationAdd BLAST50
PropeptideiPRO_0000000976150 – 185PreproAM C-terminal fragment1 PublicationAdd BLAST36

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41Arginine amide1 Publication1
Disulfide bondi107 ↔ 112By similarity
Modified residuei143Tyrosine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP43145.

PTM databases

iPTMnetiP43145.
PhosphoSitePlusiP43145.

Expressioni

Tissue specificityi

Expressed in adrenal glands, lung, kidney, heart, spleen, duodenum and submandibular glands.

Gene expression databases

BgeeiENSRNOG00000027030.
GenevisibleiP43145. RN.

Interactioni

GO - Molecular functioni

  • adrenomedullin receptor binding Source: RGD
  • hormone activity Source: UniProtKB-KW

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000035811.

Structurei

3D structure databases

SMRiP43145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adrenomedullin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IK4C. Eukaryota.
ENOG41120TV. LUCA.
GeneTreeiENSGT00390000000451.
HOGENOMiHOG000033821.
HOVERGENiHBG004181.
InParanoidiP43145.
KOiK12333.
OMAiRNKISPQ.
OrthoDBiEOG091G0QFI.
PhylomeDBiP43145.
TreeFamiTF333447.

Family and domain databases

InterProiView protein in InterPro
IPR001710. Adrenomedullin.
IPR021116. Calcitonin/adrenomedullin.
PfamiView protein in Pfam
PF00214. Calc_CGRP_IAPP. 1 hit.
PRINTSiPR00801. ADRENOMEDULN.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43145-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVSIALML LGSLAVLGAD TARLDTSSQF RKKWNKWALS RGKRELQASS
60 70 80 90 100
SYPTGLVDEK TVPTQTLGLQ DKQSTSSTPQ ASTQSTAHIR VKRYRQSMNQ
110 120 130 140 150
GSRSTGCRFG TCTMQKLAHQ IYQFTDKDKD GMAPRNKISP QGYGRRRRRS
160 170 180
LPEVLRARTV ESSQEQTHSA PASPAHQDIS RVSRL
Length:185
Mass (Da):20,636
Last modified:November 1, 1995 - v1
Checksum:i35CAD9A9DD19AE35
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D15069 mRNA. Translation: BAA03665.1.
U15419 mRNA. Translation: AAB60519.1.
BC061775 mRNA. Translation: AAH61775.1.
PIRiJN0766.
RefSeqiNP_036847.1. NM_012715.1.
XP_008757909.1. XM_008759687.2.
UniGeneiRn.10232.

Genome annotation databases

EnsembliENSRNOT00000036718; ENSRNOP00000035811; ENSRNOG00000027030.
GeneIDi25026.
KEGGirno:25026.
UCSCiRGD:2047. rat.

Similar proteinsi

Entry informationi

Entry nameiADML_RAT
AccessioniPrimary (citable) accession number: P43145
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: August 30, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families