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P43143 (ACHA6_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Neuronal acetylcholine receptor subunit alpha-6
Gene names
Name:Chrna6
Synonyms:Acra6
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length493 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Subunit structure

Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta).

Subcellular location

Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Alpha-6/CHRNA6 sub-subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3030 By similarity
Chain31 – 493463Neuronal acetylcholine receptor subunit alpha-6
PRO_0000000363

Regions

Topological domain31 – 240210Extracellular Potential
Transmembrane241 – 26525Helical; Potential
Transmembrane272 – 29019Helical; Potential
Transmembrane306 – 32722Helical; Potential
Topological domain328 – 464137Cytoplasmic Potential
Transmembrane465 – 48420Helical; Potential

Amino acid modifications

Glycosylation541N-linked (GlcNAc...) Potential
Glycosylation1711N-linked (GlcNAc...) Potential
Disulfide bond158 ↔ 172 By similarity
Disulfide bond222 ↔ 223Associated with receptor activation By similarity

Sequences

Sequence LengthMass (Da)Tools
P43143 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: A829FAF8FFB060FE

FASTA49356,947
        10         20         30         40         50         60 
MLNGWGRGDL RSGLCLWICG FLAFFKGSRG CVSEEQLFHT LFAHYNRFIR PVENVSDPVT 

        70         80         90        100        110        120 
VHFELAITQL ANVDEVNQIM ETNLWLRHVW KDYRLCWDPT EYDGIETLRV PADNIWKPDI 

       130        140        150        160        170        180 
VLYNNAVGDF QVEGKTKALL KYDGVITWTP PAIFKSSCPM DITFFPFDHQ NCSLKFGSWT 

       190        200        210        220        230        240 
YDKAEIDLLI IGSKVDMNDF WENSEWEIVD ASGYKHDIKY NCCEEIYTDI TYSFYIRRLP 

       250        260        270        280        290        300 
MFYTINLIIP CLFISFLTVL VFYLPSDCGE KVTLCISVLL SLTVFLLVIT ETIPSTSLVI 

       310        320        330        340        350        360 
PLVGEYLLFT MIFVTLSIVV TVFVLNIHYR TPATHTMPKW VKTMFLQVFP SILMMRRPLD 

       370        380        390        400        410        420 
KTKEMDGVKD PKTHTKRPAK VKFTHRKEPK LLKECRHCHK SSEIAPGKRL SQQPAQWVTE 

       430        440        450        460        470        480 
NSEHPPDVED VIDSVQFIAE NMKSHNETKE VEDDWKYMAM VVDRVFLWVF IIVCVFGTVG 

       490 
LFLQPLLGNT GAS

« Hide

References

[1]"Nucleotide sequence of a cDNA clone encoding the rat neuronal nicotinic acetylcholine receptor subunit gene alpha6."
Boulter J.
Submitted (DEC-1992) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L08227 mRNA. Translation: AAA41674.1.
IPIIPI00197477.
RefSeqNP_476532.1. NM_057184.1.
UniGeneRn.9696.

3D structure databases

ProteinModelPortalP43143.
SMRP43143. Positions 240-331.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000016452.

Proteomic databases

PRIDEP43143.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID81721.
KEGGrno:81721.
UCSCRGD:69281. rat.

Organism-specific databases

CTD8973.
RGD69281. Chrna6.

Phylogenomic databases

eggNOGNOG290206.
HOGENOMHOG000006756.
HOVERGENHBG003756.
InParanoidP43143.
KOK04808.
OrthoDBEOG45B1FG.

Gene expression databases

ArrayExpressP43143.
GenevestigatorP43143.
GermOnlineENSRNOG00000012283. Rattus norvegicus.

Family and domain databases

Gene3D2.70.170.10. 1 hit.
InterProIPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERPTHR18945. PTHR18945. 1 hit.
PfamPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMSSF90112. Neu_channel_TM. 1 hit.
SSF63712. Neur_chan_LBD. 1 hit.
TIGRFAMsTIGR00860. LIC. 1 hit.
PROSITEPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

BindingDBP43143.
ChEMBLCHEMBL4747.
NextBio615368.

Entry information

Entry nameACHA6_RAT
AccessionPrimary (citable) accession number: P43143
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 3, 2013
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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