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Protein

Neuronal acetylcholine receptor subunit alpha-6

Gene

Chrna6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal acetylcholine receptor subunit alpha-6
Gene namesi
Name:Chrna6
Synonyms:Acra6
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi69281. Chrna6.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 240210ExtracellularSequence analysisAdd
BLAST
Transmembranei241 – 26525HelicalSequence analysisAdd
BLAST
Transmembranei272 – 29019HelicalSequence analysisAdd
BLAST
Transmembranei306 – 32722HelicalSequence analysisAdd
BLAST
Topological domaini328 – 464137CytoplasmicSequence analysisAdd
BLAST
Transmembranei465 – 48420HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

  • acetylcholine-gated channel complex Source: RGD
  • cell junction Source: UniProtKB-KW
  • membrane Source: RGD
  • postsynaptic membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL3137275.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030By similarityAdd
BLAST
Chaini31 – 493463Neuronal acetylcholine receptor subunit alpha-6PRO_0000000363Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi54 – 541N-linked (GlcNAc...)Sequence analysis
Disulfide bondi158 ↔ 172By similarity
Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence analysis
Disulfide bondi222 ↔ 223Associated with receptor activationBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43143.
PRIDEiP43143.

Interactioni

Subunit structurei

Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta).

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016452.

Chemistry

BindingDBiP43143.

Structurei

3D structure databases

ProteinModelPortaliP43143.
SMRiP43143. Positions 240-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3644. Eukaryota.
ENOG410XP43. LUCA.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiP43143.
KOiK04808.
PhylomeDBiP43143.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43143-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNGWGRGDL RSGLCLWICG FLAFFKGSRG CVSEEQLFHT LFAHYNRFIR
60 70 80 90 100
PVENVSDPVT VHFELAITQL ANVDEVNQIM ETNLWLRHVW KDYRLCWDPT
110 120 130 140 150
EYDGIETLRV PADNIWKPDI VLYNNAVGDF QVEGKTKALL KYDGVITWTP
160 170 180 190 200
PAIFKSSCPM DITFFPFDHQ NCSLKFGSWT YDKAEIDLLI IGSKVDMNDF
210 220 230 240 250
WENSEWEIVD ASGYKHDIKY NCCEEIYTDI TYSFYIRRLP MFYTINLIIP
260 270 280 290 300
CLFISFLTVL VFYLPSDCGE KVTLCISVLL SLTVFLLVIT ETIPSTSLVI
310 320 330 340 350
PLVGEYLLFT MIFVTLSIVV TVFVLNIHYR TPATHTMPKW VKTMFLQVFP
360 370 380 390 400
SILMMRRPLD KTKEMDGVKD PKTHTKRPAK VKFTHRKEPK LLKECRHCHK
410 420 430 440 450
SSEIAPGKRL SQQPAQWVTE NSEHPPDVED VIDSVQFIAE NMKSHNETKE
460 470 480 490
VEDDWKYMAM VVDRVFLWVF IIVCVFGTVG LFLQPLLGNT GAS
Length:493
Mass (Da):56,947
Last modified:November 1, 1995 - v1
Checksum:iA829FAF8FFB060FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08227 mRNA. Translation: AAA41674.1.
RefSeqiNP_476532.1. NM_057184.1.
UniGeneiRn.9696.

Genome annotation databases

GeneIDi81721.
KEGGirno:81721.
UCSCiRGD:69281. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08227 mRNA. Translation: AAA41674.1.
RefSeqiNP_476532.1. NM_057184.1.
UniGeneiRn.9696.

3D structure databases

ProteinModelPortaliP43143.
SMRiP43143. Positions 240-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000016452.

Chemistry

BindingDBiP43143.
ChEMBLiCHEMBL3137275.

Proteomic databases

PaxDbiP43143.
PRIDEiP43143.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi81721.
KEGGirno:81721.
UCSCiRGD:69281. rat.

Organism-specific databases

CTDi8973.
RGDi69281. Chrna6.

Phylogenomic databases

eggNOGiKOG3644. Eukaryota.
ENOG410XP43. LUCA.
HOGENOMiHOG000006756.
HOVERGENiHBG003756.
InParanoidiP43143.
KOiK04808.
PhylomeDBiP43143.

Miscellaneous databases

PROiP43143.

Family and domain databases

Gene3Di1.20.120.370. 2 hits.
2.70.170.10. 1 hit.
InterProiIPR027361. Acetylcholine_rcpt_TM.
IPR006202. Neur_chan_lig-bd.
IPR006201. Neur_channel.
IPR006029. Neurotrans-gated_channel_TM.
IPR018000. Neurotransmitter_ion_chnl_CS.
IPR002394. Nicotinic_acetylcholine_rcpt.
[Graphical view]
PANTHERiPTHR18945. PTHR18945. 2 hits.
PfamiPF02931. Neur_chan_LBD. 1 hit.
PF02932. Neur_chan_memb. 1 hit.
[Graphical view]
PRINTSiPR00254. NICOTINICR.
PR00252. NRIONCHANNEL.
SUPFAMiSSF63712. SSF63712. 1 hit.
SSF90112. SSF90112. 1 hit.
TIGRFAMsiTIGR00860. LIC. 1 hit.
PROSITEiPS00236. NEUROTR_ION_CHANNEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACHA6_RAT
AccessioniPrimary (citable) accession number: P43143
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.