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Protein

G-protein coupled receptor 182

Gene

Gpr182

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 182
Alternative name(s):
G10D
NOW
Gene namesi
Name:Gpr182
Synonyms:Admr, Gpcr22
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:109545. Gpr182.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5353ExtracellularSequence analysisAdd
BLAST
Transmembranei54 – 7522Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini76 – 8611CytoplasmicSequence analysisAdd
BLAST
Transmembranei87 – 10923Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini110 – 12314ExtracellularSequence analysisAdd
BLAST
Transmembranei124 – 14522Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini146 – 16621CytoplasmicSequence analysisAdd
BLAST
Transmembranei167 – 18923Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini190 – 21324ExtracellularSequence analysisAdd
BLAST
Transmembranei214 – 23522Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini236 – 25419CytoplasmicSequence analysisAdd
BLAST
Transmembranei255 – 27622Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini277 – 29519ExtracellularSequence analysisAdd
BLAST
Transmembranei296 – 31621Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini317 – 39579CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 395395G-protein coupled receptor 182PRO_0000069113Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi24 – 241N-linked (GlcNAc...)Sequence analysis
Glycosylationi33 – 331N-linked (GlcNAc...)Sequence analysis
Disulfide bondi122 ↔ 198PROSITE-ProRule annotation
Modified residuei329 – 3291PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP43142.
PRIDEiP43142.

PTM databases

PhosphoSiteiP43142.

Expressioni

Tissue specificityi

Expressed in liver and lung.

Gene expression databases

CleanExiMM_GPR182.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100882.

Structurei

3D structure databases

ProteinModelPortaliP43142.
SMRiP43142. Positions 39-334.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIEW. Eukaryota.
ENOG4111H1T. LUCA.
HOGENOMiHOG000220818.
HOVERGENiHBG097691.
InParanoidiP43142.
PhylomeDBiP43142.

Family and domain databases

InterProiIPR001350. G10D_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00643. G10DORPHANR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVIPSPRPV STLEPDNDFR DIHNWTELLH LFNQTFTDCH IEFNENTKHV
60 70 80 90 100
VLFVFYLAIF VVGLVENVLV ICVNCRRSGR VGMLNLYILN MAIADLGIIL
110 120 130 140 150
SLPVWMLEVM LEYTWLWGSF SCRFIHYFYL VNMYSSIFFL TCLSIDRYVT
160 170 180 190 200
LTNTSPSWQR HQHRIRRAVC AGVWVLSAII PLPEVVHIQL LDGSEPMCLF
210 220 230 240 250
LAPFETYSAW ALAVALSATI LGFLLPFLLI AVFNILTACR LRRQRQTESR
260 270 280 290 300
RHCLLMWAYI VVFAICWLPY QVTMLLLTLH GTHIFLHCHL VNLLYFFYEI
310 320 330 340 350
IDCFSMLHCV ANPILYNFLS PSFRGRLLSL VVRYLPKEQA RAAGGRASSS
360 370 380 390
SSTQHSIIIT KEGSLPLQRI STPTPSETFR RPLRLQTPHL HSAIL
Length:395
Mass (Da):45,497
Last modified:November 1, 1995 - v1
Checksum:i879EB108982F1710
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17292 mRNA. Translation: BAA04125.1.
L20338 mRNA. Translation: AAA16849.1.
PIRiI48909.
UniGeneiMm.2857.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D17292 mRNA. Translation: BAA04125.1.
L20338 mRNA. Translation: AAA16849.1.
PIRiI48909.
UniGeneiMm.2857.

3D structure databases

ProteinModelPortaliP43142.
SMRiP43142. Positions 39-334.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100882.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP43142.

Proteomic databases

PaxDbiP43142.
PRIDEiP43142.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:109545. Gpr182.

Phylogenomic databases

eggNOGiENOG410IIEW. Eukaryota.
ENOG4111H1T. LUCA.
HOGENOMiHOG000220818.
HOVERGENiHBG097691.
InParanoidiP43142.
PhylomeDBiP43142.

Miscellaneous databases

PROiP43142.
SOURCEiSearch...

Gene expression databases

CleanExiMM_GPR182.

Family and domain databases

InterProiIPR001350. G10D_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00643. G10DORPHANR.
PR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Saeki Y., Ueno S., Nagai Y., Yanagihara T.
    Submitted (JUN-1993) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/cJ.
    Tissue: Brain.
  2. "Identification, chromosomal location, and genome organization of mammalian G-protein-coupled receptors."
    Wilkie T.M., Chen Y., Gilbert D.J., Moore K.J., Yu L., Simon M.I., Copeland N.G., Jenkins N.A.
    Genomics 18:175-184(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 149-262.
    Tissue: Testis.

Entry informationi

Entry nameiGP182_MOUSE
AccessioniPrimary (citable) accession number: P43142
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 11, 2016
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.