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Protein

Alpha-1A adrenergic receptor

Gene

Adra1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes (By similarity).By similarity

GO - Molecular functioni

  • alpha1-adrenergic receptor activity Source: RGD
  • protein heterodimerization activity Source: UniProtKB

GO - Biological processi

  • activation of phospholipase C activity Source: RGD
  • adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
  • adult heart development Source: Ensembl
  • aging Source: RGD
  • calcium ion transport into cytosol Source: BHF-UCL
  • cell growth involved in cardiac muscle cell development Source: Ensembl
  • micturition Source: RGD
  • negative regulation of autophagy Source: Ensembl
  • negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure Source: Ensembl
  • negative regulation of Rho protein signal transduction Source: MGI
  • norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure Source: GO_Central
  • phospholipase C-activating G-protein coupled receptor signaling pathway Source: GO_Central
  • pilomotor reflex Source: Ensembl
  • positive regulation of action potential Source: RGD
  • positive regulation of cardiac muscle contraction Source: BHF-UCL
  • positive regulation of cardiac muscle hypertrophy Source: Ensembl
  • positive regulation of cytosolic calcium ion concentration Source: RGD
  • positive regulation of ERK1 and ERK2 cascade Source: BHF-UCL
  • positive regulation of heart rate Source: RGD
  • positive regulation of heart rate by epinephrine-norepinephrine Source: Ensembl
  • positive regulation of MAPK cascade Source: UniProtKB
  • positive regulation of non-membrane spanning protein tyrosine kinase activity Source: Ensembl
  • positive regulation of protein kinase C signaling Source: RGD
  • positive regulation of smooth muscle contraction Source: RGD
  • positive regulation of synaptic transmission, GABAergic Source: RGD
  • positive regulation of systemic arterial blood pressure Source: RGD
  • positive regulation of the force of heart contraction by epinephrine-norepinephrine Source: Ensembl
  • positive regulation of vasoconstriction Source: RGD
  • response to drug Source: RGD
  • response to hormone Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-390696 Adrenoceptors
R-RNO-416476 G alpha (q) signalling events
R-RNO-416482 G alpha (12/13) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-1A adrenergic receptor
Alternative name(s):
Alpha-1A adrenoreceptor
Short name:
Alpha-1A adrenoceptor
Alpha-1C adrenergic receptor
Gene namesi
Name:Adra1a
Synonyms:Adra1c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi2055 Adra1a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 27ExtracellularBy similarityAdd BLAST27
Transmembranei28 – 51Helical; Name=1By similarityAdd BLAST24
Topological domaini52 – 64CytoplasmicBy similarityAdd BLAST13
Transmembranei65 – 88Helical; Name=2By similarityAdd BLAST24
Topological domaini89 – 99ExtracellularBy similarityAdd BLAST11
Transmembranei100 – 122Helical; Name=3By similarityAdd BLAST23
Topological domaini123 – 143CytoplasmicBy similarityAdd BLAST21
Transmembranei144 – 167Helical; Name=4By similarityAdd BLAST24
Topological domaini168 – 181ExtracellularBy similarityAdd BLAST14
Transmembranei182 – 205Helical; Name=5By similarityAdd BLAST24
Topological domaini206 – 273CytoplasmicBy similarityAdd BLAST68
Transmembranei274 – 297Helical; Name=6By similarityAdd BLAST24
Topological domaini298 – 305ExtracellularBy similarity8
Transmembranei306 – 329Helical; Name=7By similarityAdd BLAST24
Topological domaini330 – 466CytoplasmicBy similarityAdd BLAST137

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL319
GuidetoPHARMACOLOGYi22

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690661 – 466Alpha-1A adrenergic receptorAdd BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi22N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi99 ↔ 176PROSITE-ProRule annotation
Modified residuei215Phosphoserine; by PKASequence analysis1
Lipidationi345S-palmitoyl cysteineSequence analysis1

Post-translational modificationi

C-terminal Ser or Thr residues may be phosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDbiP43140

PTM databases

PhosphoSitePlusiP43140

Expressioni

Tissue specificityi

Abundant in heart, brain, aorta, vena cava, vas deferens, submaxillary gland, lung, and kidney. Found at lower levels in prostate, parotid gland and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSRNOG00000009522
GenevisibleiP43140 RN

Interactioni

Subunit structurei

Homo- and heterooligomer. Heterooligomerizes with ADRA1B homooligomers in cardiac myocytes. Interacts with CAVIN4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000012736

Chemistry databases

BindingDBiP43140

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2F75model-A1-466[»]
ProteinModelPortaliP43140
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi334 – 349Nuclear localization signalBy similarityAdd BLAST16

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1A sub-subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
HOGENOMiHOG000239244
HOVERGENiHBG106962
InParanoidiP43140
KOiK04135
OMAiEILGYWA
OrthoDBiEOG091G06VI
PhylomeDBiP43140
TreeFamiTF331895

Family and domain databases

InterProiView protein in InterPro
IPR002233 ADR_fam
IPR001004 ADRA1A_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR01103 ADRENERGICR
PR00557 ADRENRGCA1AR
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P43140-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLLSENASE GSNCTHPPAP VNISKAILLG VILGGLIIFG VLGNILVILS
60 70 80 90 100
VACHRHLHSV THYYIVNLAV ADLLLTSTVL PFSAIFEILG YWAFGRVFCN
110 120 130 140 150
IWAAVDVLCC TASIMGLCII SIDRYIGVSY PLRYPTIVTQ RRGVRALLCV
160 170 180 190 200
WVLSLVISIG PLFGWRQPAP EDETICQINE EPGYVLFSAL GSFYVPLAII
210 220 230 240 250
LVMYCRVYVV AKRESRGLKS GLKTDKSDSE QVTLRIHRKN VPAEGGGVSS
260 270 280 290 300
AKNKTHFSVR LLKFSREKKA AKTLGIVVGC FVLCWLPFFL VMPIGSFFPD
310 320 330 340 350
FKPSETVFKI VFWLGYLNSC INPIIYPCSS QEFKKAFQNV LRIQCLRRRQ
360 370 380 390 400
SSKHALGYTL HPPSQALEGQ HRDMVRIPVG SGETFYKISK TDGVCEWKFF
410 420 430 440 450
SSMPQGSARI TVPKDQSACT TARVRSKSFL QVCCCVGSSA PRPEENHQVP
460
TIKIHTISLG ENGEEV
Length:466
Mass (Da):51,598
Last modified:November 1, 1995 - v1
Checksum:i4962D3A72E971A36
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39F → L in AAA52103 (PubMed:7923624).Curated1
Sequence conflicti67N → G in AAA52103 (PubMed:7923624).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13368 mRNA Translation: AAA52103.1
U07126 mRNA Translation: AAA62866.1
PIRiI57959
RefSeqiNP_058887.2, NM_017191.2
XP_006252169.1, XM_006252107.3
XP_008768966.1, XM_008770744.2
UniGeneiRn.9991

Genome annotation databases

EnsembliENSRNOT00000012736; ENSRNOP00000012736; ENSRNOG00000009522
GeneIDi29412
KEGGirno:29412
UCSCiRGD:2055 rat

Entry informationi

Entry nameiADA1A_RAT
AccessioniPrimary (citable) accession number: P43140
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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