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Protein

Lithostathine-1

Gene

Reg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Might act as an inhibitor of spontaneous calcium carbonate precipitation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Lithostathine-1
Alternative name(s):
Islet of Langerhans regenerating protein 1
Short name:
REG 1
Pancreatic stone protein 1
Short name:
PSP
Pancreatic thread protein 1
Short name:
PTP
Regenerating protein 1
Gene namesi
Name:Reg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:97895 Reg1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001742622 – 165Lithostathine-1Add BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi35 ↔ 46PROSITE-ProRule annotation
Disulfide bondi63 ↔ 161PROSITE-ProRule annotation
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi136 ↔ 153PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43137
PeptideAtlasiP43137
PRIDEiP43137

PTM databases

iPTMnetiP43137
PhosphoSitePlusiP43137

Expressioni

Tissue specificityi

Expressed only in regenerating islets and normal exocrine pancreas, but not in normal pancreatic islets. Expressed strongly in pancreas, moderately in gall bladder, and weakly in liver.

Gene expression databases

BgeeiENSMUSG00000059654
CleanExiMM_REG1
ExpressionAtlasiP43137 baseline and differential
GenevisibleiP43137 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi2028485 interactors.
STRINGi10090.ENSMUSP00000078847

Structurei

3D structure databases

ProteinModelPortaliP43137
SMRiP43137
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 163C-type lectinPROSITE-ProRule annotationAdd BLAST131

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104249
HOGENOMiHOG000010281
HOVERGENiHBG004151
InParanoidiP43137
OMAiAHECVAY
OrthoDBiEOG091G0OLC
PhylomeDBiP43137

Family and domain databases

Gene3Di3.10.100.101 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43137-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARNAYFILL SCLIVLSPSQ GQEAEEDLPS ARISCPEGSN AYSSYCYYFT
60 70 80 90 100
EDRLTWADAD LFCQNMNSGY LVSVLSQAEG NFVASLIKES GTTDANVWTG
110 120 130 140 150
LHDPKRNRRW HWSSGSLFLY KSWATGSPNS SNRGYCVSLT SNTGYKKWKD
160
DNCDAQYSFV CKFKG
Length:165
Mass (Da):18,519
Last modified:November 1, 1995 - v1
Checksum:i2950174AF5D666BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14010 Genomic DNA Translation: BAA03111.1
BC028761 mRNA Translation: AAH28761.1
CCDSiCCDS20257.1
PIRiA47148
RefSeqiNP_033068.1, NM_009042.1
UniGeneiMm.142731

Genome annotation databases

EnsembliENSMUST00000079926; ENSMUSP00000078847; ENSMUSG00000059654
ENSMUST00000204601; ENSMUSP00000144840; ENSMUSG00000059654
ENSMUST00000204687; ENSMUSP00000145161; ENSMUSG00000059654
GeneIDi19692
KEGGimmu:19692
UCSCiuc009cka.1 mouse

Similar proteinsi

Entry informationi

Entry nameiLIT1_MOUSE
AccessioniPrimary (citable) accession number: P43137
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome