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Protein

Lithostathine-1

Gene

Reg1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Might act as an inhibitor of spontaneous calcium carbonate precipitation.

GO - Molecular functioni

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Lithostathine-1
Alternative name(s):
Islet of Langerhans regenerating protein 1
Short name:
REG 1
Pancreatic stone protein 1
Short name:
PSP
Pancreatic thread protein 1
Short name:
PTP
Regenerating protein 1
Gene namesi
Name:Reg1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:97895. Reg1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001742622 – 165Lithostathine-1Add BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi35 ↔ 46PROSITE-ProRule annotation
Disulfide bondi63 ↔ 161PROSITE-ProRule annotation
Glycosylationi129N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi136 ↔ 153PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP43137.
PeptideAtlasiP43137.
PRIDEiP43137.

PTM databases

iPTMnetiP43137.
PhosphoSitePlusiP43137.

Expressioni

Tissue specificityi

Expressed only in regenerating islets and normal exocrine pancreas, but not in normal pancreatic islets. Expressed strongly in pancreas, moderately in gall bladder, and weakly in liver.

Gene expression databases

BgeeiENSMUSG00000059654.
CleanExiMM_REG1.
ExpressionAtlasiP43137. baseline and differential.
GenevisibleiP43137. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi202848. 5 interactors.
STRINGi10090.ENSMUSP00000078847.

Structurei

3D structure databases

ProteinModelPortaliP43137.
SMRiP43137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 163C-type lectinPROSITE-ProRule annotationAdd BLAST131

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104249.
HOGENOMiHOG000010281.
HOVERGENiHBG004151.
InParanoidiP43137.
OMAiAHECVAY.
OrthoDBiEOG091G0OLC.
PhylomeDBiP43137.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
PfamiView protein in Pfam
PF00059. Lectin_C. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiView protein in PROSITE
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43137-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARNAYFILL SCLIVLSPSQ GQEAEEDLPS ARISCPEGSN AYSSYCYYFT
60 70 80 90 100
EDRLTWADAD LFCQNMNSGY LVSVLSQAEG NFVASLIKES GTTDANVWTG
110 120 130 140 150
LHDPKRNRRW HWSSGSLFLY KSWATGSPNS SNRGYCVSLT SNTGYKKWKD
160
DNCDAQYSFV CKFKG
Length:165
Mass (Da):18,519
Last modified:November 1, 1995 - v1
Checksum:i2950174AF5D666BA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14010 Genomic DNA. Translation: BAA03111.1.
BC028761 mRNA. Translation: AAH28761.1.
CCDSiCCDS20257.1.
PIRiA47148.
RefSeqiNP_033068.1. NM_009042.1.
UniGeneiMm.142731.

Genome annotation databases

EnsembliENSMUST00000079926; ENSMUSP00000078847; ENSMUSG00000059654.
ENSMUST00000204601; ENSMUSP00000144840; ENSMUSG00000059654.
ENSMUST00000204687; ENSMUSP00000145161; ENSMUSG00000059654.
GeneIDi19692.
KEGGimmu:19692.
UCSCiuc009cka.1. mouse.

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Litho/Reg 1alpha

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D14010 Genomic DNA. Translation: BAA03111.1.
BC028761 mRNA. Translation: AAH28761.1.
CCDSiCCDS20257.1.
PIRiA47148.
RefSeqiNP_033068.1. NM_009042.1.
UniGeneiMm.142731.

3D structure databases

ProteinModelPortaliP43137.
SMRiP43137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi202848. 5 interactors.
STRINGi10090.ENSMUSP00000078847.

PTM databases

iPTMnetiP43137.
PhosphoSitePlusiP43137.

Proteomic databases

PaxDbiP43137.
PeptideAtlasiP43137.
PRIDEiP43137.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000079926; ENSMUSP00000078847; ENSMUSG00000059654.
ENSMUST00000204601; ENSMUSP00000144840; ENSMUSG00000059654.
ENSMUST00000204687; ENSMUSP00000145161; ENSMUSG00000059654.
GeneIDi19692.
KEGGimmu:19692.
UCSCiuc009cka.1. mouse.

Organism-specific databases

CTDi19692.
MGIiMGI:97895. Reg1.

Phylogenomic databases

eggNOGiKOG4297. Eukaryota.
ENOG410XPJ1. LUCA.
GeneTreeiENSGT00700000104249.
HOGENOMiHOG000010281.
HOVERGENiHBG004151.
InParanoidiP43137.
OMAiAHECVAY.
OrthoDBiEOG091G0OLC.
PhylomeDBiP43137.

Miscellaneous databases

PROiPR:P43137.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059654.
CleanExiMM_REG1.
ExpressionAtlasiP43137. baseline and differential.
GenevisibleiP43137. MM.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiView protein in InterPro
IPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR018378. C-type_lectin_CS.
IPR016187. CTDL_fold.
PfamiView protein in Pfam
PF00059. Lectin_C. 1 hit.
SMARTiView protein in SMART
SM00034. CLECT. 1 hit.
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiView protein in PROSITE
PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLIT1_MOUSE
AccessioniPrimary (citable) accession number: P43137
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 10, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.