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Protein

Nuclear receptor subfamily 2 group F member 6

Gene

Nr2f6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi54 – 129Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri57 – 77NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri93 – 117NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • detection of temperature stimulus involved in sensory perception of pain Source: MGI
  • entrainment of circadian clock by photoperiod Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: NTNU_SB
  • neuron development Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Receptor, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 2 group F member 6
Alternative name(s):
COUP transcription factor 3
Short name:
COUP-TF3
V-erbA-related protein 2
Short name:
EAR-2
Gene namesi
Name:Nr2f6
Synonyms:Ear-2, Ear2, Erbal2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1352453 Nr2f6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Reduction of neurons in the locus coerulus of the developing cortex. Defects in circadian behavior. Hyperreactive lymphocytes, late-onset immunopathology and hypersusceptibility to Th17-dependent experimental autoimmune encephalomyelitis.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536141 – 390Nuclear receptor subfamily 2 group F member 6Add BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei35PhosphoserineCombined sources1
Modified residuei41PhosphoserineBy similarity1
Modified residuei84PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP43136
PaxDbiP43136
PeptideAtlasiP43136
PRIDEiP43136

PTM databases

iPTMnetiP43136
PhosphoSitePlusiP43136

Expressioni

Developmental stagei

Initially expressed at E8.5 in the developing rhombencephalon. At E11.5 expression in the CNS rapidly decreases and in newborn and adult expression is not detectable in the brain with the exceptions of Purkinje neurons and the choroid plexi.1 Publication

Gene expression databases

BgeeiENSMUSG00000002393
CleanExiMM_NR2F6
ExpressionAtlasiP43136 baseline and differential
GenevisibleiP43136 MM

Interactioni

Subunit structurei

Binds DNA as dimer; homodimer and heterodimer with NR2F2 and probably NR2F1. Interacts with THRB (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Rasd1O356265EBI-4319956,EBI-4319979

Protein-protein interaction databases

BioGridi199494, 4 interactors
IntActiP43136, 1 interactor
STRINGi10090.ENSMUSP00000002466

Structurei

3D structure databases

ProteinModelPortaliP43136
SMRiP43136
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini157 – 380NR LBDPROSITE-ProRule annotationAdd BLAST224

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni314 – 390Important for dimerizationBy similarityAdd BLAST77

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri57 – 77NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri93 – 117NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00760000118948
HOGENOMiHOG000260820
HOVERGENiHBG005606
InParanoidiP43136
KOiK08549
OMAiWGDPNGG
OrthoDBiEOG091G0YX6
TreeFamiTF352097

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR003068 COUP_TF
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01282 COUPTNFACTOR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

P43136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMVTGGWGD PGGDTNGVDK AGGSYPRATE DDSASPPGAT SDAEPGDEER
60 70 80 90 100
PGLQVDCVVC GDKSSGKHYG VFTCEGCKSF FKRSIRRNLS YTCRSNRDCQ
110 120 130 140 150
IDQHHRNQCQ YCRLKKCFRV GMRKEAVQRG RIPHALPGPA ACSPPGATGV
160 170 180 190 200
EPFTGPPVSE LIAQLLRAEP YPAAGRFGGG GAVLGIDNVC ELAARLLFST
210 220 230 240 250
VEWARHAPFF PELPAADQVA LLRLSWSELF VLNAAQAALP LHTAPLLAAA
260 270 280 290 300
GLHAAPMAAE RAVAFMDQVR AFQEQVDKLG RLQVDAAEYG CLKAIALFTP
310 320 330 340 350
DACGLSDPAH VESLQEKAQV ALTEYVRAQY PSQPQRFGRL LLRLPALRAV
360 370 380 390
PASLISQLFF MRLVGKTPIE TLIRDMLLSG STFNWPYGSG
Length:390
Mass (Da):41,968
Last modified:July 27, 2011 - v2
Checksum:i4C30B25C6CAE5338
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10D → G in AAA37532 (PubMed:8194772).Curated1
Sequence conflicti84S → T in CAA54097 (PubMed:7947324).Curated1
Sequence conflicti84S → T in AAA37532 (PubMed:8194772).Curated1
Sequence conflicti152P → H in AAA37532 (PubMed:8194772).Curated1
Sequence conflicti164 – 165QL → HV in AAA37532 (PubMed:8194772).Curated2
Sequence conflicti196 – 198LLF → AV in AAA37532 (PubMed:8194772).Curated3
Sequence conflicti239 – 241LPL → VAV in AAA37532 (PubMed:8194772).Curated3
Sequence conflicti357Q → K in CAA54097 (PubMed:7947324).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76654 mRNA Translation: CAA54097.1
L25674 mRNA Translation: AAA37532.1
AK131941 mRNA Translation: BAE20887.1
AK171552 mRNA Translation: BAE42523.1
CH466569 Genomic DNA Translation: EDL28911.1
BC008138 mRNA Translation: AAH08138.1
CCDSiCCDS22392.1
PIRiI48734 S44285
I49640
RefSeqiNP_034280.2, NM_010150.2
UniGeneiMm.28989
Mm.440170

Genome annotation databases

EnsembliENSMUST00000002466; ENSMUSP00000002466; ENSMUSG00000002393
GeneIDi13864
KEGGimmu:13864
UCSCiuc009mcx.1 mouse

Similar proteinsi

Entry informationi

Entry nameiNR2F6_MOUSE
AccessioniPrimary (citable) accession number: P43136
Secondary accession number(s): Q61504, Q922G8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 27, 2011
Last modified: March 28, 2018
This is version 151 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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