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P43135

- COT2_MOUSE

UniProt

P43135 - COT2_MOUSE

Protein

COUP transcription factor 2

Gene

Nr2f2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (13 Apr 2004)
      Previous versions | rss
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    Functioni

    Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi76 – 15176Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri79 – 9921NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri115 – 13925NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: MGI
    2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: UniProtKB
    3. retinoic acid binding Source: UniProtKB
    4. sequence-specific DNA binding Source: MGI
    5. steroid hormone receptor activity Source: InterPro
    6. zinc ion binding Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: MGI
    2. blood vessel morphogenesis Source: MGI
    3. fertilization Source: MGI
    4. forebrain development Source: MGI
    5. in utero embryonic development Source: MGI
    6. limb development Source: MGI
    7. lymph vessel development Source: BHF-UCL
    8. maternal placenta development Source: MGI
    9. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
    10. negative regulation of endothelial cell migration Source: Ensembl
    11. negative regulation of endothelial cell proliferation Source: Ensembl
    12. negative regulation of transcription from RNA polymerase II promoter Source: MGI
    13. neuron migration Source: MGI
    14. placenta blood vessel development Source: MGI
    15. positive regulation of transcription, DNA-templated Source: UniProtKB
    16. radial pattern formation Source: MGI
    17. regulation of transcription from RNA polymerase II promoter Source: MGI
    18. regulation of transcription involved in lymphatic endothelial cell fate commitment Source: Ensembl
    19. response to estradiol Source: Ensembl
    20. skeletal muscle tissue development Source: MGI
    21. trophoblast giant cell differentiation Source: MGI

    Keywords - Molecular functioni

    Activator, Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    COUP transcription factor 2
    Short name:
    COUP-TF2
    Alternative name(s):
    Apolipoprotein AI regulatory protein 1
    Short name:
    ARP-1
    COUP transcription factor II
    Short name:
    COUP-TF II
    Nuclear receptor subfamily 2 group F member 2
    Gene namesi
    Name:Nr2f2
    Synonyms:Aporp1, Arp-1, Arp1, Tfcoup2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 7

    Organism-specific databases

    MGIiMGI:1352452. Nr2f2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: MGI

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi363 – 3675LLLRL → RSLRF: Abolishes interaction with ZFPM2. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 414414COUP transcription factor 2PRO_0000053607Add
    BLAST

    Proteomic databases

    PaxDbiP43135.
    PRIDEiP43135.

    PTM databases

    PhosphoSiteiP43135.

    Expressioni

    Gene expression databases

    ArrayExpressiP43135.
    BgeeiP43135.
    CleanExiMM_NR2F2.
    GenevestigatoriP43135.

    Interactioni

    Subunit structurei

    Interacts with SQSTM1. Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A By similarity. Interacts with ZFPM2.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi198166. 1 interaction.
    STRINGi10090.ENSMUSP00000032768.

    Structurei

    3D structure databases

    ProteinModelPortaliP43135.
    SMRiP43135. Positions 75-407.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni117 – 414298Interaction with ZFPM2Add
    BLAST
    Regioni183 – 414232Ligand-bindingBy similarityAdd
    BLAST
    Regioni337 – 41478Important for dimerizationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi71 – 755Poly-Gln

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri79 – 9921NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri115 – 13925NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG327099.
    HOGENOMiHOG000260820.
    HOVERGENiHBG005606.
    InParanoidiP43135.
    KOiK08548.
    OMAiGPPNNTQ.
    OrthoDBiEOG72RMZ5.
    PhylomeDBiP43135.
    TreeFamiTF352097.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR003068. COUP_TF.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR01282. COUPTNFACTOR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43135-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS    50
    TPAQTAAGGQ GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK 100
    SFFKRSVRRN LSYTCRANRN CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ 150
    RGRMPPTQPT HGQFALTNGD PLNCHSYLSG YISLLLRAEP YPTSRFGSQC 200
    MQPNNIMGIE NICELAARML FSAVEWARNI PFFPDLQITD QVALLRLTWS 250
    ELFVLNAAQC SMPLHVAPLL AAAGLHASPM SADRVVAFMD HIRIFQEQVE 300
    KLKALHVDSA EYSCLKAIVL FTSDACGLSD VAHVESLQEK SQCALEEYVR 350
    SQYPNQPTRF GKLLLRLPSL RTVSSSVIEQ LFFVRLVGKT PIETLIRDML 400
    LSGSSFNWPY MAIQ 414
    Length:414
    Mass (Da):45,571
    Last modified:April 13, 2004 - v2
    Checksum:iC24CB2E8C8A27E8C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti36 – 361A → P in CAA54096. (PubMed:7947324)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76653 mRNA. Translation: CAA54096.1.
    U07635 mRNA. Translation: AAA19854.1.
    BC042484 mRNA. Translation: AAH42484.1.
    CCDSiCCDS21359.1.
    RefSeqiNP_033827.2. NM_009697.3.
    UniGeneiMm.158143.

    Genome annotation databases

    EnsembliENSMUST00000032768; ENSMUSP00000032768; ENSMUSG00000030551.
    GeneIDi11819.
    KEGGimmu:11819.
    UCSCiuc009hni.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X76653 mRNA. Translation: CAA54096.1 .
    U07635 mRNA. Translation: AAA19854.1 .
    BC042484 mRNA. Translation: AAH42484.1 .
    CCDSi CCDS21359.1.
    RefSeqi NP_033827.2. NM_009697.3.
    UniGenei Mm.158143.

    3D structure databases

    ProteinModelPortali P43135.
    SMRi P43135. Positions 75-407.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198166. 1 interaction.
    STRINGi 10090.ENSMUSP00000032768.

    PTM databases

    PhosphoSitei P43135.

    Proteomic databases

    PaxDbi P43135.
    PRIDEi P43135.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000032768 ; ENSMUSP00000032768 ; ENSMUSG00000030551 .
    GeneIDi 11819.
    KEGGi mmu:11819.
    UCSCi uc009hni.1. mouse.

    Organism-specific databases

    CTDi 7026.
    MGIi MGI:1352452. Nr2f2.

    Phylogenomic databases

    eggNOGi NOG327099.
    HOGENOMi HOG000260820.
    HOVERGENi HBG005606.
    InParanoidi P43135.
    KOi K08548.
    OMAi GPPNNTQ.
    OrthoDBi EOG72RMZ5.
    PhylomeDBi P43135.
    TreeFami TF352097.

    Miscellaneous databases

    NextBioi 279711.
    PROi P43135.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P43135.
    Bgeei P43135.
    CleanExi MM_NR2F2.
    Genevestigatori P43135.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR003068. COUP_TF.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR01282. COUPTNFACTOR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors."
      Jonk L.J.C., de Jonge M.E.J., Pals C.E.G.M., Wissink S., Vervaart J.M.A., Schoorlemmer J., Kruijer W.
      Mech. Dev. 47:81-97(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon."
      Qiu Y., Cooney A.J., Kuratani S., DeMayo F.J., Tsai S.Y., Tsai M.J.
      Proc. Natl. Acad. Sci. U.S.A. 91:4451-4455(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Eye.
    4. "Friend of GATA 2 physically interacts with chicken ovalbumin upstream promoter-TF2 (COUP-TF2) and COUP-TF3 and represses COUP-TF2-dependent activation of the atrial natriuretic factor promoter."
      Huggins G.S., Bacani C.J., Boltax J., Aikawa R., Leiden J.M.
      J. Biol. Chem. 276:28029-28036(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH ZFPM2, MUTAGENESIS OF 363-LEU--LEU-367.

    Entry informationi

    Entry nameiCOT2_MOUSE
    AccessioniPrimary (citable) accession number: P43135
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: April 13, 2004
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3