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P43135

- COT2_MOUSE

UniProt

P43135 - COT2_MOUSE

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Protein

COUP transcription factor 2

Gene
Nr2f2, Aporp1, Arp-1, Arp1, Tfcoup2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi76 – 15176Nuclear receptorAdd
BLAST
Zinc fingeri79 – 9921NR C4-typeAdd
BLAST
Zinc fingeri115 – 13925NR C4-typeAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: UniProtKB
  3. retinoic acid binding Source: UniProtKB
  4. sequence-specific DNA binding Source: MGI
  5. steroid hormone receptor activity Source: InterPro
  6. zinc ion binding Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. blood vessel morphogenesis Source: MGI
  3. fertilization Source: MGI
  4. forebrain development Source: MGI
  5. in utero embryonic development Source: MGI
  6. limb development Source: MGI
  7. lymph vessel development Source: BHF-UCL
  8. maternal placenta development Source: MGI
  9. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
  10. negative regulation of endothelial cell migration Source: Ensembl
  11. negative regulation of endothelial cell proliferation Source: Ensembl
  12. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  13. neuron migration Source: MGI
  14. placenta blood vessel development Source: MGI
  15. positive regulation of transcription, DNA-templated Source: UniProtKB
  16. radial pattern formation Source: MGI
  17. regulation of transcription from RNA polymerase II promoter Source: MGI
  18. regulation of transcription involved in lymphatic endothelial cell fate commitment Source: Ensembl
  19. response to estradiol Source: Ensembl
  20. skeletal muscle tissue development Source: MGI
  21. trophoblast giant cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
COUP transcription factor 2
Short name:
COUP-TF2
Alternative name(s):
Apolipoprotein AI regulatory protein 1
Short name:
ARP-1
COUP transcription factor II
Short name:
COUP-TF II
Nuclear receptor subfamily 2 group F member 2
Gene namesi
Name:Nr2f2
Synonyms:Aporp1, Arp-1, Arp1, Tfcoup2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1352452. Nr2f2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi363 – 3675LLLRL → RSLRF: Abolishes interaction with ZFPM2. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414COUP transcription factor 2PRO_0000053607Add
BLAST

Proteomic databases

PaxDbiP43135.
PRIDEiP43135.

PTM databases

PhosphoSiteiP43135.

Expressioni

Gene expression databases

ArrayExpressiP43135.
BgeeiP43135.
CleanExiMM_NR2F2.
GenevestigatoriP43135.

Interactioni

Subunit structurei

Interacts with SQSTM1. Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A By similarity. Interacts with ZFPM2.1 Publication

Protein-protein interaction databases

BioGridi198166. 1 interaction.
STRINGi10090.ENSMUSP00000032768.

Structurei

3D structure databases

ProteinModelPortaliP43135.
SMRiP43135. Positions 75-407.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni117 – 414298Interaction with ZFPM2Add
BLAST
Regioni183 – 414232Ligand-binding By similarityAdd
BLAST
Regioni337 – 41478Important for dimerizationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi71 – 755Poly-Gln

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG327099.
HOGENOMiHOG000260820.
HOVERGENiHBG005606.
InParanoidiP43135.
KOiK08548.
OMAiGPPNNTQ.
OrthoDBiEOG72RMZ5.
PhylomeDBiP43135.
TreeFamiTF352097.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003068. COUP_TF.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43135-1 [UniParc]FASTAAdd to Basket

« Hide

MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS    50
TPAQTAAGGQ GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK 100
SFFKRSVRRN LSYTCRANRN CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ 150
RGRMPPTQPT HGQFALTNGD PLNCHSYLSG YISLLLRAEP YPTSRFGSQC 200
MQPNNIMGIE NICELAARML FSAVEWARNI PFFPDLQITD QVALLRLTWS 250
ELFVLNAAQC SMPLHVAPLL AAAGLHASPM SADRVVAFMD HIRIFQEQVE 300
KLKALHVDSA EYSCLKAIVL FTSDACGLSD VAHVESLQEK SQCALEEYVR 350
SQYPNQPTRF GKLLLRLPSL RTVSSSVIEQ LFFVRLVGKT PIETLIRDML 400
LSGSSFNWPY MAIQ 414
Length:414
Mass (Da):45,571
Last modified:April 13, 2004 - v2
Checksum:iC24CB2E8C8A27E8C
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 361A → P in CAA54096. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76653 mRNA. Translation: CAA54096.1.
U07635 mRNA. Translation: AAA19854.1.
BC042484 mRNA. Translation: AAH42484.1.
CCDSiCCDS21359.1.
RefSeqiNP_033827.2. NM_009697.3.
UniGeneiMm.158143.

Genome annotation databases

EnsembliENSMUST00000032768; ENSMUSP00000032768; ENSMUSG00000030551.
GeneIDi11819.
KEGGimmu:11819.
UCSCiuc009hni.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X76653 mRNA. Translation: CAA54096.1 .
U07635 mRNA. Translation: AAA19854.1 .
BC042484 mRNA. Translation: AAH42484.1 .
CCDSi CCDS21359.1.
RefSeqi NP_033827.2. NM_009697.3.
UniGenei Mm.158143.

3D structure databases

ProteinModelPortali P43135.
SMRi P43135. Positions 75-407.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198166. 1 interaction.
STRINGi 10090.ENSMUSP00000032768.

PTM databases

PhosphoSitei P43135.

Proteomic databases

PaxDbi P43135.
PRIDEi P43135.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032768 ; ENSMUSP00000032768 ; ENSMUSG00000030551 .
GeneIDi 11819.
KEGGi mmu:11819.
UCSCi uc009hni.1. mouse.

Organism-specific databases

CTDi 7026.
MGIi MGI:1352452. Nr2f2.

Phylogenomic databases

eggNOGi NOG327099.
HOGENOMi HOG000260820.
HOVERGENi HBG005606.
InParanoidi P43135.
KOi K08548.
OMAi GPPNNTQ.
OrthoDBi EOG72RMZ5.
PhylomeDBi P43135.
TreeFami TF352097.

Miscellaneous databases

NextBioi 279711.
PROi P43135.
SOURCEi Search...

Gene expression databases

ArrayExpressi P43135.
Bgeei P43135.
CleanExi MM_NR2F2.
Genevestigatori P43135.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR003068. COUP_TF.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors."
    Jonk L.J.C., de Jonge M.E.J., Pals C.E.G.M., Wissink S., Vervaart J.M.A., Schoorlemmer J., Kruijer W.
    Mech. Dev. 47:81-97(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon."
    Qiu Y., Cooney A.J., Kuratani S., DeMayo F.J., Tsai S.Y., Tsai M.J.
    Proc. Natl. Acad. Sci. U.S.A. 91:4451-4455(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  4. "Friend of GATA 2 physically interacts with chicken ovalbumin upstream promoter-TF2 (COUP-TF2) and COUP-TF3 and represses COUP-TF2-dependent activation of the atrial natriuretic factor promoter."
    Huggins G.S., Bacani C.J., Boltax J., Aikawa R., Leiden J.M.
    J. Biol. Chem. 276:28029-28036(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZFPM2, MUTAGENESIS OF 363-LEU--LEU-367.

Entry informationi

Entry nameiCOT2_MOUSE
AccessioniPrimary (citable) accession number: P43135
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 13, 2004
Last modified: July 9, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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