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P43135

- COT2_MOUSE

UniProt

P43135 - COT2_MOUSE

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Protein

COUP transcription factor 2

Gene

Nr2f2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi76 – 15176Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri79 – 9921NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri115 – 13925NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: MGI
  2. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: UniProtKB
  3. retinoic acid binding Source: UniProtKB
  4. sequence-specific DNA binding Source: MGI
  5. steroid hormone receptor activity Source: InterPro
  6. zinc ion binding Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. blood vessel morphogenesis Source: MGI
  3. fertilization Source: MGI
  4. forebrain development Source: MGI
  5. intracellular receptor signaling pathway Source: GOC
  6. in utero embryonic development Source: MGI
  7. limb development Source: MGI
  8. lymph vessel development Source: BHF-UCL
  9. maternal placenta development Source: MGI
  10. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
  11. negative regulation of endothelial cell migration Source: Ensembl
  12. negative regulation of endothelial cell proliferation Source: Ensembl
  13. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  14. neuron migration Source: MGI
  15. placenta blood vessel development Source: MGI
  16. positive regulation of transcription, DNA-templated Source: UniProtKB
  17. radial pattern formation Source: MGI
  18. regulation of transcription from RNA polymerase II promoter Source: MGI
  19. regulation of transcription involved in lymphatic endothelial cell fate commitment Source: Ensembl
  20. response to estradiol Source: Ensembl
  21. skeletal muscle tissue development Source: MGI
  22. trophoblast giant cell differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
COUP transcription factor 2
Short name:
COUP-TF2
Alternative name(s):
Apolipoprotein AI regulatory protein 1
Short name:
ARP-1
COUP transcription factor II
Short name:
COUP-TF II
Nuclear receptor subfamily 2 group F member 2
Gene namesi
Name:Nr2f2
Synonyms:Aporp1, Arp-1, Arp1, Tfcoup2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 7

Organism-specific databases

MGIiMGI:1352452. Nr2f2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi363 – 3675LLLRL → RSLRF: Abolishes interaction with ZFPM2. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 414414COUP transcription factor 2PRO_0000053607Add
BLAST

Proteomic databases

MaxQBiP43135.
PaxDbiP43135.
PRIDEiP43135.

PTM databases

PhosphoSiteiP43135.

Expressioni

Gene expression databases

BgeeiP43135.
CleanExiMM_NR2F2.
ExpressionAtlasiP43135. baseline and differential.
GenevestigatoriP43135.

Interactioni

Subunit structurei

Interacts with SQSTM1. Binds DNA as a dimer; homodimer or heterodimer with NR2F6. Interacts with NCOA1, NCOA2, NCOA3 and PPARGC1A (By similarity). Interacts with ZFPM2.By similarity1 Publication

Protein-protein interaction databases

BioGridi198166. 1 interaction.
STRINGi10090.ENSMUSP00000032768.

Structurei

3D structure databases

ProteinModelPortaliP43135.
SMRiP43135. Positions 75-407.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni117 – 414298Interaction with ZFPM2Add
BLAST
Regioni183 – 414232Ligand-bindingBy similarityAdd
BLAST
Regioni337 – 41478Important for dimerizationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi71 – 755Poly-Gln

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri79 – 9921NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri115 – 13925NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG327099.
HOGENOMiHOG000260820.
HOVERGENiHBG005606.
InParanoidiP43135.
KOiK08548.
OMAiGPPNNTQ.
OrthoDBiEOG72RMZ5.
PhylomeDBiP43135.
TreeFamiTF352097.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR003068. COUP_TF.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43135-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAMVVSTWRD PQDEVPGSQG SQASQAPPVP GPPPGAPHTP QTPGQGGPAS
60 70 80 90 100
TPAQTAAGGQ GGPGGPGSDK QQQQQHIECV VCGDKSSGKH YGQFTCEGCK
110 120 130 140 150
SFFKRSVRRN LSYTCRANRN CPIDQHHRNQ CQYCRLKKCL KVGMRREAVQ
160 170 180 190 200
RGRMPPTQPT HGQFALTNGD PLNCHSYLSG YISLLLRAEP YPTSRFGSQC
210 220 230 240 250
MQPNNIMGIE NICELAARML FSAVEWARNI PFFPDLQITD QVALLRLTWS
260 270 280 290 300
ELFVLNAAQC SMPLHVAPLL AAAGLHASPM SADRVVAFMD HIRIFQEQVE
310 320 330 340 350
KLKALHVDSA EYSCLKAIVL FTSDACGLSD VAHVESLQEK SQCALEEYVR
360 370 380 390 400
SQYPNQPTRF GKLLLRLPSL RTVSSSVIEQ LFFVRLVGKT PIETLIRDML
410
LSGSSFNWPY MAIQ
Length:414
Mass (Da):45,571
Last modified:April 13, 2004 - v2
Checksum:iC24CB2E8C8A27E8C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti36 – 361A → P in CAA54096. (PubMed:7947324)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76653 mRNA. Translation: CAA54096.1.
U07635 mRNA. Translation: AAA19854.1.
BC042484 mRNA. Translation: AAH42484.1.
CCDSiCCDS21359.1.
RefSeqiNP_033827.2. NM_009697.3.
UniGeneiMm.158143.

Genome annotation databases

EnsembliENSMUST00000032768; ENSMUSP00000032768; ENSMUSG00000030551.
GeneIDi11819.
KEGGimmu:11819.
UCSCiuc009hni.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76653 mRNA. Translation: CAA54096.1 .
U07635 mRNA. Translation: AAA19854.1 .
BC042484 mRNA. Translation: AAH42484.1 .
CCDSi CCDS21359.1.
RefSeqi NP_033827.2. NM_009697.3.
UniGenei Mm.158143.

3D structure databases

ProteinModelPortali P43135.
SMRi P43135. Positions 75-407.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 198166. 1 interaction.
STRINGi 10090.ENSMUSP00000032768.

Chemistry

BindingDBi P43135.

PTM databases

PhosphoSitei P43135.

Proteomic databases

MaxQBi P43135.
PaxDbi P43135.
PRIDEi P43135.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032768 ; ENSMUSP00000032768 ; ENSMUSG00000030551 .
GeneIDi 11819.
KEGGi mmu:11819.
UCSCi uc009hni.1. mouse.

Organism-specific databases

CTDi 7026.
MGIi MGI:1352452. Nr2f2.

Phylogenomic databases

eggNOGi NOG327099.
HOGENOMi HOG000260820.
HOVERGENi HBG005606.
InParanoidi P43135.
KOi K08548.
OMAi GPPNNTQ.
OrthoDBi EOG72RMZ5.
PhylomeDBi P43135.
TreeFami TF352097.

Miscellaneous databases

NextBioi 279711.
PROi P43135.
SOURCEi Search...

Gene expression databases

Bgeei P43135.
CleanExi MM_NR2F2.
ExpressionAtlasi P43135. baseline and differential.
Genevestigatori P43135.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR003068. COUP_TF.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR01282. COUPTNFACTOR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression during development of three murine members of the COUP family of nuclear orphan receptors."
    Jonk L.J.C., de Jonge M.E.J., Pals C.E.G.M., Wissink S., Vervaart J.M.A., Schoorlemmer J., Kruijer W.
    Mech. Dev. 47:81-97(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Spatiotemporal expression patterns of chicken ovalbumin upstream promoter-transcription factors in the developing mouse central nervous system: evidence for a role in segmental patterning of the diencephalon."
    Qiu Y., Cooney A.J., Kuratani S., DeMayo F.J., Tsai S.Y., Tsai M.J.
    Proc. Natl. Acad. Sci. U.S.A. 91:4451-4455(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye.
  4. "Friend of GATA 2 physically interacts with chicken ovalbumin upstream promoter-TF2 (COUP-TF2) and COUP-TF3 and represses COUP-TF2-dependent activation of the atrial natriuretic factor promoter."
    Huggins G.S., Bacani C.J., Boltax J., Aikawa R., Leiden J.M.
    J. Biol. Chem. 276:28029-28036(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH ZFPM2, MUTAGENESIS OF 363-LEU--LEU-367.

Entry informationi

Entry nameiCOT2_MOUSE
AccessioniPrimary (citable) accession number: P43135
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: April 13, 2004
Last modified: November 26, 2014
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3