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P43132

- BRE2_YEAST

UniProt

P43132 - BRE2_YEAST

Protein

COMPASS component BRE2

Gene

BRE2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. chromatin silencing at telomere Source: SGD
    2. histone H3-K4 methylation Source: SGD
    3. histone H3-K4 trimethylation Source: SGD
    4. telomere maintenance Source: SGD

    Enzyme and pathway databases

    BioCyciYEAST:G3O-32176-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    COMPASS component BRE2
    Alternative name(s):
    Brefeldin-A sensitivity protein 2
    Complex proteins associated with SET1 protein BRE2
    Set1C component BRE2
    Gene namesi
    Name:BRE2
    Synonyms:CPS60
    Ordered Locus Names:YLR015W
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome XII

    Organism-specific databases

    CYGDiYLR015w.
    SGDiS000004005. BRE2.

    Subcellular locationi

    Nucleus Curated. Chromosometelomere Curated

    GO - Cellular componenti

    1. chromosome, telomeric region Source: UniProtKB-SubCell
    2. Set1C/COMPASS complex Source: SGD

    Keywords - Cellular componenti

    Chromosome, Nucleus, Telomere

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 505505COMPASS component BRE2PRO_0000064987Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei227 – 2271Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP43132.
    PaxDbiP43132.

    Expressioni

    Gene expression databases

    GenevestigatoriP43132.

    Interactioni

    Subunit structurei

    Component of the COMPASS (Set1C) complex which consists of SET12, BRE22, SPP12, SDC11, SHG11, SWD11, SWD21, and SWD31.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SDC1Q033238EBI-27115,EBI-38307
    SET1P388276EBI-27115,EBI-16977

    Protein-protein interaction databases

    BioGridi31289. 222 interactions.
    DIPiDIP-1935N.
    IntActiP43132. 10 interactions.
    MINTiMINT-408291.
    STRINGi4932.YLR015W.

    Structurei

    3D structure databases

    ProteinModelPortaliP43132.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    eggNOGiNOG263758.
    HOGENOMiHOG000066117.
    KOiK14967.
    OMAiEVNFGPD.
    OrthoDBiEOG70GMQJ.

    Family and domain databases

    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR018355. SPla/RYanodine_receptor_subgr.
    [Graphical view]
    SMARTiSM00449. SPRY. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    P43132-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKLGIIPYQE GTDIVYKNAL QGQQEGKRPN LPQMEATHQI KSSVQGTSYE    50
    FVRTEDIPLN RRHFVYRPCS ANPFFTILGY GCTEYPFDHS GMSVMDRSEG 100
    LSISRDGNDL VSVPDQYGWR TARSDVCIKE GMTYWEVEVI RGGNKKFADG 150
    VNNKENADDS VDEVQSGIYE KMHKQVNDTP HLRFGVCRRE ASLEAPVGFD 200
    VYGYGIRDIS LESIHEGKLN CVLENGSPLK EGDKIGFLLS LPSIHTQIKQ 250
    AKEFTKRRIF ALNSHMDTMN EPWREDAENG PSRKKLKQET TNKEFQRALL 300
    EDIEYNDVVR DQIAIRYKNQ LFFEATDYVK TTKPEYYSSD KRERQDYYQL 350
    EDSYLAIFQN GKYLGKAFEN LKPLLPPFSE LQYNEKFYLG YWQHGEARDE 400
    SNDKNTTSAK KKKQQQKKKK GLILRNKYVN NNKLGYYPTI SCFNGGTARI 450
    ISEEDKLEYL DQIRSAYCVD GNSKVNTLDT LYKEQIAEDI VWDIIDELEQ 500
    IALQQ 505
    Length:505
    Mass (Da):58,347
    Last modified:November 1, 1997 - v2
    Checksum:iD5B33221E9F10379
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X90564 Genomic DNA. Translation: CAA62158.1.
    Z73187 Genomic DNA. Translation: CAA97537.1.
    L34405 Genomic DNA. Translation: AAA34835.1.
    BK006945 Genomic DNA. Translation: DAA09333.1.
    PIRiS64837.
    RefSeqiNP_013115.1. NM_001181902.1.

    Genome annotation databases

    EnsemblFungiiYLR015W; YLR015W; YLR015W.
    GeneIDi850702.
    KEGGisce:YLR015W.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X90564 Genomic DNA. Translation: CAA62158.1 .
    Z73187 Genomic DNA. Translation: CAA97537.1 .
    L34405 Genomic DNA. Translation: AAA34835.1 .
    BK006945 Genomic DNA. Translation: DAA09333.1 .
    PIRi S64837.
    RefSeqi NP_013115.1. NM_001181902.1.

    3D structure databases

    ProteinModelPortali P43132.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 31289. 222 interactions.
    DIPi DIP-1935N.
    IntActi P43132. 10 interactions.
    MINTi MINT-408291.
    STRINGi 4932.YLR015W.

    Proteomic databases

    MaxQBi P43132.
    PaxDbi P43132.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YLR015W ; YLR015W ; YLR015W .
    GeneIDi 850702.
    KEGGi sce:YLR015W.

    Organism-specific databases

    CYGDi YLR015w.
    SGDi S000004005. BRE2.

    Phylogenomic databases

    eggNOGi NOG263758.
    HOGENOMi HOG000066117.
    KOi K14967.
    OMAi EVNFGPD.
    OrthoDBi EOG70GMQJ.

    Enzyme and pathway databases

    BioCyci YEAST:G3O-32176-MONOMER.

    Miscellaneous databases

    NextBioi 966742.
    PROi P43132.

    Gene expression databases

    Genevestigatori P43132.

    Family and domain databases

    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR018355. SPla/RYanodine_receptor_subgr.
    [Graphical view ]
    SMARTi SM00449. SPRY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "A 7.8kb fragment from chromosome XII of Saccharomyces cerevisiae does not harbour PKC2."
      Saville S.P., Atkinson S., Jamieson L., Pocklington M.J., Orr E.
      Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
      Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
      , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
      Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. "Evidence against the existence of the purported Saccharomyces cerevisiae PKC2 gene."
      Levin D.E., Stevenson W.D., Watanabe M.
      Curr. Biol. 4:990-995(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-472.
      Strain: ATCC 204508 / S288c.
    5. "The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4."
      Roguev A., Schaft D., Shevchenko A., Pijnappel W.W.M.P., Wilm M., Aasland R., Stewart A.F.
      EMBO J. 20:7137-7148(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT.
    6. "COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression."
      Krogan N.J., Dover J., Khorrami S., Greenblatt J.F., Schneider J., Johnston M., Shilatifard A.
      J. Biol. Chem. 277:10753-10755(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. Cited for: SUBUNIT.
    8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
    9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
      Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
      Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiBRE2_YEAST
    AccessioniPrimary (citable) accession number: P43132
    Secondary accession number(s): D6VY17, E9PA88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1310 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    2. Yeast chromosome XII
      Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

    External Data

    Dasty 3