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P43132 (BRE2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
COMPASS component BRE2
Alternative name(s):
Brefeldin-A sensitivity protein 2
Complex proteins associated with SET1 protein BRE2
Set1C component BRE2
Gene names
Name:BRE2
Synonyms:CPS60
Ordered Locus Names:YLR015W
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length505 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. Ref.5 Ref.6

Subunit structure

Component of the COMPASS (Set1C) complex which consists of SET12, BRE22, SPP12, SDC11, SHG11, SWD11, SWD21, and SWD31. Ref.5 Ref.7

Subcellular location

Nucleus Probable. Chromosometelomere Probable.

Miscellaneous

Present with 1310 molecules/cell in log phase SD medium.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

SDC1Q033238EBI-27115,EBI-38307
SET1P388276EBI-27115,EBI-16977

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 505505COMPASS component BRE2
PRO_0000064987

Amino acid modifications

Modified residue2271Phosphoserine Ref.9

Sequences

Sequence LengthMass (Da)Tools
P43132 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: D5B33221E9F10379

FASTA50558,347
        10         20         30         40         50         60 
MKLGIIPYQE GTDIVYKNAL QGQQEGKRPN LPQMEATHQI KSSVQGTSYE FVRTEDIPLN 

        70         80         90        100        110        120 
RRHFVYRPCS ANPFFTILGY GCTEYPFDHS GMSVMDRSEG LSISRDGNDL VSVPDQYGWR 

       130        140        150        160        170        180 
TARSDVCIKE GMTYWEVEVI RGGNKKFADG VNNKENADDS VDEVQSGIYE KMHKQVNDTP 

       190        200        210        220        230        240 
HLRFGVCRRE ASLEAPVGFD VYGYGIRDIS LESIHEGKLN CVLENGSPLK EGDKIGFLLS 

       250        260        270        280        290        300 
LPSIHTQIKQ AKEFTKRRIF ALNSHMDTMN EPWREDAENG PSRKKLKQET TNKEFQRALL 

       310        320        330        340        350        360 
EDIEYNDVVR DQIAIRYKNQ LFFEATDYVK TTKPEYYSSD KRERQDYYQL EDSYLAIFQN 

       370        380        390        400        410        420 
GKYLGKAFEN LKPLLPPFSE LQYNEKFYLG YWQHGEARDE SNDKNTTSAK KKKQQQKKKK 

       430        440        450        460        470        480 
GLILRNKYVN NNKLGYYPTI SCFNGGTARI ISEEDKLEYL DQIRSAYCVD GNSKVNTLDT 

       490        500 
LYKEQIAEDI VWDIIDELEQ IALQQ 

« Hide

References

« Hide 'large scale' references
[1]"A 7.8kb fragment from chromosome XII of Saccharomyces cerevisiae does not harbour PKC2."
Saville S.P., Atkinson S., Jamieson L., Pocklington M.J., Orr E.
Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[2]"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. expand/collapse author list , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
[4]"Evidence against the existence of the purported Saccharomyces cerevisiae PKC2 gene."
Levin D.E., Stevenson W.D., Watanabe M.
Curr. Biol. 4:990-995(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-472.
Strain: ATCC 204508 / S288c.
[5]"The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4."
Roguev A., Schaft D., Shevchenko A., Pijnappel W.W.M.P., Wilm M., Aasland R., Stewart A.F.
EMBO J. 20:7137-7148(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT.
[6]"COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression."
Krogan N.J., Dover J., Khorrami S., Greenblatt J.F., Schneider J., Johnston M., Shilatifard A.
J. Biol. Chem. 277:10753-10755(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"COMPASS: a complex of proteins associated with a trithorax-related SET domain protein."
Miller T., Krogan N.J., Dover J., Erdjument-Bromage H., Tempst P., Johnston M., Greenblatt J.F., Shilatifard A.
Proc. Natl. Acad. Sci. U.S.A. 98:12902-12907(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT.
[8]"Global analysis of protein expression in yeast."
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S.
Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[9]"A multidimensional chromatography technology for in-depth phosphoproteome analysis."
Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X90564 Genomic DNA. Translation: CAA62158.1.
Z73187 Genomic DNA. Translation: CAA97537.1.
L34405 Genomic DNA. Translation: AAA34835.1.
BK006945 Genomic DNA. Translation: DAA09333.1.
PIRS64837.
RefSeqNP_013115.1. NM_001181902.1.

3D structure databases

ProteinModelPortalP43132.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid31289. 221 interactions.
DIPDIP-1935N.
IntActP43132. 10 interactions.
MINTMINT-408291.
STRING4932.YLR015W.

Proteomic databases

PaxDbP43132.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYLR015W; YLR015W; YLR015W.
GeneID850702.
KEGGsce:YLR015W.

Organism-specific databases

CYGDYLR015w.
SGDS000004005. BRE2.

Phylogenomic databases

eggNOGNOG263758.
HOGENOMHOG000066117.
KOK14967.
OMAEVNFGPD.
OrthoDBEOG70GMQJ.

Enzyme and pathway databases

BioCycYEAST:G3O-32176-MONOMER.

Gene expression databases

GenevestigatorP43132.

Family and domain databases

InterProIPR008985. ConA-like_lec_gl_sf.
IPR018355. SPla/RYanodine_receptor_subgr.
[Graphical view]
SMARTSM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 2 hits.
ProtoNetSearch...

Other

NextBio966742.
PROP43132.

Entry information

Entry nameBRE2_YEAST
AccessionPrimary (citable) accession number: P43132
Secondary accession number(s): D6VY17, E9PA88
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD