COMPASS component BRE2 - Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

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P43132 (BRE2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 101. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
COMPASS component BRE2

Alternative name(s):
Brefeldin-A sensitivity protein 2
Complex proteins associated with SET1 protein BRE2
Set1C component BRE2

Gene names

Name:	BRE2
Synonyms:	CPS60
Ordered Locus Names:	YLR015W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces ›

Protein attributes

Sequence length	505 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. Ref.5 Ref.6
Subunit structure	Component of the COMPASS (Set1C) complex which consists of SET1₂, BRE2₂, SPP1₂, SDC1₁, SHG1₁, SWD1₁, SWD2₁, and SWD3₁. Ref.5 Ref.7
Subcellular location	Nucleus Probable. Chromosome › telomere Probable.
Miscellaneous	Present with 1310 molecules/cell in log phase SD medium.

Ontologies

Keywords
Cellular component	Chromosome Nucleus Telomere
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	chromatin silencing at telomere Inferred from mutant phenotype Ref.7 Ref.6. Source: SGD histone H3-K4 trimethylation Inferred from mutant phenotype PubMed 16921172 PubMed 16980427. Source: SGD telomere maintenance Inferred from mutant phenotype Ref.5. Source: SGD
Cellular_component	Set1C/COMPASS complex Inferred from physical interaction Ref.7 Ref.5 PubMed 11752412. Source: SGD chromosome, telomeric region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
SDC1	Q03323	8	EBI-27115,EBI-38307
SET1	P38827	7	EBI-27115,EBI-16977

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 505

505

COMPASS component BRE2

PRO_0000064987

Amino acid modifications

Modified residue

160

Phosphoserine Ref.9

Modified residue

227

Phosphoserine Ref.10

Sequences

Sequence

Length

Mass (Da)

Tools

P43132 [UniParc].

Last modified November 1, 1997. Version 2.
Checksum: D5B33221E9F10379
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FASTA

505

58,347

        10         20         30         40         50         60 
MKLGIIPYQE GTDIVYKNAL QGQQEGKRPN LPQMEATHQI KSSVQGTSYE FVRTEDIPLN 

        70         80         90        100        110        120 
RRHFVYRPCS ANPFFTILGY GCTEYPFDHS GMSVMDRSEG LSISRDGNDL VSVPDQYGWR 

       130        140        150        160        170        180 
TARSDVCIKE GMTYWEVEVI RGGNKKFADG VNNKENADDS VDEVQSGIYE KMHKQVNDTP 

       190        200        210        220        230        240 
HLRFGVCRRE ASLEAPVGFD VYGYGIRDIS LESIHEGKLN CVLENGSPLK EGDKIGFLLS 

       250        260        270        280        290        300 
LPSIHTQIKQ AKEFTKRRIF ALNSHMDTMN EPWREDAENG PSRKKLKQET TNKEFQRALL 

       310        320        330        340        350        360 
EDIEYNDVVR DQIAIRYKNQ LFFEATDYVK TTKPEYYSSD KRERQDYYQL EDSYLAIFQN 

       370        380        390        400        410        420 
GKYLGKAFEN LKPLLPPFSE LQYNEKFYLG YWQHGEARDE SNDKNTTSAK KKKQQQKKKK 

       430        440        450        460        470        480 
GLILRNKYVN NNKLGYYPTI SCFNGGTARI ISEEDKLEYL DQIRSAYCVD GNSKVNTLDT 

       490        500 
LYKEQIAEDI VWDIIDELEQ IALQQ

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A 7.8kb fragment from chromosome XII of Saccharomyces cerevisiae does not harbour PKC2." Saville S.P., Atkinson S., Jamieson L., Pocklington M.J., Orr E. Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[2]	"The nucleotide sequence of Saccharomyces cerevisiae chromosome XII." Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H. Hoheisel J.D. Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[3]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[4]	"Evidence against the existence of the purported Saccharomyces cerevisiae PKC2 gene." Levin D.E., Stevenson W.D., Watanabe M. Curr. Biol. 4:990-995(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-472. Strain: ATCC 204508 / S288c.
[5]	"The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4." Roguev A., Schaft D., Shevchenko A., Pijnappel W.W.M.P., Wilm M., Aasland R., Stewart A.F. EMBO J. 20:7137-7148(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBUNIT.
[6]	"COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression." Krogan N.J., Dover J., Khorrami S., Greenblatt J.F., Schneider J., Johnston M., Shilatifard A. J. Biol. Chem. 277:10753-10755(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[7]	"COMPASS: a complex of proteins associated with a trithorax-related SET domain protein." Miller T., Krogan N.J., Dover J., Erdjument-Bromage H., Tempst P., Johnston M., Greenblatt J.F., Shilatifard A. Proc. Natl. Acad. Sci. U.S.A. 98:12902-12907(2001) [PubMed] [Europe PMC] [Abstract] Cited for: SUBUNIT.
[8]	"Global analysis of protein expression in yeast." Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N., O'Shea E.K., Weissman J.S. Nature 425:737-741(2003) [PubMed] [Europe PMC] [Abstract] Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
[9]	"Proteome-wide identification of in vivo targets of DNA damage checkpoint kinases." Smolka M.B., Albuquerque C.P., Chen S.H., Zhou H. Proc. Natl. Acad. Sci. U.S.A. 104:10364-10369(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-160, MASS SPECTROMETRY.
[10]	"A multidimensional chromatography technology for in-depth phosphoproteome analysis." Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H. Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X90564 Genomic DNA. Translation: CAA62158.1. Z73187 Genomic DNA. Translation: CAA97537.1. L34405 Genomic DNA. Translation: AAA34835.1. BK006945 Genomic DNA. Translation: DAA09333.1.
PIR	S64837.
RefSeq	NP_013115.1. NM_001181902.1.
3D structure databases
ProteinModelPortal	P43132.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-1935N.
IntAct	P43132. 10 interactions.
MINT	MINT-408291.
STRING	4932.YLR015W.
Proteomic databases
PaxDb	P43132.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YLR015W; YLR015W; YLR015W.
GeneID	850702.
KEGG	sce:YLR015W.
Organism-specific databases
CYGD	YLR015w.
SGD	S000004005. BRE2.
Phylogenomic databases
eggNOG	NOG263758.
HOGENOM	HOG000066117.
KO	K14967.
OMA	NFGPDFW.
OrthoDB	EOG45XC4S.
Gene expression databases
Genevestigator	P43132.
GermOnline	YLR015W. Saccharomyces cerevisiae.
Family and domain databases
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR018355. SPla/RYanodine_receptor_subgr. [Graphical view]
SMART	SM00449. SPRY. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
ProtoNet	Search...
Other
NextBio	966742.

Entry information

Entry name

BRE2_YEAST

Accession

Primary (citable) accession number: P43132
Secondary accession number(s): D6VY17, E9PA88

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1997
Last modified:	April 3, 2013
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

Yeast chromosome XII

Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents