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P43132

- BRE2_YEAST

UniProt

P43132 - BRE2_YEAST

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Protein

COMPASS component BRE2

Gene

BRE2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The COMPASS (Set1C) complex specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.2 Publications

GO - Biological processi

  1. chromatin silencing at telomere Source: SGD
  2. histone H3-K4 methylation Source: SGD
  3. histone H3-K4 trimethylation Source: SGD
  4. telomere maintenance Source: SGD
Complete GO annotation...

Enzyme and pathway databases

BioCyciYEAST:G3O-32176-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
COMPASS component BRE2
Alternative name(s):
Brefeldin-A sensitivity protein 2
Complex proteins associated with SET1 protein BRE2
Set1C component BRE2
Gene namesi
Name:BRE2
Synonyms:CPS60
Ordered Locus Names:YLR015W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XII

Organism-specific databases

CYGDiYLR015w.
SGDiS000004005. BRE2.

Subcellular locationi

Nucleus Curated. Chromosometelomere Curated

GO - Cellular componenti

  1. chromosome, telomeric region Source: UniProtKB-KW
  2. Set1C/COMPASS complex Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus, Telomere

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 505505COMPASS component BRE2PRO_0000064987Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei227 – 2271Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP43132.
PaxDbiP43132.

Expressioni

Gene expression databases

GenevestigatoriP43132.

Interactioni

Subunit structurei

Component of the COMPASS (Set1C) complex which consists of SET12, BRE22, SPP12, SDC11, SHG11, SWD11, SWD21, and SWD31.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SDC1Q033238EBI-27115,EBI-38307
SET1P388276EBI-27115,EBI-16977

Protein-protein interaction databases

BioGridi31289. 223 interactions.
DIPiDIP-1935N.
IntActiP43132. 10 interactions.
MINTiMINT-408291.
STRINGi4932.YLR015W.

Structurei

3D structure databases

ProteinModelPortaliP43132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiNOG263758.
HOGENOMiHOG000066117.
InParanoidiP43132.
KOiK14967.
OMAiEVNFGPD.
OrthoDBiEOG70GMQJ.

Family and domain databases

InterProiIPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
[Graphical view]
SMARTiSM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 2 hits.

Sequencei

Sequence statusi: Complete.

P43132-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKLGIIPYQE GTDIVYKNAL QGQQEGKRPN LPQMEATHQI KSSVQGTSYE
60 70 80 90 100
FVRTEDIPLN RRHFVYRPCS ANPFFTILGY GCTEYPFDHS GMSVMDRSEG
110 120 130 140 150
LSISRDGNDL VSVPDQYGWR TARSDVCIKE GMTYWEVEVI RGGNKKFADG
160 170 180 190 200
VNNKENADDS VDEVQSGIYE KMHKQVNDTP HLRFGVCRRE ASLEAPVGFD
210 220 230 240 250
VYGYGIRDIS LESIHEGKLN CVLENGSPLK EGDKIGFLLS LPSIHTQIKQ
260 270 280 290 300
AKEFTKRRIF ALNSHMDTMN EPWREDAENG PSRKKLKQET TNKEFQRALL
310 320 330 340 350
EDIEYNDVVR DQIAIRYKNQ LFFEATDYVK TTKPEYYSSD KRERQDYYQL
360 370 380 390 400
EDSYLAIFQN GKYLGKAFEN LKPLLPPFSE LQYNEKFYLG YWQHGEARDE
410 420 430 440 450
SNDKNTTSAK KKKQQQKKKK GLILRNKYVN NNKLGYYPTI SCFNGGTARI
460 470 480 490 500
ISEEDKLEYL DQIRSAYCVD GNSKVNTLDT LYKEQIAEDI VWDIIDELEQ

IALQQ
Length:505
Mass (Da):58,347
Last modified:November 1, 1997 - v2
Checksum:iD5B33221E9F10379
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X90564 Genomic DNA. Translation: CAA62158.1.
Z73187 Genomic DNA. Translation: CAA97537.1.
L34405 Genomic DNA. Translation: AAA34835.1.
BK006945 Genomic DNA. Translation: DAA09333.1.
PIRiS64837.
RefSeqiNP_013115.1. NM_001181902.1.

Genome annotation databases

EnsemblFungiiYLR015W; YLR015W; YLR015W.
GeneIDi850702.
KEGGisce:YLR015W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X90564 Genomic DNA. Translation: CAA62158.1 .
Z73187 Genomic DNA. Translation: CAA97537.1 .
L34405 Genomic DNA. Translation: AAA34835.1 .
BK006945 Genomic DNA. Translation: DAA09333.1 .
PIRi S64837.
RefSeqi NP_013115.1. NM_001181902.1.

3D structure databases

ProteinModelPortali P43132.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 31289. 223 interactions.
DIPi DIP-1935N.
IntActi P43132. 10 interactions.
MINTi MINT-408291.
STRINGi 4932.YLR015W.

Proteomic databases

MaxQBi P43132.
PaxDbi P43132.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YLR015W ; YLR015W ; YLR015W .
GeneIDi 850702.
KEGGi sce:YLR015W.

Organism-specific databases

CYGDi YLR015w.
SGDi S000004005. BRE2.

Phylogenomic databases

eggNOGi NOG263758.
HOGENOMi HOG000066117.
InParanoidi P43132.
KOi K14967.
OMAi EVNFGPD.
OrthoDBi EOG70GMQJ.

Enzyme and pathway databases

BioCyci YEAST:G3O-32176-MONOMER.

Miscellaneous databases

NextBioi 966742.
PROi P43132.

Gene expression databases

Genevestigatori P43132.

Family and domain databases

InterProi IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
[Graphical view ]
SMARTi SM00449. SPRY. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A 7.8kb fragment from chromosome XII of Saccharomyces cerevisiae does not harbour PKC2."
    Saville S.P., Atkinson S., Jamieson L., Pocklington M.J., Orr E.
    Submitted (AUG-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XII."
    Johnston M., Hillier L.W., Riles L., Albermann K., Andre B., Ansorge W., Benes V., Brueckner M., Delius H., Dubois E., Duesterhoeft A., Entian K.-D., Floeth M., Goffeau A., Hebling U., Heumann K., Heuss-Neitzel D., Hilbert H.
    , Hilger F., Kleine K., Koetter P., Louis E.J., Messenguy F., Mewes H.-W., Miosga T., Moestl D., Mueller-Auer S., Nentwich U., Obermaier B., Piravandi E., Pohl T.M., Portetelle D., Purnelle B., Rechmann S., Rieger M., Rinke M., Rose M., Scharfe M., Scherens B., Scholler P., Schwager C., Schwarz S., Underwood A.P., Urrestarazu L.A., Vandenbol M., Verhasselt P., Vierendeels F., Voet M., Volckaert G., Voss H., Wambutt R., Wedler E., Wedler H., Zimmermann F.K., Zollner A., Hani J., Hoheisel J.D.
    Nature 387:87-90(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. "Evidence against the existence of the purported Saccharomyces cerevisiae PKC2 gene."
    Levin D.E., Stevenson W.D., Watanabe M.
    Curr. Biol. 4:990-995(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-472.
    Strain: ATCC 204508 / S288c.
  5. "The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4."
    Roguev A., Schaft D., Shevchenko A., Pijnappel W.W.M.P., Wilm M., Aasland R., Stewart A.F.
    EMBO J. 20:7137-7148(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT.
  6. "COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression."
    Krogan N.J., Dover J., Khorrami S., Greenblatt J.F., Schneider J., Johnston M., Shilatifard A.
    J. Biol. Chem. 277:10753-10755(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. Cited for: SUBUNIT.
  8. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
  9. "A multidimensional chromatography technology for in-depth phosphoproteome analysis."
    Albuquerque C.P., Smolka M.B., Payne S.H., Bafna V., Eng J., Zhou H.
    Mol. Cell. Proteomics 7:1389-1396(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-227, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiBRE2_YEAST
AccessioniPrimary (citable) accession number: P43132
Secondary accession number(s): D6VY17, E9PA88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: October 29, 2014
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1310 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

External Data

Dasty 3