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P43120

- HHEX_MOUSE

UniProt

P43120 - HHEX_MOUSE

Protein

Hematopoietically-expressed homeobox protein Hhex

Gene

Hhex

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Recognizes the DNA sequence 5'-ATTAA-3' By similarity. Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL.By similarity2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi138 – 19760HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. chromatin binding Source: MGI
    2. DNA binding, bending Source: Ensembl
    3. HMG box domain binding Source: UniProtKB
    4. sequence-specific DNA binding Source: UniProtKB
    5. sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    6. transcription regulatory region DNA binding Source: Ensembl

    GO - Biological processi

    1. anterior/posterior pattern specification Source: UniProtKB
    2. B cell differentiation Source: BHF-UCL
    3. common bile duct development Source: MGI
    4. DNA conformation change Source: Ensembl
    5. embryonic heart tube development Source: MGI
    6. embryonic organ development Source: MGI
    7. endoderm development Source: MGI
    8. forebrain development Source: MGI
    9. forebrain morphogenesis Source: MGI
    10. gall bladder development Source: MGI
    11. hemopoiesis Source: MGI
    12. hepatic duct development Source: MGI
    13. hepatoblast differentiation Source: MGI
    14. hepatocyte differentiation Source: MGI
    15. interkinetic nuclear migration Source: MGI
    16. in utero embryonic development Source: MGI
    17. liver development Source: MGI
    18. morphogenesis of an epithelium Source: MGI
    19. multicellular organism growth Source: MGI
    20. myeloid leukocyte differentiation Source: MGI
    21. negative regulation of angiogenesis Source: BHF-UCL
    22. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
    23. negative regulation of transcription, DNA-templated Source: UniProtKB
    24. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    25. negative regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
    26. organ morphogenesis Source: MGI
    27. pancreas development Source: MGI
    28. poly(A)+ mRNA export from nucleus Source: Ensembl
    29. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    30. positive regulation of Wnt signaling pathway Source: UniProtKB
    31. primary lung bud formation Source: MGI
    32. primitive streak formation Source: MGI
    33. protein localization to nucleus Source: Ensembl
    34. regulation of cell proliferation Source: MGI
    35. regulation of transcription from RNA polymerase II promoter Source: MGI
    36. response to peptide hormone Source: Ensembl
    37. response to wounding Source: Ensembl
    38. signal transduction Source: MGI
    39. thyroid gland development Source: MGI
    40. tissue morphogenesis Source: MGI
    41. transcription, DNA-templated Source: UniProtKB-KW
    42. vasculogenesis Source: MGI
    43. Wnt signaling pathway Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein, Repressor

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation, Wnt signaling pathway

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hematopoietically-expressed homeobox protein Hhex
    Short name:
    Homeobox protein HEX
    Short name:
    mHex
    Alternative name(s):
    Homeobox protein PRH
    Gene namesi
    Name:Hhex
    Synonyms:Prh, Prhx
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:96086. Hhex.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI
    3. protein-DNA complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 271271Hematopoietically-expressed homeobox protein HhexPRO_0000049075Add
    BLAST

    Proteomic databases

    PRIDEiP43120.

    PTM databases

    PhosphoSiteiP43120.

    Expressioni

    Developmental stagei

    Expressed during hematopoiesis.

    Gene expression databases

    ArrayExpressiP43120.
    BgeeiP43120.
    CleanExiMM_HHEX.
    GenevestigatoriP43120.

    Interactioni

    Protein-protein interaction databases

    BioGridi200297. 7 interactions.
    MINTiMINT-209977.

    Structurei

    3D structure databases

    ProteinModelPortaliP43120.
    SMRiP43120. Positions 142-195.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1 – 134134Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG252905.
    GeneTreeiENSGT00730000110534.
    HOGENOMiHOG000049110.
    HOVERGENiHBG055460.
    InParanoidiP43120.
    KOiK08024.
    OMAiDNSCDQR.
    OrthoDBiEOG7M0NS8.
    PhylomeDBiP43120.
    TreeFamiTF325047.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43120-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQFPHPGPAA APAVGVPLYA PTPLLQPAHP TPFYIDDILG RGPAAPTPTP    50
    TLPSPNSSFT SLVSSYRTPV YEPTPVHPAF SHHPAAALAA AYGPSGFGGP 100
    LYPFPRTVND YTHALLRHDP LGKPLLWSPF LQRPLHKRKG GQVRFSNDQT 150
    VELEKKFETQ KYLSPPERKR LAKMLQLSER QVKTWFQNRR AKWRRLKQEN 200
    PQSNKKDALD SLDTSCEQGQ DLPSEQNKGA SLDRSQCSPS PASQEDPDSE 250
    ISEDSDQEVD IEGDKGYFNA G 271
    Length:271
    Mass (Da):29,987
    Last modified:November 1, 1995 - v1
    Checksum:i376765557A71C962
    GO

    Sequence cautioni

    The sequence BAB29163.1 differs from that shown. Reason: Frameshift at position 11.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti10 – 101A → L in BAB29163. (PubMed:16141072)Curated
    Sequence conflicti33 – 331F → L in BAA76714. (PubMed:10101294)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z21524 Genomic DNA. Translation: CAA79729.1.
    AB017132 Genomic DNA. Translation: BAA76714.1.
    AF132550 Genomic DNA. Translation: AAF04349.1.
    AK014111 mRNA. Translation: BAB29163.1. Frameshift.
    AK033664 mRNA. Translation: BAC28416.1.
    BC057986 mRNA. Translation: AAH57986.1.
    CCDSiCCDS29778.1.
    PIRiS30230.
    RefSeqiNP_032271.1. NM_008245.3.
    UniGeneiMm.33896.

    Genome annotation databases

    EnsembliENSMUST00000025944; ENSMUSP00000025944; ENSMUSG00000024986.
    GeneIDi15242.
    KEGGimmu:15242.
    UCSCiuc008hio.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z21524 Genomic DNA. Translation: CAA79729.1 .
    AB017132 Genomic DNA. Translation: BAA76714.1 .
    AF132550 Genomic DNA. Translation: AAF04349.1 .
    AK014111 mRNA. Translation: BAB29163.1 . Frameshift.
    AK033664 mRNA. Translation: BAC28416.1 .
    BC057986 mRNA. Translation: AAH57986.1 .
    CCDSi CCDS29778.1.
    PIRi S30230.
    RefSeqi NP_032271.1. NM_008245.3.
    UniGenei Mm.33896.

    3D structure databases

    ProteinModelPortali P43120.
    SMRi P43120. Positions 142-195.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200297. 7 interactions.
    MINTi MINT-209977.

    PTM databases

    PhosphoSitei P43120.

    Proteomic databases

    PRIDEi P43120.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000025944 ; ENSMUSP00000025944 ; ENSMUSG00000024986 .
    GeneIDi 15242.
    KEGGi mmu:15242.
    UCSCi uc008hio.1. mouse.

    Organism-specific databases

    CTDi 3087.
    MGIi MGI:96086. Hhex.

    Phylogenomic databases

    eggNOGi NOG252905.
    GeneTreei ENSGT00730000110534.
    HOGENOMi HOG000049110.
    HOVERGENi HBG055460.
    InParanoidi P43120.
    KOi K08024.
    OMAi DNSCDQR.
    OrthoDBi EOG7M0NS8.
    PhylomeDBi P43120.
    TreeFami TF325047.

    Miscellaneous databases

    NextBioi 287843.
    PROi P43120.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P43120.
    Bgeei P43120.
    CleanExi MM_HHEX.
    Genevestigatori P43120.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human."
      Bedford F.K., Ashworth A., Enver T., Wiedemann L.M.
      Nucleic Acids Res. 21:1245-1249(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
      Strain: C57BL/6J.
    2. "Genomic organization and promoter analysis of a mouse homeobox gene, Hex."
      Myint Z., Inazu T., Tanaka T., Yamada K., Keng V.W., Inoue Y., Kuriyama M., Noguchi T.
      J. Biochem. 125:795-802(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.
    3. "Genomic structure, cDNA mapping, and chromosomal localization of the mouse homeobox gene, Hex."
      Ghosh B., Jacobs H.C., Wiedemann L.M., Brown A., Bedford F.K., Nimmakayalu M.A., Ward D.C., Bogue C.W.
      Mamm. Genome 10:1023-1025(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 129.
    4. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cecum and Head.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Liver.
    6. "Hex is a transcriptional repressor that contributes to anterior identity and suppresses Spemann organiser function."
      Brickman J.M., Jones C.M., Clements M., Smith J.C., Beddington R.S.P.
      Development 127:2303-2315(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "Hex acts with beta-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal."
      Zamparini A.L., Watts T., Gardner C.E., Tomlinson S.R., Johnston G.I., Brickman J.M.
      Development 133:3709-3722(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiHHEX_MOUSE
    AccessioniPrimary (citable) accession number: P43120
    Secondary accession number(s): Q544N6, Q9CRV1, Q9R1X2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3