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P43120

- HHEX_MOUSE

UniProt

P43120 - HHEX_MOUSE

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Protein

Hematopoietically-expressed homeobox protein Hhex

Gene

Hhex

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL.By similarity2 Publications

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi138 – 19760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. chromatin binding Source: MGI
  2. DNA binding, bending Source: Ensembl
  3. HMG box domain binding Source: UniProtKB
  4. sequence-specific DNA binding Source: UniProtKB
  5. sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  6. transcription regulatory region DNA binding Source: Ensembl

GO - Biological processi

  1. anterior/posterior pattern specification Source: UniProtKB
  2. B cell differentiation Source: BHF-UCL
  3. common bile duct development Source: MGI
  4. DNA conformation change Source: Ensembl
  5. embryonic heart tube development Source: MGI
  6. embryonic organ development Source: MGI
  7. endoderm development Source: MGI
  8. forebrain development Source: MGI
  9. forebrain morphogenesis Source: MGI
  10. gall bladder development Source: MGI
  11. hemopoiesis Source: MGI
  12. hepatic duct development Source: MGI
  13. hepatoblast differentiation Source: MGI
  14. hepatocyte differentiation Source: MGI
  15. interkinetic nuclear migration Source: MGI
  16. in utero embryonic development Source: MGI
  17. liver development Source: MGI
  18. morphogenesis of an epithelium Source: MGI
  19. multicellular organism growth Source: MGI
  20. myeloid leukocyte differentiation Source: MGI
  21. negative regulation of angiogenesis Source: BHF-UCL
  22. negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
  23. negative regulation of transcription, DNA-templated Source: UniProtKB
  24. negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  25. negative regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
  26. organ morphogenesis Source: MGI
  27. pancreas development Source: MGI
  28. poly(A)+ mRNA export from nucleus Source: Ensembl
  29. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  30. positive regulation of Wnt signaling pathway Source: UniProtKB
  31. primary lung bud formation Source: MGI
  32. primitive streak formation Source: MGI
  33. protein localization to nucleus Source: Ensembl
  34. regulation of cell proliferation Source: MGI
  35. regulation of transcription from RNA polymerase II promoter Source: MGI
  36. response to peptide hormone Source: Ensembl
  37. response to wounding Source: Ensembl
  38. signal transduction Source: MGI
  39. thyroid gland development Source: MGI
  40. tissue morphogenesis Source: MGI
  41. transcription, DNA-templated Source: UniProtKB-KW
  42. vasculogenesis Source: MGI
  43. Wnt signaling pathway Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation, Wnt signaling pathway

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hematopoietically-expressed homeobox protein Hhex
Short name:
Homeobox protein HEX
Short name:
mHex
Alternative name(s):
Homeobox protein PRH
Gene namesi
Name:Hhex
Synonyms:Prh, Prhx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 19

Organism-specific databases

MGIiMGI:96086. Hhex.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
  3. protein-DNA complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 271271Hematopoietically-expressed homeobox protein HhexPRO_0000049075Add
BLAST

Proteomic databases

MaxQBiP43120.
PRIDEiP43120.

PTM databases

PhosphoSiteiP43120.

Expressioni

Developmental stagei

Expressed during hematopoiesis.

Gene expression databases

BgeeiP43120.
CleanExiMM_HHEX.
ExpressionAtlasiP43120. baseline and differential.
GenevestigatoriP43120.

Interactioni

Protein-protein interaction databases

BioGridi200297. 7 interactions.
MINTiMINT-209977.

Structurei

3D structure databases

ProteinModelPortaliP43120.
SMRiP43120. Positions 142-195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1 – 134134Pro-richAdd
BLAST

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG252905.
GeneTreeiENSGT00730000110534.
HOGENOMiHOG000049110.
HOVERGENiHBG055460.
InParanoidiP43120.
KOiK08024.
OMAiDNSCDQR.
OrthoDBiEOG7M0NS8.
PhylomeDBiP43120.
TreeFamiTF325047.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43120-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQFPHPGPAA APAVGVPLYA PTPLLQPAHP TPFYIDDILG RGPAAPTPTP
60 70 80 90 100
TLPSPNSSFT SLVSSYRTPV YEPTPVHPAF SHHPAAALAA AYGPSGFGGP
110 120 130 140 150
LYPFPRTVND YTHALLRHDP LGKPLLWSPF LQRPLHKRKG GQVRFSNDQT
160 170 180 190 200
VELEKKFETQ KYLSPPERKR LAKMLQLSER QVKTWFQNRR AKWRRLKQEN
210 220 230 240 250
PQSNKKDALD SLDTSCEQGQ DLPSEQNKGA SLDRSQCSPS PASQEDPDSE
260 270
ISEDSDQEVD IEGDKGYFNA G
Length:271
Mass (Da):29,987
Last modified:November 1, 1995 - v1
Checksum:i376765557A71C962
GO

Sequence cautioni

The sequence BAB29163.1 differs from that shown. Reason: Frameshift at position 11.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101A → L in BAB29163. (PubMed:16141072)Curated
Sequence conflicti33 – 331F → L in BAA76714. (PubMed:10101294)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z21524 Genomic DNA. Translation: CAA79729.1.
AB017132 Genomic DNA. Translation: BAA76714.1.
AF132550 Genomic DNA. Translation: AAF04349.1.
AK014111 mRNA. Translation: BAB29163.1. Frameshift.
AK033664 mRNA. Translation: BAC28416.1.
BC057986 mRNA. Translation: AAH57986.1.
CCDSiCCDS29778.1.
PIRiS30230.
RefSeqiNP_032271.1. NM_008245.3.
UniGeneiMm.33896.

Genome annotation databases

EnsembliENSMUST00000025944; ENSMUSP00000025944; ENSMUSG00000024986.
GeneIDi15242.
KEGGimmu:15242.
UCSCiuc008hio.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z21524 Genomic DNA. Translation: CAA79729.1 .
AB017132 Genomic DNA. Translation: BAA76714.1 .
AF132550 Genomic DNA. Translation: AAF04349.1 .
AK014111 mRNA. Translation: BAB29163.1 . Frameshift.
AK033664 mRNA. Translation: BAC28416.1 .
BC057986 mRNA. Translation: AAH57986.1 .
CCDSi CCDS29778.1.
PIRi S30230.
RefSeqi NP_032271.1. NM_008245.3.
UniGenei Mm.33896.

3D structure databases

ProteinModelPortali P43120.
SMRi P43120. Positions 142-195.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 200297. 7 interactions.
MINTi MINT-209977.

PTM databases

PhosphoSitei P43120.

Proteomic databases

MaxQBi P43120.
PRIDEi P43120.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000025944 ; ENSMUSP00000025944 ; ENSMUSG00000024986 .
GeneIDi 15242.
KEGGi mmu:15242.
UCSCi uc008hio.1. mouse.

Organism-specific databases

CTDi 3087.
MGIi MGI:96086. Hhex.

Phylogenomic databases

eggNOGi NOG252905.
GeneTreei ENSGT00730000110534.
HOGENOMi HOG000049110.
HOVERGENi HBG055460.
InParanoidi P43120.
KOi K08024.
OMAi DNSCDQR.
OrthoDBi EOG7M0NS8.
PhylomeDBi P43120.
TreeFami TF325047.

Miscellaneous databases

NextBioi 287843.
PROi P43120.
SOURCEi Search...

Gene expression databases

Bgeei P43120.
CleanExi MM_HHEX.
ExpressionAtlasi P43120. baseline and differential.
Genevestigatori P43120.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "HEX: a novel homeobox gene expressed during haematopoiesis and conserved between mouse and human."
    Bedford F.K., Ashworth A., Enver T., Wiedemann L.M.
    Nucleic Acids Res. 21:1245-1249(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
    Strain: C57BL/6J.
  2. "Genomic organization and promoter analysis of a mouse homeobox gene, Hex."
    Myint Z., Inazu T., Tanaka T., Yamada K., Keng V.W., Inoue Y., Kuriyama M., Noguchi T.
    J. Biochem. 125:795-802(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  3. "Genomic structure, cDNA mapping, and chromosomal localization of the mouse homeobox gene, Hex."
    Ghosh B., Jacobs H.C., Wiedemann L.M., Brown A., Bedford F.K., Nimmakayalu M.A., Ward D.C., Bogue C.W.
    Mamm. Genome 10:1023-1025(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum and Head.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Liver.
  6. "Hex is a transcriptional repressor that contributes to anterior identity and suppresses Spemann organiser function."
    Brickman J.M., Jones C.M., Clements M., Smith J.C., Beddington R.S.P.
    Development 127:2303-2315(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "Hex acts with beta-catenin to regulate anteroposterior patterning via a Groucho-related co-repressor and Nodal."
    Zamparini A.L., Watts T., Gardner C.E., Tomlinson S.R., Johnston G.I., Brickman J.M.
    Development 133:3709-3722(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiHHEX_MOUSE
AccessioniPrimary (citable) accession number: P43120
Secondary accession number(s): Q544N6, Q9CRV1, Q9R1X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3