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Protein

Hematopoietically-expressed homeobox protein Hhex

Gene

Hhex

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Recognizes the DNA sequence 5'-ATTAA-3' (By similarity). Transcriptional repressor. May play a role in hematopoietic differentiation. Establishes anterior identity at two levels; acts early to enhance canonical WNT-signaling by repressing expression of TLE4, and acts later to inhibit NODAL-signaling by directly targeting NODAL.By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi138 – 197HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • animal organ morphogenesis Source: MGI
  • anterior/posterior pattern specification Source: UniProtKB
  • B cell differentiation Source: BHF-UCL
  • cell proliferation Source: MGI
  • common bile duct development Source: MGI
  • DNA conformation change Source: MGI
  • embryonic heart tube development Source: MGI
  • embryonic organ development Source: MGI
  • endoderm development Source: MGI
  • forebrain development Source: MGI
  • forebrain morphogenesis Source: MGI
  • gall bladder development Source: MGI
  • hemopoiesis Source: MGI
  • hepatic duct development Source: MGI
  • hepatoblast differentiation Source: MGI
  • hepatocyte differentiation Source: MGI
  • interkinetic nuclear migration Source: MGI
  • in utero embryonic development Source: MGI
  • liver development Source: MGI
  • morphogenesis of an epithelium Source: MGI
  • mRNA export from nucleus Source: MGI
  • multicellular organism growth Source: MGI
  • myeloid leukocyte differentiation Source: MGI
  • negative regulation of angiogenesis Source: BHF-UCL
  • negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: MGI
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • negative regulation of vascular endothelial growth factor receptor signaling pathway Source: BHF-UCL
  • Notch signaling pathway Source: MGI
  • pancreas development Source: MGI
  • poly(A)+ mRNA export from nucleus Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of Wnt signaling pathway Source: UniProtKB
  • primary lung bud formation Source: MGI
  • primitive streak formation Source: MGI
  • protein localization to nucleus Source: MGI
  • regulation of cell proliferation Source: MGI
  • regulation of transcription by RNA polymerase II Source: MGI
  • response to peptide hormone Source: Ensembl
  • response to wounding Source: Ensembl
  • signal transduction Source: MGI
  • thyroid gland development Source: MGI
  • tissue morphogenesis Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW
  • vasculogenesis Source: MGI
  • Wnt signaling pathway Source: UniProtKB-KW

Keywordsi

Molecular functionDevelopmental protein, DNA-binding, Repressor
Biological processDifferentiation, Transcription, Transcription regulation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Hematopoietically-expressed homeobox protein Hhex
Short name:
Homeobox protein HEX
Short name:
mHex
Alternative name(s):
Homeobox protein PRH
Gene namesi
Name:Hhex
Synonyms:Prh, Prhx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:96086 Hhex

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000490751 – 271Hematopoietically-expressed homeobox protein HhexAdd BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP43120
PaxDbiP43120
PRIDEiP43120

PTM databases

iPTMnetiP43120
PhosphoSitePlusiP43120

Expressioni

Developmental stagei

Expressed during hematopoiesis.

Gene expression databases

BgeeiENSMUSG00000024986
CleanExiMM_HHEX
ExpressionAtlasiP43120 baseline and differential
GenevisibleiP43120 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200297, 7 interactors
STRINGi10090.ENSMUSP00000025944

Structurei

3D structure databases

ProteinModelPortaliP43120
SMRiP43120
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 134Pro-richAdd BLAST134

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0483 Eukaryota
ENOG410Z2UE LUCA
GeneTreeiENSGT00910000143996
HOGENOMiHOG000049110
HOVERGENiHBG055460
InParanoidiP43120
KOiK08024
OMAiDNSCDQR
OrthoDBiEOG091G0RNV
PhylomeDBiP43120
TreeFamiTF325047

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P43120-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQFPHPGPAA APAVGVPLYA PTPLLQPAHP TPFYIDDILG RGPAAPTPTP
60 70 80 90 100
TLPSPNSSFT SLVSSYRTPV YEPTPVHPAF SHHPAAALAA AYGPSGFGGP
110 120 130 140 150
LYPFPRTVND YTHALLRHDP LGKPLLWSPF LQRPLHKRKG GQVRFSNDQT
160 170 180 190 200
VELEKKFETQ KYLSPPERKR LAKMLQLSER QVKTWFQNRR AKWRRLKQEN
210 220 230 240 250
PQSNKKDALD SLDTSCEQGQ DLPSEQNKGA SLDRSQCSPS PASQEDPDSE
260 270
ISEDSDQEVD IEGDKGYFNA G
Length:271
Mass (Da):29,987
Last modified:November 1, 1995 - v1
Checksum:i376765557A71C962
GO

Sequence cautioni

The sequence BAB29163 differs from that shown. Reason: Frameshift at position 11.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10A → L in BAB29163 (PubMed:16141072).Curated1
Sequence conflicti33F → L in BAA76714 (PubMed:10101294).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z21524 Genomic DNA Translation: CAA79729.1
AB017132 Genomic DNA Translation: BAA76714.1
AF132550 Genomic DNA Translation: AAF04349.1
AK014111 mRNA Translation: BAB29163.1 Frameshift.
AK033664 mRNA Translation: BAC28416.1
BC057986 mRNA Translation: AAH57986.1
CCDSiCCDS29778.1
PIRiS30230
RefSeqiNP_032271.1, NM_008245.3
UniGeneiMm.33896

Genome annotation databases

EnsembliENSMUST00000025944; ENSMUSP00000025944; ENSMUSG00000024986
ENSMUST00000213879; ENSMUSP00000150958; ENSMUSG00000111314
GeneIDi15242
KEGGimmu:15242
UCSCiuc008hio.1 mouse

Entry informationi

Entry nameiHHEX_MOUSE
AccessioniPrimary (citable) accession number: P43120
Secondary accession number(s): Q544N6, Q9CRV1, Q9R1X2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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