P43119 PI2R_HUMAN Prostacyclin receptor Prostanoid IP receptor Prostaglandin I2 receptor PGI2 receptor PGI receptor PTGIR PRIPR Homo sapiens Human Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Cloning and expression of a cDNA for the human prostanoid IP receptor. NUCLEOTIDE SEQUENCE [MRNA] Lung Cloning and expression of a cDNA for the human prostacyclin receptor. NUCLEOTIDE SEQUENCE [MRNA] Molecular cloning of human prostacyclin receptor cDNA and its gene expression in the cardiovascular system. NUCLEOTIDE SEQUENCE [MRNA] Lung Structural organization and chromosomal assignment of the human prostacyclin receptor gene. NUCLEOTIDE SEQUENCE [GENOMIC DNA] cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org). NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] Placenta The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] Pancreas Investigation of a functional requirement for isoprenylation by the human prostacyclin receptor. ISOPRENYLATION AT CYS-383 MUTAGENESIS OF CYS-383 Palmitoylation of the human prostacyclin receptor. Functional implications of palmitoylation and isoprenylation. PALMITOYLATION AT CYS-308 AND CYS-311 LACK OF PALMITOYLATION AT CYS-309 MUTAGENESIS OF CYS-308; CYS-309 AND CYS-311 Role of extracellular cysteine residues in dimerization/oligomerization of the human prostacyclin receptor. DISULFIDE BONDS Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. Cell membrane Multi-pass membrane protein Palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to G(s) and signaling. Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C. Belongs to the G-protein coupled receptor 1 family. Cell membrane Complete proteome Disulfide bond G-protein coupled receptor Glycoprotein Lipoprotein Membrane Methylation Palmitate Polymorphism Prenylation Receptor Transducer Transmembrane V M S W C S C S C S C S MADSCRNLTYVRGSVGPATSTLMFVAGVVGNGLALGILSARRPARPSAFAVLVTGLAATD LLGTSFLSPAVFVAYARNSSLLGLARGGPALCDAFAFAMTFFGLASMLILFAMAVERCLA LSHPYLYAQLDGPRCARLALPAIYAFCVLFCALPLLGLGQHQQYCPGSWCFLRMRWAQPG GAAFSLAYAGLVALLVAAIFLCNGSVTLSLCRMYRQQKRHQGSLGPRPRTGEDEVDHLIL LALMTVVMAVCSLPLTIRCFTQAVAPDSSSEMGDLLAFRFYAFNPILDPWVFILFRKAVF QRLKLWVCCLCLGPAHGDSQTPLSQLASGRRDPRAPSAPVGKEGSCVPLSAWGEGQVEPL PPTQQSSGSAVGTSSKAEASVACSLC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms Distributed under the Creative Commons Attribution-NoDerivs License