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Protein

Prostacyclin receptor

Gene

PTGIR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase.

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
  • cell-cell signaling Source: ProtInc
  • cellular response to prostaglandin D stimulus Source: GO_Central
  • G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: ProtInc
  • inflammatory response Source: GO_Central
  • negative regulation of platelet-derived growth factor receptor signaling pathway Source: BHF-UCL
  • negative regulation of smooth muscle cell proliferation Source: BHF-UCL
  • positive regulation of cAMP biosynthetic process Source: BHF-UCL
  • positive regulation of cAMP-mediated signaling Source: BHF-UCL
  • positive regulation of cytosolic calcium ion concentration Source: GO_Central
  • response to lipopolysaccharide Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160013-MONOMER.
ReactomeiR-HSA-391908. Prostanoid ligand receptors.
R-HSA-392851. Prostacyclin signalling through prostacyclin receptor.
R-HSA-418555. G alpha (s) signalling events.
SIGNORiP43119.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostacyclin receptor
Alternative name(s):
Prostaglandin I2 receptor
Short name:
PGI receptor
Short name:
PGI2 receptor
Prostanoid IP receptor
Gene namesi
Name:PTGIR
Synonyms:PRIPR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9602. PTGIR.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16ExtracellularSequence analysisAdd BLAST16
Transmembranei17 – 38Helical; Name=1Sequence analysisAdd BLAST22
Topological domaini39 – 51CytoplasmicSequence analysisAdd BLAST13
Transmembranei52 – 76Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini77 – 94ExtracellularSequence analysisAdd BLAST18
Transmembranei95 – 115Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini116 – 134CytoplasmicSequence analysisAdd BLAST19
Transmembranei135 – 158Helical; Name=4Sequence analysisAdd BLAST24
Topological domaini159 – 181ExtracellularSequence analysisAdd BLAST23
Transmembranei182 – 208Helical; Name=5Sequence analysisAdd BLAST27
Topological domaini209 – 235CytoplasmicSequence analysisAdd BLAST27
Transmembranei236 – 260Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini261 – 274ExtracellularSequence analysisAdd BLAST14
Transmembranei275 – 295Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini296 – 386CytoplasmicSequence analysisAdd BLAST91

GO - Cellular componenti

  • cytosol Source: BHF-UCL
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi308C → S: Reduced palmitoylation, coupling to G protein unaffected. Abolished palmitoylation and coupling to G protein; when associated with S-311. 1 Publication1
Mutagenesisi309C → S: No effect on palmitoylation level. 1 Publication1
Mutagenesisi311C → S: Reduced palmitoylation, coupling to G protein unaffected. Abolished palmitoylation and coupling to G protein; when associated with S-308. 1 Publication1
Mutagenesisi383C → S: Abolishes isoprenylation. 1 Publication1

Organism-specific databases

DisGeNETi5739.
OpenTargetsiENSG00000160013.
PharmGKBiPA291.

Chemistry databases

ChEMBLiCHEMBL1995.
DrugBankiDB01160. Dinoprost Tromethamine.
DB01240. Epoprostenol.
DB01088. Iloprost.
DB11362. Selexipag.
DB00374. Treprostinil.
GuidetoPHARMACOLOGYi345.

Polymorphism and mutation databases

BioMutaiPTGIR.
DMDMi1172500.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700751 – 383Prostacyclin receptorAdd BLAST383
PropeptideiPRO_0000240004384 – 386Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi5 ↔ 165PROSITE-ProRule annotation1 Publication
Glycosylationi7N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi92 ↔ 170PROSITE-ProRule annotation1 Publication
Lipidationi308S-palmitoyl cysteine1 Publication1
Lipidationi311S-palmitoyl cysteine1 Publication1
Modified residuei383Cysteine methyl esterCurated1
Lipidationi383S-farnesyl cysteine1 Publication1

Post-translational modificationi

Palmitoylation of either Cys-308 or Cys-311 is sufficient to maintain functional coupling to G(s) and signaling.1 Publication
Isoprenylation does not influence ligand binding but is required for efficient coupling to the effectors adenylyl cyclase and phospholipase C.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei309Not S-palmitoylated1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbiP43119.
PeptideAtlasiP43119.
PRIDEiP43119.

PTM databases

iPTMnetiP43119.
PhosphoSitePlusiP43119.
SwissPalmiP43119.

Expressioni

Gene expression databases

BgeeiENSG00000160013.
CleanExiHS_PTGIR.
ExpressionAtlasiP43119. baseline and differential.
GenevisibleiP43119. HS.

Interactioni

Subunit structurei

Interacts (non-isoprenylated C-terminus) with PDZK1.By similarity

Protein-protein interaction databases

BioGridi111711. 67 interactors.
STRINGi9606.ENSP00000291294.

Chemistry databases

BindingDBiP43119.

Structurei

3D structure databases

ProteinModelPortaliP43119.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiP43119.
KOiK04263.
OMAiFTQAIAP.
OrthoDBiEOG091G0F07.
PhylomeDBiP43119.
TreeFamiTF324982.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR000370. Prostglndn_IP_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF7. PTHR11866:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00856. PRSTNOIDIPR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43119-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADSCRNLTY VRGSVGPATS TLMFVAGVVG NGLALGILSA RRPARPSAFA
60 70 80 90 100
VLVTGLAATD LLGTSFLSPA VFVAYARNSS LLGLARGGPA LCDAFAFAMT
110 120 130 140 150
FFGLASMLIL FAMAVERCLA LSHPYLYAQL DGPRCARLAL PAIYAFCVLF
160 170 180 190 200
CALPLLGLGQ HQQYCPGSWC FLRMRWAQPG GAAFSLAYAG LVALLVAAIF
210 220 230 240 250
LCNGSVTLSL CRMYRQQKRH QGSLGPRPRT GEDEVDHLIL LALMTVVMAV
260 270 280 290 300
CSLPLTIRCF TQAVAPDSSS EMGDLLAFRF YAFNPILDPW VFILFRKAVF
310 320 330 340 350
QRLKLWVCCL CLGPAHGDSQ TPLSQLASGR RDPRAPSAPV GKEGSCVPLS
360 370 380
AWGEGQVEPL PPTQQSSGSA VGTSSKAEAS VACSLC
Length:386
Mass (Da):40,956
Last modified:November 1, 1995 - v1
Checksum:i2B6B0CDBACED1608
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02426025V → M.Corresponds to variant rs2229127dbSNPEnsembl.1
Natural variantiVAR_061226319S → W.Corresponds to variant rs28590598dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29016 mRNA. Translation: AAA36448.1.
D25418 mRNA. Translation: BAA05008.1.
D29634 mRNA. Translation: BAA06110.1.
D38127 Genomic DNA. Translation: BAA07325.1.
AY242134 mRNA. Translation: AAO92301.1.
BC075814 mRNA. Translation: AAH75814.1.
CCDSiCCDS12686.1.
PIRiA57066.
RefSeqiNP_000951.1. NM_000960.3.
UniGeneiHs.458324.

Genome annotation databases

EnsembliENST00000291294; ENSP00000291294; ENSG00000160013.
GeneIDi5739.
KEGGihsa:5739.
UCSCiuc002pex.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L29016 mRNA. Translation: AAA36448.1.
D25418 mRNA. Translation: BAA05008.1.
D29634 mRNA. Translation: BAA06110.1.
D38127 Genomic DNA. Translation: BAA07325.1.
AY242134 mRNA. Translation: AAO92301.1.
BC075814 mRNA. Translation: AAH75814.1.
CCDSiCCDS12686.1.
PIRiA57066.
RefSeqiNP_000951.1. NM_000960.3.
UniGeneiHs.458324.

3D structure databases

ProteinModelPortaliP43119.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111711. 67 interactors.
STRINGi9606.ENSP00000291294.

Chemistry databases

BindingDBiP43119.
ChEMBLiCHEMBL1995.
DrugBankiDB01160. Dinoprost Tromethamine.
DB01240. Epoprostenol.
DB01088. Iloprost.
DB11362. Selexipag.
DB00374. Treprostinil.
GuidetoPHARMACOLOGYi345.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP43119.
PhosphoSitePlusiP43119.
SwissPalmiP43119.

Polymorphism and mutation databases

BioMutaiPTGIR.
DMDMi1172500.

Proteomic databases

PaxDbiP43119.
PeptideAtlasiP43119.
PRIDEiP43119.

Protocols and materials databases

DNASUi5739.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000291294; ENSP00000291294; ENSG00000160013.
GeneIDi5739.
KEGGihsa:5739.
UCSCiuc002pex.4. human.

Organism-specific databases

CTDi5739.
DisGeNETi5739.
GeneCardsiPTGIR.
HGNCiHGNC:9602. PTGIR.
MIMi600022. gene.
neXtProtiNX_P43119.
OpenTargetsiENSG00000160013.
PharmGKBiPA291.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiP43119.
KOiK04263.
OMAiFTQAIAP.
OrthoDBiEOG091G0F07.
PhylomeDBiP43119.
TreeFamiTF324982.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160013-MONOMER.
ReactomeiR-HSA-391908. Prostanoid ligand receptors.
R-HSA-392851. Prostacyclin signalling through prostacyclin receptor.
R-HSA-418555. G alpha (s) signalling events.
SIGNORiP43119.

Miscellaneous databases

GeneWikiiProstacyclin_receptor.
GenomeRNAii5739.
PROiP43119.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000160013.
CleanExiHS_PTGIR.
ExpressionAtlasiP43119. baseline and differential.
GenevisibleiP43119. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR000370. Prostglndn_IP_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF7. PTHR11866:SF7. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01788. PROSTANOIDR.
PR00856. PRSTNOIDIPR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPI2R_HUMAN
AccessioniPrimary (citable) accession number: P43119
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 158 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.