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P43118

- PF2R_RAT

UniProt

P43118 - PF2R_RAT

Protein

Prostaglandin F2-alpha receptor

Gene

Ptgfr

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum.

    GO - Molecular functioni

    1. prostaglandin F receptor activity Source: Ensembl

    GO - Biological processi

    1. calcium-mediated signaling using intracellular calcium source Source: Ensembl
    2. negative regulation of apoptotic process Source: Ensembl
    3. response to lipopolysaccharide Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prostaglandin F2-alpha receptor
    Short name:
    PGF receptor
    Short name:
    PGF2-alpha receptor
    Alternative name(s):
    Prostanoid FP receptor
    Gene namesi
    Name:Ptgfr
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi3436. Ptgfr.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. extracellular region Source: Ensembl
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 366366Prostaglandin F2-alpha receptorPRO_0000070072Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi108 ↔ 186PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP43118.

    PTM databases

    PhosphoSiteiP43118.

    Expressioni

    Tissue specificityi

    Highest expression in pregnant ovary. Also found in a low extent in the kidney. In the brain, expressed in astrocytes and oligodendrocytes, and meningeal fibroblasts, but not in migroglia cells.

    Gene expression databases

    GenevestigatoriP43118.

    Structurei

    3D structure databases

    ProteinModelPortaliP43118.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini56 – 6914CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini91 – 10919ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini132 – 15221CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini176 – 19823ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini225 – 25026CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini268 – 28518ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini308 – 36659CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5524Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei70 – 9021Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei110 – 13122Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei153 – 17523Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 22426Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei251 – 26717Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei286 – 30722Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    GeneTreeiENSGT00690000102015.
    HOVERGENiHBG003621.
    KOiK04262.
    OMAiQGRSHHF.
    OrthoDBiEOG7PP575.
    PhylomeDBiP43118.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000141. PglndnF_rcpt.
    IPR008365. Prostanoid_rcpt.
    [Graphical view]
    PANTHERiPTHR11866. PTHR11866. 1 hit.
    PTHR11866:SF4. PTHR11866:SF4. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01788. PROSTANOIDR.
    PR00855. PRSTNOIDFPR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43118-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSINSSKQPA SSAAGLIANT TCQTENRLSV FFSIIFMTVG IVSNSLAIAI    50
    LMKAYQRFRR KSKASFLLLA SGLVITDFFG HLINGGIAVF VYASDKDWIR 100
    FDQSNILCSV FGISMVFSGL CPLFLGSTMA IERCIGVTNP LFHSTKITSK 150
    HVKMILSGVC MFAVFVALLP ILGHRDYQIQ ASRTWCFYNT EHIEDWEDRF 200
    YLLFFSSLGL LALGISFSCN AVTGVTLLRV KFRSQQHRQG RSHHLEMVIQ 250
    LLAIMCVSCV CWSPFLVTMA NIAINGNNSP VTCETTLFAL RMATWNQILD 300
    PWVYILLRKA VLRNLYKLAS RCCGVNIISL HIWELSSIKN SLKVAAISES 350
    PAAEKENQQA SSEAGL 366
    Length:366
    Mass (Da):40,655
    Last modified:November 1, 1995 - v1
    Checksum:iD44C47F18B326FBA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti10 – 101A → V in AAB19233. (PubMed:8804121)Curated
    Sequence conflicti113 – 1131I → M in AAB19233. (PubMed:8804121)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D28581 mRNA. Translation: BAA05917.1.
    S74898 mRNA. Translation: AAB32739.1.
    X83856 mRNA. Translation: CAA58736.1.
    U47287 mRNA. Translation: AAB47872.1.
    U26663 mRNA. Translation: AAB19233.1.
    PIRiS51281.
    RefSeqiNP_037247.1. NM_013115.1.
    XP_006233548.1. XM_006233486.1.
    XP_006233549.1. XM_006233487.1.
    UniGeneiRn.97602.

    Genome annotation databases

    EnsembliENSRNOT00000071195; ENSRNOP00000065253; ENSRNOG00000046468.
    GeneIDi25652.
    KEGGirno:25652.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D28581 mRNA. Translation: BAA05917.1 .
    S74898 mRNA. Translation: AAB32739.1 .
    X83856 mRNA. Translation: CAA58736.1 .
    U47287 mRNA. Translation: AAB47872.1 .
    U26663 mRNA. Translation: AAB19233.1 .
    PIRi S51281.
    RefSeqi NP_037247.1. NM_013115.1.
    XP_006233548.1. XM_006233486.1.
    XP_006233549.1. XM_006233487.1.
    UniGenei Rn.97602.

    3D structure databases

    ProteinModelPortali P43118.
    ModBasei Search...
    MobiDBi Search...

    Chemistry

    GuidetoPHARMACOLOGYi 344.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P43118.

    Proteomic databases

    PRIDEi P43118.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000071195 ; ENSRNOP00000065253 ; ENSRNOG00000046468 .
    GeneIDi 25652.
    KEGGi rno:25652.

    Organism-specific databases

    CTDi 5737.
    RGDi 3436. Ptgfr.

    Phylogenomic databases

    GeneTreei ENSGT00690000102015.
    HOVERGENi HBG003621.
    KOi K04262.
    OMAi QGRSHHF.
    OrthoDBi EOG7PP575.
    PhylomeDBi P43118.

    Miscellaneous databases

    NextBioi 607527.
    PROi P43118.

    Gene expression databases

    Genevestigatori P43118.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR000141. PglndnF_rcpt.
    IPR008365. Prostanoid_rcpt.
    [Graphical view ]
    PANTHERi PTHR11866. PTHR11866. 1 hit.
    PTHR11866:SF4. PTHR11866:SF4. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01788. PROSTANOIDR.
    PR00855. PRSTNOIDFPR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a cDNA for rat prostaglandin F2 alpha receptor."
      Kitanaka J., Hashimoto H., Sugimoto Y., Negishi M., Aino H., Gotoh M., Ichikawa A., Baba A.
      Prostaglandins 48:31-41(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Brain cortex.
    2. "Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor."
      Lake S., Gullberg H., Wahlqvist J., Sjoegren A.-M., Kinhult A., Lind P., Hellstroem-Lindahl E., Stjernschantz J.
      FEBS Lett. 355:317-325(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. de Vries C., Neuschaefer-Rube F., Haenecke K., Jungermann K., Pueschel G.P.
      Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Liver.
    4. "Characterization and regulation of a mRNA encoding the prostaglandin F2alpha receptor in the rat ovary."
      Olofsson J.I., Leung C.H.B., Bjurulf E., Ohno T., Selstam G., Peng C., Leung P.C.K.
      Mol. Cell. Endocrinol. 123:45-52(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Ovary.
    5. "Negative regulatory activity of a prostaglandin F2 alpha receptor associated protein (FPRP)."
      Orlicky D.J.
      Prostaglandins Leukot. Essent. Fatty Acids 54:247-259(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Ovary.

    Entry informationi

    Entry nameiPF2R_RAT
    AccessioniPrimary (citable) accession number: P43118
    Secondary accession number(s): Q62787
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3