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Protein

Prostaglandin F2-alpha receptor

Gene

Ptgfr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-RNO-391908. Prostanoid ligand receptors.
R-RNO-416476. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin F2-alpha receptor
Short name:
PGF receptor
Short name:
PGF2-alpha receptor
Alternative name(s):
Prostanoid FP receptor
Gene namesi
Name:Ptgfr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi3436. Ptgfr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 31ExtracellularSequence analysisAdd BLAST31
Transmembranei32 – 55Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini56 – 69CytoplasmicSequence analysisAdd BLAST14
Transmembranei70 – 90Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini91 – 109ExtracellularSequence analysisAdd BLAST19
Transmembranei110 – 131Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini132 – 152CytoplasmicSequence analysisAdd BLAST21
Transmembranei153 – 175Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini176 – 198ExtracellularSequence analysisAdd BLAST23
Transmembranei199 – 224Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini225 – 250CytoplasmicSequence analysisAdd BLAST26
Transmembranei251 – 267Helical; Name=6Sequence analysisAdd BLAST17
Topological domaini268 – 285ExtracellularSequence analysisAdd BLAST18
Transmembranei286 – 307Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini308 – 366CytoplasmicSequence analysisAdd BLAST59

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

GuidetoPHARMACOLOGYi344.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700721 – 366Prostaglandin F2-alpha receptorAdd BLAST366

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...)Sequence analysis1
Glycosylationi19N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi108 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43118.
PRIDEiP43118.

PTM databases

PhosphoSitePlusiP43118.

Expressioni

Tissue specificityi

Highest expression in pregnant ovary. Also found in a low extent in the kidney. In the brain, expressed in astrocytes and oligodendrocytes, and meningeal fibroblasts, but not in migroglia cells.

Gene expression databases

BgeeiENSRNOG00000046468.
GenevisibleiP43118. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065253.

Structurei

3D structure databases

ProteinModelPortaliP43118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOVERGENiHBG003621.
InParanoidiP43118.
KOiK04262.
OMAiQGRSHHF.
OrthoDBiEOG091G0A2S.
PhylomeDBiP43118.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000141. PglndnF_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF4. PTHR11866:SF4. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00855. PRSTNOIDFPR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43118-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSINSSKQPA SSAAGLIANT TCQTENRLSV FFSIIFMTVG IVSNSLAIAI
60 70 80 90 100
LMKAYQRFRR KSKASFLLLA SGLVITDFFG HLINGGIAVF VYASDKDWIR
110 120 130 140 150
FDQSNILCSV FGISMVFSGL CPLFLGSTMA IERCIGVTNP LFHSTKITSK
160 170 180 190 200
HVKMILSGVC MFAVFVALLP ILGHRDYQIQ ASRTWCFYNT EHIEDWEDRF
210 220 230 240 250
YLLFFSSLGL LALGISFSCN AVTGVTLLRV KFRSQQHRQG RSHHLEMVIQ
260 270 280 290 300
LLAIMCVSCV CWSPFLVTMA NIAINGNNSP VTCETTLFAL RMATWNQILD
310 320 330 340 350
PWVYILLRKA VLRNLYKLAS RCCGVNIISL HIWELSSIKN SLKVAAISES
360
PAAEKENQQA SSEAGL
Length:366
Mass (Da):40,655
Last modified:November 1, 1995 - v1
Checksum:iD44C47F18B326FBA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10A → V in AAB19233 (PubMed:8804121).Curated1
Sequence conflicti113I → M in AAB19233 (PubMed:8804121).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28581 mRNA. Translation: BAA05917.1.
S74898 mRNA. Translation: AAB32739.1.
X83856 mRNA. Translation: CAA58736.1.
U47287 mRNA. Translation: AAB47872.1.
U26663 mRNA. Translation: AAB19233.1.
PIRiS51281.
RefSeqiNP_037247.1. NM_013115.1.
XP_006233548.1. XM_006233486.3.
XP_006233549.1. XM_006233487.3.
UniGeneiRn.97602.

Genome annotation databases

EnsembliENSRNOT00000071195; ENSRNOP00000065253; ENSRNOG00000046468.
GeneIDi25652.
KEGGirno:25652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28581 mRNA. Translation: BAA05917.1.
S74898 mRNA. Translation: AAB32739.1.
X83856 mRNA. Translation: CAA58736.1.
U47287 mRNA. Translation: AAB47872.1.
U26663 mRNA. Translation: AAB19233.1.
PIRiS51281.
RefSeqiNP_037247.1. NM_013115.1.
XP_006233548.1. XM_006233486.3.
XP_006233549.1. XM_006233487.3.
UniGeneiRn.97602.

3D structure databases

ProteinModelPortaliP43118.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000065253.

Chemistry databases

GuidetoPHARMACOLOGYi344.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP43118.

Proteomic databases

PaxDbiP43118.
PRIDEiP43118.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000071195; ENSRNOP00000065253; ENSRNOG00000046468.
GeneIDi25652.
KEGGirno:25652.

Organism-specific databases

CTDi5737.
RGDi3436. Ptgfr.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOVERGENiHBG003621.
InParanoidiP43118.
KOiK04262.
OMAiQGRSHHF.
OrthoDBiEOG091G0A2S.
PhylomeDBiP43118.

Enzyme and pathway databases

ReactomeiR-RNO-391908. Prostanoid ligand receptors.
R-RNO-416476. G alpha (q) signalling events.

Miscellaneous databases

PROiP43118.

Gene expression databases

BgeeiENSRNOG00000046468.
GenevisibleiP43118. RN.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000141. PglndnF_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF4. PTHR11866:SF4. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00855. PRSTNOIDFPR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPF2R_RAT
AccessioniPrimary (citable) accession number: P43118
Secondary accession number(s): Q62787
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.