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Protein

Prostaglandin F2-alpha receptor

Gene

Ptgfr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum.

GO - Molecular functioni

  1. prostaglandin F receptor activity Source: Ensembl

GO - Biological processi

  1. calcium-mediated signaling using intracellular calcium source Source: Ensembl
  2. negative regulation of apoptotic process Source: Ensembl
  3. response to lipopolysaccharide Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_310434. Prostanoid ligand receptors.
REACT_353304. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin F2-alpha receptor
Short name:
PGF receptor
Short name:
PGF2-alpha receptor
Alternative name(s):
Prostanoid FP receptor
Gene namesi
Name:Ptgfr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi3436. Ptgfr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
BLAST
Transmembranei32 – 5524Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini56 – 6914CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei70 – 9021Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini91 – 10919ExtracellularSequence AnalysisAdd
BLAST
Transmembranei110 – 13122Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini132 – 15221CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei153 – 17523Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini176 – 19823ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 22426Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini225 – 25026CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei251 – 26717Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini268 – 28518ExtracellularSequence AnalysisAdd
BLAST
Transmembranei286 – 30722Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini308 – 36659CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. extracellular region Source: Ensembl
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 366366Prostaglandin F2-alpha receptorPRO_0000070072Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi4 – 41N-linked (GlcNAc...)Sequence Analysis
Glycosylationi19 – 191N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi108 ↔ 186PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP43118.

PTM databases

PhosphoSiteiP43118.

Expressioni

Tissue specificityi

Highest expression in pregnant ovary. Also found in a low extent in the kidney. In the brain, expressed in astrocytes and oligodendrocytes, and meningeal fibroblasts, but not in migroglia cells.

Gene expression databases

GenevestigatoriP43118.

Structurei

3D structure databases

ProteinModelPortaliP43118.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00760000119188.
HOVERGENiHBG003621.
InParanoidiP43118.
KOiK04262.
OMAiQGRSHHF.
OrthoDBiEOG7PP575.
PhylomeDBiP43118.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000141. PglndnF_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF4. PTHR11866:SF4. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00855. PRSTNOIDFPR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43118-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSINSSKQPA SSAAGLIANT TCQTENRLSV FFSIIFMTVG IVSNSLAIAI
60 70 80 90 100
LMKAYQRFRR KSKASFLLLA SGLVITDFFG HLINGGIAVF VYASDKDWIR
110 120 130 140 150
FDQSNILCSV FGISMVFSGL CPLFLGSTMA IERCIGVTNP LFHSTKITSK
160 170 180 190 200
HVKMILSGVC MFAVFVALLP ILGHRDYQIQ ASRTWCFYNT EHIEDWEDRF
210 220 230 240 250
YLLFFSSLGL LALGISFSCN AVTGVTLLRV KFRSQQHRQG RSHHLEMVIQ
260 270 280 290 300
LLAIMCVSCV CWSPFLVTMA NIAINGNNSP VTCETTLFAL RMATWNQILD
310 320 330 340 350
PWVYILLRKA VLRNLYKLAS RCCGVNIISL HIWELSSIKN SLKVAAISES
360
PAAEKENQQA SSEAGL
Length:366
Mass (Da):40,655
Last modified:November 1, 1995 - v1
Checksum:iD44C47F18B326FBA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101A → V in AAB19233 (PubMed:8804121).Curated
Sequence conflicti113 – 1131I → M in AAB19233 (PubMed:8804121).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28581 mRNA. Translation: BAA05917.1.
S74898 mRNA. Translation: AAB32739.1.
X83856 mRNA. Translation: CAA58736.1.
U47287 mRNA. Translation: AAB47872.1.
U26663 mRNA. Translation: AAB19233.1.
PIRiS51281.
RefSeqiNP_037247.1. NM_013115.1.
XP_006233548.1. XM_006233486.2.
XP_006233549.1. XM_006233487.2.
UniGeneiRn.97602.

Genome annotation databases

EnsembliENSRNOT00000071195; ENSRNOP00000065253; ENSRNOG00000046468.
GeneIDi25652.
KEGGirno:25652.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D28581 mRNA. Translation: BAA05917.1.
S74898 mRNA. Translation: AAB32739.1.
X83856 mRNA. Translation: CAA58736.1.
U47287 mRNA. Translation: AAB47872.1.
U26663 mRNA. Translation: AAB19233.1.
PIRiS51281.
RefSeqiNP_037247.1. NM_013115.1.
XP_006233548.1. XM_006233486.2.
XP_006233549.1. XM_006233487.2.
UniGeneiRn.97602.

3D structure databases

ProteinModelPortaliP43118.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

GuidetoPHARMACOLOGYi344.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP43118.

Proteomic databases

PRIDEiP43118.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000071195; ENSRNOP00000065253; ENSRNOG00000046468.
GeneIDi25652.
KEGGirno:25652.

Organism-specific databases

CTDi5737.
RGDi3436. Ptgfr.

Phylogenomic databases

GeneTreeiENSGT00760000119188.
HOVERGENiHBG003621.
InParanoidiP43118.
KOiK04262.
OMAiQGRSHHF.
OrthoDBiEOG7PP575.
PhylomeDBiP43118.

Enzyme and pathway databases

ReactomeiREACT_310434. Prostanoid ligand receptors.
REACT_353304. G alpha (q) signalling events.

Miscellaneous databases

NextBioi607527.
PROiP43118.

Gene expression databases

GenevestigatoriP43118.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR000141. PglndnF_rcpt.
IPR008365. Prostanoid_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF4. PTHR11866:SF4. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00855. PRSTNOIDFPR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and expression of a cDNA for rat prostaglandin F2 alpha receptor."
    Kitanaka J., Hashimoto H., Sugimoto Y., Negishi M., Aino H., Gotoh M., Ichikawa A., Baba A.
    Prostaglandins 48:31-41(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Brain cortex.
  2. "Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor."
    Lake S., Gullberg H., Wahlqvist J., Sjoegren A.-M., Kinhult A., Lind P., Hellstroem-Lindahl E., Stjernschantz J.
    FEBS Lett. 355:317-325(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. de Vries C., Neuschaefer-Rube F., Haenecke K., Jungermann K., Pueschel G.P.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Liver.
  4. "Characterization and regulation of a mRNA encoding the prostaglandin F2alpha receptor in the rat ovary."
    Olofsson J.I., Leung C.H.B., Bjurulf E., Ohno T., Selstam G., Peng C., Leung P.C.K.
    Mol. Cell. Endocrinol. 123:45-52(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Ovary.
  5. "Negative regulatory activity of a prostaglandin F2 alpha receptor associated protein (FPRP)."
    Orlicky D.J.
    Prostaglandins Leukot. Essent. Fatty Acids 54:247-259(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Ovary.

Entry informationi

Entry nameiPF2R_RAT
AccessioniPrimary (citable) accession number: P43118
Secondary accession number(s): Q62787
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 1, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.