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Protein

Prostaglandin E2 receptor EP2 subtype

Gene

PTGER2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

GO - Molecular functioni

  • prostaglandin E receptor activity Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125384-MONOMER.
ReactomeiR-HSA-391908. Prostanoid ligand receptors.
R-HSA-418555. G alpha (s) signalling events.
SIGNORiP43116.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E2 receptor EP2 subtype
Short name:
PGE receptor EP2 subtype
Short name:
PGE2 receptor EP2 subtype
Alternative name(s):
Prostanoid EP2 receptor
Gene namesi
Name:PTGER2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:9594. PTGER2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularSequence analysisAdd BLAST23
Transmembranei24 – 47Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini48 – 65CytoplasmicSequence analysisAdd BLAST18
Transmembranei66 – 91Helical; Name=2Sequence analysisAdd BLAST26
Topological domaini92 – 111ExtracellularSequence analysisAdd BLAST20
Transmembranei112 – 132Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini133 – 151CytoplasmicSequence analysisAdd BLAST19
Transmembranei152 – 176Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini177 – 198ExtracellularSequence analysisAdd BLAST22
Transmembranei199 – 223Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini224 – 262CytoplasmicSequence analysisAdd BLAST39
Transmembranei263 – 286Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini287 – 299ExtracellularSequence analysisAdd BLAST13
Transmembranei300 – 323Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini324 – 358CytoplasmicSequence analysisAdd BLAST35

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5732.
MalaCardsiPTGER2.
OpenTargetsiENSG00000125384.
PharmGKBiPA287.

Chemistry databases

ChEMBLiCHEMBL1881.
DrugBankiDB00770. Alprostadil.
DB00917. Dinoprostone.
DB00929. Misoprostol.
GuidetoPHARMACOLOGYi341.

Polymorphism and mutation databases

BioMutaiPTGER2.
DMDMi38258920.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700541 – 358Prostaglandin E2 receptor EP2 subtypeAdd BLAST358

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Glycosylationi6N-linked (GlcNAc...)Sequence analysis1
Glycosylationi96N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi109 ↔ 187PROSITE-ProRule annotation
Glycosylationi287N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43116.
PeptideAtlasiP43116.
PRIDEiP43116.

PTM databases

iPTMnetiP43116.
PhosphoSitePlusiP43116.

Expressioni

Tissue specificityi

Placenta and lung.

Gene expression databases

BgeeiENSG00000125384.
CleanExiHS_PTGER2.
ExpressionAtlasiP43116. baseline and differential.
GenevisibleiP43116. HS.

Organism-specific databases

HPAiCAB009260.

Interactioni

Protein-protein interaction databases

IntActiP43116. 4 interactors.
STRINGi9606.ENSP00000245457.

Chemistry databases

BindingDBiP43116.

Structurei

3D structure databases

ProteinModelPortaliP43116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiP43116.
KOiK04259.
OMAiNDSWPED.
OrthoDBiEOG091G0F07.
PhylomeDBiP43116.
TreeFamiTF324982.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001923. Prostglndn_EP2_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF8. PTHR11866:SF8. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00581. PRSTNOIDEP2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43116-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGNASNDSQS EDCETRQWLP PGESPAISSV MFSAGVLGNL IALALLARRW
60 70 80 90 100
RGDVGCSAGR RSSLSLFHVL VTELVFTDLL GTCLISPVVL ASYARNQTLV
110 120 130 140 150
ALAPESRACT YFAFAMTFFS LATMLMLFAM ALERYLSIGH PYFYQRRVSR
160 170 180 190 200
SGGLAVLPVI YAVSLLFCSL PLLDYGQYVQ YCPGTWCFIR HGRTAYLQLY
210 220 230 240 250
ATLLLLLIVS VLACNFSVIL NLIRMHRRSR RSRCGPSLGS GRGGPGARRR
260 270 280 290 300
GERVSMAEET DHLILLAIMT ITFAVCSLPF TIFAYMNETS SRKEKWDLQA
310 320 330 340 350
LRFLSINSII DPWVFAILRP PVLRLMRSVL CCRISLRTQD ATQTSCSTQS

DASKQADL
Length:358
Mass (Da):39,761
Last modified:November 7, 2003 - v2
Checksum:iB3B0E2AA3CF2E363
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti150R → A in AAA61681 (PubMed:8078484).Curated1
Sequence conflicti150R → A in AAD44177 (PubMed:10521663).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19487 mRNA. Translation: AAA61681.1.
X83868 mRNA. Translation: CAA58749.1.
AF134202, AF134201 Genomic DNA. Translation: AAD44177.1.
AY275471 mRNA. Translation: AAP32303.1.
DQ398948 Genomic DNA. Translation: ABD48958.1.
CH471078 Genomic DNA. Translation: EAW65652.1.
CH471078 Genomic DNA. Translation: EAW65654.1.
BC093927 mRNA. Translation: AAH93927.1.
BC093929 mRNA. Translation: AAH93929.1.
CCDSiCCDS9708.1.
PIRiI38920.
S51312.
RefSeqiNP_000947.2. NM_000956.3.
UniGeneiHs.2090.

Genome annotation databases

EnsembliENST00000245457; ENSP00000245457; ENSG00000125384.
GeneIDi5732.
KEGGihsa:5732.
UCSCiuc001wzr.4. human.

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19487 mRNA. Translation: AAA61681.1.
X83868 mRNA. Translation: CAA58749.1.
AF134202, AF134201 Genomic DNA. Translation: AAD44177.1.
AY275471 mRNA. Translation: AAP32303.1.
DQ398948 Genomic DNA. Translation: ABD48958.1.
CH471078 Genomic DNA. Translation: EAW65652.1.
CH471078 Genomic DNA. Translation: EAW65654.1.
BC093927 mRNA. Translation: AAH93927.1.
BC093929 mRNA. Translation: AAH93929.1.
CCDSiCCDS9708.1.
PIRiI38920.
S51312.
RefSeqiNP_000947.2. NM_000956.3.
UniGeneiHs.2090.

3D structure databases

ProteinModelPortaliP43116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP43116. 4 interactors.
STRINGi9606.ENSP00000245457.

Chemistry databases

BindingDBiP43116.
ChEMBLiCHEMBL1881.
DrugBankiDB00770. Alprostadil.
DB00917. Dinoprostone.
DB00929. Misoprostol.
GuidetoPHARMACOLOGYi341.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP43116.
PhosphoSitePlusiP43116.

Polymorphism and mutation databases

BioMutaiPTGER2.
DMDMi38258920.

Proteomic databases

PaxDbiP43116.
PeptideAtlasiP43116.
PRIDEiP43116.

Protocols and materials databases

DNASUi5732.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245457; ENSP00000245457; ENSG00000125384.
GeneIDi5732.
KEGGihsa:5732.
UCSCiuc001wzr.4. human.

Organism-specific databases

CTDi5732.
DisGeNETi5732.
GeneCardsiPTGER2.
HGNCiHGNC:9594. PTGER2.
HPAiCAB009260.
MalaCardsiPTGER2.
MIMi176804. gene.
neXtProtiNX_P43116.
OpenTargetsiENSG00000125384.
PharmGKBiPA287.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiP43116.
KOiK04259.
OMAiNDSWPED.
OrthoDBiEOG091G0F07.
PhylomeDBiP43116.
TreeFamiTF324982.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125384-MONOMER.
ReactomeiR-HSA-391908. Prostanoid ligand receptors.
R-HSA-418555. G alpha (s) signalling events.
SIGNORiP43116.

Miscellaneous databases

GeneWikiiProstaglandin_E2_receptor.
GenomeRNAii5732.
PROiP43116.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125384.
CleanExiHS_PTGER2.
ExpressionAtlasiP43116. baseline and differential.
GenevisibleiP43116. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001923. Prostglndn_EP2_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF8. PTHR11866:SF8. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00581. PRSTNOIDEP2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPE2R2_HUMAN
AccessioniPrimary (citable) accession number: P43116
Secondary accession number(s): D3DSC0, Q52LG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 7, 2003
Last modified: November 2, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.