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P43116

- PE2R2_HUMAN

UniProt

P43116 - PE2R2_HUMAN

Protein

Prostaglandin E2 receptor EP2 subtype

Gene

PTGER2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (07 Nov 2003)
      Previous versions | rss
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    Functioni

    Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

    GO - Molecular functioni

    1. prostaglandin E receptor activity Source: ProtInc

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
    2. cellular response to prostaglandin E stimulus Source: BHF-UCL
    3. G-protein coupled receptor signaling pathway Source: ProtInc
    4. regulation of cell proliferation Source: Ensembl
    5. response to lipopolysaccharide Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18425. Prostanoid ligand receptors.
    REACT_19327. G alpha (s) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prostaglandin E2 receptor EP2 subtype
    Short name:
    PGE receptor EP2 subtype
    Short name:
    PGE2 receptor EP2 subtype
    Alternative name(s):
    Prostanoid EP2 receptor
    Gene namesi
    Name:PTGER2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:9594. PTGER2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA287.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 358358Prostaglandin E2 receptor EP2 subtypePRO_0000070054Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi109 ↔ 187PROSITE-ProRule annotation
    Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP43116.
    PRIDEiP43116.

    PTM databases

    PhosphoSiteiP43116.

    Expressioni

    Tissue specificityi

    Placenta and lung.

    Gene expression databases

    ArrayExpressiP43116.
    BgeeiP43116.
    CleanExiHS_PTGER2.
    GenevestigatoriP43116.

    Interactioni

    Protein-protein interaction databases

    IntActiP43116. 4 interactions.
    STRINGi9606.ENSP00000245457.

    Structurei

    3D structure databases

    ProteinModelPortaliP43116.
    SMRiP43116. Positions 65-324.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini48 – 6518CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini92 – 11120ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini133 – 15119CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini177 – 19822ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini224 – 26239CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini287 – 29913ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini324 – 35835CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4724Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei66 – 9126Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei112 – 13221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei152 – 17625Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei199 – 22325Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei263 – 28624Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei300 – 32324Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG275624.
    HOGENOMiHOG000115475.
    HOVERGENiHBG003074.
    InParanoidiP43116.
    KOiK04259.
    OMAiCKTFIAI.
    PhylomeDBiP43116.
    TreeFamiTF324982.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008365. Prostanoid_rcpt.
    IPR001923. Prostglndn_EP2_rcpt.
    [Graphical view]
    PANTHERiPTHR11866. PTHR11866. 1 hit.
    PTHR11866:SF8. PTHR11866:SF8. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01788. PROSTANOIDR.
    PR00581. PRSTNOIDEP2R.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43116-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGNASNDSQS EDCETRQWLP PGESPAISSV MFSAGVLGNL IALALLARRW    50
    RGDVGCSAGR RSSLSLFHVL VTELVFTDLL GTCLISPVVL ASYARNQTLV 100
    ALAPESRACT YFAFAMTFFS LATMLMLFAM ALERYLSIGH PYFYQRRVSR 150
    SGGLAVLPVI YAVSLLFCSL PLLDYGQYVQ YCPGTWCFIR HGRTAYLQLY 200
    ATLLLLLIVS VLACNFSVIL NLIRMHRRSR RSRCGPSLGS GRGGPGARRR 250
    GERVSMAEET DHLILLAIMT ITFAVCSLPF TIFAYMNETS SRKEKWDLQA 300
    LRFLSINSII DPWVFAILRP PVLRLMRSVL CCRISLRTQD ATQTSCSTQS 350
    DASKQADL 358
    Length:358
    Mass (Da):39,761
    Last modified:November 7, 2003 - v2
    Checksum:iB3B0E2AA3CF2E363
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti150 – 1501R → A in AAA61681. (PubMed:8078484)Curated
    Sequence conflicti150 – 1501R → A in AAD44177. (PubMed:10521663)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19487 mRNA. Translation: AAA61681.1.
    X83868 mRNA. Translation: CAA58749.1.
    AF134202, AF134201 Genomic DNA. Translation: AAD44177.1.
    AY275471 mRNA. Translation: AAP32303.1.
    DQ398948 Genomic DNA. Translation: ABD48958.1.
    CH471078 Genomic DNA. Translation: EAW65652.1.
    CH471078 Genomic DNA. Translation: EAW65654.1.
    BC093927 mRNA. Translation: AAH93927.1.
    BC093929 mRNA. Translation: AAH93929.1.
    CCDSiCCDS9708.1.
    PIRiI38920.
    S51312.
    RefSeqiNP_000947.2. NM_000956.3.
    UniGeneiHs.2090.

    Genome annotation databases

    EnsembliENST00000245457; ENSP00000245457; ENSG00000125384.
    GeneIDi5732.
    KEGGihsa:5732.
    UCSCiuc001wzr.3. human.

    Polymorphism databases

    DMDMi38258920.

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U19487 mRNA. Translation: AAA61681.1 .
    X83868 mRNA. Translation: CAA58749.1 .
    AF134202 , AF134201 Genomic DNA. Translation: AAD44177.1 .
    AY275471 mRNA. Translation: AAP32303.1 .
    DQ398948 Genomic DNA. Translation: ABD48958.1 .
    CH471078 Genomic DNA. Translation: EAW65652.1 .
    CH471078 Genomic DNA. Translation: EAW65654.1 .
    BC093927 mRNA. Translation: AAH93927.1 .
    BC093929 mRNA. Translation: AAH93929.1 .
    CCDSi CCDS9708.1.
    PIRi I38920.
    S51312.
    RefSeqi NP_000947.2. NM_000956.3.
    UniGenei Hs.2090.

    3D structure databases

    ProteinModelPortali P43116.
    SMRi P43116. Positions 65-324.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P43116. 4 interactions.
    STRINGi 9606.ENSP00000245457.

    Chemistry

    BindingDBi P43116.
    ChEMBLi CHEMBL2363068.
    DrugBanki DB00770. Alprostadil.
    DB01088. Iloprost.
    GuidetoPHARMACOLOGYi 341.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P43116.

    Polymorphism databases

    DMDMi 38258920.

    Proteomic databases

    PaxDbi P43116.
    PRIDEi P43116.

    Protocols and materials databases

    DNASUi 5732.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000245457 ; ENSP00000245457 ; ENSG00000125384 .
    GeneIDi 5732.
    KEGGi hsa:5732.
    UCSCi uc001wzr.3. human.

    Organism-specific databases

    CTDi 5732.
    GeneCardsi GC14P052781.
    HGNCi HGNC:9594. PTGER2.
    MIMi 176804. gene.
    neXtProti NX_P43116.
    PharmGKBi PA287.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG275624.
    HOGENOMi HOG000115475.
    HOVERGENi HBG003074.
    InParanoidi P43116.
    KOi K04259.
    OMAi CKTFIAI.
    PhylomeDBi P43116.
    TreeFami TF324982.

    Enzyme and pathway databases

    Reactomei REACT_18425. Prostanoid ligand receptors.
    REACT_19327. G alpha (s) signalling events.

    Miscellaneous databases

    GeneWikii Prostaglandin_E2_receptor.
    GenomeRNAii 5732.
    NextBioi 22298.
    PROi P43116.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P43116.
    Bgeei P43116.
    CleanExi HS_PTGER2.
    Genevestigatori P43116.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR008365. Prostanoid_rcpt.
    IPR001923. Prostglndn_EP2_rcpt.
    [Graphical view ]
    PANTHERi PTHR11866. PTHR11866. 1 hit.
    PTHR11866:SF8. PTHR11866:SF8. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01788. PROSTANOIDR.
    PR00581. PRSTNOIDEP2R.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype."
      Regan J.W., Bailey T.J., Pepperl D.J., Pierce K.L., Bogardus A.M., Donello J.E., Fairbairn C.E., Kedzie K.M., Woodward D.F., Gil D.W.
      Mol. Pharmacol. 46:213-220(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Placenta.
    2. Oakley C.J.
      Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E2 receptor EP2 subtype."
      Smock S.L., Pan L.C., Castleberry T.A., Lu B., Mather R.J., Owen T.A.
      Gene 237:393-402(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
      Warren C.N., Aronstam R.S., Sharma S.V.
      Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta.
    5. SeattleSNPs variation discovery resource
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiPE2R2_HUMAN
    AccessioniPrimary (citable) accession number: P43116
    Secondary accession number(s): D3DSC0, Q52LG8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 7, 2003
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3