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P43116

- PE2R2_HUMAN

UniProt

P43116 - PE2R2_HUMAN

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Protein

Prostaglandin E2 receptor EP2 subtype

Gene

PTGER2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

GO - Molecular functioni

  1. prostaglandin E receptor activity Source: ProtInc

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
  2. cellular response to prostaglandin E stimulus Source: BHF-UCL
  3. G-protein coupled receptor signaling pathway Source: ProtInc
  4. regulation of cell proliferation Source: Ensembl
  5. response to lipopolysaccharide Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18425. Prostanoid ligand receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E2 receptor EP2 subtype
Short name:
PGE receptor EP2 subtype
Short name:
PGE2 receptor EP2 subtype
Alternative name(s):
Prostanoid EP2 receptor
Gene namesi
Name:PTGER2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:9594. PTGER2.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA287.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Prostaglandin E2 receptor EP2 subtypePRO_0000070054Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi109 ↔ 187PROSITE-ProRule annotation
Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43116.
PRIDEiP43116.

PTM databases

PhosphoSiteiP43116.

Expressioni

Tissue specificityi

Placenta and lung.

Gene expression databases

BgeeiP43116.
CleanExiHS_PTGER2.
ExpressionAtlasiP43116. baseline and differential.
GenevestigatoriP43116.

Interactioni

Protein-protein interaction databases

IntActiP43116. 4 interactions.
STRINGi9606.ENSP00000245457.

Structurei

3D structure databases

ProteinModelPortaliP43116.
SMRiP43116. Positions 65-324.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Topological domaini48 – 6518CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini92 – 11120ExtracellularSequence AnalysisAdd
BLAST
Topological domaini133 – 15119CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini177 – 19822ExtracellularSequence AnalysisAdd
BLAST
Topological domaini224 – 26239CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini287 – 29913ExtracellularSequence AnalysisAdd
BLAST
Topological domaini324 – 35835CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei24 – 4724Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei66 – 9126Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei112 – 13221Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei152 – 17625Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei199 – 22325Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei263 – 28624Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei300 – 32324Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG275624.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiP43116.
KOiK04259.
OMAiCKTFIAI.
PhylomeDBiP43116.
TreeFamiTF324982.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001923. Prostglndn_EP2_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF8. PTHR11866:SF8. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00581. PRSTNOIDEP2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43116-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNASNDSQS EDCETRQWLP PGESPAISSV MFSAGVLGNL IALALLARRW
60 70 80 90 100
RGDVGCSAGR RSSLSLFHVL VTELVFTDLL GTCLISPVVL ASYARNQTLV
110 120 130 140 150
ALAPESRACT YFAFAMTFFS LATMLMLFAM ALERYLSIGH PYFYQRRVSR
160 170 180 190 200
SGGLAVLPVI YAVSLLFCSL PLLDYGQYVQ YCPGTWCFIR HGRTAYLQLY
210 220 230 240 250
ATLLLLLIVS VLACNFSVIL NLIRMHRRSR RSRCGPSLGS GRGGPGARRR
260 270 280 290 300
GERVSMAEET DHLILLAIMT ITFAVCSLPF TIFAYMNETS SRKEKWDLQA
310 320 330 340 350
LRFLSINSII DPWVFAILRP PVLRLMRSVL CCRISLRTQD ATQTSCSTQS

DASKQADL
Length:358
Mass (Da):39,761
Last modified:November 7, 2003 - v2
Checksum:iB3B0E2AA3CF2E363
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti150 – 1501R → A in AAA61681. (PubMed:8078484)Curated
Sequence conflicti150 – 1501R → A in AAD44177. (PubMed:10521663)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19487 mRNA. Translation: AAA61681.1.
X83868 mRNA. Translation: CAA58749.1.
AF134202, AF134201 Genomic DNA. Translation: AAD44177.1.
AY275471 mRNA. Translation: AAP32303.1.
DQ398948 Genomic DNA. Translation: ABD48958.1.
CH471078 Genomic DNA. Translation: EAW65652.1.
CH471078 Genomic DNA. Translation: EAW65654.1.
BC093927 mRNA. Translation: AAH93927.1.
BC093929 mRNA. Translation: AAH93929.1.
CCDSiCCDS9708.1.
PIRiI38920.
S51312.
RefSeqiNP_000947.2. NM_000956.3.
UniGeneiHs.2090.

Genome annotation databases

EnsembliENST00000245457; ENSP00000245457; ENSG00000125384.
GeneIDi5732.
KEGGihsa:5732.
UCSCiuc001wzr.3. human.

Polymorphism databases

DMDMi38258920.

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U19487 mRNA. Translation: AAA61681.1 .
X83868 mRNA. Translation: CAA58749.1 .
AF134202 , AF134201 Genomic DNA. Translation: AAD44177.1 .
AY275471 mRNA. Translation: AAP32303.1 .
DQ398948 Genomic DNA. Translation: ABD48958.1 .
CH471078 Genomic DNA. Translation: EAW65652.1 .
CH471078 Genomic DNA. Translation: EAW65654.1 .
BC093927 mRNA. Translation: AAH93927.1 .
BC093929 mRNA. Translation: AAH93929.1 .
CCDSi CCDS9708.1.
PIRi I38920.
S51312.
RefSeqi NP_000947.2. NM_000956.3.
UniGenei Hs.2090.

3D structure databases

ProteinModelPortali P43116.
SMRi P43116. Positions 65-324.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P43116. 4 interactions.
STRINGi 9606.ENSP00000245457.

Chemistry

BindingDBi P43116.
ChEMBLi CHEMBL2363068.
DrugBanki DB00770. Alprostadil.
DB00917. Dinoprostone.
DB00929. Misoprostol.
GuidetoPHARMACOLOGYi 341.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P43116.

Polymorphism databases

DMDMi 38258920.

Proteomic databases

PaxDbi P43116.
PRIDEi P43116.

Protocols and materials databases

DNASUi 5732.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000245457 ; ENSP00000245457 ; ENSG00000125384 .
GeneIDi 5732.
KEGGi hsa:5732.
UCSCi uc001wzr.3. human.

Organism-specific databases

CTDi 5732.
GeneCardsi GC14P052781.
HGNCi HGNC:9594. PTGER2.
MIMi 176804. gene.
neXtProti NX_P43116.
PharmGKBi PA287.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG275624.
GeneTreei ENSGT00760000119188.
HOGENOMi HOG000115475.
HOVERGENi HBG003074.
InParanoidi P43116.
KOi K04259.
OMAi CKTFIAI.
PhylomeDBi P43116.
TreeFami TF324982.

Enzyme and pathway databases

Reactomei REACT_18425. Prostanoid ligand receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikii Prostaglandin_E2_receptor.
GenomeRNAii 5732.
NextBioi 22298.
PROi P43116.
SOURCEi Search...

Gene expression databases

Bgeei P43116.
CleanExi HS_PTGER2.
ExpressionAtlasi P43116. baseline and differential.
Genevestigatori P43116.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001923. Prostglndn_EP2_rcpt.
[Graphical view ]
PANTHERi PTHR11866. PTHR11866. 1 hit.
PTHR11866:SF8. PTHR11866:SF8. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00581. PRSTNOIDEP2R.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype."
    Regan J.W., Bailey T.J., Pepperl D.J., Pierce K.L., Bogardus A.M., Donello J.E., Fairbairn C.E., Kedzie K.M., Woodward D.F., Gil D.W.
    Mol. Pharmacol. 46:213-220(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. Oakley C.J.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E2 receptor EP2 subtype."
    Smock S.L., Pan L.C., Castleberry T.A., Lu B., Mather R.J., Owen T.A.
    Gene 237:393-402(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Warren C.N., Aronstam R.S., Sharma S.V.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  5. SeattleSNPs variation discovery resource
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiPE2R2_HUMAN
AccessioniPrimary (citable) accession number: P43116
Secondary accession number(s): D3DSC0, Q52LG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 7, 2003
Last modified: October 29, 2014
This is version 128 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3