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Protein

Prostaglandin E2 receptor EP2 subtype

Gene

PTGER2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

GO - Molecular functioni

  1. prostaglandin E receptor activity Source: ProtInc

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: BHF-UCL
  2. cellular response to prostaglandin E stimulus Source: BHF-UCL
  3. G-protein coupled receptor signaling pathway Source: ProtInc
  4. regulation of cell proliferation Source: Ensembl
  5. response to lipopolysaccharide Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18425. Prostanoid ligand receptors.
REACT_19327. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Prostaglandin E2 receptor EP2 subtype
Short name:
PGE receptor EP2 subtype
Short name:
PGE2 receptor EP2 subtype
Alternative name(s):
Prostanoid EP2 receptor
Gene namesi
Name:PTGER2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:9594. PTGER2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei24 – 4724Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini48 – 6518CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei66 – 9126Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini92 – 11120ExtracellularSequence AnalysisAdd
BLAST
Transmembranei112 – 13221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini133 – 15119CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei152 – 17625Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini177 – 19822ExtracellularSequence AnalysisAdd
BLAST
Transmembranei199 – 22325Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini224 – 26239CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei263 – 28624Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini287 – 29913ExtracellularSequence AnalysisAdd
BLAST
Transmembranei300 – 32324Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini324 – 35835CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA287.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 358358Prostaglandin E2 receptor EP2 subtypePRO_0000070054Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Glycosylationi6 – 61N-linked (GlcNAc...)Sequence Analysis
Glycosylationi96 – 961N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi109 ↔ 187PROSITE-ProRule annotation
Glycosylationi287 – 2871N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43116.
PRIDEiP43116.

PTM databases

PhosphoSiteiP43116.

Expressioni

Tissue specificityi

Placenta and lung.

Gene expression databases

BgeeiP43116.
CleanExiHS_PTGER2.
ExpressionAtlasiP43116. baseline and differential.
GenevestigatoriP43116.

Interactioni

Protein-protein interaction databases

IntActiP43116. 4 interactions.
STRINGi9606.ENSP00000245457.

Structurei

3D structure databases

ProteinModelPortaliP43116.
SMRiP43116. Positions 65-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG275624.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiP43116.
KOiK04259.
OMAiDPWVFAI.
PhylomeDBiP43116.
TreeFamiTF324982.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001923. Prostglndn_EP2_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF8. PTHR11866:SF8. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00581. PRSTNOIDEP2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43116-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGNASNDSQS EDCETRQWLP PGESPAISSV MFSAGVLGNL IALALLARRW
60 70 80 90 100
RGDVGCSAGR RSSLSLFHVL VTELVFTDLL GTCLISPVVL ASYARNQTLV
110 120 130 140 150
ALAPESRACT YFAFAMTFFS LATMLMLFAM ALERYLSIGH PYFYQRRVSR
160 170 180 190 200
SGGLAVLPVI YAVSLLFCSL PLLDYGQYVQ YCPGTWCFIR HGRTAYLQLY
210 220 230 240 250
ATLLLLLIVS VLACNFSVIL NLIRMHRRSR RSRCGPSLGS GRGGPGARRR
260 270 280 290 300
GERVSMAEET DHLILLAIMT ITFAVCSLPF TIFAYMNETS SRKEKWDLQA
310 320 330 340 350
LRFLSINSII DPWVFAILRP PVLRLMRSVL CCRISLRTQD ATQTSCSTQS

DASKQADL
Length:358
Mass (Da):39,761
Last modified:November 7, 2003 - v2
Checksum:iB3B0E2AA3CF2E363
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti150 – 1501R → A in AAA61681. (PubMed:8078484)Curated
Sequence conflicti150 – 1501R → A in AAD44177. (PubMed:10521663)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19487 mRNA. Translation: AAA61681.1.
X83868 mRNA. Translation: CAA58749.1.
AF134202, AF134201 Genomic DNA. Translation: AAD44177.1.
AY275471 mRNA. Translation: AAP32303.1.
DQ398948 Genomic DNA. Translation: ABD48958.1.
CH471078 Genomic DNA. Translation: EAW65652.1.
CH471078 Genomic DNA. Translation: EAW65654.1.
BC093927 mRNA. Translation: AAH93927.1.
BC093929 mRNA. Translation: AAH93929.1.
CCDSiCCDS9708.1.
PIRiI38920.
S51312.
RefSeqiNP_000947.2. NM_000956.3.
UniGeneiHs.2090.

Genome annotation databases

EnsembliENST00000245457; ENSP00000245457; ENSG00000125384.
GeneIDi5732.
KEGGihsa:5732.
UCSCiuc001wzr.3. human.

Polymorphism databases

DMDMi38258920.

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19487 mRNA. Translation: AAA61681.1.
X83868 mRNA. Translation: CAA58749.1.
AF134202, AF134201 Genomic DNA. Translation: AAD44177.1.
AY275471 mRNA. Translation: AAP32303.1.
DQ398948 Genomic DNA. Translation: ABD48958.1.
CH471078 Genomic DNA. Translation: EAW65652.1.
CH471078 Genomic DNA. Translation: EAW65654.1.
BC093927 mRNA. Translation: AAH93927.1.
BC093929 mRNA. Translation: AAH93929.1.
CCDSiCCDS9708.1.
PIRiI38920.
S51312.
RefSeqiNP_000947.2. NM_000956.3.
UniGeneiHs.2090.

3D structure databases

ProteinModelPortaliP43116.
SMRiP43116. Positions 65-324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP43116. 4 interactions.
STRINGi9606.ENSP00000245457.

Chemistry

BindingDBiP43116.
ChEMBLiCHEMBL2363068.
DrugBankiDB00770. Alprostadil.
DB00917. Dinoprostone.
DB00929. Misoprostol.
GuidetoPHARMACOLOGYi341.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiP43116.

Polymorphism databases

DMDMi38258920.

Proteomic databases

PaxDbiP43116.
PRIDEiP43116.

Protocols and materials databases

DNASUi5732.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245457; ENSP00000245457; ENSG00000125384.
GeneIDi5732.
KEGGihsa:5732.
UCSCiuc001wzr.3. human.

Organism-specific databases

CTDi5732.
GeneCardsiGC14P052781.
HGNCiHGNC:9594. PTGER2.
MIMi176804. gene.
neXtProtiNX_P43116.
PharmGKBiPA287.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG275624.
GeneTreeiENSGT00760000119188.
HOGENOMiHOG000115475.
HOVERGENiHBG003074.
InParanoidiP43116.
KOiK04259.
OMAiDPWVFAI.
PhylomeDBiP43116.
TreeFamiTF324982.

Enzyme and pathway databases

ReactomeiREACT_18425. Prostanoid ligand receptors.
REACT_19327. G alpha (s) signalling events.

Miscellaneous databases

GeneWikiiProstaglandin_E2_receptor.
GenomeRNAii5732.
NextBioi22298.
PROiP43116.
SOURCEiSearch...

Gene expression databases

BgeeiP43116.
CleanExiHS_PTGER2.
ExpressionAtlasiP43116. baseline and differential.
GenevestigatoriP43116.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001923. Prostglndn_EP2_rcpt.
[Graphical view]
PANTHERiPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF8. PTHR11866:SF8. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00581. PRSTNOIDEP2R.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype."
    Regan J.W., Bailey T.J., Pepperl D.J., Pierce K.L., Bogardus A.M., Donello J.E., Fairbairn C.E., Kedzie K.M., Woodward D.F., Gil D.W.
    Mol. Pharmacol. 46:213-220(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Placenta.
  2. Oakley C.J.
    Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E2 receptor EP2 subtype."
    Smock S.L., Pan L.C., Castleberry T.A., Lu B., Mather R.J., Owen T.A.
    Gene 237:393-402(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
    Warren C.N., Aronstam R.S., Sharma S.V.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta.
  5. SeattleSNPs variation discovery resource
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiPE2R2_HUMAN
AccessioniPrimary (citable) accession number: P43116
Secondary accession number(s): D3DSC0, Q52LG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 7, 2003
Last modified: January 7, 2015
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.