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P43116 (PE2R2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Prostaglandin E2 receptor EP2 subtype

Short name=PGE receptor EP2 subtype
Short name=PGE2 receptor EP2 subtype
Alternative name(s):
Prostanoid EP2 receptor
Gene names
Name:PTGER2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. The subsequent raise in intracellular cAMP is responsible for the relaxing effect of this receptor on smooth muscle.

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Placenta and lung.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 358358Prostaglandin E2 receptor EP2 subtype
PRO_0000070054

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4724Helical; Name=1; Potential
Topological domain48 – 6518Cytoplasmic Potential
Transmembrane66 – 9126Helical; Name=2; Potential
Topological domain92 – 11120Extracellular Potential
Transmembrane112 – 13221Helical; Name=3; Potential
Topological domain133 – 15119Cytoplasmic Potential
Transmembrane152 – 17625Helical; Name=4; Potential
Topological domain177 – 19822Extracellular Potential
Transmembrane199 – 22325Helical; Name=5; Potential
Topological domain224 – 26239Cytoplasmic Potential
Transmembrane263 – 28624Helical; Name=6; Potential
Topological domain287 – 29913Extracellular Potential
Transmembrane300 – 32324Helical; Name=7; Potential
Topological domain324 – 35835Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Glycosylation61N-linked (GlcNAc...) Potential
Glycosylation961N-linked (GlcNAc...) Potential
Glycosylation2871N-linked (GlcNAc...) Potential
Disulfide bond109 ↔ 187 By similarity

Experimental info

Sequence conflict1501R → A in AAA61681. Ref.1
Sequence conflict1501R → A in AAD44177. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P43116 [UniParc].

Last modified November 7, 2003. Version 2.
Checksum: B3B0E2AA3CF2E363

FASTA35839,761
        10         20         30         40         50         60 
MGNASNDSQS EDCETRQWLP PGESPAISSV MFSAGVLGNL IALALLARRW RGDVGCSAGR 

        70         80         90        100        110        120 
RSSLSLFHVL VTELVFTDLL GTCLISPVVL ASYARNQTLV ALAPESRACT YFAFAMTFFS 

       130        140        150        160        170        180 
LATMLMLFAM ALERYLSIGH PYFYQRRVSR SGGLAVLPVI YAVSLLFCSL PLLDYGQYVQ 

       190        200        210        220        230        240 
YCPGTWCFIR HGRTAYLQLY ATLLLLLIVS VLACNFSVIL NLIRMHRRSR RSRCGPSLGS 

       250        260        270        280        290        300 
GRGGPGARRR GERVSMAEET DHLILLAIMT ITFAVCSLPF TIFAYMNETS SRKEKWDLQA 

       310        320        330        340        350 
LRFLSINSII DPWVFAILRP PVLRLMRSVL CCRISLRTQD ATQTSCSTQS DASKQADL 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype."
Regan J.W., Bailey T.J., Pepperl D.J., Pierce K.L., Bogardus A.M., Donello J.E., Fairbairn C.E., Kedzie K.M., Woodward D.F., Gil D.W.
Mol. Pharmacol. 46:213-220(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Placenta.
[2]Oakley C.J.
Submitted (JAN-1995) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloning, structural characterization, and chromosomal localization of the gene encoding the human prostaglandin E2 receptor EP2 subtype."
Smock S.L., Pan L.C., Castleberry T.A., Lu B., Mather R.J., Owen T.A.
Gene 237:393-402(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)."
Warren C.N., Aronstam R.S., Sharma S.V.
Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[5]SeattleSNPs variation discovery resource
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U19487 mRNA. Translation: AAA61681.1.
X83868 mRNA. Translation: CAA58749.1.
AF134202, AF134201 Genomic DNA. Translation: AAD44177.1.
AY275471 mRNA. Translation: AAP32303.1.
DQ398948 Genomic DNA. Translation: ABD48958.1.
CH471078 Genomic DNA. Translation: EAW65652.1.
CH471078 Genomic DNA. Translation: EAW65654.1.
BC093927 mRNA. Translation: AAH93927.1.
BC093929 mRNA. Translation: AAH93929.1.
PIRI38920.
S51312.
RefSeqNP_000947.2. NM_000956.3.
UniGeneHs.2090.

3D structure databases

ProteinModelPortalP43116.
SMRP43116. Positions 65-324.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP43116. 4 interactions.
STRING9606.ENSP00000245457.

Chemistry

BindingDBP43116.
ChEMBLCHEMBL2363068.
DrugBankDB00770. Alprostadil.
DB01088. Iloprost.
GuidetoPHARMACOLOGY341.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteP43116.

Polymorphism databases

DMDM38258920.

Proteomic databases

PaxDbP43116.
PRIDEP43116.

Protocols and materials databases

DNASU5732.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000245457; ENSP00000245457; ENSG00000125384.
GeneID5732.
KEGGhsa:5732.
UCSCuc001wzr.3. human.

Organism-specific databases

CTD5732.
GeneCardsGC14P052781.
HGNCHGNC:9594. PTGER2.
MIM176804. gene.
neXtProtNX_P43116.
PharmGKBPA287.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG275624.
HOGENOMHOG000115475.
HOVERGENHBG003074.
InParanoidP43116.
KOK04259.
OMAAIMTITF.
PhylomeDBP43116.
TreeFamTF324982.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressP43116.
BgeeP43116.
CleanExHS_PTGER2.
GenevestigatorP43116.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR008365. Prostanoid_rcpt.
IPR001923. Prostglndn_EP2_rcpt.
[Graphical view]
PANTHERPTHR11866. PTHR11866. 1 hit.
PTHR11866:SF8. PTHR11866:SF8. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01788. PROSTANOIDR.
PR00581. PRSTNOIDEP2R.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiProstaglandin_E2_receptor.
GenomeRNAi5732.
NextBio22298.
PROP43116.
SOURCESearch...

Entry information

Entry namePE2R2_HUMAN
AccessionPrimary (citable) accession number: P43116
Secondary accession number(s): D3DSC0, Q52LG8
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 7, 2003
Last modified: April 16, 2014
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries