P43115 (PE2R3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prostaglandin E2 receptor EP3 subtype
Short name=PGE receptor EP3 subtype
Short name=PGE2 receptor EP3 subtype

Alternative name(s):
PGE2-R
Prostanoid EP3 receptor

Gene names

Name:

PTGER3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems By similarity.
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in small intestine, heart, pancreas, gastric fundic mucosa, mammary artery and pulmonary vessels. Ref.15
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Glycoprotein Lipoprotein Palmitate
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell death Traceable author statement PubMed 10947062. Source: ProtInc positive regulation of fever generation Inferred from sequence or structural similarity. Source: BHF-UCL
Cellular_component	integral to plasma membrane Traceable author statement Ref.1. Source: ProtInc nuclear envelope Traceable author statement PubMed 10336471. Source: ProtInc
Molecular_function	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Traceable author statement PubMed 10336471. Source: ProtInc prostaglandin E receptor activity Non-traceable author statement Ref.8. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 7 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.

Isoform EP3A (identifier: P43115-1)

Also known as: EP3-I; EP3a1; EP3a2; EP(3-Ic);

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform EP3C (identifier: P43115-2)

Also known as: EP3-II;

The sequence of this isoform differs from the canonical sequence as follows:
     360-390: IRYHTNNYASSSTSLPCQCSSTLMWSDHLER → VANAVSSCSNDGQKGQPISLSNEIIQTEA

Note: Known as EP3D in PubMed:8075855.

Isoform EP3B (identifier: P43115-3)

Also known as: EP3-III;

The sequence of this isoform differs from the canonical sequence as follows:
     360-390: IRYHTNNYASSSTSLPCQCSSTLMWSDHLER → EEFWGN

Note: Known as EP3E in PubMed:8075855.

Isoform EP3D (identifier: P43115-4)

Also known as: EP3-IV;

The sequence of this isoform differs from the canonical sequence as follows:
     360-390: IRYHTNNYASSSTSLPCQCSSTLMWSDHLER → MRKRRLREQEEFWGN

Note: Known as EP3F in PubMed:8075855.

Isoform EP3E (identifier: P43115-5)

The sequence of this isoform differs from the canonical sequence as follows:
     360-390: IRYHTNNYASSSTSLPCQCSSTLMWSDHLER → MRKRRLREQLICSLRTLRYRGQLHIVGKYKPIVC

Isoform EP3F (identifier: P43115-6)

The sequence of this isoform differs from the canonical sequence as follows:
     360-390: IRYHTNNYASSSTSLPCQCSSTLMWSDHLER → MRKRRLREQA...LREPCSVQLS

Isoform EP3G (identifier: P43115-7)

The sequence of this isoform differs from the canonical sequence as follows:
     360-390: IRYHTNNYASSSTSLPCQCSSTLMWSDHLER → EMGPDGRCFCHAWRQVPRTWCSSHDREPCSVQLS

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Prostaglandin E2 receptor EP3 subtype		PRO_0000070058
Regions
	Topological domain	1 – 53	53	Extracellular Potential
	Transmembrane	54 – 78	25	Helical; Name=1; Potential
	Topological domain	79 – 91	13	Cytoplasmic Potential
	Transmembrane	92 – 112	21	Helical; Name=2; Potential
	Topological domain	113 – 131	19	Extracellular Potential
	Transmembrane	132 – 153	22	Helical; Name=3; Potential
	Topological domain	154 – 175	22	Cytoplasmic Potential
	Transmembrane	176 – 197	22	Helical; Name=4; Potential
	Topological domain	198 – 227	30	Extracellular Potential
	Transmembrane	228 – 253	26	Helical; Name=5; Potential
	Topological domain	254 – 283	30	Cytoplasmic Potential
	Transmembrane	284 – 307	24	Helical; Name=6; Potential
	Topological domain	308 – 327	20	Extracellular Potential
	Transmembrane	328 – 349	22	Helical; Name=7; Potential
	Topological domain	350 – 390	41	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	18	1	N-linked (GlcNAc...) Potential
	Glycosylation	36	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	360 – 390	31	IRYHT…DHLER → EEFWGN in isoform EP3B.		VSP_001936
	Alternative sequence	360 – 390	31	IRYHT…DHLER → VANAVSSCSNDGQKGQPISL SNEIIQTEA in isoform EP3C.		VSP_001935
	Alternative sequence	360 – 390	31	IRYHT…DHLER → MRKRRLREQEEFWGN in isoform EP3D.		VSP_001937
	Alternative sequence	360 – 390	31	IRYHT…DHLER → MRKRRLREQLICSLRTLRYR GQLHIVGKYKPIVC in isoform EP3E.		VSP_001938
	Alternative sequence	360 – 390	31	IRYHT…DHLER → MRKRRLREQAPLLPTPTVID PSRFCAQPFRWFLDLSFPAM SSSHPQLPLTLASFKLLREP CSVQLS in isoform EP3F.		VSP_001939
	Alternative sequence	360 – 390	31	IRYHT…DHLER → EMGPDGRCFCHAWRQVPRTW CSSHDREPCSVQLS in isoform EP3G.		VSP_013271
	Natural variant	169	1	M → L. Corresponds to variant rs5670 [ dbSNP | Ensembl ].		VAR_014694
	Natural variant	319	1	T → M. Corresponds to variant rs13306020 [ dbSNP | Ensembl ].		VAR_049436
	Natural variant	366	1	N → S. Corresponds to variant rs13306014 [ dbSNP | Ensembl ].		VAR_029218
	Natural variant	375	1	P → L. Corresponds to variant rs5694 [ dbSNP | Ensembl ].		VAR_014695
Experimental info
	Sequence conflict	28 – 29	2	ER → DG Ref.3
	Sequence conflict	28 – 29	2	ER → DG Ref.4
	Sequence conflict	28 – 29	2	ER → DG Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Isoform EP3A (EP3-I) (EP3a1) (EP3a2) (EP(3-Ic)) [UniParc]. Last modified November 1, 1995. Version 1. Checksum: BC76EAC78FDF5420	FASTA	390	43,310
	10 20 30 40 50 60 MKETRGYGGD APFCTRLNHS YTGMWAPERS AEARGNLTRP PGSGEDCGSV SVAFPITMLL 70 80 90 100 110 120 TGFVGNALAM LLVSRSYRRR ESKRKKSFLL CIGWLALTDL VGQLLTTPVV IVVYLSKQRW 130 140 150 160 170 180 EHIDPSGRLC TFFGLTMTVF GLSSLFIASA MAVERALAIR APHWYASHMK TRATRAVLLG 190 200 210 220 230 240 VWLAVLAFAL LPVLGVGQYT VQWPGTWCFI STGRGGNGTS SSHNWGNLFF ASAFAFLGLL 250 260 270 280 290 300 ALTVTFSCNL ATIKALVSRC RAKATASQSS AQWGRITTET AIQLMGIMCV LSVCWSPLLI 310 320 330 340 350 360 MMLKMIFNQT SVEHCKTHTE KQKECNFFLI AVRLASLNQI LDPWVYLLLR KILLRKFCQI 370 380 390 RYHTNNYASS STSLPCQCSS TLMWSDHLER
	Isoform EP3C (EP3-II) [UniParc]. Checksum: 96ED050A946BDC5F	FASTA	388	42,682
	10 20 30 40 50 60 MKETRGYGGD APFCTRLNHS YTGMWAPERS AEARGNLTRP PGSGEDCGSV SVAFPITMLL 70 80 90 100 110 120 TGFVGNALAM LLVSRSYRRR ESKRKKSFLL CIGWLALTDL VGQLLTTPVV IVVYLSKQRW 130 140 150 160 170 180 EHIDPSGRLC TFFGLTMTVF GLSSLFIASA MAVERALAIR APHWYASHMK TRATRAVLLG 190 200 210 220 230 240 VWLAVLAFAL LPVLGVGQYT VQWPGTWCFI STGRGGNGTS SSHNWGNLFF ASAFAFLGLL 250 260 270 280 290 300 ALTVTFSCNL ATIKALVSRC RAKATASQSS AQWGRITTET AIQLMGIMCV LSVCWSPLLI 310 320 330 340 350 360 MMLKMIFNQT SVEHCKTHTE KQKECNFFLI AVRLASLNQI LDPWVYLLLR KILLRKFCQV 370 380 ANAVSSCSND GQKGQPISLS NEIIQTEA
	Isoform EP3B (EP3-III) [UniParc]. Checksum: 1AA2E95EB596EB46	FASTA	365	40,502
	10 20 30 40 50 60 MKETRGYGGD APFCTRLNHS YTGMWAPERS AEARGNLTRP PGSGEDCGSV SVAFPITMLL 70 80 90 100 110 120 TGFVGNALAM LLVSRSYRRR ESKRKKSFLL CIGWLALTDL VGQLLTTPVV IVVYLSKQRW 130 140 150 160 170 180 EHIDPSGRLC TFFGLTMTVF GLSSLFIASA MAVERALAIR APHWYASHMK TRATRAVLLG 190 200 210 220 230 240 VWLAVLAFAL LPVLGVGQYT VQWPGTWCFI STGRGGNGTS SSHNWGNLFF ASAFAFLGLL 250 260 270 280 290 300 ALTVTFSCNL ATIKALVSRC RAKATASQSS AQWGRITTET AIQLMGIMCV LSVCWSPLLI 310 320 330 340 350 360 MMLKMIFNQT SVEHCKTHTE KQKECNFFLI AVRLASLNQI LDPWVYLLLR KILLRKFCQE EFWGN
	Isoform EP3D (EP3-IV) [UniParc]. Checksum: 431BF492DBA231DE	FASTA	374	41,756
	10 20 30 40 50 60 MKETRGYGGD APFCTRLNHS YTGMWAPERS AEARGNLTRP PGSGEDCGSV SVAFPITMLL 70 80 90 100 110 120 TGFVGNALAM LLVSRSYRRR ESKRKKSFLL CIGWLALTDL VGQLLTTPVV IVVYLSKQRW 130 140 150 160 170 180 EHIDPSGRLC TFFGLTMTVF GLSSLFIASA MAVERALAIR APHWYASHMK TRATRAVLLG 190 200 210 220 230 240 VWLAVLAFAL LPVLGVGQYT VQWPGTWCFI STGRGGNGTS SSHNWGNLFF ASAFAFLGLL 250 260 270 280 290 300 ALTVTFSCNL ATIKALVSRC RAKATASQSS AQWGRITTET AIQLMGIMCV LSVCWSPLLI 310 320 330 340 350 360 MMLKMIFNQT SVEHCKTHTE KQKECNFFLI AVRLASLNQI LDPWVYLLLR KILLRKFCQM 370 RKRRLREQEE FWGN
	Isoform EP3E [UniParc]. Checksum: 882FA7D2A4A56427	FASTA	393	43,906
	10 20 30 40 50 60 MKETRGYGGD APFCTRLNHS YTGMWAPERS AEARGNLTRP PGSGEDCGSV SVAFPITMLL 70 80 90 100 110 120 TGFVGNALAM LLVSRSYRRR ESKRKKSFLL CIGWLALTDL VGQLLTTPVV IVVYLSKQRW 130 140 150 160 170 180 EHIDPSGRLC TFFGLTMTVF GLSSLFIASA MAVERALAIR APHWYASHMK TRATRAVLLG 190 200 210 220 230 240 VWLAVLAFAL LPVLGVGQYT VQWPGTWCFI STGRGGNGTS SSHNWGNLFF ASAFAFLGLL 250 260 270 280 290 300 ALTVTFSCNL ATIKALVSRC RAKATASQSS AQWGRITTET AIQLMGIMCV LSVCWSPLLI 310 320 330 340 350 360 MMLKMIFNQT SVEHCKTHTE KQKECNFFLI AVRLASLNQI LDPWVYLLLR KILLRKFCQM 370 380 390 RKRRLREQLI CSLRTLRYRG QLHIVGKYKP IVC
	Isoform EP3F [UniParc]. Checksum: 65447F57530539F8	FASTA	425	47,332
	10 20 30 40 50 60 MKETRGYGGD APFCTRLNHS YTGMWAPERS AEARGNLTRP PGSGEDCGSV SVAFPITMLL 70 80 90 100 110 120 TGFVGNALAM LLVSRSYRRR ESKRKKSFLL CIGWLALTDL VGQLLTTPVV IVVYLSKQRW 130 140 150 160 170 180 EHIDPSGRLC TFFGLTMTVF GLSSLFIASA MAVERALAIR APHWYASHMK TRATRAVLLG 190 200 210 220 230 240 VWLAVLAFAL LPVLGVGQYT VQWPGTWCFI STGRGGNGTS SSHNWGNLFF ASAFAFLGLL 250 260 270 280 290 300 ALTVTFSCNL ATIKALVSRC RAKATASQSS AQWGRITTET AIQLMGIMCV LSVCWSPLLI 310 320 330 340 350 360 MMLKMIFNQT SVEHCKTHTE KQKECNFFLI AVRLASLNQI LDPWVYLLLR KILLRKFCQM 370 380 390 400 410 420 RKRRLREQAP LLPTPTVIDP SRFCAQPFRW FLDLSFPAMS SSHPQLPLTL ASFKLLREPC SVQLS
	Isoform EP3G [UniParc]. Checksum: 3E9981F9C4389606	FASTA	393	43,683
	10 20 30 40 50 60 MKETRGYGGD APFCTRLNHS YTGMWAPERS AEARGNLTRP PGSGEDCGSV SVAFPITMLL 70 80 90 100 110 120 TGFVGNALAM LLVSRSYRRR ESKRKKSFLL CIGWLALTDL VGQLLTTPVV IVVYLSKQRW 130 140 150 160 170 180 EHIDPSGRLC TFFGLTMTVF GLSSLFIASA MAVERALAIR APHWYASHMK TRATRAVLLG 190 200 210 220 230 240 VWLAVLAFAL LPVLGVGQYT VQWPGTWCFI STGRGGNGTS SSHNWGNLFF ASAFAFLGLL 250 260 270 280 290 300 ALTVTFSCNL ATIKALVSRC RAKATASQSS AQWGRITTET AIQLMGIMCV LSVCWSPLLI 310 320 330 340 350 360 MMLKMIFNQT SVEHCKTHTE KQKECNFFLI AVRLASLNQI LDPWVYLLLR KILLRKFCQE 370 380 390 MGPDGRCFCH AWRQVPRTWC SSHDREPCSV QLS

References

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[1]	"Cloning and expression of three isoforms of the human EP3 prostanoid receptor." Adam M., Boie Y., Rushmore T.H., Mueller G., Bastien L., McKee K.T., Metters K.M., Abramovitz M. FEBS Lett. 338:170-174(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS EP3A; EP3B AND EP3C).
[2]	"Splice variants of the human EP3 receptor for prostaglandin E2." Schmid A., Thierauch K.H., Schleuning W.-D., Dinter H. Eur. J. Biochem. 228:23-30(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS EP3A; EP3B; EP3C; EP3D; EP3E AND EP3F). Tissue: Uterus.
[3]	"Cloning and expression of the EP3-subtype of human receptors for prostaglandin E2." Yang J., Xia M., Goetzl E.J., An S. Biochem. Biophys. Res. Commun. 198:999-1006(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM EP3A). Tissue: Kidney.
[4]	"Cloning and expression of a prostaglandin E receptor EP3 subtype from human erythroleukaemia cells." Kunapuli S.P., Fen Mao G., Bastepe M., Liu-Chen L.-Y., Li S., Cheung P.P., DeRiel J.K., Ashby B. Biochem. J. 298:263-267(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM EP3A).
[5]	"Isoforms of the EP3 subtype of human prostaglandin E2 receptor transduce both intracellular calcium and cAMP signals." An S., Yang J., So S.W., Zeng L., Goetzl E.J. Biochemistry 33:14496-14502(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS EP3B; EP3C AND EP3D). Tissue: Uterus.
[6]	"Molecular cloning and expression of multiple isoforms of human prostaglandin E receptor EP3 subtype generated by alternative messenger RNA splicing: multiple second messenger systems and tissue-specific distributions." Kotani M., Tanaka I., Ogawa Y., Usui T., Mori K., Ichikawa A., Narumiya S., Yoshimi T., Nakao K. Mol. Pharmacol. 48:869-879(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS EP3A; EP3B; EP3C AND EP3D). Tissue: Kidney.
[7]	"Molecular cloning and expression of human EP3 receptors: evidence of three variants with differing carboxyl termini." Regan J.W., Bailey T.J., Donello J.E., Pierce K.L., Pepperl D.J., Zhang D., Kedzie K.M., Fairbairn C.E., Bogardus A.M., Woodward D.F., Gil D.W. Br. J. Pharmacol. 112:377-385(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS EP3A; EP3B; EP3C AND EP3D). Tissue: Small intestine.
[8]	"Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3)." Kotani M., Tanaka I., Ogawa Y., Usui T., Tamura N., Mori K., Narumiya S., Yoshimi T., Nakao K. Genomics 40:425-434(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[9]	"cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org)." Kopatz S.A., Aronstam R.S., Sharma S.V. Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM EP3G). Tissue: Placenta.
[10]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM EP3A).
[11]	"Human protein factory for converting the transcriptome into an in vitro-expressed proteome." Goshima N., Kawamura Y., Fukumoto A., Miura A., Honma R., Satoh R., Wakamatsu A., Yamamoto J., Kimura K., Nishikawa T., Andoh T., Iida Y., Ishikawa K., Ito E., Kagawa N., Kaminaga C., Kanehori K., Kawakami B. , Kenmochi K., Kimura R., Kobayashi M., Kuroita T., Kuwayama H., Maruyama Y., Matsuo K., Minami K., Mitsubori M., Mori M., Morishita R., Murase A., Nishikawa A., Nishikawa S., Okamoto T., Sakagami N., Sakamoto Y., Sasaki Y., Seki T., Sono S., Sugiyama A., Sumiya T., Takayama T., Takayama Y., Takeda H., Togashi T., Yahata K., Yamada H., Yanagisawa Y., Endo Y., Imamoto F., Kisu Y., Tanaka S., Isogai T., Imai J., Watanabe S., Nomura N. Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM EP3B).
[12]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[13]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[14]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM EP3D). Tissue: Lung.
[15]	"A new mRNA splice variant coding for the human EP3-I receptor isoform." Kotelevets L., Foudi N., Louedec L., Couvelard A., Chastre E., Norel X. Prostaglandins Leukot. Essent. Fatty Acids 77:195-201(2007) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	S69200 mRNA. Translation: AAB29854.1. L27488 mRNA. Translation: AAC13372.1. L27489 mRNA. Translation: AAC13373.1. L27490 mRNA. Translation: AAC13374.1. X83857 mRNA. Translation: CAA58737.1. X83858 mRNA. Translation: CAA58738.1. X83859 mRNA. Translation: CAA58739.1. X83860 mRNA. Translation: CAA58740.1. X83861 mRNA. Translation: CAA58741.1. X83862 mRNA. Translation: CAA58742.1. X83863 mRNA. Translation: CAA58743.1. L26976 mRNA. Translation: AAA60076.1. S69326 mRNA. Translation: AAB30208.1. L32660 mRNA. Translation: AAA68191.1. L32661 mRNA. Translation: AAA68192.1. L32662 mRNA. Translation: AAA68193.1. D38297 mRNA. Translation: BAA07416.1. D38298 mRNA. Translation: BAA07417.1. D38299 mRNA. Translation: BAA07418.1. D38300 mRNA. Translation: BAA07419.1. D38301 mRNA. Translation: BAA07420.1. U13214 mRNA. Translation: AAA21130.1. U13215 mRNA. Translation: AAA21131.1. U13216 mRNA. Translation: AAA21132.1. U13217 mRNA. Translation: AAA21133.1. U13218 mRNA. Translation: AAA21134.1. D86096 Genomic DNA. Translation: BAA19951.1. D86098 mRNA. Translation: BAA19959.1. AY429108 mRNA. Translation: AAR07903.1. AK315825 mRNA. Translation: BAF98716.1. AB451481 mRNA. Translation: BAG70295.1. AL031429 Genomic DNA. Translation: CAI20226.1. AL031429 Genomic DNA. Translation: CAI20227.1. AL031429, AL158087 Genomic DNA. Translation: CAI20228.1. AL158087, AL031429 Genomic DNA. Translation: CAI23437.1. AL031429 Genomic DNA. Translation: CAB52459.1. CH471059 Genomic DNA. Translation: EAX06439.1. BC024229 mRNA. Translation: AAH24229.1.
IPI	IPI00221021. IPI00394835. IPI00395012. IPI00411362. IPI00478116. IPI00889746. IPI01010513.
PIR	B55995. I38747. I38748. I38750. JC2056. S43375. S51313. S68994. S51315. S68995. S51316. S68996. S51317. S68997. S51318. S68998. S51319. S68999.
RefSeq	NP_001119516.1. NM_001126044.1. NP_942007.1. NM_198714.1. NP_942008.1. NM_198715.2. NP_942009.1. NM_198716.1. NP_942010.1. NM_198717.1. NP_942011.1. NM_198718.1. NP_942012.1. NM_198719.1.
UniGene	Hs.445000.
3D structure databases
ProteinModelPortal	P43115.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000349003.
Protein family/group databases
GPCRDB	Search...
Polymorphism databases
DMDM	1172071.
Proteomic databases
PaxDb	P43115.
PRIDE	P43115.
Protocols and materials databases
DNASU	5733.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000306666; ENSP00000302313; ENSG00000050628. ENST00000370924; ENSP00000359962; ENSG00000050628. ENST00000370931; ENSP00000359969; ENSG00000050628. ENST00000370932; ENSP00000359970; ENSG00000050628. ENST00000414819; ENSP00000401423; ENSG00000050628. ENST00000460330; ENSP00000418073; ENSG00000050628. ENST00000479353; ENSP00000421583; ENSG00000050628.
GeneID	5733.
KEGG	hsa:5733.
UCSC	uc001dfg.1. human. uc001dfk.1. human. uc001dfl.1. human. uc001dfq.3. human.
Organism-specific databases
CTD	5733.
GeneCards	GC01M071318.
H-InvDB	HIX0029392.
HGNC	HGNC:9595. PTGER3.
HPA	HPA010689.
MIM	176806. gene.
neXtProt	NX_P43115.
PharmGKB	PA288.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG244691.
HOVERGEN	HBG052720.
KO	K04260.
OrthoDB	EOG42Z4QP.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	P43115.
Bgee	P43115.
CleanEx	HS_PTGER3.
Genevestigator	P43115.
GermOnline	ENSG00000050628. Homo sapiens.
Family and domain databases
InterPro	IPR001481. EP3_rcpt_2. IPR000276. GPCR_Rhodpsn. IPR017452. GPCR_Rhodpsn_7TM. IPR008365. Prostanoid_rcpt. IPR001244. Prostglndn_DP_rcpt. IPR000265. Prostglndn_EP3_rcpt. [Graphical view]
PANTHER	PTHR11866. PTHR11866. 1 hit. PTHR11866:SF10. PTHR11866:SF10. 1 hit.
Pfam	PF00001. 7tm_1. 1 hit. [Graphical view]
PRINTS	PR00237. GPCRRHODOPSN. PR00428. PROSTAGLNDNR. PR01788. PROSTANOIDR. PR00584. PRSTNOIDE32R. PR00582. PRSTNOIDEP3R.
PROSITE	PS00237. G_PROTEIN_RECEP_F1_1. False negative. PS50262. G_PROTEIN_RECEP_F1_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	P43115.
ChEMBL	CHEMBL3710.
DrugBank	DB00905. Bimatoprost.
GenomeRNAi	5733.
NextBio	22302.
SOURCE	Search...

Entry information

Entry name

PE2R3_HUMAN

Accession

Primary (citable) accession number: P43115
Secondary accession number(s): B0AZN4 , B5BUP5, O00326, Q12943, Q12944, Q12945, Q16546

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	May 1, 2013
This is version 134 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.