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P43099

- DCOR_LACS3

UniProt

P43099 - DCOR_LACS3

Protein

Ornithine decarboxylase, inducible

Gene

odcI

Organism
Lactobacillus sp. (strain 30a)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 2 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-ornithine = putrescine + CO2.

    Cofactori

    Pyridoxal phosphate.

    GO - Molecular functioni

    1. ornithine decarboxylase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. cellular amino acid metabolic process Source: InterPro

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    SABIO-RKP43099.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ornithine decarboxylase, inducible (EC:4.1.1.17)
    Short name:
    ODC
    Gene namesi
    Name:odcI
    OrganismiLactobacillus sp. (strain 30a)
    Taxonomic identifieri1593 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed
    Chaini2 – 731730Ornithine decarboxylase, induciblePRO_0000201137Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei356 – 3561N6-(pyridoxal phosphate)lysine

    Expressioni

    Inductioni

    By ornithine.

    Interactioni

    Subunit structurei

    Dodecamer.

    Structurei

    Secondary structure

    1
    731
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 94
    Helixi11 – 166
    Beta strandi27 – 293
    Beta strandi31 – 4010
    Helixi44 – 518
    Beta strandi59 – 646
    Helixi66 – 683
    Helixi71 – 744
    Beta strandi79 – 824
    Helixi92 – 10716
    Helixi110 – 11910
    Beta strandi127 – 1293
    Turni130 – 1367
    Helixi137 – 1393
    Helixi141 – 15010
    Helixi153 – 1564
    Helixi164 – 1663
    Turni169 – 1724
    Helixi175 – 18612
    Beta strandi190 – 1978
    Helixi198 – 21013
    Beta strandi216 – 2205
    Helixi225 – 2317
    Turni232 – 2354
    Beta strandi238 – 2425
    Beta strandi244 – 2463
    Beta strandi252 – 2554
    Helixi257 – 2593
    Helixi262 – 2687
    Turni269 – 2713
    Helixi274 – 2774
    Beta strandi283 – 2919
    Beta strandi295 – 2984
    Helixi300 – 3078
    Helixi308 – 3103
    Beta strandi311 – 3177
    Helixi323 – 3253
    Helixi328 – 3336
    Beta strandi347 – 3526
    Helixi354 – 3574
    Beta strandi365 – 3706
    Helixi372 – 3743
    Beta strandi375 – 3795
    Helixi383 – 39311
    Helixi400 – 41314
    Helixi415 – 43824
    Beta strandi442 – 4476
    Beta strandi449 – 4513
    Helixi456 – 4583
    Helixi461 – 4644
    Helixi468 – 4714
    Turni478 – 4803
    Beta strandi490 – 4923
    Beta strandi496 – 5005
    Beta strandi502 – 5054
    Turni506 – 5094
    Helixi518 – 52710
    Beta strandi533 – 5353
    Beta strandi537 – 5437
    Helixi550 – 56819
    Helixi573 – 5764
    Helixi578 – 5814
    Turni585 – 5873
    Helixi593 – 60513
    Turni606 – 6083
    Helixi609 – 6157
    Helixi619 – 6213
    Beta strandi624 – 6274
    Helixi629 – 6379
    Beta strandi641 – 6455
    Turni646 – 6483
    Beta strandi652 – 6565
    Beta strandi658 – 6603
    Turni661 – 6633
    Helixi676 – 69116
    Beta strandi699 – 7079
    Beta strandi710 – 7189
    Helixi720 – 7245
    Helixi727 – 7293

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1C4KX-ray2.70A2-731[»]
    1ORDX-ray3.00A/B2-731[»]
    ProteinModelPortaliP43099.
    SMRiP43099. Positions 2-731.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP43099.

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.220. 1 hit.
    3.40.640.10. 1 hit.
    3.90.100.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR011006. CheY-like_superfamily.
    IPR005308. OKR_de-COase_N.
    IPR011193. Orn/lys/arg_de-COase.
    IPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
    IPR027464. Ornithine_deCO2ase_N.
    IPR008286. Prn/Lys/Arg_de-COase_C.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF01276. OKR_DC_1. 1 hit.
    PF03711. OKR_DC_1_C. 1 hit.
    PF03709. OKR_DC_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF009393. Orn_decarb. 1 hit.
    SUPFAMiSSF52172. SSF52172. 1 hit.
    SSF53383. SSF53383. 1 hit.
    SSF55904. SSF55904. 1 hit.
    PROSITEiPS00703. OKR_DC_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P43099-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSSLKIAST QEARQYFDTD RVVVDAVGSD FTDVGAVIAM DYETDVIDAA    50
    DATKFGIPVF AVTKDAQAIS ADELKKIFHI IDLENKFDAT VNAREIETAV 100
    NNYEDSILPP FFKSLKEYVS RGLIQFDCPG HQGGQYYRKH PAGREFYDFF 150
    GETVFRADLC NADVALGDLL IHEGPAVAAE KHAARVYNAD KTYFVLGGSS 200
    NANNTVTSAL VSNGDLVLFD RNNHKSVYNS ALAMAGGRPV YLQTNRNPYG 250
    FIGGIYDSDF DEKKIRELAA KVDPERAKWK RPFRLAVIQL GTYDGTIYNA 300
    HEVVKRIGHL CDYIEFDSAW VGYEQFIPMM RNSSPLLIDD LGPEDPGIIV 350
    VQSVHKQQAG FSQTSQIHKK DSHIKGQLRY CDHKHFNNSF NLFMSTSPFY 400
    PMYAALDVNA AMQEGEAGRK LWHDLLITTI EARKKLIKAG SMFRPFVPPV 450
    VNGKKWEDGD TEDMANNIDY WRFEKGAKWH AYEGYGDNQY YVDPNKFMLT 500
    TPGINPETGD YEDFGVPATI VANYLRDHGI IPEKSDLNSI LFLMTPAETP 550
    AKMNNLITQL LQLQRLIEED APLKQVLPSI YAANEERYNG YTIRELCQEL 600
    HDFYKNNNTF TYQKRLFLRE FFPEQGMLPY EARQEFIRNH NKLVPLNKIE 650
    GEIALEGALP YPPGVFCVAP GEKWSETAVK YFTILQDGIN NFPGFAPEIQ 700
    GVYFKQEGDK VVAYGEVYDA EVAKNDDRYN N 731
    Length:731
    Mass (Da):82,688
    Last modified:January 23, 2007 - v2
    Checksum:i3652214455C956AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11816 Genomic DNA. Translation: AAA64830.1.
    PIRiA55229.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U11816 Genomic DNA. Translation: AAA64830.1 .
    PIRi A55229.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1C4K X-ray 2.70 A 2-731 [» ]
    1ORD X-ray 3.00 A/B 2-731 [» ]
    ProteinModelPortali P43099.
    SMRi P43099. Positions 2-731.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    SABIO-RK P43099.

    Miscellaneous databases

    EvolutionaryTracei P43099.

    Family and domain databases

    Gene3Di 3.40.50.220. 1 hit.
    3.40.640.10. 1 hit.
    3.90.100.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR011006. CheY-like_superfamily.
    IPR005308. OKR_de-COase_N.
    IPR011193. Orn/lys/arg_de-COase.
    IPR000310. Orn/Lys/Arg_deCO2ase_major_dom.
    IPR027464. Ornithine_deCO2ase_N.
    IPR008286. Prn/Lys/Arg_de-COase_C.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF01276. OKR_DC_1. 1 hit.
    PF03711. OKR_DC_1_C. 1 hit.
    PF03709. OKR_DC_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF009393. Orn_decarb. 1 hit.
    SUPFAMi SSF52172. SSF52172. 1 hit.
    SSF53383. SSF53383. 1 hit.
    SSF55904. SSF55904. 1 hit.
    PROSITEi PS00703. OKR_DC_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of ornithine decarboxylase from Lactobacillus sp. strain 30a."
      Hackert M.L., Carroll D.W., Davidson L., Kim S.-O., Momany C., Vaaler G.L., Zhang L.
      J. Bacteriol. 176:7391-7394(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
    2. "Crystallographic structure of a PLP-dependent ornithine decarboxylase from Lactobacillus 30a to 3.0-A resolution."
      Momany C., Ernst S., Gosh R., Chang N.-L., Hackert M.L.
      J. Mol. Biol. 252:643-655(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
    3. "Three-dimensional structure of the Gly121Tyr dimeric form of ornithine decarboxylase from Lactobacillus 30a."
      Vitali J., Carroll D., Chaudhry R.G., Hackert M.L.
      Acta Crystallogr. D 55:1978-1985(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
    4. "Structural motifs for pyridoxal-5'-phosphate binding in decarboxylases: an analysis based on the crystal structure of the Lactobacillus 30a ornithine decarboxylase."
      Momany C., Gosh R., Hackert M.L.
      Protein Sci. 4:849-854(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: DISCUSSION OF SEQUENCE.

    Entry informationi

    Entry nameiDCOR_LACS3
    AccessioniPrimary (citable) accession number: P43099
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 83 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3