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Reviewed, UniProtKB/Swiss-Prot P43099 (DCOR_LACS3)

Last modified September 22, 2009. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Ornithine decarboxylase, inducible
      Short name=ODC
    EC=4.1.1.17
Gene names
Name: odcI
OrganismLactobacillus sp. (strain 30a)
Taxonomic identifier1593 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

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Protein attributes

Sequence length731 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Catalytic activity

L-ornithine = putrescine + CO2.

Cofactor

Pyridoxal phosphate.

Subunit structure

Dodecamer.

Induction

By ornithine.

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-I family.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 731730Ornithine decarboxylase, inducible
PRO_0000201137

Amino acid modifications

Modified residue3561N6-(pyridoxal phosphate)lysine

Secondary structure

1 ............................................................................................................................................... 731
Helix Strand Turn

Details...

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Sequences

Sequence LengthMass (Da)Tools
P43099-1 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 3652214455C956AF

FASTA73182,688
        10         20         30         40         50         60 
MSSSLKIAST QEARQYFDTD RVVVDAVGSD FTDVGAVIAM DYETDVIDAA DATKFGIPVF 

        70         80         90        100        110        120 
AVTKDAQAIS ADELKKIFHI IDLENKFDAT VNAREIETAV NNYEDSILPP FFKSLKEYVS 

       130        140        150        160        170        180 
RGLIQFDCPG HQGGQYYRKH PAGREFYDFF GETVFRADLC NADVALGDLL IHEGPAVAAE 

       190        200        210        220        230        240 
KHAARVYNAD KTYFVLGGSS NANNTVTSAL VSNGDLVLFD RNNHKSVYNS ALAMAGGRPV 

       250        260        270        280        290        300 
YLQTNRNPYG FIGGIYDSDF DEKKIRELAA KVDPERAKWK RPFRLAVIQL GTYDGTIYNA 

       310        320        330        340        350        360 
HEVVKRIGHL CDYIEFDSAW VGYEQFIPMM RNSSPLLIDD LGPEDPGIIV VQSVHKQQAG 

       370        380        390        400        410        420 
FSQTSQIHKK DSHIKGQLRY CDHKHFNNSF NLFMSTSPFY PMYAALDVNA AMQEGEAGRK 

       430        440        450        460        470        480 
LWHDLLITTI EARKKLIKAG SMFRPFVPPV VNGKKWEDGD TEDMANNIDY WRFEKGAKWH 

       490        500        510        520        530        540 
AYEGYGDNQY YVDPNKFMLT TPGINPETGD YEDFGVPATI VANYLRDHGI IPEKSDLNSI 

       550        560        570        580        590        600 
LFLMTPAETP AKMNNLITQL LQLQRLIEED APLKQVLPSI YAANEERYNG YTIRELCQEL 

       610        620        630        640        650        660 
HDFYKNNNTF TYQKRLFLRE FFPEQGMLPY EARQEFIRNH NKLVPLNKIE GEIALEGALP 

       670        680        690        700        710        720 
YPPGVFCVAP GEKWSETAVK YFTILQDGIN NFPGFAPEIQ GVYFKQEGDK VVAYGEVYDA 

       730 
EVAKNDDRYN N

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References

[1]"Sequence of ornithine decarboxylase from Lactobacillus sp. strain 30a."
Hackert M.L., Carroll D.W., Davidson L., Kim S.-O., Momany C., Vaaler G.L., Zhang L.
J. Bacteriol. 176:7391-7394(1994) [PubMed: 7961515] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PARTIAL PROTEIN SEQUENCE.
[2]"Crystallographic structure of a PLP-dependent ornithine decarboxylase from Lactobacillus 30a to 3.0-A resolution."
Momany C., Ernst S., Gosh R., Chang N.-L., Hackert M.L.
J. Mol. Biol. 252:643-655(1995) [PubMed: 7563080] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS).
[3]"Three-dimensional structure of the Gly121Tyr dimeric form of ornithine decarboxylase from Lactobacillus 30a."
Vitali J., Carroll D., Chaudhry R.G., Hackert M.L.
Acta Crystallogr. D 55:1978-1985(1999) [PubMed: 10666573] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS).
[4]"Structural motifs for pyridoxal-5'-phosphate binding in decarboxylases: an analysis based on the crystal structure of the Lactobacillus 30a ornithine decarboxylase."
Momany C., Gosh R., Hackert M.L.
Protein Sci. 4:849-854(1995) [PubMed: 7663340] [Abstract]
Cited for: DISCUSSION OF SEQUENCE.

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Cross-references

Sequence databases

U11816 Genomic DNA. Translation: AAA64830.1.
PIRA55229.

3D structure databases

EntryMethodResolution (Å)ChainPositionsPDBsum
1C4KX-ray2.70A2-731[»]
1ORDX-ray3.00A/B2-731[»]
ModBaseSearch...

Family and domain databases

InterProIPR000310. Decarbxylse1.
IPR005308. OKR_de-COase_N.
IPR011193. Orn/lys/arg_de-COase.
IPR008286. Prn/Lys/Arg_de-COase_C.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
Gene3DG3DSA:3.90.100.10. Decarbxylse_C. 1 hit.
G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
G3DSA:3.90.1150.10. PyrdxlP-dep_Trfase_major_sub2. 1 hit.
PfamPF01276. OKR_DC_1. 1 hit.
PF03711. OKR_DC_1_C. 1 hit.
PF03709. OKR_DC_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF009393. Orn_decarb. 1 hit.
PROSITEPS00703. OKR_DC_1. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDCOR_LACS3
AccessionPrimary (citable) accession number: P43099
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: January 23, 2007
Last modified: September 22, 2009
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents