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Protein

Candidapepsin-6

Gene

SAP6

Organism
Candida albicans (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Preferential cleavage at the carboxyl of hydrophobic amino acids, but fails to cleave 15-Leu-|-Tyr-16, 16-Tyr-|-Leu-17 and 24-Phe-|-Phe-25 of insulin B chain. Activates trypsinogen, and degrades keratin.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108PROSITE-ProRule annotation1
Active sitei294PROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionAspartyl protease, Hydrolase, Protease

Enzyme and pathway databases

BRENDAi3.4.23.24. 1096.

Protein family/group databases

MEROPSiA01.064.

Names & Taxonomyi

Protein namesi
Recommended name:
Candidapepsin-6 (EC:3.4.23.24)
Alternative name(s):
ACP 6
Aspartate protease 6
Secreted aspartic protease 6
Gene namesi
Name:SAP6
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL6178.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000002585819 – 76Activation peptideSequence analysisAdd BLAST58
ChainiPRO_000002585977 – 418Candidapepsin-6Add BLAST342

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi123 ↔ 135By similarity
Glycosylationi138N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi332 ↔ 370By similarity

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen

Structurei

3D structure databases

ProteinModelPortaliP43095.
SMRiP43095.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini90 – 404Peptidase A1PROSITE-ProRule annotationAdd BLAST315

Sequence similaritiesi

Belongs to the peptidase A1 family.Curated

Keywords - Domaini

Signal

Family and domain databases

CDDicd05474. SAP_like. 1 hit.
Gene3Di2.40.70.10. 2 hits.
InterProiView protein in InterPro
IPR001461. Aspartic_peptidase_A1.
IPR001969. Aspartic_peptidase_AS.
IPR033121. PEPTIDASE_A1.
IPR021109. Peptidase_aspartic_dom.
IPR033876. SAP-like.
PANTHERiPTHR13683. PTHR13683. 1 hit.
PfamiView protein in Pfam
PF00026. Asp. 1 hit.
PRINTSiPR00792. PEPSIN.
SUPFAMiSSF50630. SSF50630. 1 hit.
PROSITEiView protein in PROSITE
PS00141. ASP_PROTEASE. 2 hits.
PS51767. PEPTIDASE_A1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43095-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLKNILSVL RFALLIDAAP VKRSPGFVTL DFNVKRSLVV PDDPTAESKR
60 70 80 90 100
SPLFLDLDPT QIPVDDTGRN VGVDKRGPVA VKLDNEIITY SADITVGSNN
110 120 130 140 150
QKLSVIVDTG SSDLWIPDSK AICIPKWRGD CGDFCKNNGS YSPAASSTSK
160 170 180 190 200
NLNTRFEIKY ADGSYAKGNL YQDTVGIGGA SVKNQLFANV WSTSAHKGIL
210 220 230 240 250
GIGFQTNEAT RTPYDNLPIS LKKQGIIAKN AYSLFLNSPE ASSGQIIFGG
260 270 280 290 300
IDKAKYSGSL VELPITSDRT LSVGLRSVNV MGRNVNVNAG VLLDSGTTIS
310 320 330 340 350
YFTPSIARSI IYALGGQVHF DSAGNKAYVA DCKTSGTVDF QFDKNLKISV
360 370 380 390 400
PASEFLYQLY YTNGKPYPKC EIRVRESEDN ILGDNFMRSA YIVYDLDDKK
410
ISMAQVKYTS ESNIVAIN
Length:418
Mass (Da):45,469
Last modified:November 1, 1995 - v1
Checksum:iD32AAF203E096083
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z30192 Genomic DNA. Translation: CAA82924.1.
PIRiS49057. S42073.

Similar proteinsi

Entry informationi

Entry nameiCARP6_CANAX
AccessioniPrimary (citable) accession number: P43095
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 10, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families