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P43091

- HEM1_OPSTA

UniProt

P43091 - HEM1_OPSTA

Protein

5-aminolevulinate synthase, nonspecific, mitochondrial

Gene

alas1

Organism
Opsanus tau (Oyster toadfish) (Gadus tau)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

    Cofactori

    Pyridoxal phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei204 – 2041SubstrateBy similarity
    Binding sitei321 – 3211SubstrateBy similarity
    Binding sitei340 – 3401SubstrateBy similarity
    Binding sitei373 – 3731Pyridoxal phosphateBy similarity
    Binding sitei401 – 4011Pyridoxal phosphateBy similarity
    Binding sitei429 – 4291Pyridoxal phosphateBy similarity
    Active sitei432 – 4321By similarity
    Binding sitei461 – 4611Pyridoxal phosphateBy similarity
    Binding sitei462 – 4621Pyridoxal phosphateBy similarity
    Binding sitei549 – 5491SubstrateBy similarity

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Heme biosynthesis

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00251; UER00375.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    5-aminolevulinate synthase, nonspecific, mitochondrial (EC:2.3.1.37)
    Short name:
    ALAS-H
    Alternative name(s):
    5-aminolevulinic acid synthase 1
    Delta-ALA synthase 1
    Delta-aminolevulinate synthase 1
    Gene namesi
    Name:alas1
    OrganismiOpsanus tau (Oyster toadfish) (Gadus tau)
    Taxonomic identifieri8068 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataBatrachoidimorphariaBatrachoididaeOpsanus

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 5858MitochondrionSequence AnalysisAdd
    BLAST
    Chaini59 – 6275695-aminolevulinate synthase, nonspecific, mitochondrialPRO_0000001234Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei432 – 4321N6-(pyridoxal phosphate)lysineCurated

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP43091.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    HOVERGENiHBG005954.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR015118. 5aminolev_synth_preseq.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view]
    PfamiPF00155. Aminotran_1_2. 1 hit.
    PF09029. Preseq_ALAS. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.
    TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
    PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P43091-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDVIVRRCPF LARVPQAFFQ QSKKSLAVYA QRCPFMMELA SKPMAPSLAR    50
    ALCSSSSSQQ KIEDTMSTGE VLKPKAEAKL PVGLATPPSN EAVAPKCPFL 100
    AAEMGQNNSN VVRQVGVEFQ EDVEEIRTVQ KEVSPAQLEQ PSLIGKTMGE 150
    EGHQKNLMKS LLKQRPKRVS HLLQDNLPGS FTRFYYDNFF EKKIEEKKSD 200
    HTYRVFKTVN RLANEFPMAD DFTGSLEDKR EVSVWCSNDY LGMSRHPRVA 250
    QAIMETLRKH GSGAGGTRNI SGTSKFHVEL EQELADLHRK DAALLFTSCF 300
    VANDSTLFTL AKMLPGCEIY SDAGNHASMI QGIRNSGAKK FIFRHNDVAH 350
    LRELLEKGDP TKPKIVAFET VHSMDGAVCP LEEMCDLAHE FGAITFVDEV 400
    HAVGLYGPRG GGIGDRDGIM HKMDIISGTL GKAFGCVGGY IASTATLVDT 450
    VRSYAAGFIF TTSLPPMLLA GAKQSIQILK GEEGCTLRRK HQRNVKLLRQ 500
    MLMDSGLPVV HCPSHIIPIR VSDAEKNTKV CDLMMSHHNI YVQAINYPTV 550
    ARGDELLRIA PTPHHTPEMM KYFVDRLVQT WKEVGLELKP HSSAECTFCQ 600
    QPLHFEVMNE REKSYFSGLS HLVSVCA 627
    Length:627
    Mass (Da):69,691
    Last modified:November 1, 1995 - v1
    Checksum:iB94FB3406D9FCCAF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L35915 mRNA. Translation: AAA49435.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L35915 mRNA. Translation: AAA49435.1 .

    3D structure databases

    ProteinModelPortali P43091.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG005954.

    Enzyme and pathway databases

    UniPathwayi UPA00251 ; UER00375 .

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    3.90.1150.10. 1 hit.
    InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
    IPR015118. 5aminolev_synth_preseq.
    IPR001917. Aminotrans_II_pyridoxalP_BS.
    IPR004839. Aminotransferase_I/II.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    IPR015422. PyrdxlP-dep_Trfase_major_sub2.
    [Graphical view ]
    Pfami PF00155. Aminotran_1_2. 1 hit.
    PF09029. Preseq_ALAS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
    PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Housekeeping form of 5-aminolevulinate synthase in the marine fish, Opsanus tau."
      Cornell N.W.
      Submitted (SEP-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiHEM1_OPSTA
    AccessioniPrimary (citable) accession number: P43091
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3