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P43090

- HEM0_OPSTA

UniProt

P43090 - HEM0_OPSTA

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Protein

5-aminolevulinate synthase, erythroid-specific, mitochondrial

Gene

alas2

Organism
Opsanus tau (Oyster toadfish) (Gadus tau)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2.

Cofactori

Pyridoxal phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei158 – 1581SubstrateBy similarity
Binding sitei275 – 2751SubstrateBy similarity
Binding sitei327 – 3271Pyridoxal phosphateBy similarity
Binding sitei355 – 3551Pyridoxal phosphateBy similarity
Binding sitei383 – 3831Pyridoxal phosphateBy similarity
Active sitei386 – 3861By similarity
Binding sitei415 – 4151Pyridoxal phosphateBy similarity
Binding sitei416 – 4161Pyridoxal phosphateBy similarity
Binding sitei503 – 5031SubstrateBy similarity

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: UniProtKB
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. protoporphyrinogen IX biosynthetic process Source: UniProtKB-UniPathway
  2. response to hypoxia Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Heme biosynthesis

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00251; UER00375.

Names & Taxonomyi

Protein namesi
Recommended name:
5-aminolevulinate synthase, erythroid-specific, mitochondrial (EC:2.3.1.37)
Short name:
ALAS-E
Alternative name(s):
5-aminolevulinic acid synthase 2
Delta-ALA synthase 2
Delta-aminolevulinate synthase 2
Gene namesi
Name:alas2
OrganismiOpsanus tau (Oyster toadfish) (Gadus tau)
Taxonomic identifieri8068 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataBatrachoidariaBatrachoididaeOpsanus

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB
  2. mitochondrial matrix Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 5825-aminolevulinate synthase, erythroid-specific, mitochondrialPRO_0000001228
Transit peptidei1 – ?MitochondrionSequence Analysis

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei386 – 3861N6-(pyridoxal phosphate)lysineCurated

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP43090.
SMRiP43090. Positions 139-535.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

HOVERGENiHBG005954.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR015118. 5aminolev_synth_preseq.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
PF09029. Preseq_ALAS. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01821. 5aminolev_synth. 1 hit.
PROSITEiPS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43090-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAFLHHCPF LKSMPKPALR RRVPALLSLA DRCPVIVHQV CISRLHILET
60 70 80 90 100
KLDVSPTQPK RQRLSLLDQK RLFAQTATQV AVSVSKGCPF VSSQIGMVRA
110 120 130 140 150
SPEVQEDVQA DLKSPVLPTP PQTGITQLLK DNMVGPSFDY DNFFNEKIAE
160 170 180 190 200
KKRDHTYRVF KTVNRNAVVF PFAEDYSVSD RQGSQVSVWC SNDYLGMSRH
210 220 230 240 250
PRVLEAIREV LERHGAGAGG TRNISGTSKY HVTLEKELAH LHQKDAALVF
260 270 280 290 300
SSCFVANDST LFTLAKMLPG CHIYSDAGNH ASMIQGIRNS GAKRFIFRHN
310 320 330 340 350
DSRHLEELLQ QSDPKTPKIV AFETVHSMDG AICPLEELCD VAHRHGALTF
360 370 380 390 400
VDEVHAVGLY GAHGAGVGER DNVMHKIDIV SGTLGKAFGC VGGYVASSAA
410 420 430 440 450
LVDTVRSFAA GFIFTTSLPP MILAGALESV RVLKSPEGQL LRRAHQRNVK
460 470 480 490 500
YMRQLLMDKG LPVVNCPSHI IPIRVGNAEL NTKVCDSLLE KHNIYVQAIN
510 520 530 540 550
YPTVPRGQEL LRLAPSPHHH PAMMEYFVDK LVEVWQEAGL LLNGPATVSC
560 570 580
TFCDRPLHFD LMSEWEKSYF GNMEPQYITM SA
Length:582
Mass (Da):64,531
Last modified:November 1, 1995 - v1
Checksum:iFB066EEF72E146C9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L02632 mRNA. Translation: AAA60729.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L02632 mRNA. Translation: AAA60729.1 .

3D structure databases

ProteinModelPortali P43090.
SMRi P43090. Positions 139-535.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG005954.

Enzyme and pathway databases

UniPathwayi UPA00251 ; UER00375 .

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProi IPR010961. 4pyrrol_synth_NH2levulA_synth.
IPR015118. 5aminolev_synth_preseq.
IPR001917. Aminotrans_II_pyridoxalP_BS.
IPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view ]
Pfami PF00155. Aminotran_1_2. 1 hit.
PF09029. Preseq_ALAS. 1 hit.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 1 hit.
TIGRFAMsi TIGR01821. 5aminolev_synth. 1 hit.
PROSITEi PS00599. AA_TRANSFER_CLASS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "5-aminolevulinate synthase in the marine fish, Opsanus tau."
    Hellmich H.L., Cornell N.W.
    Submitted (NOV-1992) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiHEM0_OPSTA
AccessioniPrimary (citable) accession number: P43090
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two delta-ALA synthases in vertebrates: an erythroid- specific form and one (housekeeping) which is expressed in all tissues.

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3