Reviewed, UniProtKB/Swiss-Prot P43082 (HEVL_ARATH)

Names and origin

Protein names

Recommended name:
    Hevein-like protein

Gene names

Name:	HEL
Ordered Locus Names:	At3g04720
ORF Names:	F7O18.21

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	212 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Sequence similarities

Contains 1 barwin domain. Contains 1 chitin-binding type-1 domain.

Ontologies

Keywords
Domain	Signal
Ligand	Chitin-binding
PTM	Disulfide bond
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall macromolecule catabolic process Inferred from electronic annotation. Source: InterPro chitin catabolic process Inferred from electronic annotation. Source: InterPro defense response to bacterium Inferred from electronic annotation. Source: InterPro defense response to fungus Inferred from electronic annotation. Source: InterPro response to ethylene stimulus Ref.1 Inferred from expression pattern. Source: TAIR response to herbivore Inferred from expression pattern. Source: TAIR response to salt stress Inferred from expression pattern. Source: TAIR response to virus Ref.1 Inferred from expression pattern. Source: TAIR systemic acquired resistance Inferred from expression pattern. Source: TAIR
Molecular function	chitin binding Inferred from electronic annotation. Source: UniProtKB-KW chitinase activity Inferred from electronic annotation. Source: InterPro protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BRL1	Q9ZPS9	1	EBI-2293870,EBI-2292728

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 212	191	Hevein-like protein		PRO_0000005284
Regions
	Domain	22 – 64	43	Chitin-binding type-1
	Domain	72 – 193	122	Barwin
Amino acid modifications
	Disulfide bond	24 ↔ 39		By similarity
	Disulfide bond	33 ↔ 45		By similarity
	Disulfide bond	38 ↔ 52		By similarity
	Disulfide bond	58 ↔ 62		By similarity
	Disulfide bond	100 ↔ 132		By similarity
	Disulfide bond	121 ↔ 155		By similarity
	Disulfide bond	135 ↔ 191		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43082-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: 1EDAD140A21AA692	FASTA	212	22,937
	10 20 30 40 50 60 MKIRLSITII LLSYTVATVA GQQCGRQGGG RTCPGNICCS QYGYCGTTAD YCSPTNNCQS 70 80 90 100 110 120 NCWGSGPSGP GESASNVRAT YHFYNPAQNN WDLRAVSAYC STWDADKPYA WRSKYGWTAF 130 140 150 160 170 180 CGPAGPRGQA SCGKCLRVKN TRTNAAVTVR IVDQCSNGGL DLDVAMFNQI DTDGFGYQQG 190 200 210 HLIVDYQFVD CGNELIGQPD SRNMLVSAID RV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Regulation of a hevein-like gene in Arabidopsis." Potter S., Uknes S., Lawton K., Winter A.M., Chandler D., Dimaio J., Novitzky R., Ward E., Ryals J. Mol. Plant Microbe Interact. 6:680-685(1993) [PubMed: 8118053] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana." Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. Nature 408:820-822(2000) [PubMed: 11130713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[4]	"Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	U01880 mRNA. Translation: AAA20642.1. AC011437 Genomic DNA. Translation: AAF04912.1. AF370536 mRNA. Translation: AAK48963.1. BT000046 mRNA. Translation: AAN15365.1. AY088644 mRNA. Translation: AAM66966.1.
IPI	IPI00529373.
RefSeq	NP_187123.1.
UniGene	At.252
3D structure databases
HSSP	HSSP built from PDB template 1BW4 based on UniProtKB P28814.
SMR	P43082. Positions 72-191.
ModBase	Search...
Protein family/group databases
CAZy	CBM18. Carbohydrate-Binding Module Family 18.
Proteomic databases
PRIDE	P43082.
Genome annotation databases
GeneID	819632.
GenomeReviews	Gene locus AT3G04720 in contig BA000014_GR.
KEGG	ath:AT3G04720.
NMPDR	fig|3702.1.peg.12443.
Organism-specific databases
TAIR	At3g04720.
Phylogenomic databases
OMA	P43082. CGDSINS.
Gene expression databases
ArrayExpress	P43082.
GermOnline	AT3G04720. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR001153. Barwin. IPR014733. Barwin-like_endoglucanase. IPR018226. Barwin_CS. IPR018371. Chitin-binding_1_CS. IPR001002. Chitin_bd_1. IPR000726. Glyco_hydro_19_cat. [Graphical view]
Gene3D	G3DSA:2.40.40.10. Barwin. 1 hit. G3DSA:3.30.60.10. Chitin_bd_1. 1 hit.
PANTHER	PTHR22595:SF1. Barwin. 1 hit. PTHR22595. Glyco_hydro_19_cat. 1 hit.
Pfam	PF00967. Barwin. 1 hit. PF00187. Chitin_bind_1. 1 hit. [Graphical view]
PRINTS	PR00602. BARWIN. PR00451. CHITINBINDNG.
ProDom	PD004535. Barwin. 1 hit. PD000609. Chitin_binding_1. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00270. ChtBD1. 1 hit. [Graphical view]
PROSITE	PS00771. BARWIN_1. 1 hit. PS00772. BARWIN_2. 1 hit. PS51174. BARWIN_3. 1 hit. PS00026. CHIT_BIND_I_1. 1 hit. PS50941. CHIT_BIND_I_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HEVL_ARATH

Accession

Primary (citable) accession number: P43082

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	June 16, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)