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Protein

Hevein-like preproprotein

Gene

HEL

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Fungal growth inhibitors. Neither CB-HEL nor CD-HEL have chitinase activity, but both have antimicrobial activities. CD-HEL has RNase, but no DNase activity.1 Publication

GO - Molecular functioni

  • chitin binding Source: TAIR
  • ribonuclease activity Source: UniProtKB

GO - Biological processi

  • defense response to bacterium Source: InterPro
  • defense response to fungus, incompatible interaction Source: TAIR
  • killing of cells of other organism Source: UniProtKB-KW
  • response to ethylene Source: TAIR
  • response to herbivore Source: TAIR
  • response to salt stress Source: TAIR
  • response to virus Source: TAIR
  • systemic acquired resistance Source: TAIR

Keywordsi

Molecular functionAntimicrobial, Fungicide, Hydrolase, Nuclease, Pathogenesis-related protein
Biological processPlant defense
LigandChitin-binding

Protein family/group databases

CAZyiCBM18 Carbohydrate-Binding Module Family 18

Names & Taxonomyi

Protein namesi
Recommended name:
Hevein-like preproprotein
Cleaved into the following 2 chains:
Alternative name(s):
RNase
Gene namesi
Name:HEL
Ordered Locus Names:At3g04720
ORF Names:F7O18.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G04720
TAIRilocus:2084918 AT3G04720

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000421569? – 212CD-HEL
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000528422 – 212Hevein-like preproproteinAdd BLAST191
ChainiPRO_000042156822 – ?CB-HEL

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 391 Publication
Disulfide bondi33 ↔ 451 Publication
Disulfide bondi38 ↔ 521 Publication
Disulfide bondi58 ↔ 621 Publication
Disulfide bondi100 ↔ 132PROSITE-ProRule annotation
Disulfide bondi121 ↔ 155PROSITE-ProRule annotation
Disulfide bondi135 ↔ 191PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP43082
PRIDEiP43082

Expressioni

Inductioni

Up-regulated by ethylene, methyl jasmonate, wounding and virus infection. Weakly induced by salicylic acid and 2,6-dichlorisonicotinic acid.2 Publications

Gene expression databases

ExpressionAtlasiP43082 baseline and differential
GenevisibleiP43082 AT

Interactioni

Subunit structurei

CB-HEL interacts strongly with a fungal fruiting body lectin.1 Publication

Protein-protein interaction databases

BioGridi4967, 1 interactor
IntActiP43082, 1 interactor
STRINGi3702.AT3G04720.1

Structurei

3D structure databases

ProteinModelPortaliP43082
SMRiP43082
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 64Chitin-binding type-1PROSITE-ProRule annotationAdd BLAST43
Domaini72 – 193BarwinPROSITE-ProRule annotationAdd BLAST122

Domaini

The C-terminal vacuolar sorting signal (VSS) (194-212) is required for vacuolar localization.1 Publication

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4742 Eukaryota
COG3979 LUCA
HOGENOMiHOG000090989
InParanoidiP43082
OMAiCPGNICC
OrthoDBiEOG09360QTL
PhylomeDBiP43082

Family and domain databases

Gene3Di2.40.40.10, 1 hit
3.30.60.10, 1 hit
InterProiView protein in InterPro
IPR018226 Barwin_CS
IPR001153 Barwin_dom
IPR001002 Chitin-bd_1
IPR018371 Chitin-binding_1_CS
IPR036861 Endochitinase-like_sf
IPR036908 RlpA-like_sf
PfamiView protein in Pfam
PF00967 Barwin, 1 hit
PF00187 Chitin_bind_1, 1 hit
PRINTSiPR00602 BARWIN
PR00451 CHITINBINDNG
ProDomiView protein in ProDom or Entries sharing at least one domain
PD004535 Barwin, 1 hit
PD000609 Chitin_bd_1, 1 hit
SMARTiView protein in SMART
SM00270 ChtBD1, 1 hit
SUPFAMiSSF50685 SSF50685, 1 hit
SSF57016 SSF57016, 1 hit
PROSITEiView protein in PROSITE
PS00771 BARWIN_1, 1 hit
PS00772 BARWIN_2, 1 hit
PS51174 BARWIN_3, 1 hit
PS00026 CHIT_BIND_I_1, 1 hit
PS50941 CHIT_BIND_I_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIRLSITII LLSYTVATVA GQQCGRQGGG RTCPGNICCS QYGYCGTTAD
60 70 80 90 100
YCSPTNNCQS NCWGSGPSGP GESASNVRAT YHFYNPAQNN WDLRAVSAYC
110 120 130 140 150
STWDADKPYA WRSKYGWTAF CGPAGPRGQA SCGKCLRVKN TRTNAAVTVR
160 170 180 190 200
IVDQCSNGGL DLDVAMFNQI DTDGFGYQQG HLIVDYQFVD CGNELIGQPD
210
SRNMLVSAID RV
Length:212
Mass (Da):22,937
Last modified:November 1, 1995 - v1
Checksum:i1EDAD140A21AA692
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U01880 mRNA Translation: AAA20642.1
AC011437 Genomic DNA Translation: AAF04912.1
CP002686 Genomic DNA Translation: AEE74125.1
AF370536 mRNA Translation: AAK48963.1
BT000046 mRNA Translation: AAN15365.1
AY088644 mRNA Translation: AAM66966.1
RefSeqiNP_187123.1, NM_111344.6
UniGeneiAt.252

Genome annotation databases

EnsemblPlantsiAT3G04720.1; AT3G04720.1; AT3G04720
GeneIDi819632
GrameneiAT3G04720.1; AT3G04720.1; AT3G04720
KEGGiath:AT3G04720

Similar proteinsi

Entry informationi

Entry nameiHEVL_ARATH
AccessioniPrimary (citable) accession number: P43082
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 25, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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