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P43078

- PTPX_CANAW

UniProt

P43078 - PTPX_CANAW

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Protein
Probable tyrosine-protein phosphatase
Gene
CPP1, CAWG_00432
Organism
Candida albicans (strain WO-1) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei516 – 5161Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
  2. protein tyrosine/serine/threonine phosphatase activity Source: InterPro
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable tyrosine-protein phosphatase (EC:3.1.3.48)
    Gene namesi
    Name:CPP1
    ORF Names:CAWG_00432
    OrganismiCandida albicans (strain WO-1) (Yeast)
    Taxonomic identifieri294748 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000001429: Chromosome 1, Supercontig 1.1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 597597Probable tyrosine-protein phosphatase
    PRO_0000094918Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP43078.

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi56 – 594Poly-Ser
    Compositional biasi68 – 747Poly-Thr
    Compositional biasi375 – 38511Poly-Asn
    Add
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    HOGENOMiHOG000093420.
    OMAiREYIARI.
    OrthoDBiEOG7HF1WG.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43078-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTPLSSYST TVTNHHPTFS FESLNSISSN NSTRNNQSNS VNSLLYFNSS    50
    GSSMVSSSSD AAPTSISTTT TSTTSMTDAS ANADNQQVYT ITEEDSINDI 100
    NRKEQNSFSI QPNQTPTMLP TSSYTLQRPP GLHEYTSSIS SISSTSSNST 150
    SAPVSPALIN YSPKHSRKPN SLNLNRNMKN LSLNLHDSTN GYTSPLPKST 200
    NSNQPRGNFI MDSPSKKSTP VNRIGNNNGN DYINATLLQT PSITQTPTMP 250
    PPLSLAQGPP SSVGSESVYK FPLISNACLN YSAGDSDSEV ESISMKQAAK 300
    NTIIPPMAPP FALQSKSSPL STPPRLHSPL GVDRGLPISM SPIQSSLNQK 350
    FNNITLQTPL NSSFSINNDE ATNFNNKNNK NNNNNSTATT TITNTILSTP 400
    QNVRYNSKKF HPPEELQEST SINAYPNGPK NVLNNLIYLY SDPAQGKIDI 450
    NKFDLVINVA KECDNMSLQY MNQVPNQREY VYIPWSHNSN ISKDLFQITN 500
    KIDQFFTNGR KILIHCQCGV SRSACVVVAF YMKKFQLGVN EAYELLKNGD 550
    QKYIDACDRI CPNMNLIFEL MEFGDKLNNN EISTQQLLMN SPPTINL 597
    Length:597
    Mass (Da):65,586
    Last modified:October 19, 2011 - v2
    Checksum:iB0F1DE22ACC9C78C
    GO

    Sequence conflict

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti504 – 5041Q → K in AAC05307. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L01038 Genomic DNA. Translation: AAC05307.1.
    CH672346 Genomic DNA. Translation: EEQ42230.1.
    PIRiS43743.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L01038 Genomic DNA. Translation: AAC05307.1 .
    CH672346 Genomic DNA. Translation: EEQ42230.1 .
    PIRi S43743.

    3D structure databases

    ProteinModelPortali P43078.
    ModBasei Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG2453.
    HOGENOMi HOG000093420.
    OMAi REYIARI.
    OrthoDBi EOG7HF1WG.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    « Hide 'large scale' publications
    1. Csank C., Dignard D., Thomas D.Y., Whiteway M.
      Submitted (AUG-1992) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: WO-1.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: WO-1.

    Entry informationi

    Entry nameiPTPX_CANAW
    AccessioniPrimary (citable) accession number: P43078
    Secondary accession number(s): C4YD44
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: October 19, 2011
    Last modified: June 11, 2014
    This is version 60 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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