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P43077

- HEX1_CANAX

UniProt

P43077 - HEX1_CANAX

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Protein

Beta-hexosaminidase

Gene

HEX1

Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Has a broad substrate specificity.

Catalytic activityi

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

GO - Molecular functioni

  1. beta-N-acetylhexosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Protein family/group databases

CAZyiGH20. Glycoside Hydrolase Family 20.
mycoCLAPiHEX20A_CANAL.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-hexosaminidase (EC:3.2.1.52)
Alternative name(s):
Beta-GlcNAcase
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene namesi
Name:HEX1
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 22221 PublicationAdd
BLAST
Chaini23 – 562540Beta-hexosaminidasePRO_0000012014Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi38 – 381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
Glycosylationi337 – 3371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi382 – 3821N-linked (GlcNAc...)Sequence Analysis
Glycosylationi396 – 3961N-linked (GlcNAc...)Sequence Analysis
Glycosylationi463 – 4631N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Expressioni

Inductioni

By growth on N-acetylglucosamine.

Structurei

3D structure databases

ProteinModelPortaliP43077.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 20 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG3525.

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProiIPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
[Graphical view]
PfamiPF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
[Graphical view]
PIRSFiPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSiPR00738. GLHYDRLASE20.
SUPFAMiSSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43077-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLDKMIIFH LLLWLCNVVV HAAKVEILPA PQSVTWENDT AIIINPRLLQ
60 70 80 90 100
ANTSCPLLED AFVRTVSAIE KSKWHPFPID DFNTANGKNI KTSLVHIQVD
110 120 130 140 150
DATVDLQLGV NESYTLKINT DGINIHAATT WGALHGLVSL QQLIIHTSED
160 170 180 190 200
KYVVPSSVTI SDFPNFKHRG LMIDSGRNFL TVDSILEQID IMALSKMNSL
210 220 230 240 250
HWHLADSQSW PVALESYPHM IKDAYSNDEV YSKNDLKYIV DYARARGVRV
260 270 280 290 300
IPEIDMPGHA RAGWKQVDPT IVECADAFWT DAAVEPPPGQ LNIESEKTYE
310 320 330 340 350
VISNVYNELS DIFIDDVFHV GNDELQEKCY SAQLSPNNTV TDLLKRYLKK
360 370 380 390 400
ALPIFNKVNH RKLTMWDDVL LSDVSADKIP SNITLQVWHE ISGVKNLTSR
410 420 430 440 450
GYDVVVSSSD FLYLDCGNAG WVTNDPRYVE TPENVDFNTG QGGSWCGPYK
460 470 480 490 500
SYQRIYNFDF TANLTETEKN HVLGREAALW SEQVDSTVLT TKIWPRTAAL
510 520 530 540 550
AELTWSGNKD SNGHHRGYEF TQRILNFREY LVKLGYGVSP LVPKYCLLNP
560
HACDLYKNPP VY
Length:562
Mass (Da):63,491
Last modified:November 1, 1995 - v1
Checksum:iCC70FEA69FB3E836
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L26488 Genomic DNA. Translation: AAA34346.2.
PIRiA55588.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L26488 Genomic DNA. Translation: AAA34346.2 .
PIRi A55588.

3D structure databases

ProteinModelPortali P43077.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH20. Glycoside Hydrolase Family 20.
mycoCLAPi HEX20A_CANAL.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG3525.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
3.30.379.10. 1 hit.
InterProi IPR025705. Beta_hexosaminidase_sua/sub.
IPR029018. Chitobiase/Hex_dom_2-like.
IPR015883. Glyco_hydro_20_cat-core.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR029019. HEX_eukaryotic_N.
[Graphical view ]
Pfami PF00728. Glyco_hydro_20. 1 hit.
PF14845. Glycohydro_20b2. 1 hit.
[Graphical view ]
PIRSFi PIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSi PR00738. GLHYDRLASE20.
SUPFAMi SSF51445. SSF51445. 1 hit.
SSF55545. SSF55545. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of the Candida albicans beta-N-acetylglucosaminidase (HEX1) gene."
    Cannon R.D., Niimi K., Jenkinson H.F., Shepherd M.G.
    J. Bacteriol. 176:2640-2647(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 23-42.
    Strain: A72.

Entry informationi

Entry nameiHEX1_CANAX
AccessioniPrimary (citable) accession number: P43077
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3