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P43077 (HEX1_CANAX) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Beta-hexosaminidase
EC=3.2.1.52
Alternative name(s):
Beta-GlcNAcase
Beta-N-acetylhexosaminidase
N-acetyl-beta-glucosaminidase
Gene names
Name:HEX1
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length562 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Has a broad substrate specificity.

Catalytic activity

Hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides.

Induction

By growth on N-acetylglucosamine.

Sequence similarities

Belongs to the glycosyl hydrolase 20 family.

Ontologies

Keywords
   DomainSignal
   Molecular functionGlycosidase
Hydrolase
   PTMGlycoprotein
   Technical termDirect protein sequencing
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular_functionbeta-N-acetylhexosaminidase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Ref.1
Chain23 – 562540Beta-hexosaminidase
PRO_0000012014

Amino acid modifications

Glycosylation381N-linked (GlcNAc...) Potential
Glycosylation521N-linked (GlcNAc...) Potential
Glycosylation1111N-linked (GlcNAc...) Potential
Glycosylation3371N-linked (GlcNAc...) Potential
Glycosylation3821N-linked (GlcNAc...) Potential
Glycosylation3961N-linked (GlcNAc...) Potential
Glycosylation4631N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
P43077 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: CC70FEA69FB3E836

FASTA56263,491
        10         20         30         40         50         60 
MVLDKMIIFH LLLWLCNVVV HAAKVEILPA PQSVTWENDT AIIINPRLLQ ANTSCPLLED 

        70         80         90        100        110        120 
AFVRTVSAIE KSKWHPFPID DFNTANGKNI KTSLVHIQVD DATVDLQLGV NESYTLKINT 

       130        140        150        160        170        180 
DGINIHAATT WGALHGLVSL QQLIIHTSED KYVVPSSVTI SDFPNFKHRG LMIDSGRNFL 

       190        200        210        220        230        240 
TVDSILEQID IMALSKMNSL HWHLADSQSW PVALESYPHM IKDAYSNDEV YSKNDLKYIV 

       250        260        270        280        290        300 
DYARARGVRV IPEIDMPGHA RAGWKQVDPT IVECADAFWT DAAVEPPPGQ LNIESEKTYE 

       310        320        330        340        350        360 
VISNVYNELS DIFIDDVFHV GNDELQEKCY SAQLSPNNTV TDLLKRYLKK ALPIFNKVNH 

       370        380        390        400        410        420 
RKLTMWDDVL LSDVSADKIP SNITLQVWHE ISGVKNLTSR GYDVVVSSSD FLYLDCGNAG 

       430        440        450        460        470        480 
WVTNDPRYVE TPENVDFNTG QGGSWCGPYK SYQRIYNFDF TANLTETEKN HVLGREAALW 

       490        500        510        520        530        540 
SEQVDSTVLT TKIWPRTAAL AELTWSGNKD SNGHHRGYEF TQRILNFREY LVKLGYGVSP 

       550        560 
LVPKYCLLNP HACDLYKNPP VY

« Hide

References

[1]"Molecular cloning and expression of the Candida albicans beta-N-acetylglucosaminidase (HEX1) gene."
Cannon R.D., Niimi K., Jenkinson H.F., Shepherd M.G.
J. Bacteriol. 176:2640-2647(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 23-42.
Strain: A72.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L26488 Genomic DNA. Translation: AAA34346.2.
PIRA55588.

3D structure databases

ProteinModelPortalP43077.
ModBaseSearch...

Protein family/group databases

CAZyGH20. Glycoside Hydrolase Family 20.
mycoCLAPHEX20A_CANAL.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG3525.

Family and domain databases

Gene3D3.20.20.80. 1 hit.
InterProIPR025705. Beta_hexosaminidase_sua/sub.
IPR015883. Glyco_hydro_20_cat-core.
IPR015882. Glyco_hydro_20b.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamPF00728. Glyco_hydro_20. 1 hit.
PF02838. Glyco_hydro_20b. 1 hit.
[Graphical view]
PIRSFPIRSF001093. B-hxosamndse_ab_euk_. 1 hit.
PRINTSPR00738. GLHYDRLASE20.
SUPFAMSSF51445. Glyco_hydro_cat. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHEX1_CANAX
AccessionPrimary (citable) accession number: P43077
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 1, 2013
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

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