pH-responsive protein 1 precursor - Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

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P43076 (PHR1_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 63. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
pH-responsive protein 1

Alternative name(s):
pH-regulated protein 1

Gene names

Name:	PHR1
ORF Names:	CaO19.3829, CaO19.11310

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	548 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Required for apical cell growth and plays an essential role in morphogenesis. May be integral to the pathogenic ability of the organism.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor Potential.
Induction	Strongly expressed under conditions of alkaline pH but not expressed at any pH below 5.5.
Sequence similarities	Belongs to the glycosyl hydrolase 72 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal
PTM	GPI-anchor Glycoprotein Lipoprotein
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro cellular response to drug Inferred from mutant phenotype. Source: CGD development of symbiont in host Inferred from mutant phenotype. Source: CGD entry into host Inferred from mutant phenotype. Source: CGD fungal-type cell wall organization Inferred from direct assay. Source: CGD growth of symbiont in host Inferred from mutant phenotype. Source: CGD hyphal growth Inferred from mutant phenotype. Source: CGD pathogenesis Inferred from mutant phenotype. Source: CGD
Cellular component	anchored to plasma membrane Inferred from direct assay. Source: CGD cell septum Inferred from direct assay. Source: CGD cell surface Inferred from direct assay. Source: CGD cellular bud membrane Inferred from direct assay. Source: CGD cellular bud scar Inferred from direct assay. Source: CGD extracellular region Inferred from direct assay. Source: CGD hyphal cell wall Inferred from direct assay. Source: CGD membrane raft Inferred from direct assay. Source: CGD yeast-form cell wall Inferred from direct assay. Source: CGD
Molecular function	cation binding Inferred from electronic annotation. Source: InterPro glucanosyltransferase activity Inferred from direct assay. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 20

Potential

Chain

21 – 517

497

pH-responsive protein 1

PRO_0000010483

Propeptide

518 – 548

Removed in mature form Potential

PRO_0000010484

Regions

Compositional bias

453 – 499

Ser-rich

Compositional bias

500 – 517

Poly-Ser

Amino acid modifications

Lipidation

517

GPI-anchor amidated serine Potential

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

173

N-linked (GlcNAc...) Potential

Glycosylation

261

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

V → A in AAA68196. Ref.1

Sequence conflict

A → R in AAA68196. Ref.1

Sequence conflict

501

T → A in AAA68196. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P43076 [UniParc].

Last modified October 19, 2011. Version 3.
Checksum: 0836B7A293FAB3CC
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FASTA

548

59,515

        10         20         30         40         50         60 
MYSLIKSLVT FATLFSLTLA KFESSTPPVE VVGNKFYFSN NGSQFLIRGI AYQQDAAGSV 

        70         80         90        100        110        120 
SSGYDADPNR KYNDPLADAD ACKRDVKYFK ESNTNTLRVY AIDPDKDHEE CMKIFSDAGI 

       130        140        150        160        170        180 
YIVADLSEPT VSINRNNPEW NLDLYKRYTK VIDKMQEYSN VLGFFAGNEV TNNRSNTDAS 

       190        200        210        220        230        240 
AFVKAAIRDM KKYIKESDYR QIPVGYSSND DEEIRVAIAD YFSCGSLDDR ADFFGINMYE 

       250        260        270        280        290        300 
WCGKSTFETS GYKDRTEEIK NLTIPAFFSE YGCNANRPRL FQEIGTLYSD KMTDVWSGGI 

       310        320        330        340        350        360 
VYMYFEEANK YGLVSVDGNS VKTLSDYNNY KSEMNKISPS LAHTSTLSSS DASKTLQCPG 

       370        380        390        400        410        420 
TAASTWKAAT NLPPTPDESY CDCISKSLEC VVADDVDKED YGDLFGQVCG YIDCSAISAD 

       430        440        450        460        470        480 
GSKGEYGVAS FCSDKDRLSY VLNQYYLDQD KKSSACDFKG SASINSKASA SGSCKAVSGV 

       490        500        510        520        530        540 
ATGKASSSGG SSKSGSSSAS TSGSSSSSTS SGSSSSSGVK ATQQMSMVKL VSIITIVTAF 


VGGMSVVF

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"PHR1, a pH-regulated gene of Candida albicans, is required for morphogenesis." Saporito-Irwin S.M., Birse C.E., Sypherd P.S., Fonzi W.A. Mol. Cell. Biol. 15:601-613(1995) [PubMed: 7823929] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed: 15123810] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M90812 Genomic DNA. Translation: AAA68196.1. AACQ01000057 Genomic DNA. Translation: EAK98260.1. AACQ01000056 Genomic DNA. Translation: EAK98337.1.
RefSeq	XP_717233.1. XM_712140.1. XP_717309.1. XM_712216.1.
3D structure databases
ProteinModelPortal	P43076.
ModBase	Search...
Protein family/group databases
CAZy	CBM43. Carbohydrate-Binding Module Family 43. GH72. Glycoside Hydrolase Family 72.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3641088. 3641108.
KEGG	cal:CaO19.11310. cal:CaO19.3829.
Organism-specific databases
CGD	CAL0002002. PHR1.
Family and domain databases
InterPro	IPR004886. GAS1. IPR013781. Glyco_hydro_subgr_catalytic. IPR017853. Glycoside_hydrolase_SF. IPR012946. X8. [Graphical view]
Gene3D	G3DSA:3.20.20.80. Glyco_hydro_cat. 1 hit.
Pfam	PF03198. Glyco_hydro_72. 1 hit. PF07983. X8. 1 hit. [Graphical view]
SMART	SM00768. X8. 1 hit. [Graphical view]
SUPFAM	SSF51445. Glyco_hydro_cat. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PHR1_CANAL

Accession

Primary (citable) accession number: P43076
Secondary accession number(s): Q5A661

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	October 19, 2011
Last modified:	January 25, 2012
This is version 63 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program

Relevant documents

Candida albicans

Candida albicans: entries and gene names

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Family and domain databases

Entry information

Relevant documents