Reviewed, UniProtKB/Swiss-Prot P43076 (PHR1_CANAL)

Names and origin

Protein names

Recommended name:
    pH-responsive protein 1
Alternative name(s):
    pH-regulated protein 1

Gene names

Name:

PHR1

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	548 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Required for apical cell growth and plays an essential role in morphogenesis. May be integral to the pathogenic ability of the organism.
Subcellular location	Cell membrane; Lipid-anchor › GPI-anchor Potential.
Induction	Strongly expressed under conditions of alkaline pH but not expressed at any pH below 5.5.
Sequence similarities	Belongs to the glycosyl hydrolase 72 family.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Domain	Signal
PTM	GPI-anchor Glycoprotein Lipoprotein
Gene Ontology (GO)
Cellular component	anchored to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Chain	21 – 517	497	pH-responsive protein 1		PRO_0000010483
	Propeptide	518 – 548	31	Removed in mature form Potential		PRO_0000010484
Regions
	Compositional bias	453 – 499	47	Ser-rich
	Compositional bias	500 – 517	18	Poly-Ser
Amino acid modifications
	Lipidation	517	1	GPI-anchor amidated serine Potential
	Glycosylation	41	1	N-linked (GlcNAc...) Potential
	Glycosylation	173	1	N-linked (GlcNAc...) Potential
	Glycosylation	261	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	P43076-1 [UniParc]. Last modified February 1, 1996. Version 2. Checksum: 34C34068DD2D25B6	FASTA	548	59,542
	10 20 30 40 50 60 MYSLIKSLAT FATLFSLTLA KFESSTPPVE VVGNKFYFSN NGSQFLIRGI AYQQDAAGSV 70 80 90 100 110 120 SSGYDADPNR KYNDPLADRD ACKRDVKYFK ESNTNTLRVY AIDPDKDHEE CMKIFSDAGI 130 140 150 160 170 180 YIVADLSEPT VSINRNNPEW NLDLYKRYTK VIDKMQEYSN VLGFFAGNEV TNNRSNTDAS 190 200 210 220 230 240 AFVKAAIRDM KKYIKESDYR QIPVGYSSND DEEIRVAIAD YFSCGSLDDR ADFFGINMYE 250 260 270 280 290 300 WCGKSTFETS GYKDRTEEIK NLTIPAFFSE YGCNANRPRL FQEIGTLYSD KMTDVWSGGI 310 320 330 340 350 360 VYMYFEEANK YGLVSVDGNS VKTLSDYNNY KSEMNKISPS LAHTSTLSSS DASKTLQCPG 370 380 390 400 410 420 TAASTWKAAT NLPPTPDESY CDCISKSLEC VVADDVDKED YGDLFGQVCG YIDCSAISAD 430 440 450 460 470 480 GSKGEYGVAS FCSDKDRLSY VLNQYYLDQD KKSSACDFKG SASINSKASA SGSCKAVSGV 490 500 510 520 530 540 ATGKASSSGG SSKSGSSSAS ASGSSSSSTS SGSSSSSGVK ATQQMSMVKL VSIITIVTAF VGGMSVVF

References

[1]	"PHR1, a pH-regulated gene of Candida albicans, is required for morphogenesis." Saporito-Irwin S.M., Birse C.E., Sypherd P.S., Fonzi W.A. Mol. Cell. Biol. 15:601-613(1995) [PubMed: 7823929] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SC5314.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M90812 Genomic DNA. Translation: AAA68196.1.
3D structure databases
ModBase	Search...
Protein family/group databases
CAZy	CBM43. Carbohydrate-Binding Module Family 43. GH72. Glycoside Hydrolase Family 72.
Family and domain databases
InterPro	IPR004886. GAS1. IPR012946. X8. [Graphical view]
Pfam	PF03198. Glyco_hydro_72. 1 hit. PF07983. X8. 1 hit. [Graphical view]
SMART	SM00768. X8. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PHR1_CANAL

Accession

Primary (citable) accession number: P43076

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	February 1, 1996
Last modified:	June 16, 2009
This is version 48 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)