P43073 (TRPF_CANAL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase
Short name=PRAI
EC=5.3.1.24

Gene names

Name:	TRP1
ORF Names:	CaO19.13515, CaO19.6096

Organism

Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]

Taxonomic identifier

237561 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida › Candida albicans

Protein attributes

Sequence length	226 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5.
Sequence similarities	Belongs to the TrpF family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	tryptophan biosynthetic process Inferred from mutant phenotype PubMed 20141603Ref.1. Source: CGD
Molecular_function	phosphoribosylanthranilate isomerase activity Inferred from genetic interaction PubMed 3900642Ref.1. Source: CGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 226	226	N-(5'-phosphoribosyl)anthranilate isomerase		PRO_0000154330
Experimental info
	Sequence conflict	160	1	G → S in CAA55217. Ref.1
	Sequence conflict	206 – 208	3	NGV → SGA in CAA55217. Ref.1
	Sequence conflict	216	1	K → Q in CAA55217. Ref.1
	Sequence conflict	220 – 226	7	KGHAQSS → QAHSLI in CAA55217. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	P43073 [UniParc]. Last modified October 19, 2011. Version 2. Checksum: 384C76FAD3AAB12A	FASTA	226	24,768
	10 20 30 40 50 60 MKVVKICGIK TVEAASVAID NGANLLGCIL VPNRARTIDL EVAKQIARMV KRDRNPPPKF 70 80 90 100 110 120 AGGTSTQHFE QVAQWIIENG PFLVGVFRNQ PKEEVFRIAR EVGLDFIQLH GSEDKLEFLG 130 140 150 160 170 180 TEFGLIPRYV VPDELDLLEE QSLSLTQCVS LPLLDSEVGG EGKLLDWTFI EKLPTKAILA 190 200 210 220 GGLTPENLPT FDNILGYDVS GGVETNGVKD SLKIIKFIQK GHAQSS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the Candida albicans TRP1 gene and construction of a homozygous trp1 mutant by sequential co-transformation." Ostrander D.B., Gorman J.A. Gene 148:179-185(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.
[2]	"The diploid genome sequence of Candida albicans." Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S. Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X78466 Genomic DNA. Translation: CAA55217.1. AACQ01000036 Genomic DNA. Translation: EAL00050.1. AACQ01000035 Genomic DNA. Translation: EAL00157.1.
RefSeq	XP_718951.1. XM_713858.1. XP_719055.1. XM_713962.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	5476.CAF0006885.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3639321. 3639444.
KEGG	cal:CaO19.13515. cal:CaO19.6096.
Organism-specific databases
CGD	CAF0006885. TRP1.
Phylogenomic databases
eggNOG	COG0135.
KO	K01817.
Enzyme and pathway databases
UniPathway	UPA00035; UER00042.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR013785. Aldolase_TIM. IPR001240. PRAI. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Pfam	PF00697. PRAI. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPF_CANAL

Accession

Primary (citable) accession number: P43073
Secondary accession number(s): Q5AB75

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	October 19, 2011
Last modified:	April 3, 2013
This is version 57 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program