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P43073

- TRPF_CANAL

UniProt

P43073 - TRPF_CANAL

Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

TRP1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 2 (19 Oct 2011)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

    Pathwayi

    GO - Molecular functioni

    1. phosphoribosylanthranilate isomerase activity Source: CGD

    GO - Biological processi

    1. tryptophan biosynthetic process Source: CGD

    Keywords - Molecular functioni

    Isomerase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00035; UER00042.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
    Short name:
    PRAI
    Gene namesi
    Name:TRP1
    ORF Names:CaO19.13515, CaO19.6096
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAF0006885. TRP1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 226226N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154330Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAF0006885.

    Structurei

    3D structure databases

    ProteinModelPortaliP43073.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TrpF family.Curated

    Phylogenomic databases

    eggNOGiCOG0135.
    KOiK01817.
    OrthoDBiEOG76MKM7.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00135. PRAI.
    InterProiIPR013785. Aldolase_TIM.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00697. PRAI. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    P43073-1 [UniParc]FASTAAdd to Basket

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    MKVVKICGIK TVEAASVAID NGANLLGCIL VPNRARTIDL EVAKQIARMV    50
    KRDRNPPPKF AGGTSTQHFE QVAQWIIENG PFLVGVFRNQ PKEEVFRIAR 100
    EVGLDFIQLH GSEDKLEFLG TEFGLIPRYV VPDELDLLEE QSLSLTQCVS 150
    LPLLDSEVGG EGKLLDWTFI EKLPTKAILA GGLTPENLPT FDNILGYDVS 200
    GGVETNGVKD SLKIIKFIQK GHAQSS 226
    Length:226
    Mass (Da):24,768
    Last modified:October 19, 2011 - v2
    Checksum:i384C76FAD3AAB12A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti160 – 1601G → S in CAA55217. (PubMed:7958943)Curated
    Sequence conflicti206 – 2083NGV → SGA in CAA55217. (PubMed:7958943)Curated
    Sequence conflicti216 – 2161K → Q in CAA55217. (PubMed:7958943)Curated
    Sequence conflicti220 – 2267KGHAQSS → QAHSLI in CAA55217. (PubMed:7958943)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78466 Genomic DNA. Translation: CAA55217.1.
    AACQ01000036 Genomic DNA. Translation: EAL00050.1.
    AACQ01000035 Genomic DNA. Translation: EAL00157.1.
    RefSeqiXP_718951.1. XM_713858.1.
    XP_719055.1. XM_713962.1.

    Genome annotation databases

    GeneIDi3639321.
    3639444.
    KEGGical:CaO19.13515.
    cal:CaO19.6096.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X78466 Genomic DNA. Translation: CAA55217.1 .
    AACQ01000036 Genomic DNA. Translation: EAL00050.1 .
    AACQ01000035 Genomic DNA. Translation: EAL00157.1 .
    RefSeqi XP_718951.1. XM_713858.1.
    XP_719055.1. XM_713962.1.

    3D structure databases

    ProteinModelPortali P43073.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAF0006885.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3639321.
    3639444.
    KEGGi cal:CaO19.13515.
    cal:CaO19.6096.

    Organism-specific databases

    CGDi CAF0006885. TRP1.

    Phylogenomic databases

    eggNOGi COG0135.
    KOi K01817.
    OrthoDBi EOG76MKM7.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00042 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00135. PRAI.
    InterProi IPR013785. Aldolase_TIM.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00697. PRAI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the Candida albicans TRP1 gene and construction of a homozygous trp1 mutant by sequential co-transformation."
      Ostrander D.B., Gorman J.A.
      Gene 148:179-185(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiTRPF_CANAL
    AccessioniPrimary (citable) accession number: P43073
    Secondary accession number(s): Q5AB75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: October 19, 2011
    Last modified: October 1, 2014
    This is version 63 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3