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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

TRP1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. N-(5'-phosphoribosyl)anthranilate isomerase (TRP1)
  4. no protein annotated in this organism
  5. Tryptophan synthase (TRP5)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

  • phosphoribosylanthranilate isomerase activity Source: CGD

GO - Biological processi

  • tryptophan biosynthetic process Source: CGD

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:TRP1
Ordered Locus Names:CAALFM_C100120CA
ORF Names:CaO19.13515, CaO19.6096
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 1

Organism-specific databases

CGDiCAL0000186853 TRP1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001543301 – 226N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST226

Structurei

3D structure databases

ProteinModelPortaliP43073
SMRiP43073
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.Curated

Phylogenomic databases

InParanoidiP43073
KOiK01817
OMAiFYAKSPR
OrthoDBiEOG092C59PB

Family and domain databases

CDDicd00405 PRAI, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00135 PRAI, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001240 PRAI
IPR011060 RibuloseP-bd_barrel
PfamiView protein in Pfam
PF00697 PRAI, 1 hit
SUPFAMiSSF51366 SSF51366, 2 hits

Sequencei

Sequence statusi: Complete.

P43073-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVVKICGIK TVEAASVAID NGANLLGCIL VPNRARTIDL EVAKQIARMV
60 70 80 90 100
KRDRNPPPKF AGGTSTQHFE QVAQWIIENG PFLVGVFRNQ PKEEVFRIAR
110 120 130 140 150
EVGLDFIQLH GSEDKLEFLG TEFGLIPRYV VPDELDLLEE QSLSLTQCVS
160 170 180 190 200
LPLLDSEVGG EGKLLDWTFI EKLPTKAILA GGLTPENLPT FDNILGYDVS
210 220
GGVETNGVKD SLKIIKFIQK GHAQSS
Length:226
Mass (Da):24,768
Last modified:October 19, 2011 - v2
Checksum:i384C76FAD3AAB12A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160G → S in CAA55217 (PubMed:7958943).Curated1
Sequence conflicti206 – 208NGV → SGA in CAA55217 (PubMed:7958943).Curated3
Sequence conflicti216K → Q in CAA55217 (PubMed:7958943).Curated1
Sequence conflicti220 – 226KGHAQSS → QAHSLI in CAA55217 (PubMed:7958943).Curated7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78466 Genomic DNA Translation: CAA55217.1
CP017623 Genomic DNA Translation: AOW25714.1
RefSeqiXP_719055.1, XM_713962.1

Genome annotation databases

EnsemblFungiiAOW25714; AOW25714; CAALFM_C100120CA
GeneIDi3639321
KEGGical:CAALFM_C100120CA

Similar proteinsi

Entry informationi

Entry nameiTRPF_CANAL
AccessioniPrimary (citable) accession number: P43073
Secondary accession number(s): A0A1D8PC52, Q5AB75
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 19, 2011
Last modified: May 23, 2018
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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