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P43073

- TRPF_CANAL

UniProt

P43073 - TRPF_CANAL

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Protein
N-(5'-phosphoribosyl)anthranilate isomerase
Gene
TRP1, CaO19.13515, CaO19.6096
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. phosphoribosylanthranilate isomerase activity Source: CGD
Complete GO annotation...

GO - Biological processi

  1. tryptophan biosynthetic process Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:TRP1
ORF Names:CaO19.13515, CaO19.6096
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAF0006885. TRP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation
PRO_0000154330Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAF0006885.

Structurei

3D structure databases

ProteinModelPortaliP43073.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.

Phylogenomic databases

eggNOGiCOG0135.
KOiK01817.
OrthoDBiEOG76MKM7.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.

Sequencei

Sequence statusi: Complete.

P43073-1 [UniParc]FASTAAdd to Basket

« Hide

MKVVKICGIK TVEAASVAID NGANLLGCIL VPNRARTIDL EVAKQIARMV    50
KRDRNPPPKF AGGTSTQHFE QVAQWIIENG PFLVGVFRNQ PKEEVFRIAR 100
EVGLDFIQLH GSEDKLEFLG TEFGLIPRYV VPDELDLLEE QSLSLTQCVS 150
LPLLDSEVGG EGKLLDWTFI EKLPTKAILA GGLTPENLPT FDNILGYDVS 200
GGVETNGVKD SLKIIKFIQK GHAQSS 226
Length:226
Mass (Da):24,768
Last modified:October 19, 2011 - v2
Checksum:i384C76FAD3AAB12A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601G → S in CAA55217. 1 Publication
Sequence conflicti206 – 2083NGV → SGA in CAA55217. 1 Publication
Sequence conflicti216 – 2161K → Q in CAA55217. 1 Publication
Sequence conflicti220 – 2267KGHAQSS → QAHSLI in CAA55217. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78466 Genomic DNA. Translation: CAA55217.1.
AACQ01000036 Genomic DNA. Translation: EAL00050.1.
AACQ01000035 Genomic DNA. Translation: EAL00157.1.
RefSeqiXP_718951.1. XM_713858.1.
XP_719055.1. XM_713962.1.

Genome annotation databases

GeneIDi3639321.
3639444.
KEGGical:CaO19.13515.
cal:CaO19.6096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X78466 Genomic DNA. Translation: CAA55217.1 .
AACQ01000036 Genomic DNA. Translation: EAL00050.1 .
AACQ01000035 Genomic DNA. Translation: EAL00157.1 .
RefSeqi XP_718951.1. XM_713858.1.
XP_719055.1. XM_713962.1.

3D structure databases

ProteinModelPortali P43073.
ModBasei Search...

Protein-protein interaction databases

STRINGi 5476.CAF0006885.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3639321.
3639444.
KEGGi cal:CaO19.13515.
cal:CaO19.6096.

Organism-specific databases

CGDi CAF0006885. TRP1.

Phylogenomic databases

eggNOGi COG0135.
KOi K01817.
OrthoDBi EOG76MKM7.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00042 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00697. PRAI. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the Candida albicans TRP1 gene and construction of a homozygous trp1 mutant by sequential co-transformation."
    Ostrander D.B., Gorman J.A.
    Gene 148:179-185(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiTRPF_CANAL
AccessioniPrimary (citable) accession number: P43073
Secondary accession number(s): Q5AB75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 19, 2011
Last modified: February 19, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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