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P43073 (TRPF_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N-(5'-phosphoribosyl)anthranilate isomerase

Short name=PRAI
EC=5.3.1.24
Gene names
Name:TRP1
ORF Names:CaO19.13515, CaO19.6096
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length226 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate. HAMAP-Rule MF_00135

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 3/5. HAMAP-Rule MF_00135

Sequence similarities

Belongs to the TrpF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 226226N-(5'-phosphoribosyl)anthranilate isomerase HAMAP-Rule MF_00135
PRO_0000154330

Experimental info

Sequence conflict1601G → S in CAA55217. Ref.1
Sequence conflict206 – 2083NGV → SGA in CAA55217. Ref.1
Sequence conflict2161K → Q in CAA55217. Ref.1
Sequence conflict220 – 2267KGHAQSS → QAHSLI in CAA55217. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P43073 [UniParc].

Last modified October 19, 2011. Version 2.
Checksum: 384C76FAD3AAB12A

FASTA22624,768
        10         20         30         40         50         60 
MKVVKICGIK TVEAASVAID NGANLLGCIL VPNRARTIDL EVAKQIARMV KRDRNPPPKF 

        70         80         90        100        110        120 
AGGTSTQHFE QVAQWIIENG PFLVGVFRNQ PKEEVFRIAR EVGLDFIQLH GSEDKLEFLG 

       130        140        150        160        170        180 
TEFGLIPRYV VPDELDLLEE QSLSLTQCVS LPLLDSEVGG EGKLLDWTFI EKLPTKAILA 

       190        200        210        220 
GGLTPENLPT FDNILGYDVS GGVETNGVKD SLKIIKFIQK GHAQSS 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the Candida albicans TRP1 gene and construction of a homozygous trp1 mutant by sequential co-transformation."
Ostrander D.B., Gorman J.A.
Gene 148:179-185(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.
[2]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X78466 Genomic DNA. Translation: CAA55217.1.
AACQ01000036 Genomic DNA. Translation: EAL00050.1.
AACQ01000035 Genomic DNA. Translation: EAL00157.1.
RefSeqXP_718951.1. XM_713858.1.
XP_719055.1. XM_713962.1.

3D structure databases

ProteinModelPortalP43073.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAF0006885.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3639321.
3639444.
KEGGcal:CaO19.13515.
cal:CaO19.6096.

Organism-specific databases

CGDCAF0006885. TRP1.

Phylogenomic databases

eggNOGCOG0135.
KOK01817.
OrthoDBEOG76MKM7.

Enzyme and pathway databases

UniPathwayUPA00035; UER00042.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_00135. PRAI.
InterProIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 2 hits.
ProtoNetSearch...

Entry information

Entry nameTRPF_CANAL
AccessionPrimary (citable) accession number: P43073
Secondary accession number(s): Q5AB75
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 19, 2011
Last modified: February 19, 2014
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Candida albicans

Candida albicans: entries and gene names