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P43073

- TRPF_CANAL

UniProt

P43073 - TRPF_CANAL

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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

TRP1

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.

Pathwayi

GO - Molecular functioni

  1. phosphoribosylanthranilate isomerase activity Source: CGD

GO - Biological processi

  1. tryptophan biosynthetic process Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:TRP1
ORF Names:CaO19.13515, CaO19.6096
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAF0006885. TRP1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226N-(5'-phosphoribosyl)anthranilate isomerasePRO_0000154330Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAF0006885.

Structurei

3D structure databases

ProteinModelPortaliP43073.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.Curated

Phylogenomic databases

eggNOGiCOG0135.
InParanoidiP43073.
KOiK01817.
OrthoDBiEOG76MKM7.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.

Sequencei

Sequence statusi: Complete.

P43073-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKVVKICGIK TVEAASVAID NGANLLGCIL VPNRARTIDL EVAKQIARMV
60 70 80 90 100
KRDRNPPPKF AGGTSTQHFE QVAQWIIENG PFLVGVFRNQ PKEEVFRIAR
110 120 130 140 150
EVGLDFIQLH GSEDKLEFLG TEFGLIPRYV VPDELDLLEE QSLSLTQCVS
160 170 180 190 200
LPLLDSEVGG EGKLLDWTFI EKLPTKAILA GGLTPENLPT FDNILGYDVS
210 220
GGVETNGVKD SLKIIKFIQK GHAQSS
Length:226
Mass (Da):24,768
Last modified:October 19, 2011 - v2
Checksum:i384C76FAD3AAB12A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti160 – 1601G → S in CAA55217. (PubMed:7958943)Curated
Sequence conflicti206 – 2083NGV → SGA in CAA55217. (PubMed:7958943)Curated
Sequence conflicti216 – 2161K → Q in CAA55217. (PubMed:7958943)Curated
Sequence conflicti220 – 2267KGHAQSS → QAHSLI in CAA55217. (PubMed:7958943)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78466 Genomic DNA. Translation: CAA55217.1.
AACQ01000036 Genomic DNA. Translation: EAL00050.1.
AACQ01000035 Genomic DNA. Translation: EAL00157.1.
RefSeqiXP_718951.1. XM_713858.1.
XP_719055.1. XM_713962.1.

Genome annotation databases

GeneIDi3639321.
3639444.
KEGGical:CaO19.13515.
cal:CaO19.6096.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78466 Genomic DNA. Translation: CAA55217.1 .
AACQ01000036 Genomic DNA. Translation: EAL00050.1 .
AACQ01000035 Genomic DNA. Translation: EAL00157.1 .
RefSeqi XP_718951.1. XM_713858.1.
XP_719055.1. XM_713962.1.

3D structure databases

ProteinModelPortali P43073.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAF0006885.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3639321.
3639444.
KEGGi cal:CaO19.13515.
cal:CaO19.6096.

Organism-specific databases

CGDi CAF0006885. TRP1.

Phylogenomic databases

eggNOGi COG0135.
InParanoidi P43073.
KOi K01817.
OrthoDBi EOG76MKM7.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00042 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00697. PRAI. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the Candida albicans TRP1 gene and construction of a homozygous trp1 mutant by sequential co-transformation."
    Ostrander D.B., Gorman J.A.
    Gene 148:179-185(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiTRPF_CANAL
AccessioniPrimary (citable) accession number: P43073
Secondary accession number(s): Q5AB75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 19, 2011
Last modified: October 29, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3