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Protein

Cell division control protein 25

Gene

CDC25

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Promotes the exchange of Ras-bound GDP by GTP. This protein positively controls the level of cellular cAMP at start, the stage at which the yeast cell division cycle is triggered.

GO - Molecular functioni

  • Ras guanyl-nucleotide exchange factor activity Source: CGD

GO - Biological processi

  • cAMP-mediated signaling Source: CGD
  • cell cycle Source: UniProtKB-KW
  • cell division Source: UniProtKB-KW
  • cellular response to glucose stimulus Source: CGD
  • cellular response to starvation Source: CGD
  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  • Ras protein signal transduction Source: CGD

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processCell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 25
Gene namesi
Name:CDC25
Synonyms:CSC25
Ordered Locus Names:CAALFM_C303890WA
ORF Names:CaO19.14188, CaO19.6926
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
Proteomesi
  • UP000000559 Componenti: Chromosome 3

Organism-specific databases

CGDiCAL0000178834 CSC25

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000688611 – 1333Cell division control protein 25Add BLAST1333

Proteomic databases

PRIDEiP43069

Interactioni

GO - Molecular functioni

  • Ras guanyl-nucleotide exchange factor activity Source: CGD

Structurei

3D structure databases

ProteinModelPortaliP43069
SMRiP43069
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 94SH3PROSITE-ProRule annotationAdd BLAST65
Domaini900 – 1034N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST135
Domaini1068 – 1305Ras-GEFPROSITE-ProRule annotationAdd BLAST238

Keywords - Domaini

SH3 domain

Phylogenomic databases

InParanoidiP43069
KOiK03099
OMAiYATRVMH
OrthoDBiEOG092C0VYU

Family and domain databases

CDDicd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di1.10.840.10, 2 hits
InterProiView protein in InterPro
IPR000651 Ras-like_Gua-exchang_fac_N
IPR019804 Ras_G-nucl-exch_fac_CS
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
PF00018 SH3_1, 1 hit
SMARTiView protein in SMART
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00720 RASGEF, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

P43069-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSANYISDE VPPDMVSPHD HRPSKDEPLK HLDTVIALYD FPGTQSSHLP
60 70 80 90 100
LNLGDTIHVL SKSATGWWDG VVMGNSGELQ RGWFPHNYVR SVNYVQPVLK
110 120 130 140 150
KLKDNKDLDS ITAANTAANV VMPSLTNLIQ KSLQESERNS PANSTRKNSV
160 170 180 190 200
VSFASSETSM PSDSKYTQQQ TNTNQNSPEY QSISLPSTRD HSTVEMQLPS
210 220 230 240 250
QQSSISHTLT GFGIGDDEII PMEVEEAEKL VEEYRLKYNK TVTWIPRTST
260 270 280 290 300
KGDIIFYCEQ LDVYCESLPL ILFDGEASSP NLEYPGSDVI MDPTPISVQG
310 320 330 340 350
SQSMENVLDT REGSAAGSFD STKRDSNVSM STQSSGSSYH RFSRPFFSVD
360 370 380 390 400
NLFYKHSSDI GTWNELKEQC NYILDLMLKA IKDQNRQFFS THFSRLNKLV
410 420 430 440 450
VALCAAVRLN QEDYIDTKYE NTTRRKLKRV CASFAQIYIN GILHLSVLHY
460 470 480 490 500
SLEGFNEGRL FGYDMGKLNR SSSSSAFQSP ASSLSTIRQG SDDSTRFAQK
510 520 530 540 550
LSQDRNSEGN GDMNYINQLV YEIDNLRENV NSIVKIFLKL SANKKIKNSD
560 570 580 590 600
YDSSDASDDE GEDRFDILPQ VYPRFLVDEF NGGNWCNPFF STKNTVLNVS
610 620 630 640 650
GDDLKNRYHT KIIIDHSAYD SLSQYVDKIV DACENILEAL DPKVQNTFYY
660 670 680 690 700
NEMLRNERNT QILRLTYKSL YHCSAMVDLI ESFDFTVFCS VKRHTGNAID
710 720 730 740 750
TEDESYENPS VWGDHYDSNL SFDYPVVLEF FRLKQELHDL VAKIIMATQS
760 770 780 790 800
LTLEDPEVFK GLKEEDPLFY NREISKIPKE KAALLLSSIL KEQLSFKDGG
810 820 830 840 850
AISLNPDTLL SGYLVEIAKT TKTVLLITQQ LIEERETIIN YATRVMQDNF
860 870 880 890 900
DVQLLLVERN NTSSSEKADD NSYYVGGHKK STDVPWYLEG DDEYELLLDV
910 920 930 940 950
KGNIKGGSKE ALVSHLTHHL SLDSNFNAVF LLMFSSMMSL GELISLLIAR
960 970 980 990 1000
FNIEPPEGLS YEEYNLWVSK KRNPIRLRVI NIMKLLLEKN WSMSYYNEPV
1010 1020 1030 1040 1050
LRRWLTFAHS DQVQTYSLGN LLVNYLERLL RGERIYVERD PVIPNTKPPA
1060 1070 1080 1090 1100
PLTKGSSLSK KPRVMDIDYV ELARQLTLRE FKLYCKITKF ACLAKVWGKK
1110 1120 1130 1140 1150
SGLSESIDSI TQFIKASNQL TNFVGYMILR KADPKKRVQI IRYFIQVADK
1160 1170 1180 1190 1200
CRQYNNFSSM TAIISALYSS PIHRLKKTWE YMNADALSNL KNMNKLMNSS
1210 1220 1230 1240 1250
RNFNEYRDVL KFIGSEPCVP FFGVYLSDLT FVYHGNPDYL YNRTRQVNFA
1260 1270 1280 1290 1300
KRAKTSEIVS GIDRFKTTGY NFQEVPEIQK FLDAWFEKCP TIDEQYQISL
1310 1320 1330
NLEPREQAVG ASNSNSTTNA TTNIKSFKPF SLK
Length:1,333
Mass (Da):152,031
Last modified:March 15, 2017 - v2
Checksum:i77AE469FF95834C2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti198L → P in AAA34329 (PubMed:8477693).Curated1
Sequence conflicti1308 – 1309AV → PA in AAA34329 (PubMed:8477693).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94160 Genomic DNA Translation: AAA34329.2
CP017625 Genomic DNA Translation: AOW28416.1
PIRiS30356
RefSeqiXP_712727.2, XM_707634.2

Genome annotation databases

EnsemblFungiiAOW28416; AOW28416; CAALFM_C303890WA
GeneIDi3645660
KEGGical:CAALFM_C303890WA

Similar proteinsi

Entry informationi

Entry nameiCDC25_CANAL
AccessioniPrimary (citable) accession number: P43069
Secondary accession number(s): A0A1D8PJT3, Q59SU3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: March 15, 2017
Last modified: March 28, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health