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P43069

- CDC25_CANAL

UniProt

P43069 - CDC25_CANAL

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Protein

Cell division control protein 25

Gene
CDC25, CSC25, CaO19.14188, CaO19.6926
Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein predictedi

Functioni

Promotes the exchange of Ras-bound GDP by GTP. This protein positively controls the level of cellular cAMP at start, the stage at which the yeast cell division cycle is triggered.

GO - Molecular functioni

  1. Ras guanyl-nucleotide exchange factor activity Source: CGD

GO - Biological processi

  1. cAMP-mediated signaling Source: CGD
  2. cellular response to glucose stimulus Source: CGD
  3. cellular response to starvation Source: CGD
  4. filamentous growth Source: CGD
  5. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  6. filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  7. mitotic nuclear division Source: UniProtKB-KW
  8. Ras protein signal transduction Source: CGD
  9. regulation of Ras GTPase activity Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 25
Gene namesi
Name:CDC25
Synonyms:CSC25
ORF Names:CaO19.14188, CaO19.6926
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
ProteomesiUP000000559: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000207. CSC25.

Subcellular locationi

GO - Cellular componenti

  1. hyphal tip Source: CGD
  2. intracellular Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13331333Cell division control protein 25PRO_0000068861Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi5476.CAL0000207.

Structurei

3D structure databases

ProteinModelPortaliP43069.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 9465SH3Add
BLAST
Domaini900 – 1034135N-terminal Ras-GEFAdd
BLAST
Domaini1068 – 1305238Ras-GEFAdd
BLAST

Sequence similaritiesi

Contains 1 Ras-GEF domain.
Contains 1 SH3 domain.

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG265981.
OrthoDBiEOG78WM2F.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43069-1 [UniParc]FASTAAdd to Basket

« Hide

MSSANYISDE VPPDMVSPHD HRPSKDEPLK HLDTVIALYD FPGTQSSHLP     50
LNLGDTIHVL SKSATGWWDG VVMGNSGELQ RGWFPHNYVR SVNYVQPVLK 100
KLKDNKDLDS ITAANTAANV VMPSLTNLIQ KSLQESERNS PANSTRKNSV 150
VSFASSETSM PSDSKYTQQQ TNTNQNSPEY QSISLPSTRD HSTVEMQPPS 200
QQSSISHTLT GFGIGDDEII PMEVEEAEKL VEEYRLKYNK TVTWIPRTST 250
KGDIIFYCEQ LDVYCESLPL ILFDGEASSP NLEYPGSDVI MDPTPISVQG 300
SQSMENVLDT REGSAAGSFD STKRDSNVSM STQSSGSSYH RFSRPFFSVD 350
NLFYKHSSDI GTWNELKEQC NYILDLMLKA IKDQNRQFFS THFSRLNKLV 400
VALCAAVRLN QEDYIDTKYE NTTRRKLKRV CASFAQIYIN GILHLSVLHY 450
SLEGFNEGRL FGYDMGKLNR SSSSSAFQSP ASSLSTIRQG SDDSTRFAQK 500
LSQDRNSEGN GDMNYINQLV YEIDNLRENV NSIVKIFLKL SANKKIKNSD 550
YDSSDASDDE GEDRFDILPQ VYPRFLVDEF NGGNWCNPFF STKNTVLNVS 600
GDDLKNRYHT KIIIDHSAYD SLSQYVDKIV DACENILEAL DPKVQNTFYY 650
NEMLRNERNT QILRLTYKSL YHCSAMVDLI ESFDFTVFCS VKRHTGNAID 700
TEDESYENPS VWGDHYDSNL SFDYPVVLEF FRLKQELHDL VAKIIMATQS 750
LTLEDPEVFK GLKEEDPLFY NREISKIPKE KAALLLSSIL KEQLSFKDGG 800
AISLNPDTLL SGYLVEIAKT TKTVLLITQQ LIEERETIIN YATRVMQDNF 850
DVQLLLVERN NTSSSEKADD NSYYVGGHKK STDVPWYLEG DDEYELLLDV 900
KGNIKGGSKE ALVSHLTHHL SLDSNFNAVF LLMFSSMMSL GELISLLIAR 950
FNIEPPEGLS YEEYNLWVSK KRNPIRLRVI NIMKLLLEKN WSMSYYNEPV 1000
LRRWLTFAHS DQVQTYSLGN LLVNYLERLL RGERIYVERD PVIPNTKPPA 1050
PLTKGSSLSK KPRVMDIDYV ELARQLTLRE FKLYCKITKF ACLAKVWGKK 1100
SGLSESIDSI TQFIKASNQL TNFVGYMILR KADPKKRVQI IRYFIQVADK 1150
CRQYNNFSSM TAIISALYSS PIHRLKKTWE YMNADALSNL KNMNKLMNSS 1200
RNFNEYRDVL KFIGSEPCVP FFGVYLSDLT FVYHGNPDYL YNRTRQVNFA 1250
KRAKTSEIVS GIDRFKTTGY NFQEVPEIQK FLDAWFEKCP TIDEQYQISL 1300
NLEPREQPAG ASNSNSTTNA TTNIKSFKPF SLK 1333
Length:1,333
Mass (Da):152,012
Last modified:November 1, 1995 - v1
Checksum:iDAFE90D6AC192483
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94160 Genomic DNA. Translation: AAA34329.2.
AACQ01000148 Genomic DNA. Translation: EAK93519.1.
AACQ01000147 Genomic DNA. Translation: EAK93556.1.
PIRiS30356.
RefSeqiXP_712690.1. XM_707597.1.
XP_712727.1. XM_707634.1.

Genome annotation databases

GeneIDi3645660.
3645697.
KEGGical:CaO19.14188.
cal:CaO19.6926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M94160 Genomic DNA. Translation: AAA34329.2 .
AACQ01000148 Genomic DNA. Translation: EAK93519.1 .
AACQ01000147 Genomic DNA. Translation: EAK93556.1 .
PIRi S30356.
RefSeqi XP_712690.1. XM_707597.1.
XP_712727.1. XM_707634.1.

3D structure databases

ProteinModelPortali P43069.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 5476.CAL0000207.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3645660.
3645697.
KEGGi cal:CaO19.14188.
cal:CaO19.6926.

Organism-specific databases

CGDi CAL0000207. CSC25.

Phylogenomic databases

eggNOGi NOG265981.
OrthoDBi EOG78WM2F.

Family and domain databases

Gene3Di 1.10.840.10. 1 hit.
InterProi IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR001452. SH3_domain.
[Graphical view ]
Pfami PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view ]
SMARTi SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view ]
SUPFAMi SSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEi PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A Candida albicans homolog of CDC25 is functional in Saccharomyces cerevisiae."
    Goldberg D., Marbach I., Gross E., Levitzki A., Simchen G.
    Eur. J. Biochem. 213:195-204(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 792-1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiCDC25_CANAL
AccessioniPrimary (citable) accession number: P43069
Secondary accession number(s): Q59SU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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