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P43069 (CDC25_CANAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cell division control protein 25
Gene names
Name:CDC25
Synonyms:CSC25
ORF Names:CaO19.14188, CaO19.6926
OrganismCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast) [Reference proteome]
Taxonomic identifier237561 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length1333 AA.
Sequence statusComplete.
Protein existencePredicted

General annotation (Comments)

Function

Promotes the exchange of Ras-bound GDP by GTP. This protein positively controls the level of cellular cAMP at start, the stage at which the yeast cell division cycle is triggered.

Sequence similarities

Contains 1 N-terminal Ras-GEF domain.

Contains 1 Ras-GEF domain.

Contains 1 SH3 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13331333Cell division control protein 25
PRO_0000068861

Regions

Domain30 – 9465SH3
Domain900 – 1034135N-terminal Ras-GEF
Domain1068 – 1305238Ras-GEF

Sequences

Sequence LengthMass (Da)Tools
P43069 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: DAFE90D6AC192483

FASTA1,333152,012
        10         20         30         40         50         60 
MSSANYISDE VPPDMVSPHD HRPSKDEPLK HLDTVIALYD FPGTQSSHLP LNLGDTIHVL 

        70         80         90        100        110        120 
SKSATGWWDG VVMGNSGELQ RGWFPHNYVR SVNYVQPVLK KLKDNKDLDS ITAANTAANV 

       130        140        150        160        170        180 
VMPSLTNLIQ KSLQESERNS PANSTRKNSV VSFASSETSM PSDSKYTQQQ TNTNQNSPEY 

       190        200        210        220        230        240 
QSISLPSTRD HSTVEMQPPS QQSSISHTLT GFGIGDDEII PMEVEEAEKL VEEYRLKYNK 

       250        260        270        280        290        300 
TVTWIPRTST KGDIIFYCEQ LDVYCESLPL ILFDGEASSP NLEYPGSDVI MDPTPISVQG 

       310        320        330        340        350        360 
SQSMENVLDT REGSAAGSFD STKRDSNVSM STQSSGSSYH RFSRPFFSVD NLFYKHSSDI 

       370        380        390        400        410        420 
GTWNELKEQC NYILDLMLKA IKDQNRQFFS THFSRLNKLV VALCAAVRLN QEDYIDTKYE 

       430        440        450        460        470        480 
NTTRRKLKRV CASFAQIYIN GILHLSVLHY SLEGFNEGRL FGYDMGKLNR SSSSSAFQSP 

       490        500        510        520        530        540 
ASSLSTIRQG SDDSTRFAQK LSQDRNSEGN GDMNYINQLV YEIDNLRENV NSIVKIFLKL 

       550        560        570        580        590        600 
SANKKIKNSD YDSSDASDDE GEDRFDILPQ VYPRFLVDEF NGGNWCNPFF STKNTVLNVS 

       610        620        630        640        650        660 
GDDLKNRYHT KIIIDHSAYD SLSQYVDKIV DACENILEAL DPKVQNTFYY NEMLRNERNT 

       670        680        690        700        710        720 
QILRLTYKSL YHCSAMVDLI ESFDFTVFCS VKRHTGNAID TEDESYENPS VWGDHYDSNL 

       730        740        750        760        770        780 
SFDYPVVLEF FRLKQELHDL VAKIIMATQS LTLEDPEVFK GLKEEDPLFY NREISKIPKE 

       790        800        810        820        830        840 
KAALLLSSIL KEQLSFKDGG AISLNPDTLL SGYLVEIAKT TKTVLLITQQ LIEERETIIN 

       850        860        870        880        890        900 
YATRVMQDNF DVQLLLVERN NTSSSEKADD NSYYVGGHKK STDVPWYLEG DDEYELLLDV 

       910        920        930        940        950        960 
KGNIKGGSKE ALVSHLTHHL SLDSNFNAVF LLMFSSMMSL GELISLLIAR FNIEPPEGLS 

       970        980        990       1000       1010       1020 
YEEYNLWVSK KRNPIRLRVI NIMKLLLEKN WSMSYYNEPV LRRWLTFAHS DQVQTYSLGN 

      1030       1040       1050       1060       1070       1080 
LLVNYLERLL RGERIYVERD PVIPNTKPPA PLTKGSSLSK KPRVMDIDYV ELARQLTLRE 

      1090       1100       1110       1120       1130       1140 
FKLYCKITKF ACLAKVWGKK SGLSESIDSI TQFIKASNQL TNFVGYMILR KADPKKRVQI 

      1150       1160       1170       1180       1190       1200 
IRYFIQVADK CRQYNNFSSM TAIISALYSS PIHRLKKTWE YMNADALSNL KNMNKLMNSS 

      1210       1220       1230       1240       1250       1260 
RNFNEYRDVL KFIGSEPCVP FFGVYLSDLT FVYHGNPDYL YNRTRQVNFA KRAKTSEIVS 

      1270       1280       1290       1300       1310       1320 
GIDRFKTTGY NFQEVPEIQK FLDAWFEKCP TIDEQYQISL NLEPREQPAG ASNSNSTTNA 

      1330 
TTNIKSFKPF SLK 

« Hide

References

« Hide 'large scale' references
[1]"A Candida albicans homolog of CDC25 is functional in Saccharomyces cerevisiae."
Goldberg D., Marbach I., Gross E., Levitzki A., Simchen G.
Eur. J. Biochem. 213:195-204(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 792-1.
[2]"The diploid genome sequence of Candida albicans."
Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B., Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W., Scherer S.
Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: SC5314 / ATCC MYA-2876.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M94160 Genomic DNA. Translation: AAA34329.2.
AACQ01000148 Genomic DNA. Translation: EAK93519.1.
AACQ01000147 Genomic DNA. Translation: EAK93556.1.
PIRS30356.
RefSeqXP_712690.1. XM_707597.1.
XP_712727.1. XM_707634.1.

3D structure databases

ProteinModelPortalP43069.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING5476.CAL0000207.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3645660.
3645697.
KEGGcal:CaO19.14188.
cal:CaO19.6926.

Organism-specific databases

CGDCAL0000207. CSC25.

Phylogenomic databases

eggNOGNOG265981.
OrthoDBEOG78WM2F.

Family and domain databases

Gene3D1.10.840.10. 1 hit.
InterProIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR008937. Ras_GEF.
IPR023578. Ras_GEF_dom.
IPR001895. RasGRF_CDC25.
IPR001452. SH3_domain.
[Graphical view]
PANTHERPTHR23113. PTHR23113. 1 hit.
PfamPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMSSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCDC25_CANAL
AccessionPrimary (citable) accession number: P43069
Secondary accession number(s): Q59SU3
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Candida albicans

Candida albicans: entries and gene names