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Protein

Cell division control protein 25

Gene

CDC25

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Promotes the exchange of Ras-bound GDP by GTP. This protein positively controls the level of cellular cAMP at start, the stage at which the yeast cell division cycle is triggered.

GO - Molecular functioni

  • Ras guanyl-nucleotide exchange factor activity Source: CGD

GO - Biological processi

  • cAMP-mediated signaling Source: CGD
  • cell division Source: UniProtKB-KW
  • cellular response to glucose stimulus Source: CGD
  • cellular response to starvation Source: CGD
  • filamentous growth Source: CGD
  • filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
  • filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
  • mitotic nuclear division Source: UniProtKB-KW
  • positive regulation of GTPase activity Source: GOC
  • Ras protein signal transduction Source: CGD
Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Cell division control protein 25
Gene namesi
Name:CDC25
Synonyms:CSC25
ORF Names:CaO19.14188, CaO19.6926
OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Taxonomic identifieri237561 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida
ProteomesiUP000000559 Componenti: Unassembled WGS sequence

Organism-specific databases

CGDiCAL0000207. CSC25.

Subcellular locationi

GO - Cellular componenti

  • cell Source: GOC
  • intracellular Source: GOC
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13331333Cell division control protein 25PRO_0000068861Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP43069.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini30 – 9465SH3PROSITE-ProRule annotationAdd
BLAST
Domaini900 – 1034135N-terminal Ras-GEFPROSITE-ProRule annotationAdd
BLAST
Domaini1068 – 1305238Ras-GEFPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation
Contains 1 SH3 domain.PROSITE-ProRule annotation

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiNOG265981.
InParanoidiP43069.
OrthoDBiEOG78WM2F.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43069-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSANYISDE VPPDMVSPHD HRPSKDEPLK HLDTVIALYD FPGTQSSHLP
60 70 80 90 100
LNLGDTIHVL SKSATGWWDG VVMGNSGELQ RGWFPHNYVR SVNYVQPVLK
110 120 130 140 150
KLKDNKDLDS ITAANTAANV VMPSLTNLIQ KSLQESERNS PANSTRKNSV
160 170 180 190 200
VSFASSETSM PSDSKYTQQQ TNTNQNSPEY QSISLPSTRD HSTVEMQPPS
210 220 230 240 250
QQSSISHTLT GFGIGDDEII PMEVEEAEKL VEEYRLKYNK TVTWIPRTST
260 270 280 290 300
KGDIIFYCEQ LDVYCESLPL ILFDGEASSP NLEYPGSDVI MDPTPISVQG
310 320 330 340 350
SQSMENVLDT REGSAAGSFD STKRDSNVSM STQSSGSSYH RFSRPFFSVD
360 370 380 390 400
NLFYKHSSDI GTWNELKEQC NYILDLMLKA IKDQNRQFFS THFSRLNKLV
410 420 430 440 450
VALCAAVRLN QEDYIDTKYE NTTRRKLKRV CASFAQIYIN GILHLSVLHY
460 470 480 490 500
SLEGFNEGRL FGYDMGKLNR SSSSSAFQSP ASSLSTIRQG SDDSTRFAQK
510 520 530 540 550
LSQDRNSEGN GDMNYINQLV YEIDNLRENV NSIVKIFLKL SANKKIKNSD
560 570 580 590 600
YDSSDASDDE GEDRFDILPQ VYPRFLVDEF NGGNWCNPFF STKNTVLNVS
610 620 630 640 650
GDDLKNRYHT KIIIDHSAYD SLSQYVDKIV DACENILEAL DPKVQNTFYY
660 670 680 690 700
NEMLRNERNT QILRLTYKSL YHCSAMVDLI ESFDFTVFCS VKRHTGNAID
710 720 730 740 750
TEDESYENPS VWGDHYDSNL SFDYPVVLEF FRLKQELHDL VAKIIMATQS
760 770 780 790 800
LTLEDPEVFK GLKEEDPLFY NREISKIPKE KAALLLSSIL KEQLSFKDGG
810 820 830 840 850
AISLNPDTLL SGYLVEIAKT TKTVLLITQQ LIEERETIIN YATRVMQDNF
860 870 880 890 900
DVQLLLVERN NTSSSEKADD NSYYVGGHKK STDVPWYLEG DDEYELLLDV
910 920 930 940 950
KGNIKGGSKE ALVSHLTHHL SLDSNFNAVF LLMFSSMMSL GELISLLIAR
960 970 980 990 1000
FNIEPPEGLS YEEYNLWVSK KRNPIRLRVI NIMKLLLEKN WSMSYYNEPV
1010 1020 1030 1040 1050
LRRWLTFAHS DQVQTYSLGN LLVNYLERLL RGERIYVERD PVIPNTKPPA
1060 1070 1080 1090 1100
PLTKGSSLSK KPRVMDIDYV ELARQLTLRE FKLYCKITKF ACLAKVWGKK
1110 1120 1130 1140 1150
SGLSESIDSI TQFIKASNQL TNFVGYMILR KADPKKRVQI IRYFIQVADK
1160 1170 1180 1190 1200
CRQYNNFSSM TAIISALYSS PIHRLKKTWE YMNADALSNL KNMNKLMNSS
1210 1220 1230 1240 1250
RNFNEYRDVL KFIGSEPCVP FFGVYLSDLT FVYHGNPDYL YNRTRQVNFA
1260 1270 1280 1290 1300
KRAKTSEIVS GIDRFKTTGY NFQEVPEIQK FLDAWFEKCP TIDEQYQISL
1310 1320 1330
NLEPREQPAG ASNSNSTTNA TTNIKSFKPF SLK
Length:1,333
Mass (Da):152,012
Last modified:November 1, 1995 - v1
Checksum:iDAFE90D6AC192483
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94160 Genomic DNA. Translation: AAA34329.2.
AACQ01000148 Genomic DNA. Translation: EAK93519.1.
AACQ01000147 Genomic DNA. Translation: EAK93556.1.
PIRiS30356.
RefSeqiXP_712690.1. XM_707597.1.
XP_712727.1. XM_707634.1.

Genome annotation databases

GeneIDi3645660.
3645697.
KEGGical:CaO19.14188.
cal:CaO19.6926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M94160 Genomic DNA. Translation: AAA34329.2.
AACQ01000148 Genomic DNA. Translation: EAK93519.1.
AACQ01000147 Genomic DNA. Translation: EAK93556.1.
PIRiS30356.
RefSeqiXP_712690.1. XM_707597.1.
XP_712727.1. XM_707634.1.

3D structure databases

ProteinModelPortaliP43069.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3645660.
3645697.
KEGGical:CaO19.14188.
cal:CaO19.6926.

Organism-specific databases

CGDiCAL0000207. CSC25.

Phylogenomic databases

eggNOGiNOG265981.
InParanoidiP43069.
OrthoDBiEOG78WM2F.

Family and domain databases

Gene3Di1.10.840.10. 1 hit.
InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR001452. SH3_domain.
[Graphical view]
PfamiPF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
[Graphical view]
SMARTiSM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiPS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A Candida albicans homolog of CDC25 is functional in Saccharomyces cerevisiae."
    Goldberg D., Marbach I., Gross E., Levitzki A., Simchen G.
    Eur. J. Biochem. 213:195-204(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 792-1.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: SC5314 / ATCC MYA-2876.

Entry informationi

Entry nameiCDC25_CANAL
AccessioniPrimary (citable) accession number: P43069
Secondary accession number(s): Q59SU3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 24, 2015
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Candida albicans
    Candida albicans: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.