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P43069

- CDC25_CANAL

UniProt

P43069 - CDC25_CANAL

Protein

Cell division control protein 25

Gene

CDC25

Organism
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Promotes the exchange of Ras-bound GDP by GTP. This protein positively controls the level of cellular cAMP at start, the stage at which the yeast cell division cycle is triggered.

    GO - Molecular functioni

    1. Ras guanyl-nucleotide exchange factor activity Source: CGD

    GO - Biological processi

    1. cAMP-mediated signaling Source: CGD
    2. cellular response to glucose stimulus Source: CGD
    3. cellular response to starvation Source: CGD
    4. filamentous growth Source: CGD
    5. filamentous growth of a population of unicellular organisms in response to biotic stimulus Source: CGD
    6. filamentous growth of a population of unicellular organisms in response to starvation Source: CGD
    7. mitotic nuclear division Source: UniProtKB-KW
    8. positive regulation of Ras GTPase activity Source: GOC
    9. Ras protein signal transduction Source: CGD

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cell division control protein 25
    Gene namesi
    Name:CDC25
    Synonyms:CSC25
    ORF Names:CaO19.14188, CaO19.6926
    OrganismiCandida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
    Taxonomic identifieri237561 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida
    ProteomesiUP000000559: Unassembled WGS sequence

    Organism-specific databases

    CGDiCAL0000207. CSC25.

    Subcellular locationi

    GO - Cellular componenti

    1. hyphal tip Source: CGD
    2. intracellular Source: InterPro

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13331333Cell division control protein 25PRO_0000068861Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi5476.CAL0000207.

    Structurei

    3D structure databases

    ProteinModelPortaliP43069.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini30 – 9465SH3PROSITE-ProRule annotationAdd
    BLAST
    Domaini900 – 1034135N-terminal Ras-GEFPROSITE-ProRule annotationAdd
    BLAST
    Domaini1068 – 1305238Ras-GEFPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 N-terminal Ras-GEF domain.PROSITE-ProRule annotation
    Contains 1 Ras-GEF domain.PROSITE-ProRule annotation
    Contains 1 SH3 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    SH3 domain

    Phylogenomic databases

    eggNOGiNOG265981.
    OrthoDBiEOG78WM2F.

    Family and domain databases

    Gene3Di1.10.840.10. 1 hit.
    InterProiIPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR001452. SH3_domain.
    [Graphical view]
    PfamiPF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view]
    SMARTiSM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEiPS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43069-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSANYISDE VPPDMVSPHD HRPSKDEPLK HLDTVIALYD FPGTQSSHLP     50
    LNLGDTIHVL SKSATGWWDG VVMGNSGELQ RGWFPHNYVR SVNYVQPVLK 100
    KLKDNKDLDS ITAANTAANV VMPSLTNLIQ KSLQESERNS PANSTRKNSV 150
    VSFASSETSM PSDSKYTQQQ TNTNQNSPEY QSISLPSTRD HSTVEMQPPS 200
    QQSSISHTLT GFGIGDDEII PMEVEEAEKL VEEYRLKYNK TVTWIPRTST 250
    KGDIIFYCEQ LDVYCESLPL ILFDGEASSP NLEYPGSDVI MDPTPISVQG 300
    SQSMENVLDT REGSAAGSFD STKRDSNVSM STQSSGSSYH RFSRPFFSVD 350
    NLFYKHSSDI GTWNELKEQC NYILDLMLKA IKDQNRQFFS THFSRLNKLV 400
    VALCAAVRLN QEDYIDTKYE NTTRRKLKRV CASFAQIYIN GILHLSVLHY 450
    SLEGFNEGRL FGYDMGKLNR SSSSSAFQSP ASSLSTIRQG SDDSTRFAQK 500
    LSQDRNSEGN GDMNYINQLV YEIDNLRENV NSIVKIFLKL SANKKIKNSD 550
    YDSSDASDDE GEDRFDILPQ VYPRFLVDEF NGGNWCNPFF STKNTVLNVS 600
    GDDLKNRYHT KIIIDHSAYD SLSQYVDKIV DACENILEAL DPKVQNTFYY 650
    NEMLRNERNT QILRLTYKSL YHCSAMVDLI ESFDFTVFCS VKRHTGNAID 700
    TEDESYENPS VWGDHYDSNL SFDYPVVLEF FRLKQELHDL VAKIIMATQS 750
    LTLEDPEVFK GLKEEDPLFY NREISKIPKE KAALLLSSIL KEQLSFKDGG 800
    AISLNPDTLL SGYLVEIAKT TKTVLLITQQ LIEERETIIN YATRVMQDNF 850
    DVQLLLVERN NTSSSEKADD NSYYVGGHKK STDVPWYLEG DDEYELLLDV 900
    KGNIKGGSKE ALVSHLTHHL SLDSNFNAVF LLMFSSMMSL GELISLLIAR 950
    FNIEPPEGLS YEEYNLWVSK KRNPIRLRVI NIMKLLLEKN WSMSYYNEPV 1000
    LRRWLTFAHS DQVQTYSLGN LLVNYLERLL RGERIYVERD PVIPNTKPPA 1050
    PLTKGSSLSK KPRVMDIDYV ELARQLTLRE FKLYCKITKF ACLAKVWGKK 1100
    SGLSESIDSI TQFIKASNQL TNFVGYMILR KADPKKRVQI IRYFIQVADK 1150
    CRQYNNFSSM TAIISALYSS PIHRLKKTWE YMNADALSNL KNMNKLMNSS 1200
    RNFNEYRDVL KFIGSEPCVP FFGVYLSDLT FVYHGNPDYL YNRTRQVNFA 1250
    KRAKTSEIVS GIDRFKTTGY NFQEVPEIQK FLDAWFEKCP TIDEQYQISL 1300
    NLEPREQPAG ASNSNSTTNA TTNIKSFKPF SLK 1333
    Length:1,333
    Mass (Da):152,012
    Last modified:November 1, 1995 - v1
    Checksum:iDAFE90D6AC192483
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M94160 Genomic DNA. Translation: AAA34329.2.
    AACQ01000148 Genomic DNA. Translation: EAK93519.1.
    AACQ01000147 Genomic DNA. Translation: EAK93556.1.
    PIRiS30356.
    RefSeqiXP_712690.1. XM_707597.1.
    XP_712727.1. XM_707634.1.

    Genome annotation databases

    GeneIDi3645660.
    3645697.
    KEGGical:CaO19.14188.
    cal:CaO19.6926.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M94160 Genomic DNA. Translation: AAA34329.2 .
    AACQ01000148 Genomic DNA. Translation: EAK93519.1 .
    AACQ01000147 Genomic DNA. Translation: EAK93556.1 .
    PIRi S30356.
    RefSeqi XP_712690.1. XM_707597.1.
    XP_712727.1. XM_707634.1.

    3D structure databases

    ProteinModelPortali P43069.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 5476.CAL0000207.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3645660.
    3645697.
    KEGGi cal:CaO19.14188.
    cal:CaO19.6926.

    Organism-specific databases

    CGDi CAL0000207. CSC25.

    Phylogenomic databases

    eggNOGi NOG265981.
    OrthoDBi EOG78WM2F.

    Family and domain databases

    Gene3Di 1.10.840.10. 1 hit.
    InterProi IPR000651. Ras-like_Gua-exchang_fac_N.
    IPR019804. Ras_G-nucl-exch_fac_CS.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR001452. SH3_domain.
    [Graphical view ]
    Pfami PF00617. RasGEF. 1 hit.
    PF00618. RasGEF_N. 1 hit.
    PF00018. SH3_1. 1 hit.
    [Graphical view ]
    SMARTi SM00147. RasGEF. 1 hit.
    SM00229. RasGEFN. 1 hit.
    SM00326. SH3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 1 hit.
    SSF50044. SSF50044. 1 hit.
    PROSITEi PS00720. RASGEF. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    PS50212. RASGEF_NTER. 1 hit.
    PS50002. SH3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A Candida albicans homolog of CDC25 is functional in Saccharomyces cerevisiae."
      Goldberg D., Marbach I., Gross E., Levitzki A., Simchen G.
      Eur. J. Biochem. 213:195-204(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 792-1.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: SC5314 / ATCC MYA-2876.

    Entry informationi

    Entry nameiCDC25_CANAL
    AccessioniPrimary (citable) accession number: P43069
    Secondary accession number(s): Q59SU3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Candida albicans
      Candida albicans: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3