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P43068 (MKC1_CANAX) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mitogen-activated protein kinase MKC1

Short name=MAP kinase MKC1
EC=2.7.11.24
Gene names
Name:MKC1
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length501 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Cofactor

Magnesium By similarity.

Enzyme regulation

Activated by tyrosine and threonine phosphorylation By similarity.

Domain

The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.

Post-translational modification

Dually phosphorylated on Thr-211 and Tyr-213, which activates the enzyme By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Biological processCell cycle
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Serine/threonine-protein kinase
Transferase
   PTMPhosphoprotein
Gene Ontology (GO)
   Biological_processcell cycle

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

MAP kinase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 501501Mitogen-activated protein kinase MKC1
PRO_0000186334

Regions

Domain28 – 339312Protein kinase
Nucleotide binding34 – 429ATP By similarity
Motif211 – 2133TXY

Sites

Active site1741Proton acceptor By similarity
Binding site741ATP By similarity

Amino acid modifications

Modified residue2111Phosphothreonine By similarity
Modified residue2131Phosphotyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
P43068 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 0EA9F8B6CB97AB07

FASTA50158,192
        10         20         30         40         50         60 
MDQQEAPIYY GRSVNKVYNQ EFIIDSRFKI VKELGHGAYG IVCSAKYDNG SKKVPDSNNG 

        70         80         90        100        110        120 
NASSSANASF VAIKKITNIF SKNILCKRAL RELKLLQFFR GHKNITCLYD LDIIPNPMTG 

       130        140        150        160        170        180 
EFNEIYLYEE LMECDMHQII RSGQPLSDQH YQSFIYQVLC GLNFIHSADV LHRDLKPGNL 

       190        200        210        220        230        240 
LVNADCELKI CDFGLARGFS ENPDENAGFM TEYVATRWYR APEIMLSFTN YTKAIDIWSV 

       250        260        270        280        290        300 
GCILAELLGG KPLFRGKDYV DQLNQILMIL GTPPESTLQR IGSHRAQNYV RSLPITRKAS 

       310        320        330        340        350        360 
YEELFPDANP LALDLLERML TLDPRERITV RDALNHKYLE LWHDPKEEIE CQVKFDFKSF 

       370        380        390        400        410        420 
ETVDGLDEMK QLIMDEVQKF REFVRKPIEE QQRIQMQLHM QKREEQRQEE EEKELLEQQR 

       430        440        450        460        470        480 
QFPAQESMDI SQTPYNNLET NIGTPQVEDD YPRPQELDEF TFSNLESSSS MNLFQDMAKP 

       490        500 
SGEEYIKLEE ELGFGLDWCY V 

« Hide

References

[1]"Functional characterization of the MKC1 gene of Candida albicans, which encodes a mitogen-activated protein kinase homolog related to cell integrity."
Navarro-Garcia F., Sanchez M., Pla J., Nombela C.
Mol. Cell. Biol. 15:2197-2206(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 64385 / 1001.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X76708 Genomic DNA. Translation: CAA54129.1.

3D structure databases

ProteinModelPortalP43068.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0515.

Family and domain databases

InterProIPR011009. Kinase-like_dom.
IPR003527. MAP_kinase_CS.
IPR008352. MAPK_p38.
IPR000719. Prot_kinase_dom.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
PRINTSPR01773. P38MAPKINASE.
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS01351. MAPK. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMKC1_CANAX
AccessionPrimary (citable) accession number: P43068
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 16, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families