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P43067 (ADH1_CANAX) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alcohol dehydrogenase 1

EC=1.1.1.1
Alternative name(s):
40 kDa allergen
Allergen Can a 1
Allergen Can a I
Allergen=Cand a 1
Gene names
Name:ADH1
Synonyms:CAD
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length350 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subunit structure

Homotetramer By similarity.

Subcellular location

Cytoplasm Probable.

Allergenic properties

Causes an allergic reaction in human.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   DiseaseAllergen
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionalcohol dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: UniProtKB-EC

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 350350Alcohol dehydrogenase 1
PRO_0000160717

Regions

Nucleotide binding180 – 1867NAD By similarity
Nucleotide binding271 – 2733NAD By similarity

Sites

Metal binding461Zinc 1; catalytic By similarity
Metal binding691Zinc 1; catalytic By similarity
Metal binding1001Zinc 2 By similarity
Metal binding1031Zinc 2 By similarity
Metal binding1061Zinc 2 By similarity
Metal binding1141Zinc 2 By similarity
Metal binding1561Zinc 1; catalytic By similarity
Binding site2041NAD By similarity
Binding site2091NAD By similarity
Binding site3431NAD By similarity

Experimental info

Sequence conflict391H → N in AAA53300. Ref.2
Sequence conflict531R → W in AAA53300. Ref.2
Sequence conflict1401A → T no nucleotide entry Ref.3
Sequence conflict2121F → L in AAA53300. Ref.2
Sequence conflict2271D → A no nucleotide entry Ref.3
Sequence conflict3131R → S no nucleotide entry Ref.3
Sequence conflict3271D → E in AAA53300. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P43067 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: C3DFE2E70F42D634

FASTA35036,879
        10         20         30         40         50         60 
MSEQIPKTQK AVVFDTNGGQ LVYKDYPVPT PKPNELLIHV KYSGVCHTDL HARKGDWPLA 

        70         80         90        100        110        120 
TKLPLVGGHE GAGVVVGMGE NVKGWKIGDF AGIKWLNGSC MSCEFCQQGA EPNCGEADLS 

       130        140        150        160        170        180 
GYTHDGSFEQ YATADAVQAA KIPAGTDLAN VAPILCAGVT VYKALKTADL AAGQWVAISG 

       190        200        210        220        230        240 
AGGGLGSLAV QYARAMGLRV VAIDGGDEKG EFVKSLGAEA YVDFTKDKDI VEAVKKATDG 

       250        260        270        280        290        300 
GPHGAINVSV SEKAIDQSVE YVRPLGKVVL VGLPAHAKVT APVFDAVVKS IEIKGSYVGN 

       310        320        330        340        350 
RKDTAEAIDF FSRGLIKCPI KIVGLSDLPE VFKLMEEGKI LGRYVLDTSK 

« Hide

References

[1]"Structure and regulation of the Candida albicans ADH1 gene encoding an immunogenic alcohol dehydrogenase."
Bertram G., Swoboda R.K., Gooday G.W., Gow N.A.R., Brown A.J.P.
Yeast 12:115-127(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]Pendrak M.L., Klotz S.A., Smith R.L.
Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: B311A.
[3]"The 40-kilodalton allergen of Candida albicans is an alcohol dehydrogenase: molecular cloning and immunological analysis using monoclonal antibodies."
Shen H.D., Choo K.B., Lee H.H., Hsieh J.C., Lin W.L., Lee W.R., Han S.H.
Clin. Exp. Allergy 21:675-681(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 104-313.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X81694 Genomic DNA. Translation: CAA57342.1.
U15924 mRNA. Translation: AAA53300.1.
PIRS52153. S63781.

3D structure databases

ProteinModelPortalP43067.
SMRP43067. Positions 5-350.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome177. Cand a 1.
3173. Cand a 1.0101.

2D gel databases

COMPLUYEAST-2DPAGEP43067.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG1064.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR11695. PTHR11695. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. SSF50129. 1 hit.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADH1_CANAX
AccessionPrimary (citable) accession number: P43067
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 16, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries