Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Candida albicans (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi46Zinc 1; catalyticBy similarity1
Metal bindingi69Zinc 1; catalyticBy similarity1
Metal bindingi100Zinc 2By similarity1
Metal bindingi103Zinc 2By similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi114Zinc 2By similarity1
Metal bindingi156Zinc 1; catalyticBy similarity1
Binding sitei204NADBy similarity1
Binding sitei209NADBy similarity1
Binding sitei343NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi180 – 186NADBy similarity7
Nucleotide bindingi271 – 273NADBy similarity3

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Alternative name(s):
40 kDa allergen
Allergen Can a 1
Allergen Can a I
Allergen: Cand a 1
Gene namesi
Name:ADH1
Synonyms:CAD
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei177. Cand a 1.
3173. Cand a 1.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001607171 – 350Alcohol dehydrogenase 1Add BLAST350

Proteomic databases

PRIDEiP43067.

2D gel databases

COMPLUYEAST-2DPAGEP43067.

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP43067.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEQIPKTQK AVVFDTNGGQ LVYKDYPVPT PKPNELLIHV KYSGVCHTDL
60 70 80 90 100
HARKGDWPLA TKLPLVGGHE GAGVVVGMGE NVKGWKIGDF AGIKWLNGSC
110 120 130 140 150
MSCEFCQQGA EPNCGEADLS GYTHDGSFEQ YATADAVQAA KIPAGTDLAN
160 170 180 190 200
VAPILCAGVT VYKALKTADL AAGQWVAISG AGGGLGSLAV QYARAMGLRV
210 220 230 240 250
VAIDGGDEKG EFVKSLGAEA YVDFTKDKDI VEAVKKATDG GPHGAINVSV
260 270 280 290 300
SEKAIDQSVE YVRPLGKVVL VGLPAHAKVT APVFDAVVKS IEIKGSYVGN
310 320 330 340 350
RKDTAEAIDF FSRGLIKCPI KIVGLSDLPE VFKLMEEGKI LGRYVLDTSK
Length:350
Mass (Da):36,879
Last modified:November 1, 1995 - v1
Checksum:iC3DFE2E70F42D634
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39H → N in AAA53300 (Ref. 2) Curated1
Sequence conflicti53R → W in AAA53300 (Ref. 2) Curated1
Sequence conflicti140A → T no nucleotide entry (PubMed:1777830).Curated1
Sequence conflicti212F → L in AAA53300 (Ref. 2) Curated1
Sequence conflicti227D → A no nucleotide entry (PubMed:1777830).Curated1
Sequence conflicti313R → S no nucleotide entry (PubMed:1777830).Curated1
Sequence conflicti327D → E in AAA53300 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81694 Genomic DNA. Translation: CAA57342.1.
U15924 mRNA. Translation: AAA53300.1.
PIRiS63781. S52153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81694 Genomic DNA. Translation: CAA57342.1.
U15924 mRNA. Translation: AAA53300.1.
PIRiS63781. S52153.

3D structure databases

ProteinModelPortaliP43067.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei177. Cand a 1.
3173. Cand a 1.0101.

2D gel databases

COMPLUYEAST-2DPAGEP43067.

Proteomic databases

PRIDEiP43067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_N.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
IPR020843. PKS_ER.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SMARTiSM00829. PKS_ER. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
SSF51735. SSF51735. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiADH1_CANAX
AccessioniPrimary (citable) accession number: P43067
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 5, 2016
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.