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P43067

- ADH1_CANAX

UniProt

P43067 - ADH1_CANAX

Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    An alcohol + NAD+ = an aldehyde or ketone + NADH.

    Cofactori

    Binds 2 zinc ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi46 – 461Zinc 1; catalyticBy similarity
    Metal bindingi69 – 691Zinc 1; catalyticBy similarity
    Metal bindingi100 – 1001Zinc 2By similarity
    Metal bindingi103 – 1031Zinc 2By similarity
    Metal bindingi106 – 1061Zinc 2By similarity
    Metal bindingi114 – 1141Zinc 2By similarity
    Metal bindingi156 – 1561Zinc 1; catalyticBy similarity
    Binding sitei204 – 2041NADBy similarity
    Binding sitei209 – 2091NADBy similarity
    Binding sitei343 – 3431NADBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi180 – 1867NADBy similarity
    Nucleotide bindingi271 – 2733NADBy similarity

    GO - Molecular functioni

    1. alcohol dehydrogenase (NAD) activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alcohol dehydrogenase 1 (EC:1.1.1.1)
    Alternative name(s):
    40 kDa allergen
    Allergen Can a 1
    Allergen Can a I
    Allergen: Cand a 1
    Gene namesi
    Name:ADH1
    Synonyms:CAD
    OrganismiCandida albicans (Yeast)
    Taxonomic identifieri5476 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei177. Cand a 1.
    3173. Cand a 1.0101.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 350350Alcohol dehydrogenase 1PRO_0000160717Add
    BLAST

    2D gel databases

    COMPLUYEAST-2DPAGEP43067.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP43067.
    SMRiP43067. Positions 5-350.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1064.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProiIPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR11695. PTHR11695. 1 hit.
    PfamiPF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF50129. SSF50129. 1 hit.
    PROSITEiPS00059. ADH_ZINC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43067-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEQIPKTQK AVVFDTNGGQ LVYKDYPVPT PKPNELLIHV KYSGVCHTDL    50
    HARKGDWPLA TKLPLVGGHE GAGVVVGMGE NVKGWKIGDF AGIKWLNGSC 100
    MSCEFCQQGA EPNCGEADLS GYTHDGSFEQ YATADAVQAA KIPAGTDLAN 150
    VAPILCAGVT VYKALKTADL AAGQWVAISG AGGGLGSLAV QYARAMGLRV 200
    VAIDGGDEKG EFVKSLGAEA YVDFTKDKDI VEAVKKATDG GPHGAINVSV 250
    SEKAIDQSVE YVRPLGKVVL VGLPAHAKVT APVFDAVVKS IEIKGSYVGN 300
    RKDTAEAIDF FSRGLIKCPI KIVGLSDLPE VFKLMEEGKI LGRYVLDTSK 350
    Length:350
    Mass (Da):36,879
    Last modified:November 1, 1995 - v1
    Checksum:iC3DFE2E70F42D634
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti39 – 391H → N in AAA53300. 1 PublicationCurated
    Sequence conflicti53 – 531R → W in AAA53300. 1 PublicationCurated
    Sequence conflicti140 – 1401A → T no nucleotide entry (PubMed:1777830)Curated
    Sequence conflicti212 – 2121F → L in AAA53300. 1 PublicationCurated
    Sequence conflicti227 – 2271D → A no nucleotide entry (PubMed:1777830)Curated
    Sequence conflicti313 – 3131R → S no nucleotide entry (PubMed:1777830)Curated
    Sequence conflicti327 – 3271D → E in AAA53300. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81694 Genomic DNA. Translation: CAA57342.1.
    U15924 mRNA. Translation: AAA53300.1.
    PIRiS63781. S52153.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X81694 Genomic DNA. Translation: CAA57342.1 .
    U15924 mRNA. Translation: AAA53300.1 .
    PIRi S63781. S52153.

    3D structure databases

    ProteinModelPortali P43067.
    SMRi P43067. Positions 5-350.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 177. Cand a 1.
    3173. Cand a 1.0101.

    2D gel databases

    COMPLUYEAST-2DPAGE P43067.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG1064.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.180.10. 1 hit.
    InterProi IPR013149. ADH_C.
    IPR013154. ADH_GroES-like.
    IPR002085. ADH_SF_Zn-type.
    IPR002328. ADH_Zn_CS.
    IPR011032. GroES-like.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR11695. PTHR11695. 1 hit.
    Pfami PF08240. ADH_N. 1 hit.
    PF00107. ADH_zinc_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50129. SSF50129. 1 hit.
    PROSITEi PS00059. ADH_ZINC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structure and regulation of the Candida albicans ADH1 gene encoding an immunogenic alcohol dehydrogenase."
      Bertram G., Swoboda R.K., Gooday G.W., Gow N.A.R., Brown A.J.P.
      Yeast 12:115-127(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Pendrak M.L., Klotz S.A., Smith R.L.
      Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: B311A.
    3. "The 40-kilodalton allergen of Candida albicans is an alcohol dehydrogenase: molecular cloning and immunological analysis using monoclonal antibodies."
      Shen H.D., Choo K.B., Lee H.H., Hsieh J.C., Lin W.L., Lee W.R., Han S.H.
      Clin. Exp. Allergy 21:675-681(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 104-313.

    Entry informationi

    Entry nameiADH1_CANAX
    AccessioniPrimary (citable) accession number: P43067
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3