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P43067

- ADH1_CANAX

UniProt

P43067 - ADH1_CANAX

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Protein

Alcohol dehydrogenase 1

Gene

ADH1

Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Zn2+By similarityNote: Binds 2 Zn(2+) ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi46 – 461Zinc 1; catalyticBy similarity
Metal bindingi69 – 691Zinc 1; catalyticBy similarity
Metal bindingi100 – 1001Zinc 2By similarity
Metal bindingi103 – 1031Zinc 2By similarity
Metal bindingi106 – 1061Zinc 2By similarity
Metal bindingi114 – 1141Zinc 2By similarity
Metal bindingi156 – 1561Zinc 1; catalyticBy similarity
Binding sitei204 – 2041NADBy similarity
Binding sitei209 – 2091NADBy similarity
Binding sitei343 – 3431NADBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi180 – 1867NADBy similarity
Nucleotide bindingi271 – 2733NADBy similarity

GO - Molecular functioni

  1. alcohol dehydrogenase (NAD) activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Alternative name(s):
40 kDa allergen
Allergen Can a 1
Allergen Can a I
Allergen: Cand a 1
Gene namesi
Name:ADH1
Synonyms:CAD
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei177. Cand a 1.
3173. Cand a 1.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Alcohol dehydrogenase 1PRO_0000160717Add
BLAST

2D gel databases

COMPLUYEAST-2DPAGEP43067.

Interactioni

Subunit structurei

Homotetramer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP43067.
SMRiP43067. Positions 5-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1064.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43067-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEQIPKTQK AVVFDTNGGQ LVYKDYPVPT PKPNELLIHV KYSGVCHTDL
60 70 80 90 100
HARKGDWPLA TKLPLVGGHE GAGVVVGMGE NVKGWKIGDF AGIKWLNGSC
110 120 130 140 150
MSCEFCQQGA EPNCGEADLS GYTHDGSFEQ YATADAVQAA KIPAGTDLAN
160 170 180 190 200
VAPILCAGVT VYKALKTADL AAGQWVAISG AGGGLGSLAV QYARAMGLRV
210 220 230 240 250
VAIDGGDEKG EFVKSLGAEA YVDFTKDKDI VEAVKKATDG GPHGAINVSV
260 270 280 290 300
SEKAIDQSVE YVRPLGKVVL VGLPAHAKVT APVFDAVVKS IEIKGSYVGN
310 320 330 340 350
RKDTAEAIDF FSRGLIKCPI KIVGLSDLPE VFKLMEEGKI LGRYVLDTSK
Length:350
Mass (Da):36,879
Last modified:November 1, 1995 - v1
Checksum:iC3DFE2E70F42D634
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391H → N in AAA53300. 1 PublicationCurated
Sequence conflicti53 – 531R → W in AAA53300. 1 PublicationCurated
Sequence conflicti140 – 1401A → T no nucleotide entry (PubMed:1777830)Curated
Sequence conflicti212 – 2121F → L in AAA53300. 1 PublicationCurated
Sequence conflicti227 – 2271D → A no nucleotide entry (PubMed:1777830)Curated
Sequence conflicti313 – 3131R → S no nucleotide entry (PubMed:1777830)Curated
Sequence conflicti327 – 3271D → E in AAA53300. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81694 Genomic DNA. Translation: CAA57342.1.
U15924 mRNA. Translation: AAA53300.1.
PIRiS63781. S52153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81694 Genomic DNA. Translation: CAA57342.1 .
U15924 mRNA. Translation: AAA53300.1 .
PIRi S63781. S52153.

3D structure databases

ProteinModelPortali P43067.
SMRi P43067. Positions 5-350.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 177. Cand a 1.
3173. Cand a 1.0101.

2D gel databases

COMPLUYEAST-2DPAGE P43067.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG1064.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
PROSITEi PS00059. ADH_ZINC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and regulation of the Candida albicans ADH1 gene encoding an immunogenic alcohol dehydrogenase."
    Bertram G., Swoboda R.K., Gooday G.W., Gow N.A.R., Brown A.J.P.
    Yeast 12:115-127(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Pendrak M.L., Klotz S.A., Smith R.L.
    Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: B311A.
  3. "The 40-kilodalton allergen of Candida albicans is an alcohol dehydrogenase: molecular cloning and immunological analysis using monoclonal antibodies."
    Shen H.D., Choo K.B., Lee H.H., Hsieh J.C., Lin W.L., Lee W.R., Han S.H.
    Clin. Exp. Allergy 21:675-681(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 104-313.

Entry informationi

Entry nameiADH1_CANAX
AccessioniPrimary (citable) accession number: P43067
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 26, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3