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P43067

- ADH1_CANAX

UniProt

P43067 - ADH1_CANAX

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Protein
Alcohol dehydrogenase 1
Gene
ADH1, CAD
Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactori

Binds 2 zinc ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi46 – 461Zinc 1; catalytic By similarity
Metal bindingi69 – 691Zinc 1; catalytic By similarity
Metal bindingi100 – 1001Zinc 2 By similarity
Metal bindingi103 – 1031Zinc 2 By similarity
Metal bindingi106 – 1061Zinc 2 By similarity
Metal bindingi114 – 1141Zinc 2 By similarity
Metal bindingi156 – 1561Zinc 1; catalytic By similarity
Binding sitei204 – 2041NAD By similarity
Binding sitei209 – 2091NAD By similarity
Binding sitei343 – 3431NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi180 – 1867NAD By similarity
Nucleotide bindingi271 – 2733NAD By similarity

GO - Molecular functioni

  1. alcohol dehydrogenase (NAD) activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Metal-binding, NAD, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase 1 (EC:1.1.1.1)
Alternative name(s):
40 kDa allergen
Allergen Can a 1
Allergen Can a I
Allergen: Cand a 1
Gene namesi
Name:ADH1
Synonyms:CAD
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Subcellular locationi

Cytoplasm Inferred

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei177. Cand a 1.
3173. Cand a 1.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 350350Alcohol dehydrogenase 1
PRO_0000160717Add
BLAST

2D gel databases

COMPLUYEAST-2DPAGEP43067.

Interactioni

Subunit structurei

Homotetramer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP43067.
SMRiP43067. Positions 5-350.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1064.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProiIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11695. PTHR11695. 1 hit.
PfamiPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMiSSF50129. SSF50129. 1 hit.
PROSITEiPS00059. ADH_ZINC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43067-1 [UniParc]FASTAAdd to Basket

« Hide

MSEQIPKTQK AVVFDTNGGQ LVYKDYPVPT PKPNELLIHV KYSGVCHTDL    50
HARKGDWPLA TKLPLVGGHE GAGVVVGMGE NVKGWKIGDF AGIKWLNGSC 100
MSCEFCQQGA EPNCGEADLS GYTHDGSFEQ YATADAVQAA KIPAGTDLAN 150
VAPILCAGVT VYKALKTADL AAGQWVAISG AGGGLGSLAV QYARAMGLRV 200
VAIDGGDEKG EFVKSLGAEA YVDFTKDKDI VEAVKKATDG GPHGAINVSV 250
SEKAIDQSVE YVRPLGKVVL VGLPAHAKVT APVFDAVVKS IEIKGSYVGN 300
RKDTAEAIDF FSRGLIKCPI KIVGLSDLPE VFKLMEEGKI LGRYVLDTSK 350
Length:350
Mass (Da):36,879
Last modified:November 1, 1995 - v1
Checksum:iC3DFE2E70F42D634
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391H → N in AAA53300. 1 Publication
Sequence conflicti53 – 531R → W in AAA53300. 1 Publication
Sequence conflicti140 – 1401A → T no nucleotide entry 1 Publication
Sequence conflicti212 – 2121F → L in AAA53300. 1 Publication
Sequence conflicti227 – 2271D → A no nucleotide entry 1 Publication
Sequence conflicti313 – 3131R → S no nucleotide entry 1 Publication
Sequence conflicti327 – 3271D → E in AAA53300. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X81694 Genomic DNA. Translation: CAA57342.1.
U15924 mRNA. Translation: AAA53300.1.
PIRiS63781. S52153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X81694 Genomic DNA. Translation: CAA57342.1 .
U15924 mRNA. Translation: AAA53300.1 .
PIRi S63781. S52153.

3D structure databases

ProteinModelPortali P43067.
SMRi P43067. Positions 5-350.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 177. Cand a 1.
3173. Cand a 1.0101.

2D gel databases

COMPLUYEAST-2DPAGE P43067.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG1064.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.180.10. 1 hit.
InterProi IPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11695. PTHR11695. 1 hit.
Pfami PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view ]
SUPFAMi SSF50129. SSF50129. 1 hit.
PROSITEi PS00059. ADH_ZINC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Structure and regulation of the Candida albicans ADH1 gene encoding an immunogenic alcohol dehydrogenase."
    Bertram G., Swoboda R.K., Gooday G.W., Gow N.A.R., Brown A.J.P.
    Yeast 12:115-127(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Pendrak M.L., Klotz S.A., Smith R.L.
    Submitted (OCT-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: B311A.
  3. "The 40-kilodalton allergen of Candida albicans is an alcohol dehydrogenase: molecular cloning and immunological analysis using monoclonal antibodies."
    Shen H.D., Choo K.B., Lee H.H., Hsieh J.C., Lin W.L., Lee W.R., Han S.H.
    Clin. Exp. Allergy 21:675-681(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 104-313.

Entry informationi

Entry nameiADH1_CANAX
AccessioniPrimary (citable) accession number: P43067
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 16, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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