Reviewed, UniProtKB/Swiss-Prot P43066 (ARDH_CANAL)

Names and origin

Protein names

Recommended name:
    D-arabinitol 2-dehydrogenase [ribulose-forming]
      Short name=ARDH
    EC=1.1.1.250

Gene names

Name:	ARD1
Synonyms:	ARDH

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	281 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-arabinitol + NAD+ = D-ribulose + NADH.
Pathway	Carbohydrate metabolism; D-arabinitol metabolism.
Sequence similarities	Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	D-arabinitol 2-dehydrogenase activity Inferred from electronic annotation. Source: EC binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 281	281	D-arabinitol 2-dehydrogenase [ribulose-forming]		PRO_0000054517
Regions
	Nucleotide binding	25 – 47	23	NAD By similarity
Sites
	Active site	184	1	Proton acceptor By similarity
	Binding site	169	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43066-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: B302A6411691F892	FASTA	281	30,643
	10 20 30 40 50 60 MDSAYWSYDN IVPSFRLDGK LVILTGGSGG LAAVVSRALL AKGADVALVD MNLERTQQAA 70 80 90 100 110 120 RDVLQWGEEQ MKGKYESPIG QVSAWSCNIG DAEAVDLTFK AINEHHGKIS SVLVNTAGYA 130 140 150 160 170 180 ENFPAEEYPA KNAENLMKVN GLGSFYVSQA FARPLIQNNM TGSIILIGSM SGTIVNDPQP 190 200 210 220 230 240 QCMYNMSKAG VIHLARSLAC EWAKYNIRVN TLSPGYILTP LTRNVISGHT EMKTEWESKI 250 260 270 280 PMKRMAEPKE FVGSILYLAS ESASSYTTGH NLVVDGGYEC W

References

[1]

"D-arabitol metabolism in Candida albicans: studies of the biosynthetic pathway and the gene that encodes NAD-dependent D-arabitol dehydrogenase." Wong B., Murray J.S., Castellanos M., Croen K.D. J. Bacteriol. 175:6314-6320(1993) [PubMed: 8407803] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: WO-1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L16227 Genomic DNA. Translation: AAC37430.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	1.1.1.250. 1124.
Family and domain databases
InterPro	IPR002198. DH_sc/Rdtase_SDR. IPR002347. Glc/ribitol_DH. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHER	PTHR19410. ADH_short_C2. 1 hit.
Pfam	PF00106. adh_short. 1 hit. [Graphical view]
PRINTS	PR00081. GDHRDH. PR00080. SDRFAMILY.
PROSITE	PS00061. ADH_SHORT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARDH_CANAL

Accession

Primary (citable) accession number: P43066

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	November 24, 2009
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)