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P43065 (LYS1_CANAX) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Saccharopine dehydrogenase [NAD+, L-lysine-forming]

Short name=SDH
EC=1.5.1.7
Alternative name(s):
Lysine--2-oxoglutarate reductase
Gene names
Name:LYS1
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

Protein attributes

Sequence length382 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH.

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via AAA pathway; L-lysine from L-alpha-aminoadipate (fungal route): step 3/3.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the AlaDH/PNT family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Lysine biosynthesis
   LigandNAD
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Biological processlysine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionsaccharopine dehydrogenase (NAD+, L-lysine-forming) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 382382Saccharopine dehydrogenase [NAD+, L-lysine-forming]
PRO_0000199010

Sites

Active site2171 By similarity

Sequences

Sequence LengthMass (Da)Tools
P43065 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: A3620191DF04B88F

FASTA38242,394
        10         20         30         40         50         60 
MSKSPVILHL RAETKPLEAR AALTPSTTKQ LLDAGFEIYV EESSQSTFDI KEYEAVGAKI 

        70         80         90        100        110        120 
VPEGSWKTAP KERIIFGLKE LPENETFPLI HEHIQFAHCY KDQAGWQDVL KRFPQGNGIL 

       130        140        150        160        170        180 
YDLEFLENDQ GRRVAAFGFY AGFAGAAIGV LDWSFKQLNG NTKGTKGEGE GGELPGVTPY 

       190        200        210        220        230        240 
PNENELIKDV KIELEKALTK NGGQYPKCLV IGALGRCGSG AIDLFKKIGI PDDNIAKWDM 

       250        260        270        280        290        300 
AETAKGGPFQ EIVDSDIFIN CIYLSKPIPP FINKEILNNE NRKLTTIVDV SADTTNPHNP 

       310        320        330        340        350        360 
IPVYEIATVF NEPTVEVKLD KGPKLSVCSI DHLPSLLPRE ASEFFAKDLM PSLLELPNRD 

       370        380 
TSPVWVRAKQ LFDKHVARLD KE 

« Hide

References

[1]"Molecular and functional analysis of the LYS1 gene of Candida albicans."
Garrad R.C., Schmidt T.M., Bhattacharjee J.K.
Infect. Immun. 62:5027-5031(1994) [PubMed: 7927784] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U13233 Genomic DNA. Translation: AAA21362.1.

3D structure databases

ProteinModelPortalP43065.
SMRP43065. Positions 4-381.
ModBaseSearch...

Protein-protein interaction databases

STRINGP43065.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR007886. AlaDH/PNT_N.
IPR007698. AlaDH/PNT_NAD(H)-bd.
[Graphical view]
PfamPF01262. AlaDh_PNT_C. 1 hit.
PF05222. AlaDh_PNT_N. 1 hit.
[Graphical view]
SMARTSM01002. AlaDh_PNT_C. 1 hit.
SM01003. AlaDh_PNT_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameLYS1_CANAX
AccessionPrimary (citable) accession number: P43065
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families