Reviewed,
UniProtKB/Swiss-Prot P43065 (LYS1_CANAL)
Last modified
June 16, 2009.
Version 49.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Saccharopine dehydrogenase [NAD+, L-lysine-forming] Short name=SDH EC=1.5.1.7 Alternative name(s): Lysine--2-oxoglutarate reductase | ||
| Gene names |
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| Organism | Candida albicans (Yeast) | ||
| Taxonomic identifier | 5476 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida |
Protein attributes
| Sequence length | 382 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | N(6)-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH. |
| Pathway | |
| Subunit structure | Monomer By similarity. |
| Sequence similarities | Belongs to the AlaDH/PNT family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Lysine biosynthesis |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Gene Ontology (GO) | |
| Biological process | lysine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | binding Inferred from electronic annotation. Source: InterPro electron carrier activityInferred from electronic annotation. Source: InterPro saccharopine dehydrogenase (NAD+, L-lysine-forming) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "Molecular and functional analysis of the LYS1 gene of Candida albicans." Garrad R.C., Schmidt T.M., Bhattacharjee J.K. Infect. Immun. 62:5027-5031(1994) [PubMed: 7927784] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| U13233 Genomic DNA. Translation: AAA21362.1. | |
3D structure databases | |
| ModBase | Search... |
Enzyme and pathway databases | |
| BRENDA | 1.5.1.7. 1124. |
Family and domain databases | |
| InterPro | IPR007698. Ala_DH/PNT_C. IPR007886. Ala_DH/PNT_N. [Graphical view] |
| Pfam | PF01262. AlaDh_PNT_C. 1 hit. PF05222. AlaDh_PNT_N. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LYS1_CANAL | ||||||||
| Accession | Primary (citable) accession number: P43065 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | FPAP (Fungal Proteome Annotation Project) | ||||||||
Relevant documents
| Candida albicans Candida albicans: entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


