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P43064

- EFG1_CANAX

UniProt

P43064 - EFG1_CANAX

Protein

Enhanced filamentous growth protein

Gene

EFG1

Organism
Candida albicans (Yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Putative transcription factor that stimulates pseudohyphal morphogenesis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi238 – 25922H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Enhanced filamentous growth protein
    Gene namesi
    Name:EFG1
    Synonyms:EFG
    OrganismiCandida albicans (Yeast)
    Taxonomic identifieri5476 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesmitosporic SaccharomycetalesCandida

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 552552Enhanced filamentous growth proteinPRO_0000086939Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP43064.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini204 – 310107HTH APSES-typePROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi34 – 374Poly-Gln
    Compositional biasi46 – 505Poly-Gln
    Compositional biasi83 – 9311Poly-GlnAdd
    BLAST
    Compositional biasi315 – 32612Poly-AlaAdd
    BLAST
    Compositional biasi332 – 3387Poly-Pro
    Compositional biasi438 – 4469Poly-Gln
    Compositional biasi470 – 4734Poly-Gln
    Compositional biasi483 – 49311Poly-GlnAdd
    BLAST
    Compositional biasi496 – 4994Poly-Gln

    Sequence similaritiesi

    Belongs to the EFG1/PHD1/stuA family.Curated
    Contains 1 HTH APSES-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG41372.

    Family and domain databases

    Gene3Di3.10.260.10. 1 hit.
    InterProiIPR018004. KilA_N/APSES_HTH.
    IPR003163. Tscrpt_reg_HTH_APSES-type.
    [Graphical view]
    PfamiPF04383. KilA-N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54616. SSF54616. 1 hit.
    PROSITEiPS51299. HTH_APSES. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P43064-1 [UniParc]FASTAAdd to Basket

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    MSTYSIPYYN QMNGNYNNGM PQQTTAANQQ AFPQQQQPTT TGNASQQQQQ    50
    AAATAAAVQQ PYNYMFYQQQ GQPGQQTGQT AGQQQQQQQQ QQQYDYNTYN 100
    RYQYPAATSQ GNYYQQTIPN QLSQPQPQHY NGSNRNYTSA PSGAPIPSNS 150
    TSGPSQQPPL PGQQAVPIPP HVSTMQQPTP VQDTLNASST STVGQFQPPG 200
    IRPRVTTTMW EDEKTLCYQV DANNVSVVRR ADNNMINGTK LLNVAQMTRG 250
    RRDGILKSEK VRHVVKIGSM HLKGVWIPFE RALAMAQREQ IVDMLYPLFV 300
    RDIKRVIQTG VTPNAAAATA AAAATATSAS APPPPPPPVA AATTTAATAI 350
    SKSSSGNGNS ISATSGGSNV SGASGAGSTT SPVNTKAATA AGIPQGNYYQ 400
    TYNQQQYPQQ YGQYNAPGKN QNTPASQPGS TTNDQYLQQQ QQQQQQMYGY 450
    QSNYYQGGAA NSSYYPNYYQ QQQPNYASSY PYQQQQQKQQ QQQPNQQQQS 500
    DQQQTSTPSG GAGTRSVHQS PQVQSLTQGS VHPSPQQHQA NQSASTVAKE 550
    EK 552
    Length:552
    Mass (Da):59,964
    Last modified:November 1, 1995 - v1
    Checksum:iF94FD94FC2E06EB7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z32687 Genomic DNA. Translation: CAA83640.1.
    PIRiS49338.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z32687 Genomic DNA. Translation: CAA83640.1 .
    PIRi S49338.

    3D structure databases

    ProteinModelPortali P43064.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi NOG41372.

    Family and domain databases

    Gene3Di 3.10.260.10. 1 hit.
    InterProi IPR018004. KilA_N/APSES_HTH.
    IPR003163. Tscrpt_reg_HTH_APSES-type.
    [Graphical view ]
    Pfami PF04383. KilA-N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54616. SSF54616. 1 hit.
    PROSITEi PS51299. HTH_APSES. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi."
      Stoldt V.R., Sonneborn A., Leuker C.E., Ernst J.F.
      EMBO J. 16:1982-1991(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 10231 / CBS 6431 / DSM 1386 / NBRC 1594.

    Entry informationi

    Entry nameiEFG1_CANAX
    AccessioniPrimary (citable) accession number: P43064
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3