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Protein

Enhanced filamentous growth protein

Gene

EFG1

Organism
Candida albicans (Yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Putative transcription factor that stimulates pseudohyphal morphogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi238 – 25922H-T-H motifPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. growth Source: InterPro
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Enhanced filamentous growth protein
Gene namesi
Name:EFG1
Synonyms:EFG
OrganismiCandida albicans (Yeast)
Taxonomic identifieri5476 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesDebaryomycetaceaeCandida/Lodderomyces cladeCandida

Subcellular locationi

  1. Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 552552Enhanced filamentous growth proteinPRO_0000086939Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP43064.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini204 – 310107HTH APSES-typePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi34 – 374Poly-Gln
Compositional biasi46 – 505Poly-Gln
Compositional biasi83 – 9311Poly-GlnAdd
BLAST
Compositional biasi315 – 32612Poly-AlaAdd
BLAST
Compositional biasi332 – 3387Poly-Pro
Compositional biasi438 – 4469Poly-Gln
Compositional biasi470 – 4734Poly-Gln
Compositional biasi483 – 49311Poly-GlnAdd
BLAST
Compositional biasi496 – 4994Poly-Gln

Sequence similaritiesi

Belongs to the EFG1/PHD1/stuA family.Curated
Contains 1 HTH APSES-type DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG41372.

Family and domain databases

Gene3Di3.10.260.10. 1 hit.
InterProiIPR029790. EFG1/Phd1/StuA.
IPR018004. KilA_N/APSES_HTH.
IPR003163. Tscrpt_reg_HTH_APSES-type.
[Graphical view]
PANTHERiPTHR11707:SF14. PTHR11707:SF14. 1 hit.
PfamiPF04383. KilA-N. 1 hit.
[Graphical view]
SUPFAMiSSF54616. SSF54616. 1 hit.
PROSITEiPS51299. HTH_APSES. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43064-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTYSIPYYN QMNGNYNNGM PQQTTAANQQ AFPQQQQPTT TGNASQQQQQ
60 70 80 90 100
AAATAAAVQQ PYNYMFYQQQ GQPGQQTGQT AGQQQQQQQQ QQQYDYNTYN
110 120 130 140 150
RYQYPAATSQ GNYYQQTIPN QLSQPQPQHY NGSNRNYTSA PSGAPIPSNS
160 170 180 190 200
TSGPSQQPPL PGQQAVPIPP HVSTMQQPTP VQDTLNASST STVGQFQPPG
210 220 230 240 250
IRPRVTTTMW EDEKTLCYQV DANNVSVVRR ADNNMINGTK LLNVAQMTRG
260 270 280 290 300
RRDGILKSEK VRHVVKIGSM HLKGVWIPFE RALAMAQREQ IVDMLYPLFV
310 320 330 340 350
RDIKRVIQTG VTPNAAAATA AAAATATSAS APPPPPPPVA AATTTAATAI
360 370 380 390 400
SKSSSGNGNS ISATSGGSNV SGASGAGSTT SPVNTKAATA AGIPQGNYYQ
410 420 430 440 450
TYNQQQYPQQ YGQYNAPGKN QNTPASQPGS TTNDQYLQQQ QQQQQQMYGY
460 470 480 490 500
QSNYYQGGAA NSSYYPNYYQ QQQPNYASSY PYQQQQQKQQ QQQPNQQQQS
510 520 530 540 550
DQQQTSTPSG GAGTRSVHQS PQVQSLTQGS VHPSPQQHQA NQSASTVAKE

EK
Length:552
Mass (Da):59,964
Last modified:November 1, 1995 - v1
Checksum:iF94FD94FC2E06EB7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z32687 Genomic DNA. Translation: CAA83640.1.
PIRiS49338.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z32687 Genomic DNA. Translation: CAA83640.1.
PIRiS49338.

3D structure databases

ProteinModelPortaliP43064.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiNOG41372.

Family and domain databases

Gene3Di3.10.260.10. 1 hit.
InterProiIPR029790. EFG1/Phd1/StuA.
IPR018004. KilA_N/APSES_HTH.
IPR003163. Tscrpt_reg_HTH_APSES-type.
[Graphical view]
PANTHERiPTHR11707:SF14. PTHR11707:SF14. 1 hit.
PfamiPF04383. KilA-N. 1 hit.
[Graphical view]
SUPFAMiSSF54616. SSF54616. 1 hit.
PROSITEiPS51299. HTH_APSES. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi."
    Stoldt V.R., Sonneborn A., Leuker C.E., Ernst J.F.
    EMBO J. 16:1982-1991(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 10231 / CBS 6431 / DSM 1386 / NBRC 1594.

Entry informationi

Entry nameiEFG1_CANAX
AccessioniPrimary (citable) accession number: P43064
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 4, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.