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P43064 (EFG1_CANAX) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Enhanced filamentous growth protein
Gene names
Name:EFG1
Synonyms:EFG
OrganismCandida albicans (Yeast)
Taxonomic identifier5476 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length552 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Putative transcription factor that stimulates pseudohyphal morphogenesis.

Subcellular location

Nucleus Potential.

Sequence similarities

Belongs to the EFG1/PHD1/stuA family.

Contains 1 HTH APSES-type DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   LigandDNA-binding
Gene Ontology (GO)
   Biological_processtranscription, DNA-dependent

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-KW

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 552552Enhanced filamentous growth protein
PRO_0000086939

Regions

Domain204 – 310107HTH APSES-type
DNA binding238 – 25922H-T-H motif By similarity
Compositional bias34 – 374Poly-Gln
Compositional bias46 – 505Poly-Gln
Compositional bias83 – 9311Poly-Gln
Compositional bias315 – 32612Poly-Ala
Compositional bias332 – 3387Poly-Pro
Compositional bias438 – 4469Poly-Gln
Compositional bias470 – 4734Poly-Gln
Compositional bias483 – 49311Poly-Gln
Compositional bias496 – 4994Poly-Gln

Sequences

Sequence LengthMass (Da)Tools
P43064 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: F94FD94FC2E06EB7

FASTA55259,964
        10         20         30         40         50         60 
MSTYSIPYYN QMNGNYNNGM PQQTTAANQQ AFPQQQQPTT TGNASQQQQQ AAATAAAVQQ 

        70         80         90        100        110        120 
PYNYMFYQQQ GQPGQQTGQT AGQQQQQQQQ QQQYDYNTYN RYQYPAATSQ GNYYQQTIPN 

       130        140        150        160        170        180 
QLSQPQPQHY NGSNRNYTSA PSGAPIPSNS TSGPSQQPPL PGQQAVPIPP HVSTMQQPTP 

       190        200        210        220        230        240 
VQDTLNASST STVGQFQPPG IRPRVTTTMW EDEKTLCYQV DANNVSVVRR ADNNMINGTK 

       250        260        270        280        290        300 
LLNVAQMTRG RRDGILKSEK VRHVVKIGSM HLKGVWIPFE RALAMAQREQ IVDMLYPLFV 

       310        320        330        340        350        360 
RDIKRVIQTG VTPNAAAATA AAAATATSAS APPPPPPPVA AATTTAATAI SKSSSGNGNS 

       370        380        390        400        410        420 
ISATSGGSNV SGASGAGSTT SPVNTKAATA AGIPQGNYYQ TYNQQQYPQQ YGQYNAPGKN 

       430        440        450        460        470        480 
QNTPASQPGS TTNDQYLQQQ QQQQQQMYGY QSNYYQGGAA NSSYYPNYYQ QQQPNYASSY 

       490        500        510        520        530        540 
PYQQQQQKQQ QQQPNQQQQS DQQQTSTPSG GAGTRSVHQS PQVQSLTQGS VHPSPQQHQA 

       550 
NQSASTVAKE EK

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References

[1]"Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi."
Stoldt V.R., Sonneborn A., Leuker C.E., Ernst J.F.
EMBO J. 16:1982-1991(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 10231 / CBS 6431 / DSM 1386 / NBRC 1594.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Z32687 Genomic DNA. Translation: CAA83640.1.
PIRS49338.

3D structure databases

ProteinModelPortalP43064.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGNOG41372.

Family and domain databases

Gene3D3.10.260.10. 1 hit.
InterProIPR018004. KilA_N/APSES_HTH.
IPR003163. Tscrpt_reg_HTH_APSES-type.
[Graphical view]
PfamPF04383. KilA-N. 1 hit.
[Graphical view]
SUPFAMSSF54616. Mlu1-box-bd_prot_DNA-bd. 1 hit.
PROSITEPS51299. HTH_APSES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameEFG1_CANAX
AccessionPrimary (citable) accession number: P43064
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: April 3, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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