P43061 (ARLY_CANAX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Argininosuccinate lyase
Short name=ASAL
EC=4.3.2.1

Alternative name(s):
Arginosuccinase

Gene names

Name:

ARG4

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	468 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine.
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.
Subunit structure	Homotetramer By similarity.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Molecular function	Lyase
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 468	468	Argininosuccinate lyase		PRO_0000137724

Sequences

	Sequence		Length	Mass (Da)
	P43061 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: D17136267B098222	FASTA	468	52,793
	10 20 30 40 50 60 MSQQQDKQPS ENKLWGGRFT GATDPLMDLY NASLPYDKVM YDADLTGTKV YTQGLNKLGL 70 80 90 100 110 120 ITTEELNLIH QGLEQIRQEW HDNKFIIKAG DEDIHTANER RLGEIIGKNI SGKVHTGRSR 130 140 150 160 170 180 NDQVATDMRI FVRESLLNLS KILHQFITAI LERAHKEIDV LMPGYTHLQK AQPIRWAHWL 190 200 210 220 230 240 SSYATYFTED YKRLQEIITR VNQSPLGSGA LAGHPYGIDR EFLAKGLGFD GVIGNSLTAV 250 260 270 280 290 300 SDRDFVVESL FWSTLFMNHI SRFSEDLIIY SSGEFGFIKL ADAYSTGSSL MPQKKNPDSL 310 320 330 340 350 360 ELLRGKSGRV FGQLSGFLMS IKSIPSTYNK DMQEDKEPLF DALTTVEHSI LIATGVISTL 370 380 390 400 410 420 SIDKQNMEKA LTMDMLATDL ADYLVRKGVP FRETHHISGE CVRKAEEEKL SGIDQLSFEQ 430 440 450 460 FQQIDSRFEK DVMETFDFEA SVERRDALGG TAKSAVLKQL ENLKSILS

References

[1]	"The ARG4 gene of Candida albicans." Hoyer L.L., Magee B.B., Rikkerink E.H., Scherer S. Gene 142:213-218(1994) [PubMed: 8194754] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L25051 Genomic DNA. Translation: AAA34323.2.
3D structure databases
ProteinModelPortal	P43061.
SMR	P43061. Positions 26-467.
ModBase	Search...
Protein-protein interaction databases
STRING	P43061.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. IPR008948. L-Aspartase-like. IPR022761. Lyase1_N. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
SUPFAM	SSF48557. L-Aspartase-like. 1 hit.
TIGRFAMs	TIGR00838. ArgH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_CANAX

Accession

Primary (citable) accession number: P43061

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	October 19, 2011
This is version 66 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program