P43060 (PUR7_CANAX) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoribosylaminoimidazole-succinocarboxamide synthase
EC=6.3.2.6

Alternative name(s):
SAICAR synthetase

Gene names

Name:

ADE1

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	291 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate.
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 1/2.
Sequence similarities	Belongs to the SAICAR synthetase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Gene Ontology (GO)
Biological process	purine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylaminoimidazolesuccinocarboxamide synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 291	291	Phosphoribosylaminoimidazole-succinocarboxamide synthase		PRO_0000100923

Sequences

	Sequence		Length	Mass (Da)
	P43060 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: C0A3B7912A49B659	FASTA	291	32,910
	10 20 30 40 50 60 MTSTNLEGTF PLIARGKVRD IYQVDDNTLL FVATDRISAY DVIMANGIPN KGKILTKLSE 70 80 90 100 110 120 FWFAFLPIDN HLIKGDIFEK YPQLEKYRDQ LEGRSLLVRK LKLIPLEVIV RGYITGSGWK 130 140 150 160 170 180 EYTKSKTVHG IPIGDVVESQ QITPIFTPST KAEQGEHDEN ITKEQADKIV GKELCDRIEK 190 200 210 220 230 240 IAIDLYTKAR DYAATKGIII ADTKFEFGLD GDKIVLVDEV LTPDSSRFWS AAKYKLGQSQ 250 260 270 280 290 ESYDKQFLRD WLTANGVAGK DGVAMPEDIA VQTKQKYVEA YENLTGEKWQ D

References

[1]	"Disruption of the C. albicans ADE1 gene." Scherer S., Grindle S.M. Submitted (MAR-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L12463 Genomic DNA. Translation: AAA34317.1.
3D structure databases
ProteinModelPortal	P43060.
SMR	P43060. Positions 1-289.
ModBase	Search...
Protein-protein interaction databases
STRING	P43060.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR013816. ATP_grasp_subdomain_2. IPR001636. SAICAR_synth. IPR018236. SAICAR_synthetase_CS. [Graphical view]
Gene3D	G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit.
PANTHER	PTHR11609. SAICAR_synt. 1 hit.
Pfam	PF01259. SAICAR_synt. 1 hit. [Graphical view]
TIGRFAMs	TIGR00081. PurC. 1 hit.
PROSITE	PS01057. SAICAR_SYNTHETASE_1. 1 hit. PS01058. SAICAR_SYNTHETASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PUR7_CANAX

Accession

Primary (citable) accession number: P43060

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	October 19, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program