Reviewed, UniProtKB/Swiss-Prot P43057 (KPC1_CANAL)

Names and origin

Protein names

Recommended name:
    Protein kinase C-like 1
      Short name=PKC 1
    EC=2.7.11.13

Gene names

Name:

PKC1

Organism

Candida albicans (Yeast)

Taxonomic identifier

5476 [NCBI]

Taxonomic lineage

Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › mitosporic Saccharomycetales › Candida

Protein attributes

Sequence length	1097 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Necessary for osmotic stability.
Catalytic activity	ATP + a protein = ADP + a phosphoprotein.
Sequence similarities	Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. Contains 1 AGC-kinase C-terminal domain. Contains 2 phorbol-ester/DAG-type zinc fingers. Contains 1 protein kinase domain. Contains 2 REM (Hr1) repeats.

Ontologies

Keywords
Domain	Phorbol-ester binding Repeat Zinc-finger
Ligand	ATP-binding Calcium Metal-binding Nucleotide-binding Zinc
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Gene Ontology (GO)
Biological process	intracellular signaling cascade Inferred from electronic annotation. Source: InterPro protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro
Cellular component	intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW calcium ion binding Inferred from electronic annotation. Source: UniProtKB-KW diacylglycerol binding Inferred from electronic annotation. Source: UniProtKB-KW protein kinase C activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1097	1097	Protein kinase C-like 1		PRO_0000055739
Regions
	Repeat	14 – 86	73	REM 1
	Repeat	118 – 193	76	REM 2
	Domain	770 – 1029	260	Protein kinase
	Domain	1030 – 1097	68	AGC-kinase C-terminal
	Zinc finger	415 – 462	48	Phorbol-ester/DAG-type 1
	Zinc finger	480 – 530	51	Phorbol-ester/DAG-type 2
	Nucleotide binding	776 – 784	9	ATP By similarity
Sites
	Active site	895	1	Proton acceptor By similarity
	Binding site	799	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	P43057-1 [UniParc]. Last modified November 1, 1995. Version 1. Checksum: EC48A14575F26CD5	FASTA	1,097	125,312
	10 20 30 40 50 60 MSTSQPSQQQ NPEQVVNDIR QKIEKERKII QGFNDVKRNT NNPEVIQKWK SKIIESQSMI 70 80 90 100 110 120 DYYQETMNKL TRQMQRLNTN SSSRTASRSS VISEYKPSYS NFDLIKYECP SLGNKIQFML 130 140 150 160 170 180 QYLEFKLQVE NKYSEANKKL SHLYLMDGDK SSSNAAEGGR AESDQRIQLL EKALKKYQKF 190 200 210 220 230 240 SINDHEFDRD YEIMDSTKHS RKLLTGRLTV SITCIRDVDH IATALAKKRE TVVVIKVDDL 250 260 270 280 290 300 EKARTKPSKN DNWNEEMVID VDKSHEIELA VMDKQNGIYV PVAVNWFSLF DLAEEIRKKK 310 320 330 340 350 360 VAKDQGSSGW LPAANLPQTG GSGAGTGSSM TGGASYGATS PLPAHNDLRP SVSPSSDAKE 370 380 390 400 410 420 NKVSVSTWLS LEPGGQMLIN LNFEKSITNG KQFRGPLGRH GAIRQKKEEV FEKHGHQFVQ 430 440 450 460 470 480 KQFYNIMSCA LCGEFLRYTG YQCQDCKFLC HKKCYQKVVT KCISKSGSDY DAAQLNHRIP 490 500 510 520 530 540 HRFEPITNHG TKWCCHCGYI LPWGKKNVRK CTECGVMCHA QCTHLVPDFC GMSLQMANEI 550 560 570 580 590 600 LATIESTKVS PKKAQHQQSH AKPLPPKPPI ESKPSMDSEE TLHNEPSYKS LRPASVVHQD 610 620 630 640 650 660 TNFVSKLPTT VQNKYQEPVE LPPQQQNQVV PSTRRRGHGS TDLSFETGYG QQQHQHHRDV 670 680 690 700 710 720 PQIVVEDHQH YNSNDNRDVE MEESKDEFDN FDYNNKYTEN EILTDVQQDQ VRSPFADQIQ 730 740 750 760 770 780 GVPETSHAKQ QNQQVQQVQQ QEELGHQRTH SSGKSGKSKR RKRKVGLDDF QFLAVLGKGN 790 800 810 820 830 840 FGKVMLAESR HTSKLCAIKV LKKDFIVEND EAESVKSEKR VFLTANKEMH PFLLNLHCCF 850 860 870 880 890 900 QTENRIYFVM EYISGGDLMW HIQKNRFTAK RAKFYACEVL LGLKYFHDNG IVYRDLKLDN 910 920 930 940 950 960 ILLTTKGHIK IGDYGLCKED MWHKSTTSTF CGTPEFMAPE IVAGKAYDRS VDWWAFGVLL 970 980 990 1000 1010 1020 FQMLLCQSPF KGDDEDDIFN AIENDEVKYP INLSRQTVLV LQALLTKDPS QRLGSGPKDA 1030 1040 1050 1060 1070 1080 EEIMEHPYFH DVNFDDVLNC RIPAPYIPEV QSEHDYSNFD KEFTSETPRL TPVETVLTSE 1090 MQEQFRGFSH ISDNATI

References

[1]

"The Candida albicans PKC1 gene encodes a protein kinase C homolog necessary for cellular integrity but not dimorphism." Paravicini G., Mendoza A., Antonsson B., Cooper M., Losberger C., Payton M.A. Yeast 12:741-756(1996) [PubMed: 8813761] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 10261 / CBS 2718 / IFO 1061.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X81142 Genomic DNA. Translation: CAA57048.1.
PIR	S47220.
3D structure databases
HSSP	HSSP built from PDB template 1A06 based on UniProtKB Q63450.
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.11.13. 1124.
Family and domain databases
InterPro	IPR000961. AGC-kinase_C. IPR000008. C2_Ca-dep. IPR000861. HR1-like_rho-bd. IPR011072. HR1_rho-bd. IPR015745. PKC. IPR017892. Pkinase_C. IPR002219. Prot_Kinase_C-like_PE/DAG_bd. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR002290. Ser_thr_pkinase. [Graphical view]
PANTHER	PTHR22985:SF86. PKC. 1 hit.
Pfam	PF00130. C1_1. 2 hits. PF00168. C2. 1 hit. PF02185. HR1. 2 hits. PF00069. Pkinase. 1 hit. PF00433. Pkinase_C. 1 hit. [Graphical view]
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
SMART	SM00109. C1. 2 hits. SM00239. C2. 1 hit. SM00742. Hr1. 2 hits. SM00133. S_TK_X. 1 hit. SM00220. S_TKc. 1 hit. [Graphical view]
PROSITE	PS51285. AGC_KINASE_CTER. 1 hit. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. PS00479. ZF_DAG_PE_1. 2 hits. PS50081. ZF_DAG_PE_2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KPC1_CANAL

Accession

Primary (citable) accession number: P43057

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	November 1, 1995
Last modified:	July 28, 2009
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)