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P43050

- TYPH_MYCHO

UniProt

P43050 - TYPH_MYCHO

Protein

Thymidine phosphorylase

Gene

deoA

Organism
Mycoplasma hominis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 61 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

    Catalytic activityi

    Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

    GO - Molecular functioni

    1. phosphorylase activity Source: InterPro
    2. thymidine phosphorylase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyrimidine nucleobase metabolic process Source: InterPro
    2. pyrimidine nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine phosphorylase (EC:2.4.2.4)
    Alternative name(s):
    TdRPase
    Gene namesi
    Name:deoA
    OrganismiMycoplasma hominis
    Taxonomic identifieri2098 [NCBI]
    Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 272›272Thymidine phosphorylasePRO_0000059079Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliP43050.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0213.

    Family and domain databases

    Gene3Di3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    InterProiIPR000312. Glycosyl_Trfase_fam3.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    [Graphical view]
    PANTHERiPTHR10515. PTHR10515. 1 hit.
    PfamiPF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view]
    SMARTiSM00941. PYNP_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.

    Sequencei

    Sequence statusi: Fragment.

    P43050-1 [UniParc]FASTAAdd to Basket

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    DKKIYALRDV TGTVQSIPLI ASSIMSKKLA TGSNCILLDV KCGNGAFMKD    50
    INEAKKLGKL MIEIGKKLNR KIAVEITNMQ QPLGKTIGNK IEVLEAIDTL 100
    NGHGPKDFTE IIYSSGSTLL VLAQKAKDEV EARKMIDEVI NNKKAYNKFL 150
    EWISRQGGNI KVFEKDSKWF NPQYKQEIIA SQSGYLKIKS RIDFGLVAMK 200
    LGAGRSKKED SIDYEAGIYL NKSSNEYVNK GDVLFTMYSS KPINPELQKE 250
    LLSAIEFSES KHDIQTVFAK LM 272
    Length:272
    Mass (Da):30,411
    Last modified:November 1, 1995 - v1
    Checksum:iB06BFB86FB6008EB
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z27121 Genomic DNA. Translation: CAA81645.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z27121 Genomic DNA. Translation: CAA81645.1 .

    3D structure databases

    ProteinModelPortali P43050.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    eggNOGi COG0213.

    Family and domain databases

    Gene3Di 3.40.1030.10. 1 hit.
    3.90.1170.30. 1 hit.
    InterProi IPR000312. Glycosyl_Trfase_fam3.
    IPR013102. PYNP_C.
    IPR000053. Pyrmidine_PPase.
    [Graphical view ]
    PANTHERi PTHR10515. PTHR10515. 1 hit.
    Pfami PF00591. Glycos_transf_3. 1 hit.
    PF07831. PYNP_C. 1 hit.
    [Graphical view ]
    SMARTi SM00941. PYNP_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52418. SSF52418. 1 hit.
    SSF54680. SSF54680. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Schuchart K.
      Thesis (1993), Heinrich-Heine University / Duesseldorf, Germany
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: FBG.

    Entry informationi

    Entry nameiTYPH_MYCHO
    AccessioniPrimary (citable) accession number: P43050
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 61 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3