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Protein

Thymidine phosphorylase

Gene

deoA

Organism
Mycoplasma hominis
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylase (EC:2.4.2.4)
Alternative name(s):
TdRPase
Gene namesi
Name:deoA
OrganismiMycoplasma hominis
Taxonomic identifieri2098 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000059079‹1 – 272Thymidine phosphorylaseAdd BLAST›272

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP43050
SMRiP43050
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105CMW Bacteria
COG0213 LUCA

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
3.90.1170.30, 1 hit
InterProiView protein in InterPro
IPR000312 Glycosyl_Trfase_fam3
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit

Sequencei

Sequence statusi: Fragment.

P43050-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DKKIYALRDV TGTVQSIPLI ASSIMSKKLA TGSNCILLDV KCGNGAFMKD
60 70 80 90 100
INEAKKLGKL MIEIGKKLNR KIAVEITNMQ QPLGKTIGNK IEVLEAIDTL
110 120 130 140 150
NGHGPKDFTE IIYSSGSTLL VLAQKAKDEV EARKMIDEVI NNKKAYNKFL
160 170 180 190 200
EWISRQGGNI KVFEKDSKWF NPQYKQEIIA SQSGYLKIKS RIDFGLVAMK
210 220 230 240 250
LGAGRSKKED SIDYEAGIYL NKSSNEYVNK GDVLFTMYSS KPINPELQKE
260 270
LLSAIEFSES KHDIQTVFAK LM
Length:272
Mass (Da):30,411
Last modified:November 1, 1995 - v1
Checksum:iB06BFB86FB6008EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27121 Genomic DNA Translation: CAA81645.1

Entry informationi

Entry nameiTYPH_MYCHO
AccessioniPrimary (citable) accession number: P43050
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: March 28, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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