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P43050 (TYPH_MYCHO) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine phosphorylase

EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:deoA
OrganismMycoplasma hominis
Taxonomic identifier2098 [NCBI]
Taxonomic lineageBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

Protein attributes

Sequence length272 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 272›272Thymidine phosphorylase
PRO_0000059079

Experimental info

Non-terminal residue11

Sequences

Sequence LengthMass (Da)Tools
P43050 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: B06BFB86FB6008EB

FASTA27230,411
        10         20         30         40         50         60 
DKKIYALRDV TGTVQSIPLI ASSIMSKKLA TGSNCILLDV KCGNGAFMKD INEAKKLGKL 

        70         80         90        100        110        120 
MIEIGKKLNR KIAVEITNMQ QPLGKTIGNK IEVLEAIDTL NGHGPKDFTE IIYSSGSTLL 

       130        140        150        160        170        180 
VLAQKAKDEV EARKMIDEVI NNKKAYNKFL EWISRQGGNI KVFEKDSKWF NPQYKQEIIA 

       190        200        210        220        230        240 
SQSGYLKIKS RIDFGLVAMK LGAGRSKKED SIDYEAGIYL NKSSNEYVNK GDVLFTMYSS 

       250        260        270 
KPINPELQKE LLSAIEFSES KHDIQTVFAK LM 

« Hide

References

[1]Schuchart K.
Thesis (1993), Heinrich-Heine University / Duesseldorf, Germany
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: FBG.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z27121 Genomic DNA. Translation: CAA81645.1.

3D structure databases

ProteinModelPortalP43050.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

eggNOGCOG0213.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTYPH_MYCHO
AccessionPrimary (citable) accession number: P43050
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families