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Protein

Thymidine phosphorylase

Gene

deoA

Organism
Mycoplasma hominis
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylase (EC:2.4.2.4)
Alternative name(s):
TdRPase
Gene namesi
Name:deoA
OrganismiMycoplasma hominis
Taxonomic identifieri2098 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 272›272Thymidine phosphorylasePRO_0000059079Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi347256.MHO_3340.

Structurei

3D structure databases

ProteinModelPortaliP43050.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0213.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR013102. PYNP_C.
IPR000053. Thymidine/pyrmidine_PPase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.

Sequencei

Sequence statusi: Fragment.

P43050-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
DKKIYALRDV TGTVQSIPLI ASSIMSKKLA TGSNCILLDV KCGNGAFMKD
60 70 80 90 100
INEAKKLGKL MIEIGKKLNR KIAVEITNMQ QPLGKTIGNK IEVLEAIDTL
110 120 130 140 150
NGHGPKDFTE IIYSSGSTLL VLAQKAKDEV EARKMIDEVI NNKKAYNKFL
160 170 180 190 200
EWISRQGGNI KVFEKDSKWF NPQYKQEIIA SQSGYLKIKS RIDFGLVAMK
210 220 230 240 250
LGAGRSKKED SIDYEAGIYL NKSSNEYVNK GDVLFTMYSS KPINPELQKE
260 270
LLSAIEFSES KHDIQTVFAK LM
Length:272
Mass (Da):30,411
Last modified:November 1, 1995 - v1
Checksum:iB06BFB86FB6008EB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27121 Genomic DNA. Translation: CAA81645.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z27121 Genomic DNA. Translation: CAA81645.1.

3D structure databases

ProteinModelPortaliP43050.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi347256.MHO_3340.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiCOG0213.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR013102. PYNP_C.
IPR000053. Thymidine/pyrmidine_PPase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Schuchart K.
    Thesis (1993), Heinrich-Heine University / Duesseldorf, Germany
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FBG.

Entry informationi

Entry nameiTYPH_MYCHO
AccessioniPrimary (citable) accession number: P43050
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: June 24, 2015
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.