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P43050

- TYPH_MYCHO

UniProt

P43050 - TYPH_MYCHO

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Protein

Thymidine phosphorylase

Gene

deoA

Organism
Mycoplasma hominis
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. thymidine phosphorylase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyrimidine nucleobase metabolic process Source: InterPro
  2. pyrimidine nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylase (EC:2.4.2.4)
Alternative name(s):
TdRPase
Gene namesi
Name:deoA
OrganismiMycoplasma hominis
Taxonomic identifieri2098 [NCBI]
Taxonomic lineageiBacteriaTenericutesMollicutesMycoplasmataceaeMycoplasma

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 272›272Thymidine phosphorylasePRO_0000059079Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP43050.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0213.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.

Sequencei

Sequence statusi: Fragment.

P43050-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
DKKIYALRDV TGTVQSIPLI ASSIMSKKLA TGSNCILLDV KCGNGAFMKD
60 70 80 90 100
INEAKKLGKL MIEIGKKLNR KIAVEITNMQ QPLGKTIGNK IEVLEAIDTL
110 120 130 140 150
NGHGPKDFTE IIYSSGSTLL VLAQKAKDEV EARKMIDEVI NNKKAYNKFL
160 170 180 190 200
EWISRQGGNI KVFEKDSKWF NPQYKQEIIA SQSGYLKIKS RIDFGLVAMK
210 220 230 240 250
LGAGRSKKED SIDYEAGIYL NKSSNEYVNK GDVLFTMYSS KPINPELQKE
260 270
LLSAIEFSES KHDIQTVFAK LM
Length:272
Mass (Da):30,411
Last modified:November 1, 1995 - v1
Checksum:iB06BFB86FB6008EB
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z27121 Genomic DNA. Translation: CAA81645.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z27121 Genomic DNA. Translation: CAA81645.1 .

3D structure databases

ProteinModelPortali P43050.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

eggNOGi COG0213.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
InterProi IPR000312. Glycosyl_Trfase_fam3.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Schuchart K.
    Thesis (1993), Heinrich-Heine University / Duesseldorf, Germany
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: FBG.

Entry informationi

Entry nameiTYPH_MYCHO
AccessioniPrimary (citable) accession number: P43050
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 1, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3