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Protein

Growth/differentiation factor 7

Gene

Gdf7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • activin receptor signaling pathway Source: MGI
  • axon guidance Source: MGI
  • BMP signaling pathway Source: MGI
  • branching morphogenesis of an epithelial tube Source: MGI
  • cell fate commitment Source: MGI
  • epithelial cell differentiation Source: MGI
  • forebrain morphogenesis Source: MGI
  • gland morphogenesis Source: MGI
  • growth Source: InterPro
  • midbrain development Source: MGI
  • morphogenesis of an epithelial fold Source: MGI
  • neural tube development Source: MGI
  • pathway-restricted SMAD protein phosphorylation Source: MGI
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of neuron differentiation Source: MGI
  • positive regulation of pathway-restricted SMAD protein phosphorylation Source: MGI
  • positive regulation of tendon cell differentiation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: MGI
  • regulation of apoptotic process Source: GO_Central
  • regulation of MAPK cascade Source: GO_Central
  • reproductive structure development Source: MGI
  • roof plate formation Source: MGI
  • SMAD protein signal transduction Source: GO_Central
  • spinal cord association neuron differentiation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Growth/differentiation factor 7
Short name:
GDF-7
Gene namesi
Name:Gdf7
Synonyms:Gdf-7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:95690. Gdf7.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: MGI
  • extracellular space Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Sequence analysisAdd
BLAST
Propeptidei20 – 315296Sequence analysisPRO_0000033924Add
BLAST
Chaini316 – 461146Growth/differentiation factor 7PRO_0000033925Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi79 – 791N-linked (GlcNAc...)Sequence analysis
Disulfide bondi360 ↔ 426By similarity
Disulfide bondi389 ↔ 458By similarity
Disulfide bondi393 ↔ 460By similarity
Disulfide bondi425 – 425InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP43029.
PeptideAtlasiP43029.
PRIDEiP43029.

Expressioni

Gene expression databases

BgeeiP43029.
CleanExiMM_GDF7.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi231945. 1 interaction.
IntActiP43029. 3 interactions.
MINTiMINT-4095937.
STRINGi10090.ENSMUSP00000038301.

Structurei

3D structure databases

ProteinModelPortaliP43029.
SMRiP43029. Positions 358-461.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi311 – 3155Poly-Arg
Compositional biasi326 – 35126Poly-GlyAdd
BLAST

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000231514.
HOVERGENiHBG107938.
InParanoidiP43029.
KOiK20013.
OMAiFGWPGGG.
OrthoDBiEOG7WMCK0.
PhylomeDBiP43029.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 3 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P43029-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDLSAAAALC LWLLSACRPR DGLEAAAVLR AAGAGPAWSP GGGGGGRTLA
60 70 80 90 100
RAPGPSALQA AAVPGPRAVR RAAGSGFRNG SVVPHHFMMS LYRSLAGRAP
110 120 130 140 150
VAAASGHGRV DTITGFTDQA TQDETAAAEP GQSFLFDVSS LSEADEVVNA
160 170 180 190 200
ELRVLRRRSP EPDRDSATLL PRLLLSTCPD EAGTAHLLHS RAAEPLGGAR
210 220 230 240 250
WEAFDVTDAV QSHRRWPRAS RKFCLVLRAV TASESSPLAL RRLGFGWPGG
260 270 280 290 300
GDGGGTAAEE RALLVISSRT QRKESLFREI RAQARALRAA AEPPPDPGPG
310 320 330 340 350
AGSRKANLGG RRRRRTALAG TRGAQGSGGG GGGGGGGGGG GGGGGGGAGR
360 370 380 390 400
GHGRRGRSRC SRKSLHVDFK ELGWDDWIIA PLDYEAYHCE GVCDFPLRSH
410 420 430 440 450
LEPTNHAIIQ TLLNSMAPDA APASCCVPAR LSPISILYID AANNVVYKQY
460
EDMVVEACGC R
Length:461
Mass (Da):47,891
Last modified:July 19, 2004 - v2
Checksum:i92C2511C86EDE478
GO
Isoform 2 (identifier: P43029-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-130: Missing.

Show »
Length:453
Mass (Da):47,106
Checksum:iCB9D5A45E7D22648
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei123 – 1308Missing in isoform 2. 1 PublicationVSP_010764

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525752 mRNA. Translation: AAP97721.1.
AH010605 Genomic DNA. Translation: AAK30843.1.
U08339 Unassigned DNA. Translation: AAA18780.1.
PIRiS43296.
RefSeqiNP_001299805.1. NM_001312876.1. [P43029-1]
NP_038555.1. NM_013527.1. [P43029-2]
UniGeneiMm.271308.

Genome annotation databases

EnsembliENSMUST00000037313; ENSMUSP00000038301; ENSMUSG00000037660. [P43029-1]
GeneIDi238057.
KEGGimmu:238057.
UCSCiuc007mzl.1. mouse. [P43029-2]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF525752 mRNA. Translation: AAP97721.1.
AH010605 Genomic DNA. Translation: AAK30843.1.
U08339 Unassigned DNA. Translation: AAA18780.1.
PIRiS43296.
RefSeqiNP_001299805.1. NM_001312876.1. [P43029-1]
NP_038555.1. NM_013527.1. [P43029-2]
UniGeneiMm.271308.

3D structure databases

ProteinModelPortaliP43029.
SMRiP43029. Positions 358-461.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231945. 1 interaction.
IntActiP43029. 3 interactions.
MINTiMINT-4095937.
STRINGi10090.ENSMUSP00000038301.

Proteomic databases

PaxDbiP43029.
PeptideAtlasiP43029.
PRIDEiP43029.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037313; ENSMUSP00000038301; ENSMUSG00000037660. [P43029-1]
GeneIDi238057.
KEGGimmu:238057.
UCSCiuc007mzl.1. mouse. [P43029-2]

Organism-specific databases

CTDi151449.
MGIiMGI:95690. Gdf7.

Phylogenomic databases

eggNOGiKOG3900. Eukaryota.
ENOG410XT8Z. LUCA.
GeneTreeiENSGT00760000118883.
HOGENOMiHOG000231514.
HOVERGENiHBG107938.
InParanoidiP43029.
KOiK20013.
OMAiFGWPGGG.
OrthoDBiEOG7WMCK0.
PhylomeDBiP43029.
TreeFamiTF316134.

Miscellaneous databases

PROiP43029.
SOURCEiSearch...

Gene expression databases

BgeeiP43029.
CleanExiMM_GDF7.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 3 hits.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSiPR00669. INHIBINA.
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Guo J.H., Yu L.
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Strain: BALB/cJ.
    Tissue: Testis.
  2. "Growth/differentiation factor 7 is preferentially expressed in the primary motor area of the monkey neocortex."
    Watakabe A., Fujita H., Hayashi M., Yamamori T.
    J. Neurochem. 76:1455-1464(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-441 (ISOFORM 1).
    Strain: TT2.
  3. "Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily."
    Storm E.E., Huynh T.V., Copeland N.G., Jenkins N.A., Kingsley D.M., Lee S.-J.
    Nature 368:639-643(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 311-461.
    Strain: BALB/cJ.
    Tissue: Liver.

Entry informationi

Entry nameiGDF7_MOUSE
AccessioniPrimary (citable) accession number: P43029
Secondary accession number(s): Q7TNX4, Q99MY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 19, 2004
Last modified: July 6, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.