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P43028 (GDF6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Growth/differentiation factor 6
Short name=GDF-6
Alternative name(s):
Growth/differentiation factor 16
Gene names
Name:Gdf6
Synonyms:Gdf-6, Gdf16
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length454 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Required for normal formation of bones and joints in the limbs, skull, and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Ref.3

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Secreted Probable.

Tissue specificity

Expressed in different subsets of developing joints. Ref.3

Sequence similarities

Belongs to the TGF-beta family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Propeptide23 – 329307 Potential
PRO_0000342207
Chain335 – 454120Growth/differentiation factor 6
PRO_0000033919

Regions

Compositional bias27 – 359Poly-Ser
Compositional bias330 – 3345Poly-Arg

Amino acid modifications

Glycosylation1171N-linked (GlcNAc...) Potential
Disulfide bond353 ↔ 419 By similarity
Disulfide bond382 ↔ 451 By similarity
Disulfide bond386 ↔ 453 By similarity
Disulfide bond418Interchain By similarity

Sequences

Sequence LengthMass (Da)Tools
P43028 [UniParc].

Last modified October 11, 2005. Version 2.
Checksum: 5A3FADDA539CCB38

FASTA45450,942
        10         20         30         40         50         60 
MDTPRVLLWA IFLISFLWDL PGFQQASISS SSSSSTELDS TKDVGNRKEG KMQRTPQESA 

        70         80         90        100        110        120 
EGRTPPEHGL RQKDLRRRPP GQHQGQEPPG RGLRVVPHEY MLSIYKTYSI AEKLGINASF 

       130        140        150        160        170        180 
FQSSKSANTI TSFVDRGLDD LSHTPLRRQK YLFDVSTLSD KEELVGAELR LYRQAPPTPW 

       190        200        210        220        230        240 
GLPARPLHLQ LFPCLSPLLL DARTLDPQGP TQAGWEVFDV WQGLRPQPWK QLCLELRAAW 

       250        260        270        280        290        300 
GELDAGDTGA RARGPQQPPP LDLRSLGFGR RVRPPQERAL LVVFTRSQRK NLFTEMHEQL 

       310        320        330        340        350        360 
GSAEAAGAEG SWPAPSGSPD AGSWLPSPGR RRRRTAFASR HGKRHGKKSR LRCSRKPLHV 

       370        380        390        400        410        420 
NFKELGWDDW IIAPLEYEAY HCEGVCDFPL RSHLEPTNHA IIQTLMNSMD PGSTPPSCCV 

       430        440        450 
PTKLTPISIL YIDAGNNVVY KQYEDMVVES CGCR

« Hide

References

[1]"Cloning of human GDF16 and functional assocatied analysis."
Guo J.H.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Kunming.
Tissue: Brain.
[2]"Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily."
Storm E.E., Huynh T.V., Copeland N.G., Jenkins N.A., Kingsley D.M., Lee S.-J.
Nature 368:639-643(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 330-454.
Strain: BALB/c.
Tissue: Liver.
[3]"Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes."
Settle S.H. Jr., Rountree R.B., Sinha A., Thacker A., Higgins K., Kingsley D.M.
Dev. Biol. 254:116-130(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AJ537425 mRNA. Translation: CAD60935.1.
U08338 Unassigned DNA. Translation: AAA18779.1.
IPIIPI00400434.
PIRS43295.
RefSeqNP_038554.1. NM_013526.1.
UniGeneMm.302555.

3D structure databases

ProteinModelPortalP43028.
SMRP43028. Positions 352-454.
ModBaseSearch...

Proteomic databases

PRIDEP43028.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000057613; ENSMUSP00000062884; ENSMUSG00000051279.
GeneID242316.
KEGGmmu:242316.

Organism-specific databases

CTD392255.
MGIMGI:95689. Gdf6.

Phylogenomic databases

eggNOGNOG317866.
GeneTreeENSGT00690000101685.
HOGENOMHOG000231514.
HOVERGENHBG107938.
InParanoidP43028.
KOK04664.
OMAFTRSQRK.
OrthoDBEOG4S4PG9.

Gene expression databases

ArrayExpressP43028.
BgeeP43028.
CleanExMM_GDF6.
GenevestigatorP43028.

Family and domain databases

InterProIPR002405. Inhibin_asu.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERPTHR11848. PTHR11848. 1 hit.
PfamPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
PRINTSPR00669. INHIBINA.
SMARTSM00204. TGFB. 1 hit.
[Graphical view]
PROSITEPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio385300.
SOURCESearch...

Entry information

Entry nameGDF6_MOUSE
AccessionPrimary (citable) accession number: P43028
Secondary accession number(s): Q70UT4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: October 11, 2005
Last modified: April 3, 2013
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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