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Protein

Cytochrome c oxidase subunit 6A2, mitochondrial

Gene

Cox6a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6A2, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIa-heart
Short name:
COXVIAH
Gene namesi
Name:Cox6a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:104649. Cox6a2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain complex IV Source: InterPro
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1212MitochondrionBy similarityAdd
BLAST
Chaini13 – 9785Cytochrome c oxidase subunit 6A2, mitochondrialPRO_0000006117Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki70 – 70Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP43023.
PaxDbiP43023.
PeptideAtlasiP43023.
PRIDEiP43023.

PTM databases

iPTMnetiP43023.
PhosphoSiteiP43023.

Expressioni

Gene expression databases

BgeeiP43023.
CleanExiMM_COX6A2.
GenevisibleiP43023. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033049.

Structurei

3D structure databases

ProteinModelPortaliP43023.
SMRiP43023. Positions 13-95.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3469. Eukaryota.
ENOG411253X. LUCA.
GeneTreeiENSGT00390000002756.
HOGENOMiHOG000193965.
HOVERGENiHBG060482.
InParanoidiP43023.
KOiK02266.
OMAiNSWLHAG.
OrthoDBiEOG757D0Z.
PhylomeDBiP43023.
TreeFamiTF105064.

Family and domain databases

Gene3Di4.10.95.10. 1 hit.
InterProiIPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view]
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiPF02046. COX6A. 1 hit.
[Graphical view]
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiPD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiPS01329. COX6A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43023-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPLKVLSR SMASAAKGDH GGAGANTWRL LTFVLALPGV ALCSLNCWMH
60 70 80 90
AGHHERPEFI PYHHLRIRTK PFAWGDGNHT LFHNPHVNPL PTGYEHP
Length:97
Mass (Da):10,749
Last modified:November 1, 1997 - v2
Checksum:iCECCAC26D332A47F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391G → S in AAA17835 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08439 mRNA. Translation: AAA17835.1.
U34801 Genomic DNA. Translation: AAC52280.1.
U63716 Genomic DNA. Translation: AAB41683.1.
AK002506 mRNA. Translation: BAB22151.1.
CCDSiCCDS21891.1.
PIRiI49360.
RefSeqiNP_034073.2. NM_009943.2.
UniGeneiMm.43824.

Genome annotation databases

EnsembliENSMUST00000033049; ENSMUSP00000033049; ENSMUSG00000030785.
GeneIDi12862.
KEGGimmu:12862.
UCSCiuc009jyi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08439 mRNA. Translation: AAA17835.1.
U34801 Genomic DNA. Translation: AAC52280.1.
U63716 Genomic DNA. Translation: AAB41683.1.
AK002506 mRNA. Translation: BAB22151.1.
CCDSiCCDS21891.1.
PIRiI49360.
RefSeqiNP_034073.2. NM_009943.2.
UniGeneiMm.43824.

3D structure databases

ProteinModelPortaliP43023.
SMRiP43023. Positions 13-95.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000033049.

PTM databases

iPTMnetiP43023.
PhosphoSiteiP43023.

Proteomic databases

MaxQBiP43023.
PaxDbiP43023.
PeptideAtlasiP43023.
PRIDEiP43023.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033049; ENSMUSP00000033049; ENSMUSG00000030785.
GeneIDi12862.
KEGGimmu:12862.
UCSCiuc009jyi.1. mouse.

Organism-specific databases

CTDi1339.
MGIiMGI:104649. Cox6a2.

Phylogenomic databases

eggNOGiKOG3469. Eukaryota.
ENOG411253X. LUCA.
GeneTreeiENSGT00390000002756.
HOGENOMiHOG000193965.
HOVERGENiHBG060482.
InParanoidiP43023.
KOiK02266.
OMAiNSWLHAG.
OrthoDBiEOG757D0Z.
PhylomeDBiP43023.
TreeFamiTF105064.

Miscellaneous databases

PROiP43023.
SOURCEiSearch...

Gene expression databases

BgeeiP43023.
CleanExiMM_COX6A2.
GenevisibleiP43023. MM.

Family and domain databases

Gene3Di4.10.95.10. 1 hit.
InterProiIPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view]
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiPF02046. COX6A. 1 hit.
[Graphical view]
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiPD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiPS01329. COX6A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Newton D., Bowman L.H.
    Submitted (APR-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: BALB/cJ.
  2. "Structural characterization and regulatory element analysis of the heart isoform of cytochrome c oxidase VIa."
    Wan B., Moreadith R.W.
    J. Biol. Chem. 270:26433-26440(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 129/Sv.
  3. Schmidt T.A., Jaradat S.A., Goodman M., Lomax M.I., Grossman L.I.
    Submitted (FEB-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Kidney.
  5. "A proteomics approach to identify the ubiquitinated proteins in mouse heart."
    Jeon H.B., Choi E.S., Yoon J.H., Hwang J.H., Chang J.W., Lee E.K., Choi H.W., Park Z.-Y., Yoo Y.J.
    Biochem. Biophys. Res. Commun. 357:731-736(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-70.
    Tissue: Heart.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Heart.

Entry informationi

Entry nameiCX6A2_MOUSE
AccessioniPrimary (citable) accession number: P43023
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.