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Protein

Cytochrome c oxidase subunit 6A2, mitochondrial

Gene

Cox6a2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 6A2, mitochondrial
Alternative name(s):
Cytochrome c oxidase polypeptide VIa-heart
Short name:
COXVIAH
Gene namesi
Name:Cox6a2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:104649. Cox6a2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain complex IV Source: GO_Central
  • mitochondrion Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 12MitochondrionBy similarityAdd BLAST12
ChainiPRO_000000611713 – 97Cytochrome c oxidase subunit 6A2, mitochondrialAdd BLAST85

Proteomic databases

MaxQBiP43023.
PaxDbiP43023.
PeptideAtlasiP43023.
PRIDEiP43023.

PTM databases

iPTMnetiP43023.
PhosphoSitePlusiP43023.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030785.
CleanExiMM_COX6A2.
GenevisibleiP43023. MM.

Interactioni

Protein-protein interaction databases

IntActiP43023. 1 interactor.
STRINGi10090.ENSMUSP00000033049.

Structurei

3D structure databases

ProteinModelPortaliP43023.
SMRiP43023.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3469. Eukaryota.
ENOG411253X. LUCA.
GeneTreeiENSGT00390000002756.
HOGENOMiHOG000193965.
HOVERGENiHBG060482.
InParanoidiP43023.
KOiK02266.
OMAiNSWLHAG.
OrthoDBiEOG091G0C5F.
PhylomeDBiP43023.
TreeFamiTF105064.

Family and domain databases

CDDicd00925. Cyt_c_Oxidase_VIa. 1 hit.
Gene3Di4.10.95.10. 1 hit.
InterProiIPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view]
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiPF02046. COX6A. 1 hit.
[Graphical view]
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiPD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiPS01329. COX6A. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43023-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPLKVLSR SMASAAKGDH GGAGANTWRL LTFVLALPGV ALCSLNCWMH
60 70 80 90
AGHHERPEFI PYHHLRIRTK PFAWGDGNHT LFHNPHVNPL PTGYEHP
Length:97
Mass (Da):10,749
Last modified:November 1, 1997 - v2
Checksum:iCECCAC26D332A47F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti39G → S in AAA17835 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08439 mRNA. Translation: AAA17835.1.
U34801 Genomic DNA. Translation: AAC52280.1.
U63716 Genomic DNA. Translation: AAB41683.1.
AK002506 mRNA. Translation: BAB22151.1.
CCDSiCCDS21891.1.
PIRiI49360.
RefSeqiNP_034073.2. NM_009943.2.
UniGeneiMm.43824.

Genome annotation databases

EnsembliENSMUST00000033049; ENSMUSP00000033049; ENSMUSG00000030785.
GeneIDi12862.
KEGGimmu:12862.
UCSCiuc009jyi.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08439 mRNA. Translation: AAA17835.1.
U34801 Genomic DNA. Translation: AAC52280.1.
U63716 Genomic DNA. Translation: AAB41683.1.
AK002506 mRNA. Translation: BAB22151.1.
CCDSiCCDS21891.1.
PIRiI49360.
RefSeqiNP_034073.2. NM_009943.2.
UniGeneiMm.43824.

3D structure databases

ProteinModelPortaliP43023.
SMRiP43023.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP43023. 1 interactor.
STRINGi10090.ENSMUSP00000033049.

PTM databases

iPTMnetiP43023.
PhosphoSitePlusiP43023.

Proteomic databases

MaxQBiP43023.
PaxDbiP43023.
PeptideAtlasiP43023.
PRIDEiP43023.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000033049; ENSMUSP00000033049; ENSMUSG00000030785.
GeneIDi12862.
KEGGimmu:12862.
UCSCiuc009jyi.1. mouse.

Organism-specific databases

CTDi1339.
MGIiMGI:104649. Cox6a2.

Phylogenomic databases

eggNOGiKOG3469. Eukaryota.
ENOG411253X. LUCA.
GeneTreeiENSGT00390000002756.
HOGENOMiHOG000193965.
HOVERGENiHBG060482.
InParanoidiP43023.
KOiK02266.
OMAiNSWLHAG.
OrthoDBiEOG091G0C5F.
PhylomeDBiP43023.
TreeFamiTF105064.

Miscellaneous databases

PROiP43023.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030785.
CleanExiMM_COX6A2.
GenevisibleiP43023. MM.

Family and domain databases

CDDicd00925. Cyt_c_Oxidase_VIa. 1 hit.
Gene3Di4.10.95.10. 1 hit.
InterProiIPR001349. Cyt_c_oxidase_su6a.
IPR018507. Cyt_c_oxidase_su6a_CS.
[Graphical view]
PANTHERiPTHR11504. PTHR11504. 1 hit.
PfamiPF02046. COX6A. 1 hit.
[Graphical view]
PIRSFiPIRSF000277. COX6A1. 1 hit.
ProDomiPD006036. Cyt_c_oxidase_su6a. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF81411. SSF81411. 1 hit.
PROSITEiPS01329. COX6A. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCX6A2_MOUSE
AccessioniPrimary (citable) accession number: P43023
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 123 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.