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P43021

- NODAL_MOUSE

UniProt

P43021 - NODAL_MOUSE

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Protein

Nodal

Gene

Nodal

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Essential for mesoderm formation and axial patterning during embryonic development.2 Publications

GO - Molecular functioni

  1. receptor agonist activity Source: UniProtKB

GO - Biological processi

  1. anatomical structure formation involved in morphogenesis Source: MGI
  2. anterior/posterior axis specification Source: MGI
  3. anterior/posterior pattern specification Source: MGI
  4. axial mesodermal cell fate specification Source: MGI
  5. brain development Source: MGI
  6. cell fate commitment Source: MGI
  7. cell migration Source: MGI
  8. cell migration involved in gastrulation Source: MGI
  9. determination of left/right symmetry Source: BHF-UCL
  10. digestive system development Source: MGI
  11. digestive tract morphogenesis Source: MGI
  12. embryonic cranial skeleton morphogenesis Source: MGI
  13. embryonic heart tube development Source: MGI
  14. embryonic pattern specification Source: MGI
  15. embryonic placenta development Source: MGI
  16. embryonic process involved in female pregnancy Source: MGI
  17. endodermal cell differentiation Source: Ensembl
  18. endoderm development Source: MGI
  19. epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification Source: MGI
  20. floor plate morphogenesis Source: MGI
  21. formation of anatomical boundary Source: MGI
  22. gastrulation Source: MGI
  23. gastrulation with mouth forming second Source: MGI
  24. growth Source: InterPro
  25. heart development Source: MGI
  26. heart looping Source: MGI
  27. inhibition of neuroepithelial cell differentiation Source: MGI
  28. in utero embryonic development Source: MGI
  29. left lung morphogenesis Source: MGI
  30. liver development Source: MGI
  31. lung development Source: MGI
  32. maternal placenta development Source: MGI
  33. maternal process involved in parturition Source: MGI
  34. mesendoderm development Source: MGI
  35. mesoderm formation Source: BHF-UCL
  36. negative regulation of androgen receptor signaling pathway Source: Ensembl
  37. negative regulation of cell development Source: MGI
  38. negative regulation of cell differentiation Source: MGI
  39. negative regulation of chorionic trophoblast cell proliferation Source: Ensembl
  40. negative regulation of transcription from RNA polymerase II promoter Source: MGI
  41. negative regulation of trophoblast cell migration Source: Ensembl
  42. nervous system development Source: MGI
  43. neural fold formation Source: MGI
  44. nodal signaling pathway Source: UniProtKB
  45. nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry Source: BHF-UCL
  46. polarity specification of proximal/distal axis Source: MGI
  47. positive regulation of activin receptor signaling pathway Source: Ensembl
  48. positive regulation of angiogenesis Source: BHF-UCL
  49. positive regulation of cell-cell adhesion Source: Ensembl
  50. positive regulation of cell proliferation Source: MGI
  51. positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
  52. positive regulation of epithelial cell proliferation Source: Ensembl
  53. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
  54. positive regulation of pathway-restricted SMAD protein phosphorylation Source: Ensembl
  55. positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  56. positive regulation of SMAD protein import into nucleus Source: Ensembl
  57. positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  58. positive regulation vascular endothelial growth factor production Source: Ensembl
  59. primitive streak formation Source: MGI
  60. regulation of gastrulation Source: MGI
  61. regulation of signal transduction Source: MGI
  62. SMAD protein signal transduction Source: MGI
  63. stem cell maintenance Source: MGI
  64. tissue morphogenesis Source: MGI
  65. transforming growth factor beta receptor signaling pathway Source: MGI
  66. transforming growth factor beta receptor signaling pathway involved in primitive streak formation Source: MGI
  67. trophectodermal cell differentiation Source: MGI
  68. trophectodermal cellular morphogenesis Source: MGI
  69. vasculature development Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Developmental protein, Growth factor

Enzyme and pathway databases

ReactomeiREACT_199125. Regulation of signaling by NODAL.
REACT_220645. Signaling by NODAL.

Names & Taxonomyi

Protein namesi
Recommended name:
Nodal
Gene namesi
Name:Nodal
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:97359. Nodal.

Subcellular locationi

Secreted By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
  2. extracellular space Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Propeptidei27 – 244218Sequence AnalysisPRO_0000034000Add
BLAST
Chaini245 – 354110NodalPRO_0000034001Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi254 ↔ 320By similarity
Disulfide bondi283 ↔ 351By similarity
Disulfide bondi287 ↔ 353By similarity
Disulfide bondi319 – 319InterchainBy similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP43021.

Expressioni

Developmental stagei

Expressed in the node during gastrulation. Expression is first detected in primitive streak-stage embryos at about the time of mesoderm formation. It then becomes highly localized in the node at the anterior of the primitive streak.1 Publication

Gene expression databases

BgeeiP43021.
CleanExiMM_NODAL.
ExpressionAtlasiP43021. baseline and differential.
GenevestigatoriP43021.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

BioGridi201801. 2 interactions.
STRINGi10090.ENSMUSP00000039653.

Structurei

3D structure databases

ProteinModelPortaliP43021.
SMRiP43021. Positions 253-353.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TGF-beta family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG278576.
GeneTreeiENSGT00740000114888.
HOGENOMiHOG000113815.
HOVERGENiHBG108195.
InParanoidiP43021.
KOiK04666.
OMAiHRVPSTC.
OrthoDBiEOG7DFXD1.
TreeFamiTF316134.

Family and domain databases

Gene3Di2.10.90.10. 1 hit.
InterProiIPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view]
PANTHERiPTHR11848. PTHR11848. 1 hit.
PfamiPF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view]
SMARTiSM00204. TGFB. 1 hit.
[Graphical view]
SUPFAMiSSF57501. SSF57501. 1 hit.
PROSITEiPS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P43021-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSAHSLRILL LQACWALLHP RAPTAAALPL WTRGQPSSPS PLAYMLSLYR
60 70 80 90 100
DPLPRADIIR SLQAQDVDVT GQNWTFTFDF SFLSQEEDLV WAELRLQLPG
110 120 130 140 150
PMDIPTEGPL TIDIFHQAKG DPERDPADCL ERIWMETFTV IPSQVTFASG
160 170 180 190 200
STVLEVTKPL SKWLKDPRAL EKQVSSRAEK CWHQPYTPPV PVASTNVLML
210 220 230 240 250
YSNRPQEQRQ LGGATLLWEA ESSWRAQEGQ LSVERGGWGR RQRRHHLPDR
260 270 280 290 300
SQLCRRVKFQ VDFNLIGWGS WIIYPKQYNA YRCEGECPNP VGEEFHPTNH
310 320 330 340 350
AYIQSLLKRY QPHRVPSTCC APVKTKPLSM LYVDNGRVLL EHHKDMIVEE

CGCL
Length:354
Mass (Da):40,476
Last modified:July 27, 2011 - v2
Checksum:i40ECFC6785BB5826
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti93 – 942EL → DV in CAA49914. (PubMed:8429908)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70514 mRNA. Translation: CAA49914.1.
AK049290 mRNA. Translation: BAC33661.1.
AK082823 mRNA. Translation: BAC38637.1.
CH466553 Genomic DNA. Translation: EDL32144.1.
CCDSiCCDS23878.1.
PIRiS29718.
RefSeqiNP_038639.2. NM_013611.4.
UniGeneiMm.57195.

Genome annotation databases

EnsembliENSMUST00000049339; ENSMUSP00000039653; ENSMUSG00000037171.
GeneIDi18119.
KEGGimmu:18119.
UCSCiuc007ffy.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X70514 mRNA. Translation: CAA49914.1 .
AK049290 mRNA. Translation: BAC33661.1 .
AK082823 mRNA. Translation: BAC38637.1 .
CH466553 Genomic DNA. Translation: EDL32144.1 .
CCDSi CCDS23878.1.
PIRi S29718.
RefSeqi NP_038639.2. NM_013611.4.
UniGenei Mm.57195.

3D structure databases

ProteinModelPortali P43021.
SMRi P43021. Positions 253-353.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 201801. 2 interactions.
STRINGi 10090.ENSMUSP00000039653.

Proteomic databases

PRIDEi P43021.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000049339 ; ENSMUSP00000039653 ; ENSMUSG00000037171 .
GeneIDi 18119.
KEGGi mmu:18119.
UCSCi uc007ffy.2. mouse.

Organism-specific databases

CTDi 4838.
MGIi MGI:97359. Nodal.

Phylogenomic databases

eggNOGi NOG278576.
GeneTreei ENSGT00740000114888.
HOGENOMi HOG000113815.
HOVERGENi HBG108195.
InParanoidi P43021.
KOi K04666.
OMAi HRVPSTC.
OrthoDBi EOG7DFXD1.
TreeFami TF316134.

Enzyme and pathway databases

Reactomei REACT_199125. Regulation of signaling by NODAL.
REACT_220645. Signaling by NODAL.

Miscellaneous databases

NextBioi 293328.
PROi P43021.
SOURCEi Search...

Gene expression databases

Bgeei P43021.
CleanExi MM_NODAL.
ExpressionAtlasi P43021. baseline and differential.
Genevestigatori P43021.

Family and domain databases

Gene3Di 2.10.90.10. 1 hit.
InterProi IPR029034. Cystine-knot_cytokine.
IPR001839. TGF-b_C.
IPR001111. TGF-b_N.
IPR015615. TGF-beta-rel.
IPR017948. TGFb_CS.
[Graphical view ]
PANTHERi PTHR11848. PTHR11848. 1 hit.
Pfami PF00019. TGF_beta. 1 hit.
PF00688. TGFb_propeptide. 1 hit.
[Graphical view ]
SMARTi SM00204. TGFB. 1 hit.
[Graphical view ]
SUPFAMi SSF57501. SSF57501. 1 hit.
PROSITEi PS00250. TGF_BETA_1. 1 hit.
PS51362. TGF_BETA_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Nodal is a novel TGF-beta-like gene expressed in the mouse node during gastrulation."
    Zhou X., Sasaki H., Lowe L., Hogan B.L., Kuehn M.R.
    Nature 361:543-547(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
    Tissue: Embryo.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "Nodal-related signals induce axial mesoderm and dorsalize mesoderm during gastrulation."
    Jones C.M., Kuehn M.R., Hogan B.L.M., Smith J.C., Wright C.V.E.
    Development 121:3651-3662(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiNODAL_MOUSE
AccessioniPrimary (citable) accession number: P43021
Secondary accession number(s): Q8BH87
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: July 27, 2011
Last modified: October 29, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3