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Reviewed, UniProtKB/Swiss-Prot P43010 (PNTB_HAEIN)

Last modified November 25, 2008. Version 54. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    NAD(P) transhydrogenase subunit beta
    EC=1.6.1.2
Alternative name(s):
    Nicotinamide nucleotide transhydrogenase subunit beta
    Pyridine nucleotide transhydrogenase subunit beta
Gene names
Name: pntB
Ordered Locus Names: HI1363
OrganismHaemophilus influenzae [Complete proteome] [HAMAP]
Taxonomic identifier727 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Function

The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane By similarity.

Catalytic activity

NADPH + NAD(+) = NADP(+) + NADH.

Subunit structure

Heterodimer of an alpha and a beta chain By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane proteinBy similarity.

Sequence similarities

Belongs to the PNT beta subunit family.

Ontologies

Keywords

   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
   LigandNAD
NADP
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: InterPro

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionNAD(P)+ transhydrogenase (AB-specific) activity

Inferred from electronic annotation. Source: InterPro

NADP binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 474474NAD(P) transhydrogenase subunit beta
PRO_0000199026

Regions

Transmembrane4 – 2421 Potential
Transmembrane46 – 6621 Potential
Transmembrane83 – 10321 Potential
Transmembrane132 – 15221 Potential
Transmembrane181 – 20020 Potential
Transmembrane202 – 22221 Potential
Transmembrane229 – 24921 Potential
Transmembrane253 – 27321 Potential
Transmembrane321 – 34121 Potential

Experimental info

Sequence conflict3431A → P in AAC43725. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P43010-1 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 5F914630211FF844

FASTA47450,163
        10         20         30         40         50         60 
MSEGLVQAAY ILAALLFIMS LAGLSKHETA KAGCWFGIVG MTIALIATIF GPHSEGTFWI 

        70         80         90        100        110        120 
IIAMIIGGAI GVQRALKVEM TEMPELVAIL HSFVGLAAVL VGFNSYGLHH EALMPEGLDA 

       130        140        150        160        170        180 
AAQAAFVAEQ AVLTNIHNVE VFLGIFIGAV TFTGSVVAFG KLSGKINSKA LMLPHRHKLN 

       190        200        210        220        230        240 
LAALVVSALL MVAFLNNPES IFPVLLMTAI ALAFGWHLVA SIGGADMPVV VSMLNSYSGW 

       250        260        270        280        290        300 
AAAAAGFILN NDLLIVTGAL VGSSGAILSY IMCKAMNRSF VSVIAGGFGN DVQVSSSEEQ 

       310        320        330        340        350        360 
GEHRETTAEE VAELLKNASS VIITPGYGMA VAQAQYPVAD ITAKLRERGV NVRFGIHPVA 

       370        380        390        400        410        420 
GRLPGHMNVL LAEAKVPYDV VLEMDEINDD FADTDVVLVI GANDTVNPAA MEDPNSPIAG 

       430        440        450        460        470 
MPVLEVWKAQ NVIVFKRSMA VGYAGVQNPL FFKENTQMLF GDAKDRVEDI LKAL 

« Hide

References

Cross-references

Sequence databases

L42023 Genomic DNA. Translation: AAC23010.1.
U20964 Genomic DNA. Translation: AAC43725.1.
PIRF64119.
RefSeqNP_439514.1.

3D structure databases

HSSPHSSP built from PDB template 1D4O based on UniProtKB P11024.
SMRP43010. Positions 308-474.
ModBaseSearch...

Genome annotation databases

GeneID950280.
GenomeReviewsGene locus HI1363 in contig L42023_GR.
KEGGhin:HI1363.
NMPDRfig|71421.1.peg.1299.
TIGRHI1363.

Phylogenomic databases

HOGENOMP43010.

Enzyme and pathway databases

BioCycHINF71421:HI_1363-MON.

Family and domain databases

InterProIPR012136. NADH_DH_b.
IPR004003. NADP_transhyd_b.
[Graphical view]
PfamPF02233. PNTB. 1 hit.
[Graphical view]
PIRSFPIRSF000204. PNTB. 1 hit.
ProtoNetSearch...

Entry information

Entry namePNTB_HAEIN
AccessionPrimary (citable) accession number: P43010
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: November 25, 2008
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents