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P43010 (PNTB_HAEIN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD(P) transhydrogenase subunit beta

EC=1.6.1.2
Alternative name(s):
Nicotinamide nucleotide transhydrogenase subunit beta
Pyridine nucleotide transhydrogenase subunit beta
Gene names
Name:pntB
Ordered Locus Names:HI_1363
OrganismHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [Reference proteome] [HAMAP]
Taxonomic identifier71421 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus

Protein attributes

Sequence length474 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane By similarity.

Catalytic activity

NADPH + NAD+ = NADP+ + NADH.

Subunit structure

Heterodimer of an alpha and a beta chain By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the PNT beta subunit family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 474474NAD(P) transhydrogenase subunit beta
PRO_0000199026

Regions

Transmembrane4 – 2421Helical; Potential
Transmembrane46 – 6621Helical; Potential
Transmembrane83 – 10321Helical; Potential
Transmembrane132 – 15221Helical; Potential
Transmembrane181 – 20020Helical; Potential
Transmembrane202 – 22221Helical; Potential
Transmembrane229 – 24921Helical; Potential
Transmembrane253 – 27321Helical; Potential
Transmembrane321 – 34121Helical; Potential

Experimental info

Sequence conflict3431A → P in AAC43725. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P43010 [UniParc].

Last modified November 1, 1995. Version 1.
Checksum: 5F914630211FF844

FASTA47450,163
        10         20         30         40         50         60 
MSEGLVQAAY ILAALLFIMS LAGLSKHETA KAGCWFGIVG MTIALIATIF GPHSEGTFWI 

        70         80         90        100        110        120 
IIAMIIGGAI GVQRALKVEM TEMPELVAIL HSFVGLAAVL VGFNSYGLHH EALMPEGLDA 

       130        140        150        160        170        180 
AAQAAFVAEQ AVLTNIHNVE VFLGIFIGAV TFTGSVVAFG KLSGKINSKA LMLPHRHKLN 

       190        200        210        220        230        240 
LAALVVSALL MVAFLNNPES IFPVLLMTAI ALAFGWHLVA SIGGADMPVV VSMLNSYSGW 

       250        260        270        280        290        300 
AAAAAGFILN NDLLIVTGAL VGSSGAILSY IMCKAMNRSF VSVIAGGFGN DVQVSSSEEQ 

       310        320        330        340        350        360 
GEHRETTAEE VAELLKNASS VIITPGYGMA VAQAQYPVAD ITAKLRERGV NVRFGIHPVA 

       370        380        390        400        410        420 
GRLPGHMNVL LAEAKVPYDV VLEMDEINDD FADTDVVLVI GANDTVNPAA MEDPNSPIAG 

       430        440        450        460        470 
MPVLEVWKAQ NVIVFKRSMA VGYAGVQNPL FFKENTQMLF GDAKDRVEDI LKAL 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L42023 Genomic DNA. Translation: AAC23010.1.
U20964 Genomic DNA. Translation: AAC43725.1.
PIRF64119.
RefSeqNP_439514.1. NC_000907.1.

3D structure databases

ProteinModelPortalP43010.
SMRP43010. Positions 308-474.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING71421.HI1363.

Protocols and materials databases

DNASU950280.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC23010; AAC23010; HI_1363.
GeneID950280.
KEGGhin:HI1363.
PATRIC20191413. VBIHaeInf48452_1417.

Phylogenomic databases

eggNOGCOG1282.
KOK00325.
OMAYPVHDIT.
OrthoDBEOG6WDSHK.
ProtClustDBPRK09444.

Family and domain databases

InterProIPR012136. NADH_DH_b.
[Graphical view]
PfamPF02233. PNTB. 1 hit.
[Graphical view]
PIRSFPIRSF000204. PNTB. 1 hit.
ProtoNetSearch...

Entry information

Entry namePNTB_HAEIN
AccessionPrimary (citable) accession number: P43010
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 19, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Haemophilus influenzae

Haemophilus influenzae (strain Rd): entries and gene names