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P43010

- PNTB_HAEIN

UniProt

P43010 - PNTB_HAEIN

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Protein

NAD(P) transhydrogenase subunit beta

Gene
pntB, HI_1363
Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane By similarity.

Catalytic activityi

NADPH + NAD+ = NADP+ + NADH.

GO - Molecular functioni

  1. NAD(P)+ transhydrogenase (AB-specific) activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P) transhydrogenase subunit beta (EC:1.6.1.2)
Alternative name(s):
Nicotinamide nucleotide transhydrogenase subunit beta
Pyridine nucleotide transhydrogenase subunit beta
Gene namesi
Name:pntB
Ordered Locus Names:HI_1363
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421Helical; Reviewed predictionAdd
BLAST
Transmembranei46 – 6621Helical; Reviewed predictionAdd
BLAST
Transmembranei83 – 10321Helical; Reviewed predictionAdd
BLAST
Transmembranei132 – 15221Helical; Reviewed predictionAdd
BLAST
Transmembranei181 – 20020Helical; Reviewed predictionAdd
BLAST
Transmembranei202 – 22221Helical; Reviewed predictionAdd
BLAST
Transmembranei229 – 24921Helical; Reviewed predictionAdd
BLAST
Transmembranei253 – 27321Helical; Reviewed predictionAdd
BLAST
Transmembranei321 – 34121Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474NAD(P) transhydrogenase subunit betaPRO_0000199026Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain By similarity.

Protein-protein interaction databases

STRINGi71421.HI1363.

Structurei

3D structure databases

ProteinModelPortaliP43010.
SMRiP43010. Positions 308-474.

Family & Domainsi

Sequence similaritiesi

Belongs to the PNT beta subunit family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1282.
KOiK00325.
OMAiYPVHDIT.
OrthoDBiEOG6WDSHK.
PhylomeDBiP43010.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR012136. NADH_DH_b.
[Graphical view]
PfamiPF02233. PNTB. 1 hit.
[Graphical view]
PIRSFiPIRSF000204. PNTB. 1 hit.
SUPFAMiSSF52467. SSF52467. 1 hit.

Sequencei

Sequence statusi: Complete.

P43010-1 [UniParc]FASTAAdd to Basket

« Hide

MSEGLVQAAY ILAALLFIMS LAGLSKHETA KAGCWFGIVG MTIALIATIF    50
GPHSEGTFWI IIAMIIGGAI GVQRALKVEM TEMPELVAIL HSFVGLAAVL 100
VGFNSYGLHH EALMPEGLDA AAQAAFVAEQ AVLTNIHNVE VFLGIFIGAV 150
TFTGSVVAFG KLSGKINSKA LMLPHRHKLN LAALVVSALL MVAFLNNPES 200
IFPVLLMTAI ALAFGWHLVA SIGGADMPVV VSMLNSYSGW AAAAAGFILN 250
NDLLIVTGAL VGSSGAILSY IMCKAMNRSF VSVIAGGFGN DVQVSSSEEQ 300
GEHRETTAEE VAELLKNASS VIITPGYGMA VAQAQYPVAD ITAKLRERGV 350
NVRFGIHPVA GRLPGHMNVL LAEAKVPYDV VLEMDEINDD FADTDVVLVI 400
GANDTVNPAA MEDPNSPIAG MPVLEVWKAQ NVIVFKRSMA VGYAGVQNPL 450
FFKENTQMLF GDAKDRVEDI LKAL 474
Length:474
Mass (Da):50,163
Last modified:November 1, 1995 - v1
Checksum:i5F914630211FF844
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti343 – 3431A → P in AAC43725. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23010.1.
U20964 Genomic DNA. Translation: AAC43725.1.
PIRiF64119.
RefSeqiNP_439514.1. NC_000907.1.
WP_005693997.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23010; AAC23010; HI_1363.
GeneIDi950280.
KEGGihin:HI1363.
PATRICi20191413. VBIHaeInf48452_1417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23010.1 .
U20964 Genomic DNA. Translation: AAC43725.1 .
PIRi F64119.
RefSeqi NP_439514.1. NC_000907.1.
WP_005693997.1. NC_000907.1.

3D structure databases

ProteinModelPortali P43010.
SMRi P43010. Positions 308-474.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1363.

Protocols and materials databases

DNASUi 950280.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC23010 ; AAC23010 ; HI_1363 .
GeneIDi 950280.
KEGGi hin:HI1363.
PATRICi 20191413. VBIHaeInf48452_1417.

Phylogenomic databases

eggNOGi COG1282.
KOi K00325.
OMAi YPVHDIT.
OrthoDBi EOG6WDSHK.
PhylomeDBi P43010.

Family and domain databases

Gene3Di 3.40.50.1220. 1 hit.
InterProi IPR029035. DHS-like_NAD/FAD-binding_dom.
IPR012136. NADH_DH_b.
[Graphical view ]
Pfami PF02233. PNTB. 1 hit.
[Graphical view ]
PIRSFi PIRSF000204. PNTB. 1 hit.
SUPFAMi SSF52467. SSF52467. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. "Characterization of the Haemophilus influenzae topA locus: DNA topoisomerase I is required for genetic competence."
    Chandler M.S., Smith R.A.
    Gene 169:25-31(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 244-474.
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiPNTB_HAEIN
AccessioniPrimary (citable) accession number: P43010
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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