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P43010

- PNTB_HAEIN

UniProt

P43010 - PNTB_HAEIN

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Protein

NAD(P) transhydrogenase subunit beta

Gene

pntB

Organism
Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.By similarity

Catalytic activityi

NADPH + NAD+ = NADP+ + NADH.

GO - Molecular functioni

  1. NAD(P)+ transhydrogenase (AB-specific) activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P) transhydrogenase subunit beta (EC:1.6.1.2)
Alternative name(s):
Nicotinamide nucleotide transhydrogenase subunit beta
Pyridine nucleotide transhydrogenase subunit beta
Gene namesi
Name:pntB
Ordered Locus Names:HI_1363
OrganismiHaemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)
Taxonomic identifieri71421 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeHaemophilus
ProteomesiUP000000579: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 474474NAD(P) transhydrogenase subunit betaPRO_0000199026Add
BLAST

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta chain.By similarity

Protein-protein interaction databases

STRINGi71421.HI1363.

Structurei

3D structure databases

ProteinModelPortaliP43010.
SMRiP43010. Positions 308-474.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei4 – 2421HelicalSequence AnalysisAdd
BLAST
Transmembranei46 – 6621HelicalSequence AnalysisAdd
BLAST
Transmembranei83 – 10321HelicalSequence AnalysisAdd
BLAST
Transmembranei132 – 15221HelicalSequence AnalysisAdd
BLAST
Transmembranei181 – 20020HelicalSequence AnalysisAdd
BLAST
Transmembranei202 – 22221HelicalSequence AnalysisAdd
BLAST
Transmembranei229 – 24921HelicalSequence AnalysisAdd
BLAST
Transmembranei253 – 27321HelicalSequence AnalysisAdd
BLAST
Transmembranei321 – 34121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the PNT beta subunit family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1282.
KOiK00325.
OMAiYPVHDIT.
OrthoDBiEOG6WDSHK.
PhylomeDBiP43010.

Family and domain databases

Gene3Di3.40.50.1220. 1 hit.
InterProiIPR029035. DHS-like_NAD/FAD-binding_dom.
IPR012136. NADH_DH_b.
[Graphical view]
PfamiPF02233. PNTB. 1 hit.
[Graphical view]
PIRSFiPIRSF000204. PNTB. 1 hit.
SUPFAMiSSF52467. SSF52467. 1 hit.

Sequencei

Sequence statusi: Complete.

P43010-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEGLVQAAY ILAALLFIMS LAGLSKHETA KAGCWFGIVG MTIALIATIF
60 70 80 90 100
GPHSEGTFWI IIAMIIGGAI GVQRALKVEM TEMPELVAIL HSFVGLAAVL
110 120 130 140 150
VGFNSYGLHH EALMPEGLDA AAQAAFVAEQ AVLTNIHNVE VFLGIFIGAV
160 170 180 190 200
TFTGSVVAFG KLSGKINSKA LMLPHRHKLN LAALVVSALL MVAFLNNPES
210 220 230 240 250
IFPVLLMTAI ALAFGWHLVA SIGGADMPVV VSMLNSYSGW AAAAAGFILN
260 270 280 290 300
NDLLIVTGAL VGSSGAILSY IMCKAMNRSF VSVIAGGFGN DVQVSSSEEQ
310 320 330 340 350
GEHRETTAEE VAELLKNASS VIITPGYGMA VAQAQYPVAD ITAKLRERGV
360 370 380 390 400
NVRFGIHPVA GRLPGHMNVL LAEAKVPYDV VLEMDEINDD FADTDVVLVI
410 420 430 440 450
GANDTVNPAA MEDPNSPIAG MPVLEVWKAQ NVIVFKRSMA VGYAGVQNPL
460 470
FFKENTQMLF GDAKDRVEDI LKAL
Length:474
Mass (Da):50,163
Last modified:November 1, 1995 - v1
Checksum:i5F914630211FF844
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti343 – 3431A → P in AAC43725. (PubMed:8635745)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23010.1.
U20964 Genomic DNA. Translation: AAC43725.1.
PIRiF64119.
RefSeqiNP_439514.1. NC_000907.1.
WP_005693997.1. NC_000907.1.

Genome annotation databases

EnsemblBacteriaiAAC23010; AAC23010; HI_1363.
GeneIDi950280.
KEGGihin:HI1363.
PATRICi20191413. VBIHaeInf48452_1417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L42023 Genomic DNA. Translation: AAC23010.1 .
U20964 Genomic DNA. Translation: AAC43725.1 .
PIRi F64119.
RefSeqi NP_439514.1. NC_000907.1.
WP_005693997.1. NC_000907.1.

3D structure databases

ProteinModelPortali P43010.
SMRi P43010. Positions 308-474.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 71421.HI1363.

Protocols and materials databases

DNASUi 950280.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAC23010 ; AAC23010 ; HI_1363 .
GeneIDi 950280.
KEGGi hin:HI1363.
PATRICi 20191413. VBIHaeInf48452_1417.

Phylogenomic databases

eggNOGi COG1282.
KOi K00325.
OMAi YPVHDIT.
OrthoDBi EOG6WDSHK.
PhylomeDBi P43010.

Family and domain databases

Gene3Di 3.40.50.1220. 1 hit.
InterProi IPR029035. DHS-like_NAD/FAD-binding_dom.
IPR012136. NADH_DH_b.
[Graphical view ]
Pfami PF02233. PNTB. 1 hit.
[Graphical view ]
PIRSFi PIRSF000204. PNTB. 1 hit.
SUPFAMi SSF52467. SSF52467. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.
  2. "Characterization of the Haemophilus influenzae topA locus: DNA topoisomerase I is required for genetic competence."
    Chandler M.S., Smith R.A.
    Gene 169:25-31(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 244-474.
    Strain: ATCC 51907 / DSM 11121 / KW20 / Rd.

Entry informationi

Entry nameiPNTB_HAEIN
AccessioniPrimary (citable) accession number: P43010
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: October 29, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Haemophilus influenzae
    Haemophilus influenzae (strain Rd): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3