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Protein

Excitatory amino acid transporter 3

Gene

SLC1A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transports L-glutamate, L- and D-aspartate and L-cystein (PubMed:21123949). Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • cysteine transmembrane transport Source: GOC
  • cysteine transport Source: UniProtKB
  • D-aspartate import Source: UniProtKB
  • glutamate secretion Source: Reactome
  • ion transport Source: Reactome
  • L-glutamate import Source: UniProtKB
  • L-glutamate transmembrane transport Source: UniProtKB
  • neurotransmitter secretion Source: Reactome
  • protein homooligomerization Source: Ensembl
  • synaptic transmission Source: Reactome
  • transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

ReactomeiREACT_12591. Glutamate Neurotransmitter Release Cycle.
REACT_19397. Transport of inorganic cations/anions and amino acids/oligopeptides.

Protein family/group databases

TCDBi2.A.23.2.3. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Excitatory amino acid transporter 3
Alternative name(s):
Excitatory amino-acid carrier 1
Neuronal and epithelial glutamate transporter
Sodium-dependent glutamate/aspartate transporter 3
Solute carrier family 1 member 1
Gene namesi
Name:SLC1A1
Synonyms:EAAC1, EAAT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:10939. SLC1A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1818CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei19 – 3820HelicalSequence AnalysisAdd
BLAST
Transmembranei62 – 8221HelicalSequence AnalysisAdd
BLAST
Transmembranei94 – 11421HelicalSequence AnalysisAdd
BLAST
Topological domaini115 – 20995ExtracellularSequence AnalysisAdd
BLAST
Transmembranei210 – 22920HelicalSequence AnalysisAdd
BLAST
Transmembranei254 – 27320HelicalSequence AnalysisAdd
BLAST
Transmembranei290 – 30920HelicalSequence AnalysisAdd
BLAST
Transmembranei316 – 33520HelicalSequence AnalysisAdd
BLAST
Transmembranei362 – 38120HelicalSequence AnalysisAdd
BLAST
Transmembranei392 – 41120HelicalSequence AnalysisAdd
BLAST
Transmembranei420 – 43920HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: UniProtKB
  • extracellular exosome Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: ProtInc
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Dicarboxylic aminoaciduria (DCBXA)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAn autosomal recessive disorder characterized by abnormal excretion of urinary glutamate and aspartate, resulting from the incomplete reabsorption of anionic amino acids from the glomerular filtrate in the kidney. It can be associated with mental retardation.

See also OMIM:222730
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti395 – 3951Missing in DCBXA; inhibits L-glutamate and L-cystein transport activities. 1 Publication
VAR_071953
Natural varianti445 – 4451R → W in DCBXA; reduces L-glutamate and L-cystein transport activities; reduces cell membrane expression. 1 Publication
VAR_071954
Schizophrenia 18 (SCZD18)2 Publications

Disease susceptibility is associated with variations affecting the gene represented in this entry. A deletion at the chromosome 9p24.2 locus, including SLC1A1, has been identified in patients with psychotic disorders (PubMed:21982423). This 84 kb deletion is immediately upstream of the SLC1A1 gene in a regulatory region that contains the full native promoter sequence, extends through exon 1 of the SLC1A1 mRNA, co-segregates with disease in an extended 5-generation pedigree and increases disease risk more than 18-fold for family members (PubMed:23341099).

Disease descriptionA complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder.

See also OMIM:615232

Keywords - Diseasei

Disease mutation, Schizophrenia

Organism-specific databases

MIMi222730. phenotype.
615232. phenotype.
Orphaneti2195. Dicarboxylic aminoaciduria.
3140. Schizophrenia.
PharmGKBiPA35826.

Chemistry

DrugBankiDB00128. L-Aspartic Acid.
DB00230. Pregabalin.

Polymorphism and mutation databases

BioMutaiSLC1A1.
DMDMi1352332.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Excitatory amino acid transporter 3PRO_0000202065Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi43 – 431N-linked (GlcNAc...)Sequence Analysis
Glycosylationi178 – 1781N-linked (GlcNAc...)Sequence Analysis
Glycosylationi195 – 1951N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Glycosylated.

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiP43005.
PaxDbiP43005.
PRIDEiP43005.

PTM databases

PhosphoSiteiP43005.

Expressioni

Tissue specificityi

Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers).3 Publications

Gene expression databases

BgeeiP43005.
CleanExiHS_SLC1A1.
ExpressionAtlasiP43005. baseline and differential.
GenevestigatoriP43005.

Organism-specific databases

HPAiCAB015466.
HPA020086.

Interactioni

Subunit structurei

Interacts with ARL6IP5/PRAF3.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
LDLRAD1Q5T7003EBI-745376,EBI-10173166
RNF5Q999423EBI-745376,EBI-348482

Protein-protein interaction databases

BioGridi112396. 43 interactions.
IntActiP43005. 3 interactions.
STRINGi9606.ENSP00000262352.

Structurei

3D structure databases

ProteinModelPortaliP43005.
SMRiP43005. Positions 20-464.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1301.
GeneTreeiENSGT00760000119117.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiP43005.
KOiK05612.
OMAiFTETSQF.
OrthoDBiEOG7RV9G2.
PhylomeDBiP43005.
TreeFamiTF315206.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P43005-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKPARKGCE WKRFLKNNWV LLSTVAAVVL GITTGVLVRE HSNLSTLEKF
60 70 80 90 100
YFAFPGEILM RMLKLIILPL IISSMITGVA ALDSNVSGKI GLRAVVYYFC
110 120 130 140 150
TTLIAVILGI VLVVSIKPGV TQKVGEIART GSTPEVSTVD AMLDLIRNMF
160 170 180 190 200
PENLVQACFQ QYKTKREEVK PPSDPEMNMT EESFTAVMTT AISKNKTKEY
210 220 230 240 250
KIVGMYSDGI NVLGLIVFCL VFGLVIGKMG EKGQILVDFF NALSDATMKI
260 270 280 290 300
VQIIMCYMPL GILFLIAGKI IEVEDWEIFR KLGLYMATVL TGLAIHSIVI
310 320 330 340 350
LPLIYFIVVR KNPFRFAMGM AQALLTALMI SSSSATLPVT FRCAEENNQV
360 370 380 390 400
DKRITRFVLP VGATINMDGT ALYEAVAAVF IAQLNDLDLG IGQIITISIT
410 420 430 440 450
ATSASIGAAG VPQAGLVTMV IVLSAVGLPA EDVTLIIAVD WLLDRFRTMV
460 470 480 490 500
NVLGDAFGTG IVEKLSKKEL EQMDVSSEVN IVNPFALEST ILDNEDSDTK
510 520
KSYVNGGFAV DKSDTISFTQ TSQF
Length:524
Mass (Da):57,100
Last modified:February 1, 1996 - v2
Checksum:iFC6244ADC9EA228F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti10 – 101E → PS in AAA50430 (PubMed:7521911).Curated
Sequence conflicti92 – 921L → V in AAH33040 (PubMed:15489334).Curated
Sequence conflicti94 – 941A → V in AAA68628 (PubMed:7859077).Curated
Sequence conflicti94 – 941A → V in AAC27511 (PubMed:11317217).Curated
Sequence conflicti96 – 961V → L in AAA53215 (PubMed:7914198).Curated
Sequence conflicti170 – 1701K → N in AAA53215 (PubMed:7914198).Curated
Sequence conflicti172 – 1721P → A in AAA53215 (PubMed:7914198).Curated
Sequence conflicti260 – 2601L → H in AAA53215 (PubMed:7914198).Curated
Sequence conflicti280 – 2801R → A in AAA68628 (PubMed:7859077).Curated
Sequence conflicti376 – 3761V → G in AAC25029 (Ref. 8) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti27 – 271A → G.
Corresponds to variant rs2229885 [ dbSNP | Ensembl ].
VAR_023309
Natural varianti50 – 501F → Y.
Corresponds to variant rs16921449 [ dbSNP | Ensembl ].
VAR_023308
Natural varianti395 – 3951Missing in DCBXA; inhibits L-glutamate and L-cystein transport activities. 1 Publication
VAR_071953
Natural varianti445 – 4451R → W in DCBXA; reduces L-glutamate and L-cystein transport activities; reduces cell membrane expression. 1 Publication
VAR_071954

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08989 mRNA. Translation: AAA68628.1.
U06469 mRNA. Translation: AAA53215.1.
U03506 mRNA. Translation: AAA50430.1.
AF074911
, AF143773, AF074903, AF074904, AF074905, AF074906, AF074907, AF074908, AF074909, AF074910 Genomic DNA. Translation: AAC27511.3.
AB008536 mRNA. Translation: BAB83767.1.
AL162587, AL136231 Genomic DNA. Translation: CAH71965.1.
AL136231, AL162587 Genomic DNA. Translation: CAI41264.1.
BC033040 mRNA. Translation: AAH33040.1.
AF037982 mRNA. Translation: AAC25029.1.
CCDSiCCDS6452.1.
PIRiA54856.
I38433.
I38560.
RefSeqiNP_004161.4. NM_004170.5.
UniGeneiHs.444915.

Genome annotation databases

EnsembliENST00000262352; ENSP00000262352; ENSG00000106688.
GeneIDi6505.
KEGGihsa:6505.
UCSCiuc003zij.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08989 mRNA. Translation: AAA68628.1.
U06469 mRNA. Translation: AAA53215.1.
U03506 mRNA. Translation: AAA50430.1.
AF074911
, AF143773, AF074903, AF074904, AF074905, AF074906, AF074907, AF074908, AF074909, AF074910 Genomic DNA. Translation: AAC27511.3.
AB008536 mRNA. Translation: BAB83767.1.
AL162587, AL136231 Genomic DNA. Translation: CAH71965.1.
AL136231, AL162587 Genomic DNA. Translation: CAI41264.1.
BC033040 mRNA. Translation: AAH33040.1.
AF037982 mRNA. Translation: AAC25029.1.
CCDSiCCDS6452.1.
PIRiA54856.
I38433.
I38560.
RefSeqiNP_004161.4. NM_004170.5.
UniGeneiHs.444915.

3D structure databases

ProteinModelPortaliP43005.
SMRiP43005. Positions 20-464.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112396. 43 interactions.
IntActiP43005. 3 interactions.
STRINGi9606.ENSP00000262352.

Chemistry

BindingDBiP43005.
ChEMBLiCHEMBL2721.
DrugBankiDB00128. L-Aspartic Acid.
DB00230. Pregabalin.
GuidetoPHARMACOLOGYi870.

Protein family/group databases

TCDBi2.A.23.2.3. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

PTM databases

PhosphoSiteiP43005.

Polymorphism and mutation databases

BioMutaiSLC1A1.
DMDMi1352332.

Proteomic databases

MaxQBiP43005.
PaxDbiP43005.
PRIDEiP43005.

Protocols and materials databases

DNASUi6505.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262352; ENSP00000262352; ENSG00000106688.
GeneIDi6505.
KEGGihsa:6505.
UCSCiuc003zij.2. human.

Organism-specific databases

CTDi6505.
GeneCardsiGC09P004490.
HGNCiHGNC:10939. SLC1A1.
HPAiCAB015466.
HPA020086.
MIMi133550. gene.
222730. phenotype.
615232. phenotype.
neXtProtiNX_P43005.
Orphaneti2195. Dicarboxylic aminoaciduria.
3140. Schizophrenia.
PharmGKBiPA35826.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1301.
GeneTreeiENSGT00760000119117.
HOGENOMiHOG000208776.
HOVERGENiHBG000080.
InParanoidiP43005.
KOiK05612.
OMAiFTETSQF.
OrthoDBiEOG7RV9G2.
PhylomeDBiP43005.
TreeFamiTF315206.

Enzyme and pathway databases

ReactomeiREACT_12591. Glutamate Neurotransmitter Release Cycle.
REACT_19397. Transport of inorganic cations/anions and amino acids/oligopeptides.

Miscellaneous databases

ChiTaRSiSLC1A1. human.
GeneWikiiSLC1A1.
GenomeRNAii6505.
NextBioi25293.
PROiP43005.
SOURCEiSearch...

Gene expression databases

BgeeiP43005.
CleanExiHS_SLC1A1.
ExpressionAtlasiP43005. baseline and differential.
GenevestigatoriP43005.

Family and domain databases

Gene3Di1.10.3860.10. 2 hits.
InterProiIPR001991. Na-dicarboxylate_symporter.
IPR018107. Na-dicarboxylate_symporter_CS.
[Graphical view]
PANTHERiPTHR11958. PTHR11958. 1 hit.
PfamiPF00375. SDF. 1 hit.
[Graphical view]
PRINTSiPR00173. EDTRNSPORT.
SUPFAMiSSF118215. SSF118215. 2 hits.
PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Neuron-specific human glutamate transporter: molecular cloning, characterization and expression in human brain."
    Shashidharan P., Huntley G.W., Meyer T., Morrison J.H., Plaitakis A.
    Brain Res. 662:245-250(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Brain.
  2. "The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport."
    Kanai Y., Stelzner M., Nussberger S., Khawaja S., Hebert S.C., Smith C.P., Hediger M.A.
    J. Biol. Chem. 269:20599-20606(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  3. "Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex."
    Arriza J.L., Fairman W.A., Wendy A., Wadiche J.I., Murdoch G.H., Kavanaugh M.P., Amara S.G.
    J. Neurosci. 14:5559-5569(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Brain cortex.
  4. "Genomic organization of the SLC1A1/EAAC1 gene and mutation screening in early-onset obsessive-compulsive disorder."
    Veenstra-VanderWeele J., Kim S.J., Gonen D., Hanna G.L., Leventhal B.L., Cook E.H. Jr.
    Mol. Psychiatry 6:160-167(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "A glutamate transporter related to EAAT3 from human brain."
    Yasuda-Kamatani Y.
    Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Brain.
  6. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  8. Rome S., Mertani H.C., Lee K.O., Lobie P.E., Tome D.
    Submitted (DEC-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 268-446.
    Tissue: Placenta.
  9. "Copy number variants for schizophrenia and related psychotic disorders in Oceanic Palau: risk and transmission in extended pedigrees."
    Melhem N., Middleton F., McFadden K., Klei L., Faraone S.V., Vinogradov S., Tiobech J., Yano V., Kuartei S., Roeder K., Byerley W., Devlin B., Myles-Worsley M.
    Biol. Psychiatry 70:1115-1121(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SCZD18.
  10. "Deletion at the SLC1A1 glutamate transporter gene co-segregates with schizophrenia and bipolar schizoaffective disorder in a 5-generation family."
    Myles-Worsley M., Tiobech J., Browning S.R., Korn J., Goodman S., Gentile K., Melhem N., Byerley W., Faraone S.V., Middleton F.A.
    Am. J. Med. Genet. B Neuropsychiatr. Genet. 162B:87-95(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN SCZD18.
  11. "Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria."
    Bailey C.G., Ryan R.M., Thoeng A.D., Ng C., King K., Vanslambrouck J.M., Auray-Blais C., Vandenberg R.J., Broer S., Rasko J.E.
    J. Clin. Invest. 121:446-453(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS DCBXA ILE-395 DEL AND TRP-445, CHARACTERIZATION OF VARIANTS DCBXA ILE-395 DEL AND TRP-445, INVOLVEMENT IN DCBXA, FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiEAA3_HUMAN
AccessioniPrimary (citable) accession number: P43005
Secondary accession number(s): O75587
, Q5VZ24, Q8N199, Q9UEW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: February 1, 1996
Last modified: May 27, 2015
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.