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P43004

- EAA2_HUMAN

UniProt

P43004 - EAA2_HUMAN

Protein

Excitatory amino acid transporter 2

Gene

SLC1A2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

    GO - Molecular functioni

    1. glutamate:sodium symporter activity Source: Ensembl
    2. L-glutamate transmembrane transporter activity Source: BHF-UCL
    3. protein binding Source: IntAct
    4. sodium:dicarboxylate symporter activity Source: InterPro

    GO - Biological processi

    1. adult behavior Source: Ensembl
    2. cellular response to extracellular stimulus Source: Ensembl
    3. D-aspartate import Source: UniProtKB
    4. ion transport Source: Reactome
    5. L-glutamate import Source: UniProtKB
    6. multicellular organismal aging Source: Ensembl
    7. multicellular organism growth Source: Ensembl
    8. positive regulation of glucose import Source: Ensembl
    9. response to amino acid Source: Ensembl
    10. response to drug Source: Ensembl
    11. response to wounding Source: Ensembl
    12. synaptic transmission Source: ProtInc
    13. telencephalon development Source: Ensembl
    14. transmembrane transport Source: Reactome
    15. visual behavior Source: Ensembl

    Keywords - Biological processi

    Symport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_13639. Astrocytic Glutamate-Glutamine Uptake And Metabolism.
    REACT_19397. Transport of inorganic cations/anions and amino acids/oligopeptides.

    Protein family/group databases

    TCDBi2.A.23.2.7. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Excitatory amino acid transporter 2
    Alternative name(s):
    Glutamate/aspartate transporter II
    Sodium-dependent glutamate/aspartate transporter 2
    Solute carrier family 1 member 2
    Gene namesi
    Name:SLC1A2
    Synonyms:EAAT2, GLT1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:10940. SLC1A2.

    Subcellular locationi

    GO - Cellular componenti

    1. axolemma Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. membrane Source: ProtInc
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35827.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 574574Excitatory amino acid transporter 2PRO_0000202061Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Lipidationi38 – 381S-palmitoyl cysteineBy similarity
    Glycosylationi206 – 2061N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis
    Modified residuei539 – 5391PhosphotyrosineBy similarity

    Post-translational modificationi

    Glycosylated.
    Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity.By similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

    Proteomic databases

    PaxDbiP43004.
    PRIDEiP43004.

    PTM databases

    PhosphoSiteiP43004.

    Miscellaneous databases

    PMAP-CutDBP43004.

    Expressioni

    Gene expression databases

    ArrayExpressiP43004.
    BgeeiP43004.
    CleanExiHS_SLC1A2.
    GenevestigatoriP43004.

    Organism-specific databases

    HPAiCAB002574.
    HPA009172.

    Interactioni

    Subunit structurei

    Homotrimer. Isoform 3 can oligomerize with isoform 1. Interacts with AJUBA By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MAPTP106364EBI-3440986,EBI-366182

    Protein-protein interaction databases

    BioGridi112397. 3 interactions.
    IntActiP43004. 2 interactions.
    STRINGi9606.ENSP00000278379.

    Structurei

    3D structure databases

    ProteinModelPortaliP43004.
    SMRiP43004. Positions 46-493.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 4444CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini143 – 23997ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei45 – 6420HelicalSequence AnalysisAdd
    BLAST
    Transmembranei88 – 10821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei121 – 14222HelicalSequence AnalysisAdd
    BLAST
    Transmembranei240 – 25920HelicalSequence AnalysisAdd
    BLAST
    Transmembranei280 – 30122HelicalSequence AnalysisAdd
    BLAST
    Transmembranei317 – 33923HelicalSequence AnalysisAdd
    BLAST
    Transmembranei406 – 43025HelicalSequence AnalysisAdd
    BLAST
    Transmembranei437 – 45923HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1301.
    HOVERGENiHBG000080.
    InParanoidiP43004.
    KOiK05613.
    OMAiFIAFGIC.
    OrthoDBiEOG7RV9G2.
    PhylomeDBiP43004.
    TreeFamiTF315206.

    Family and domain databases

    Gene3Di1.10.3860.10. 2 hits.
    InterProiIPR001991. Na-dicarboxylate_symporter.
    IPR018107. Na-dicarboxylate_symporter_CS.
    [Graphical view]
    PANTHERiPTHR11958. PTHR11958. 1 hit.
    PfamiPF00375. SDF. 1 hit.
    [Graphical view]
    PRINTSiPR00173. EDTRNSPORT.
    SUPFAMiSSF118215. SSF118215. 2 hits.
    PROSITEiPS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
    PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P43004-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MASTEGANNM PKQVEVRMHD SHLGSEEPKH RHLGLRLCDK LGKNLLLTLT    50
    VFGVILGAVC GGLLRLASPI HPDVVMLIAF PGDILMRMLK MLILPLIISS 100
    LITGLSGLDA KASGRLGTRA MVYYMSTTII AAVLGVILVL AIHPGNPKLK 150
    KQLGPGKKND EVSSLDAFLD LIRNLFPENL VQACFQQIQT VTKKVLVAPP 200
    PDEEANATSA VVSLLNETVT EVPEETKMVI KKGLEFKDGM NVLGLIGFFI 250
    AFGIAMGKMG DQAKLMVDFF NILNEIVMKL VIMIMWYSPL GIACLICGKI 300
    IAIKDLEVVA RQLGMYMVTV IIGLIIHGGI FLPLIYFVVT RKNPFSFFAG 350
    IFQAWITALG TASSAGTLPV TFRCLEENLG IDKRVTRFVL PVGATINMDG 400
    TALYEAVAAI FIAQMNGVVL DGGQIVTVSL TATLASVGAA SIPSAGLVTM 450
    LLILTAVGLP TEDISLLVAV DWLLDRMRTS VNVVGDSFGA GIVYHLSKSE 500
    LDTIDSQHRV HEDIEMTKTQ SIYDDMKNHR ESNSNQCVYA AHNSVIVDEC 550
    KVTLAANGKS ADCSVEEEPW KREK 574
    Length:574
    Mass (Da):62,104
    Last modified:July 15, 1998 - v2
    Checksum:iC8104E6727979435
    GO
    Isoform 2 (identifier: P43004-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-9: Missing.

    Show »
    Length:565
    Mass (Da):61,228
    Checksum:iA7286207F550252F
    GO
    Isoform 3 (identifier: P43004-3) [UniParc]FASTAAdd to Basket

    Also known as: EEAT2b

    The sequence of this isoform differs from the canonical sequence as follows:
         553-574: TLAANGKSADCSVEEEPWKREK → HFPFMDIETCI

    Show »
    Length:563
    Mass (Da):61,008
    Checksum:iC13903644ADD1802
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti7 – 71A → T in BAG60911. (PubMed:14702039)Curated
    Sequence conflicti19 – 191H → P in AAA50429. (PubMed:7521911)Curated
    Sequence conflicti27 – 271E → G in CAA83532. (PubMed:7522567)Curated
    Sequence conflicti50 – 501T → Q in AAA18900. (PubMed:8172925)Curated
    Sequence conflicti58 – 581A → S in AAA18900. (PubMed:8172925)Curated
    Sequence conflicti141 – 1411A → G in CAA83532. (PubMed:7522567)Curated
    Sequence conflicti155 – 1551P → A in CAA83532. (PubMed:7522567)Curated
    Sequence conflicti211 – 2111V → E in AAA50429. (PubMed:7521911)Curated
    Sequence conflicti253 – 2553GIA → AIP in CAA83532. (PubMed:7522567)Curated
    Sequence conflicti263 – 28927AKLMV…MWYSP → GQADGGFLQHFERDCNEVSD HDHVVLS in CAA83532. (PubMed:7522567)CuratedAdd
    BLAST
    Sequence conflicti347 – 3471F → L in AAA50429. (PubMed:7521911)Curated
    Sequence conflicti539 – 5391Y → F in CAA83532. (PubMed:7522567)Curated
    Sequence conflicti556 – 5561A → G in CAA83532. (PubMed:7522567)Curated
    Sequence conflicti563 – 5653CSV → RVL in CAA83532. (PubMed:7522567)Curated
    Sequence conflicti570 – 5701W → G in CAA83532. (PubMed:7522567)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 99Missing in isoform 2. 1 PublicationVSP_037152
    Alternative sequencei553 – 57422TLAAN…WKREK → HFPFMDIETCI in isoform 3. 1 PublicationVSP_054934Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03505 mRNA. Translation: AAA50429.1.
    U01824 mRNA. Translation: AAA18900.1.
    Z32517 mRNA. Translation: CAA83532.1.
    D85884 mRNA. Translation: BAA28706.1.
    AY066021 mRNA. Translation: AAL57716.1.
    AK298769 mRNA. Translation: BAG60911.1.
    AL133330, AC090625 Genomic DNA. Translation: CAM28291.1.
    CH471064 Genomic DNA. Translation: EAW68143.1.
    BC132768 mRNA. Translation: AAI32769.1.
    CCDSiCCDS31459.1. [P43004-1]
    CCDS55756.1. [P43004-2]
    PIRiI37426.
    I38432.
    RefSeqiNP_001182657.1. NM_001195728.2. [P43004-2]
    NP_001239581.1. NM_001252652.1. [P43004-2]
    NP_004162.2. NM_004171.3. [P43004-1]
    UniGeneiHs.502338.

    Genome annotation databases

    EnsembliENST00000278379; ENSP00000278379; ENSG00000110436. [P43004-1]
    ENST00000395750; ENSP00000379099; ENSG00000110436. [P43004-2]
    ENST00000395753; ENSP00000379102; ENSG00000110436. [P43004-2]
    ENST00000606205; ENSP00000476124; ENSG00000110436. [P43004-3]
    GeneIDi6506.
    KEGGihsa:6506.
    UCSCiuc001mwd.3. human. [P43004-1]

    Polymorphism databases

    DMDMi3041668.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U03505 mRNA. Translation: AAA50429.1 .
    U01824 mRNA. Translation: AAA18900.1 .
    Z32517 mRNA. Translation: CAA83532.1 .
    D85884 mRNA. Translation: BAA28706.1 .
    AY066021 mRNA. Translation: AAL57716.1 .
    AK298769 mRNA. Translation: BAG60911.1 .
    AL133330 , AC090625 Genomic DNA. Translation: CAM28291.1 .
    CH471064 Genomic DNA. Translation: EAW68143.1 .
    BC132768 mRNA. Translation: AAI32769.1 .
    CCDSi CCDS31459.1. [P43004-1 ]
    CCDS55756.1. [P43004-2 ]
    PIRi I37426.
    I38432.
    RefSeqi NP_001182657.1. NM_001195728.2. [P43004-2 ]
    NP_001239581.1. NM_001252652.1. [P43004-2 ]
    NP_004162.2. NM_004171.3. [P43004-1 ]
    UniGenei Hs.502338.

    3D structure databases

    ProteinModelPortali P43004.
    SMRi P43004. Positions 46-493.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112397. 3 interactions.
    IntActi P43004. 2 interactions.
    STRINGi 9606.ENSP00000278379.

    Chemistry

    BindingDBi P43004.
    ChEMBLi CHEMBL4973.
    DrugBanki DB00142. L-Glutamic Acid.
    GuidetoPHARMACOLOGYi 869.

    Protein family/group databases

    TCDBi 2.A.23.2.7. the dicarboxylate/amino acid:cation (na(+) or h(+)) symporter (daacs) family.

    PTM databases

    PhosphoSitei P43004.

    Polymorphism databases

    DMDMi 3041668.

    Proteomic databases

    PaxDbi P43004.
    PRIDEi P43004.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000278379 ; ENSP00000278379 ; ENSG00000110436 . [P43004-1 ]
    ENST00000395750 ; ENSP00000379099 ; ENSG00000110436 . [P43004-2 ]
    ENST00000395753 ; ENSP00000379102 ; ENSG00000110436 . [P43004-2 ]
    ENST00000606205 ; ENSP00000476124 ; ENSG00000110436 . [P43004-3 ]
    GeneIDi 6506.
    KEGGi hsa:6506.
    UCSCi uc001mwd.3. human. [P43004-1 ]

    Organism-specific databases

    CTDi 6506.
    GeneCardsi GC11M035272.
    HGNCi HGNC:10940. SLC1A2.
    HPAi CAB002574.
    HPA009172.
    MIMi 600300. gene.
    neXtProti NX_P43004.
    PharmGKBi PA35827.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1301.
    HOVERGENi HBG000080.
    InParanoidi P43004.
    KOi K05613.
    OMAi FIAFGIC.
    OrthoDBi EOG7RV9G2.
    PhylomeDBi P43004.
    TreeFami TF315206.

    Enzyme and pathway databases

    Reactomei REACT_13639. Astrocytic Glutamate-Glutamine Uptake And Metabolism.
    REACT_19397. Transport of inorganic cations/anions and amino acids/oligopeptides.

    Miscellaneous databases

    ChiTaRSi SLC1A2. human.
    GeneWikii SLC1A2.
    GenomeRNAii 6506.
    NextBioi 25297.
    PMAP-CutDB P43004.
    PROi P43004.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P43004.
    Bgeei P43004.
    CleanExi HS_SLC1A2.
    Genevestigatori P43004.

    Family and domain databases

    Gene3Di 1.10.3860.10. 2 hits.
    InterProi IPR001991. Na-dicarboxylate_symporter.
    IPR018107. Na-dicarboxylate_symporter_CS.
    [Graphical view ]
    PANTHERi PTHR11958. PTHR11958. 1 hit.
    Pfami PF00375. SDF. 1 hit.
    [Graphical view ]
    PRINTSi PR00173. EDTRNSPORT.
    SUPFAMi SSF118215. SSF118215. 2 hits.
    PROSITEi PS00713. NA_DICARBOXYL_SYMP_1. 1 hit.
    PS00714. NA_DICARBOXYL_SYMP_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex."
      Arriza J.L., Fairman W.A., Wendy A., Wadiche J.I., Murdoch G.H., Kavanaugh M.P., Amara S.G.
      J. Neurosci. 14:5559-5569(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain cortex.
    2. "Molecular cloning of human brain glutamate/aspartate transporter II."
      Shashidharan P., Wittenberg I., Plaitakis A.
      Biochim. Biophys. Acta 1191:393-396(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Brain.
    3. "Cloning and characterization of a glutamate transporter cDNA from human brain and pancreas."
      Manfras B.J., Rudert W.A., Trucco M., Boehm B.O.
      Biochim. Biophys. Acta 1195:185-188(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Pancreas.
    4. "DL-threo-beta-benzyloxyaspartate, a potent blocker of excitatory amino acid transporters."
      Shimamoto K., Lebrun B., Yasuda-Kamatani Y., Sakaitani M., Shigeri Y., Yumoto N., Nakajima T.
      Mol. Pharmacol. 53:195-201(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    5. "Cloning and characterization of the 3'-untranslated region of the human excitatory amino acid transporter 2 transcript."
      Kim S.Y., Chao W., Choi S.Y., Volsky D.J.
      J. Neurochem. 86:1458-1467(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    10. "A trimeric quaternary structure is conserved in bacterial and human glutamate transporters."
      Gendreau S., Voswinkel S., Torres-Salazar D., Lang N., Heidtmann H., Detro-Dassen S., Schmalzing G., Hidalgo P., Fahlke C.
      J. Biol. Chem. 279:39505-39512(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: QUATERNARY STRUCTURE.
    11. "Exon-skipping splice variants of excitatory amino acid transporter-2 (EAAT2) form heteromeric complexes with full-length EAAT2."
      Gebhardt F.M., Mitrovic A.D., Gilbert D.F., Vandenberg R.J., Lynch J.W., Dodd P.R.
      J. Biol. Chem. 285:31313-31324(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ALTERNATIVE SPLICING (ISOFORM 3), SUBUNIT.

    Entry informationi

    Entry nameiEAA2_HUMAN
    AccessioniPrimary (citable) accession number: P43004
    Secondary accession number(s): B4DQE9
    , Q14417, Q541G6, U3KQQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3