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Protein

Methylglyoxal synthase

Gene

mgsA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the formation of methylglyoxal from dihydroxyacetone phosphate.UniRule annotation

Catalytic activityi

Glycerone phosphate = methylglyoxal + phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei8SubstrateUniRule annotation1
Binding sitei12SubstrateUniRule annotation1
Active sitei60Proton donor/acceptorUniRule annotation1
Binding sitei87SubstrateUniRule annotation1

GO - Molecular functioni

  • methylglyoxal synthase activity Source: CACAO

GO - Biological processi

Keywordsi

Molecular functionLyase

Enzyme and pathway databases

BioCyciBSUB:BSU22480-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methylglyoxal synthaseUniRule annotation (EC:4.2.3.3UniRule annotation)
Short name:
MGSUniRule annotation
Gene namesi
Name:mgsAUniRule annotation
Synonyms:ypjF
Ordered Locus Names:BSU22480
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001786131 – 137Methylglyoxal synthaseAdd BLAST137

Proteomic databases

PaxDbiP42980
PRIDEiP42980

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100012356

Structurei

Secondary structure

1137
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 7Combined sources6
Helixi9 – 11Combined sources3
Helixi12 – 21Combined sources10
Helixi23 – 26Combined sources4
Beta strandi29 – 34Combined sources6
Helixi36 – 45Combined sources10
Beta strandi49 – 52Combined sources4
Helixi55 – 57Combined sources3
Helixi59 – 68Combined sources10
Beta strandi73 – 78Combined sources6
Helixi88 – 100Combined sources13
Beta strandi105 – 108Combined sources4
Helixi109 – 119Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6F2CX-ray2.34A/B/C/D/E/F/G/H/I/J/K/L1-137[»]
ProteinModelPortaliP42980
SMRiP42980
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 137MGS-likeUniRule annotationAdd BLAST137

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni34 – 37Substrate bindingUniRule annotation4
Regioni54 – 55Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the methylglyoxal synthase family.UniRule annotationCurated

Phylogenomic databases

eggNOGiENOG4108Z5K Bacteria
COG1803 LUCA
HOGENOMiHOG000283729
InParanoidiP42980
KOiK01734
OMAiRACDVHN
PhylomeDBiP42980

Family and domain databases

CDDicd01422 MGS, 1 hit
Gene3Di3.40.50.1380, 1 hit
HAMAPiMF_00549 Methylglyoxal_synth, 1 hit
InterProiView protein in InterPro
IPR004363 Methylgl_synth
IPR018148 Methylglyoxal_synth_AS
IPR011607 MGS-like_dom
IPR036914 MGS-like_dom_sf
PANTHERiPTHR30492 PTHR30492, 1 hit
PfamiView protein in Pfam
PF02142 MGS, 1 hit
PIRSFiPIRSF006614 Methylglyox_syn, 1 hit
SMARTiView protein in SMART
SM00851 MGS, 1 hit
SUPFAMiSSF52335 SSF52335, 1 hit
TIGRFAMsiTIGR00160 MGSA, 1 hit
PROSITEiView protein in PROSITE
PS01335 METHYLGLYOXAL_SYNTH, 1 hit
PS51855 MGS, 1 hit

Sequencei

Sequence statusi: Complete.

P42980-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIALIAHDK KKQDMVQFTT AYRDILKNHD LYATGTTGLK IHEATGLQIE
60 70 80 90 100
RFQSGPLGGD QQIGALIAAN ALDLVIFLRD PLTAQPHEPD VSALIRLCDV
110 120 130
YSIPLATNMG TAEILVRTLD EGVFEFRDLL RGEEPNV
Length:137
Mass (Da):15,128
Last modified:November 1, 1995 - v1
Checksum:i01FC7883A3837F98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38424 Genomic DNA Translation: AAA92875.1
L47709 Genomic DNA Translation: AAB38443.1
AL009126 Genomic DNA Translation: CAB14164.1
PIRiE69937
RefSeqiNP_390129.1, NC_000964.3
WP_003230640.1, NZ_JNCM01000036.1

Genome annotation databases

EnsemblBacteriaiCAB14164; CAB14164; BSU22480
GeneIDi939027
KEGGibsu:BSU22480
PATRICifig|224308.179.peg.2452

Similar proteinsi

Entry informationi

Entry nameiMGSA_BACSU
AccessioniPrimary (citable) accession number: P42980
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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