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Protein

Methylglyoxal synthase

Gene

mgsA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Glycerone phosphate = methylglyoxal + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei60 – 601By similarity

GO - Molecular functioni

  • methylglyoxal synthase activity Source: CACAO

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciBSUB:BSU22480-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylglyoxal synthase (EC:4.2.3.3)
Short name:
MGS
Gene namesi
Name:mgsA
Synonyms:ypjF
Ordered Locus Names:BSU22480
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 137137Methylglyoxal synthasePRO_0000178613Add
BLAST

Proteomic databases

PaxDbiP42980.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100012356.

Structurei

3D structure databases

ProteinModelPortaliP42980.
SMRiP42980. Positions 3-116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methylglyoxal synthase family.Curated

Phylogenomic databases

eggNOGiENOG4108Z5K. Bacteria.
COG1803. LUCA.
HOGENOMiHOG000283729.
InParanoidiP42980.
KOiK01734.
OMAiEPQPHDP.
OrthoDBiEOG644ZN1.
PhylomeDBiP42980.

Family and domain databases

Gene3Di3.40.50.1380. 1 hit.
HAMAPiMF_00549. Methylglyoxal_synth.
InterProiIPR004363. Methylgl_synth.
IPR018148. Methylglyoxal_synth_AS.
IPR011607. MGS-like_dom.
[Graphical view]
PfamiPF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF006614. Methylglyox_syn. 1 hit.
SMARTiSM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
TIGRFAMsiTIGR00160. MGSA. 1 hit.
PROSITEiPS01335. METHYLGLYOXAL_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42980-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIALIAHDK KKQDMVQFTT AYRDILKNHD LYATGTTGLK IHEATGLQIE
60 70 80 90 100
RFQSGPLGGD QQIGALIAAN ALDLVIFLRD PLTAQPHEPD VSALIRLCDV
110 120 130
YSIPLATNMG TAEILVRTLD EGVFEFRDLL RGEEPNV
Length:137
Mass (Da):15,128
Last modified:November 1, 1995 - v1
Checksum:i01FC7883A3837F98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38424 Genomic DNA. Translation: AAA92875.1.
L47709 Genomic DNA. Translation: AAB38443.1.
AL009126 Genomic DNA. Translation: CAB14164.1.
PIRiE69937.
RefSeqiNP_390129.1. NC_000964.3.
WP_003230640.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14164; CAB14164; BSU22480.
GeneIDi939027.
KEGGibsu:BSU22480.
PATRICi18976305. VBIBacSub10457_2343.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38424 Genomic DNA. Translation: AAA92875.1.
L47709 Genomic DNA. Translation: AAB38443.1.
AL009126 Genomic DNA. Translation: CAB14164.1.
PIRiE69937.
RefSeqiNP_390129.1. NC_000964.3.
WP_003230640.1. NZ_JNCM01000036.1.

3D structure databases

ProteinModelPortaliP42980.
SMRiP42980. Positions 3-116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100012356.

Proteomic databases

PaxDbiP42980.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14164; CAB14164; BSU22480.
GeneIDi939027.
KEGGibsu:BSU22480.
PATRICi18976305. VBIBacSub10457_2343.

Phylogenomic databases

eggNOGiENOG4108Z5K. Bacteria.
COG1803. LUCA.
HOGENOMiHOG000283729.
InParanoidiP42980.
KOiK01734.
OMAiEPQPHDP.
OrthoDBiEOG644ZN1.
PhylomeDBiP42980.

Enzyme and pathway databases

BioCyciBSUB:BSU22480-MONOMER.

Family and domain databases

Gene3Di3.40.50.1380. 1 hit.
HAMAPiMF_00549. Methylglyoxal_synth.
InterProiIPR004363. Methylgl_synth.
IPR018148. Methylglyoxal_synth_AS.
IPR011607. MGS-like_dom.
[Graphical view]
PfamiPF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF006614. Methylglyox_syn. 1 hit.
SMARTiSM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
TIGRFAMsiTIGR00160. MGSA. 1 hit.
PROSITEiPS01335. METHYLGLYOXAL_SYNTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the Bacillus subtilis chromosome region between the serA and kdg loci cloned in a yeast artificial chromosome."
    Sorokin A.V., Azevedo V., Zumstein E., Galleron N., Ehrlich S.D., Serror P.
    Microbiology 142:2005-2016(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168 / Marburg / ATCC 6051 / DSM 10 / JCM 1465 / NBRC 13719 / NCIMB 3610 / VKM B-501.
  2. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.

Entry informationi

Entry nameiMGSA_BACSU
AccessioniPrimary (citable) accession number: P42980
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: February 17, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.