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Protein

Penicillin-binding protein 3

Gene

pbpC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei410Acyl-ester intermediateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBSUB:BSU04140-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Penicillin-binding protein 3
Short name:
PBP 3
Alternative name(s):
PSPB20
Penicillin-binding protein C
Gene namesi
Name:pbpC
Synonyms:ycsM, yzsA
Ordered Locus Names:BSU04140
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 23HelicalSequence analysisAdd BLAST17

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3112383.
DrugBankiDB00355. Aztreonam.
DB00493. Cefotaxime.
DB01598. Imipenem.
DB04570. Latamoxef.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001954641 – 668Penicillin-binding protein 3Add BLAST668

Proteomic databases

PaxDbiP42971.

Interactioni

Protein-protein interaction databases

IntActiP42971. 1 interactor.
STRINGi224308.Bsubs1_010100002358.

Structurei

3D structure databases

ProteinModelPortaliP42971.
SMRiP42971.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transpeptidase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4107RVG. Bacteria.
COG0768. LUCA.
HOGENOMiHOG000236144.
InParanoidiP42971.
KOiK21467.
OMAiTLACKTG.
PhylomeDBiP42971.

Family and domain databases

InterProiView protein in InterPro
IPR012338. Beta-lactam/transpept-like.
IPR007887. MecA_N.
IPR032710. NTF2-like_dom.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
PfamiView protein in Pfam
PF05223. MecA_N. 1 hit.
PF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
SUPFAMiSSF54427. SSF54427. 1 hit.
SSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.

Sequencei

Sequence statusi: Complete.

P42971-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKKCILLVF LCVGLIGLIG CSKTDSPEDR MEAFVKQWND QQFDDMYQSL
60 70 80 90 100
TKDVKKEISK KDFVNRYKAI YEQAGVKNLK VTAGEVDKDD QDNKTMKHIP
110 120 130 140 150
YKVSMNTNAG KVSFKNTAVL KLEKTDDEES WNIDWDPSFI FKQLADDKTV
160 170 180 190 200
QIMSIEPKRG QIYDKNGKGL AVNTDVPEIG IVPGELGDKK EKVIKELAKK
210 220 230 240 250
LDLTEDDIKK KLDQGWVKDD SFVPLKKVKP DQEKLVSEAT SLQGVTRTNV
260 270 280 290 300
SSRYYPYGEK TAHLTGYVRA ITAEELKKKK EGTYSDTSNI GIAGLENVYE
310 320 330 340 350
DKLRGTTGWK IYVPQTGEVI AEKKAKDGED LHLTIDIKTQ MKLYDELKDD
360 370 380 390 400
SGAAVALQPK TGETLALVSA PSYDPNGFIF GWSDKEWKKL NKDKNNPFSA
410 420 430 440 450
KFNKTYAPGS TIKPIAAAIG IKNGTLKADE KKTIKGKEWQ KDSSWGGYSV
460 470 480 490 500
TRVSERLQQV DLENALITSD NIYFAQNALD MGADTFTKGL KTFGFSEDVP
510 520 530 540 550
YEFPIQKSSI ANDKLDSDIL LADTGYGQGQ MQMSPLHLAT AYTPFVDNGD
560 570 580 590 600
LVKPTLIKKD SQTADVWHKQ VVTKEGAADI TKGLKGVVED ERGSAYQPVV
610 620 630 640 650
KGITVAGKTG TAELKTSKDD KDGTENGWFV GYDYENKDLL VAMMIQNVQD
660
RGGSHYVVEK AKKQFQSN
Length:668
Mass (Da):74,406
Last modified:November 1, 1995 - v1
Checksum:iA877A27B188ECAFC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9V → D in AAA22829 (PubMed:3145906).Curated1
Sequence conflicti30 – 37RMEAFVKQ → PLESTAQA in AAA22829 (PubMed:3145906).Curated8

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38161 Genomic DNA. Translation: BAA07365.1.
D50453 Genomic DNA. Translation: BAA09043.1.
AL009126 Genomic DNA. Translation: CAB12221.1.
M22913 Genomic DNA. Translation: AAA22829.1.
PIRiI39902.
RefSeqiNP_388295.1. NC_000964.3.
WP_003246590.1. NZ_JNCM01000031.1.

Genome annotation databases

EnsemblBacteriaiCAB12221; CAB12221; BSU04140.
GeneIDi940139.
KEGGibsu:BSU04140.
PATRICifig|224308.179.peg.440.

Similar proteinsi

Entry informationi

Entry nameiPBPC_BACSU
AccessioniPrimary (citable) accession number: P42971
Secondary accession number(s): P40772
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 27, 2017
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families