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P42971

- PBPC_BACSU

UniProt

P42971 - PBPC_BACSU

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Protein

Penicillin-binding protein 3

Gene
pbpC, ycsM, yzsA, BSU04140
Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei410 – 4101Acyl-ester intermediate By similarity

GO - Molecular functioni

  1. penicillin binding Source: InterPro
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. peptidoglycan biosynthetic process Source: UniProtKB-KW
  2. regulation of cell shape Source: UniProtKB-KW
  3. response to antibiotic Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBSUB:BSU04140-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Penicillin-binding protein 3
Short name:
PBP 3
Alternative name(s):
PSPB20
Penicillin-binding protein C
Gene namesi
Name:pbpC
Synonyms:ycsM, yzsA
Ordered Locus Names:BSU04140
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
ProteomesiUP000001570: Chromosome

Organism-specific databases

GenoListiBSU04140. [Micado]

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei7 – 2317Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 668668Penicillin-binding protein 3PRO_0000195464Add
BLAST

Proteomic databases

PaxDbiP42971.

Interactioni

Protein-protein interaction databases

IntActiP42971. 1 interaction.
STRINGi224308.BSU04140.

Structurei

3D structure databases

ProteinModelPortaliP42971.
SMRiP42971. Positions 28-668.

Family & Domainsi

Sequence similaritiesi

Belongs to the transpeptidase family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0768.
HOGENOMiHOG000236144.
KOiK18149.
OMAiEGPVPFK.
OrthoDBiEOG6N0HHV.
PhylomeDBiP42971.

Family and domain databases

Gene3Di3.40.710.10. 1 hit.
InterProiIPR012338. Beta-lactam/transpept-like.
IPR007887. MecA_N.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamiPF05223. MecA_N. 1 hit.
PF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SUPFAMiSSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.

Sequencei

Sequence statusi: Complete.

P42971-1 [UniParc]FASTAAdd to Basket

« Hide

MLKKCILLVF LCVGLIGLIG CSKTDSPEDR MEAFVKQWND QQFDDMYQSL    50
TKDVKKEISK KDFVNRYKAI YEQAGVKNLK VTAGEVDKDD QDNKTMKHIP 100
YKVSMNTNAG KVSFKNTAVL KLEKTDDEES WNIDWDPSFI FKQLADDKTV 150
QIMSIEPKRG QIYDKNGKGL AVNTDVPEIG IVPGELGDKK EKVIKELAKK 200
LDLTEDDIKK KLDQGWVKDD SFVPLKKVKP DQEKLVSEAT SLQGVTRTNV 250
SSRYYPYGEK TAHLTGYVRA ITAEELKKKK EGTYSDTSNI GIAGLENVYE 300
DKLRGTTGWK IYVPQTGEVI AEKKAKDGED LHLTIDIKTQ MKLYDELKDD 350
SGAAVALQPK TGETLALVSA PSYDPNGFIF GWSDKEWKKL NKDKNNPFSA 400
KFNKTYAPGS TIKPIAAAIG IKNGTLKADE KKTIKGKEWQ KDSSWGGYSV 450
TRVSERLQQV DLENALITSD NIYFAQNALD MGADTFTKGL KTFGFSEDVP 500
YEFPIQKSSI ANDKLDSDIL LADTGYGQGQ MQMSPLHLAT AYTPFVDNGD 550
LVKPTLIKKD SQTADVWHKQ VVTKEGAADI TKGLKGVVED ERGSAYQPVV 600
KGITVAGKTG TAELKTSKDD KDGTENGWFV GYDYENKDLL VAMMIQNVQD 650
RGGSHYVVEK AKKQFQSN 668
Length:668
Mass (Da):74,406
Last modified:November 1, 1995 - v1
Checksum:iA877A27B188ECAFC
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91V → D in AAA22829. 1 Publication
Sequence conflicti30 – 378RMEAFVKQ → PLESTAQA in AAA22829. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38161 Genomic DNA. Translation: BAA07365.1.
D50453 Genomic DNA. Translation: BAA09043.1.
AL009126 Genomic DNA. Translation: CAB12221.1.
M22913 Genomic DNA. Translation: AAA22829.1.
PIRiI39902.
RefSeqiNP_388295.1. NC_000964.3.
WP_003246590.1. NC_000964.3.

Genome annotation databases

EnsemblBacteriaiCAB12221; CAB12221; BSU04140.
GeneIDi940139.
KEGGibsu:BSU04140.
PATRICi18972406. VBIBacSub10457_0431.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38161 Genomic DNA. Translation: BAA07365.1 .
D50453 Genomic DNA. Translation: BAA09043.1 .
AL009126 Genomic DNA. Translation: CAB12221.1 .
M22913 Genomic DNA. Translation: AAA22829.1 .
PIRi I39902.
RefSeqi NP_388295.1. NC_000964.3.
WP_003246590.1. NC_000964.3.

3D structure databases

ProteinModelPortali P42971.
SMRi P42971. Positions 28-668.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi P42971. 1 interaction.
STRINGi 224308.BSU04140.

Chemistry

DrugBanki DB00355. Aztreonam.
DB00493. Cefotaxime.

Proteomic databases

PaxDbi P42971.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAB12221 ; CAB12221 ; BSU04140 .
GeneIDi 940139.
KEGGi bsu:BSU04140.
PATRICi 18972406. VBIBacSub10457_0431.

Organism-specific databases

GenoListi BSU04140. [Micado ]

Phylogenomic databases

eggNOGi COG0768.
HOGENOMi HOG000236144.
KOi K18149.
OMAi EGPVPFK.
OrthoDBi EOG6N0HHV.
PhylomeDBi P42971.

Enzyme and pathway databases

BioCyci BSUB:BSU04140-MONOMER.

Family and domain databases

Gene3Di 3.40.710.10. 1 hit.
InterProi IPR012338. Beta-lactam/transpept-like.
IPR007887. MecA_N.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view ]
Pfami PF05223. MecA_N. 1 hit.
PF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view ]
SUPFAMi SSF56519. SSF56519. 1 hit.
SSF56601. SSF56601. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Determination of a 17,484 bp nucleotide sequence around the 39 degrees region of the Bacillus subtilis chromosome and similarity analysis of the products of putative ORFs."
    Akagawa E., Kurita K., Sugawara T., Nakamura K., Kasahara Y., Ogasawara N., Yamane K.
    Microbiology 141:3241-3245(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  2. "The 25 degrees-36 degrees region of the Bacillus subtilis chromosome: determination of the sequence of a 146 kb segment and identification of 113 genes."
    Yamane K., Kumano M., Kurita K.
    Microbiology 142:3047-3056(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 168.
  3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
    Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
    , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
    Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 168.
  4. "Characterization of signal-sequence-coding regions selected from the Bacillus subtilis chromosome."
    Smith H., de Jong A., Bron S., Venema G.
    Gene 70:351-361(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-37.

Entry informationi

Entry nameiPBPC_BACSU
AccessioniPrimary (citable) accession number: P42971
Secondary accession number(s): P40772
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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