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P42971

- PBPC_BACSU

UniProt

P42971 - PBPC_BACSU

Protein

Penicillin-binding protein 3

Gene

pbpC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (01 Nov 1995)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei410 – 4101Acyl-ester intermediateBy similarity

    GO - Molecular functioni

    1. penicillin binding Source: InterPro
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. peptidoglycan biosynthetic process Source: UniProtKB-KW
    2. regulation of cell shape Source: UniProtKB-KW
    3. response to antibiotic Source: InterPro

    Keywords - Biological processi

    Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

    Enzyme and pathway databases

    BioCyciBSUB:BSU04140-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Penicillin-binding protein 3
    Short name:
    PBP 3
    Alternative name(s):
    PSPB20
    Penicillin-binding protein C
    Gene namesi
    Name:pbpC
    Synonyms:ycsM, yzsA
    Ordered Locus Names:BSU04140
    OrganismiBacillus subtilis (strain 168)
    Taxonomic identifieri224308 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
    ProteomesiUP000001570: Chromosome

    Organism-specific databases

    GenoListiBSU04140. [Micado]

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 668668Penicillin-binding protein 3PRO_0000195464Add
    BLAST

    Proteomic databases

    PaxDbiP42971.

    Interactioni

    Protein-protein interaction databases

    IntActiP42971. 1 interaction.
    STRINGi224308.BSU04140.

    Structurei

    3D structure databases

    ProteinModelPortaliP42971.
    SMRiP42971. Positions 28-668.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei7 – 2317HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the transpeptidase family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0768.
    HOGENOMiHOG000236144.
    KOiK18149.
    OMAiEGPVPFK.
    OrthoDBiEOG6N0HHV.
    PhylomeDBiP42971.

    Family and domain databases

    Gene3Di3.40.710.10. 1 hit.
    InterProiIPR012338. Beta-lactam/transpept-like.
    IPR007887. MecA_N.
    IPR005311. PBP_dimer.
    IPR001460. PCN-bd_Tpept.
    [Graphical view]
    PfamiPF05223. MecA_N. 1 hit.
    PF03717. PBP_dimer. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56519. SSF56519. 1 hit.
    SSF56601. SSF56601. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    P42971-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLKKCILLVF LCVGLIGLIG CSKTDSPEDR MEAFVKQWND QQFDDMYQSL    50
    TKDVKKEISK KDFVNRYKAI YEQAGVKNLK VTAGEVDKDD QDNKTMKHIP 100
    YKVSMNTNAG KVSFKNTAVL KLEKTDDEES WNIDWDPSFI FKQLADDKTV 150
    QIMSIEPKRG QIYDKNGKGL AVNTDVPEIG IVPGELGDKK EKVIKELAKK 200
    LDLTEDDIKK KLDQGWVKDD SFVPLKKVKP DQEKLVSEAT SLQGVTRTNV 250
    SSRYYPYGEK TAHLTGYVRA ITAEELKKKK EGTYSDTSNI GIAGLENVYE 300
    DKLRGTTGWK IYVPQTGEVI AEKKAKDGED LHLTIDIKTQ MKLYDELKDD 350
    SGAAVALQPK TGETLALVSA PSYDPNGFIF GWSDKEWKKL NKDKNNPFSA 400
    KFNKTYAPGS TIKPIAAAIG IKNGTLKADE KKTIKGKEWQ KDSSWGGYSV 450
    TRVSERLQQV DLENALITSD NIYFAQNALD MGADTFTKGL KTFGFSEDVP 500
    YEFPIQKSSI ANDKLDSDIL LADTGYGQGQ MQMSPLHLAT AYTPFVDNGD 550
    LVKPTLIKKD SQTADVWHKQ VVTKEGAADI TKGLKGVVED ERGSAYQPVV 600
    KGITVAGKTG TAELKTSKDD KDGTENGWFV GYDYENKDLL VAMMIQNVQD 650
    RGGSHYVVEK AKKQFQSN 668
    Length:668
    Mass (Da):74,406
    Last modified:November 1, 1995 - v1
    Checksum:iA877A27B188ECAFC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91V → D in AAA22829. (PubMed:3145906)Curated
    Sequence conflicti30 – 378RMEAFVKQ → PLESTAQA in AAA22829. (PubMed:3145906)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38161 Genomic DNA. Translation: BAA07365.1.
    D50453 Genomic DNA. Translation: BAA09043.1.
    AL009126 Genomic DNA. Translation: CAB12221.1.
    M22913 Genomic DNA. Translation: AAA22829.1.
    PIRiI39902.
    RefSeqiNP_388295.1. NC_000964.3.
    WP_003246590.1. NC_000964.3.

    Genome annotation databases

    EnsemblBacteriaiCAB12221; CAB12221; BSU04140.
    GeneIDi940139.
    KEGGibsu:BSU04140.
    PATRICi18972406. VBIBacSub10457_0431.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38161 Genomic DNA. Translation: BAA07365.1 .
    D50453 Genomic DNA. Translation: BAA09043.1 .
    AL009126 Genomic DNA. Translation: CAB12221.1 .
    M22913 Genomic DNA. Translation: AAA22829.1 .
    PIRi I39902.
    RefSeqi NP_388295.1. NC_000964.3.
    WP_003246590.1. NC_000964.3.

    3D structure databases

    ProteinModelPortali P42971.
    SMRi P42971. Positions 28-668.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P42971. 1 interaction.
    STRINGi 224308.BSU04140.

    Chemistry

    DrugBanki DB00355. Aztreonam.
    DB00493. Cefotaxime.

    Proteomic databases

    PaxDbi P42971.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai CAB12221 ; CAB12221 ; BSU04140 .
    GeneIDi 940139.
    KEGGi bsu:BSU04140.
    PATRICi 18972406. VBIBacSub10457_0431.

    Organism-specific databases

    GenoListi BSU04140. [Micado ]

    Phylogenomic databases

    eggNOGi COG0768.
    HOGENOMi HOG000236144.
    KOi K18149.
    OMAi EGPVPFK.
    OrthoDBi EOG6N0HHV.
    PhylomeDBi P42971.

    Enzyme and pathway databases

    BioCyci BSUB:BSU04140-MONOMER.

    Family and domain databases

    Gene3Di 3.40.710.10. 1 hit.
    InterProi IPR012338. Beta-lactam/transpept-like.
    IPR007887. MecA_N.
    IPR005311. PBP_dimer.
    IPR001460. PCN-bd_Tpept.
    [Graphical view ]
    Pfami PF05223. MecA_N. 1 hit.
    PF03717. PBP_dimer. 1 hit.
    PF00905. Transpeptidase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56519. SSF56519. 1 hit.
    SSF56601. SSF56601. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Determination of a 17,484 bp nucleotide sequence around the 39 degrees region of the Bacillus subtilis chromosome and similarity analysis of the products of putative ORFs."
      Akagawa E., Kurita K., Sugawara T., Nakamura K., Kasahara Y., Ogasawara N., Yamane K.
      Microbiology 141:3241-3245(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    2. "The 25 degrees-36 degrees region of the Bacillus subtilis chromosome: determination of the sequence of a 146 kb segment and identification of 113 genes."
      Yamane K., Kumano M., Kurita K.
      Microbiology 142:3047-3056(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 168.
    3. "The complete genome sequence of the Gram-positive bacterium Bacillus subtilis."
      Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V.
      , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A.
      Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 168.
    4. "Characterization of signal-sequence-coding regions selected from the Bacillus subtilis chromosome."
      Smith H., de Jong A., Bron S., Venema G.
      Gene 70:351-361(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-37.

    Entry informationi

    Entry nameiPBPC_BACSU
    AccessioniPrimary (citable) accession number: P42971
    Secondary accession number(s): P40772
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1995
    Last sequence update: November 1, 1995
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Bacillus subtilis
      Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3