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Protein

Signal peptidase I U

Gene

sipU

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei46 – 461By similarity
Active sitei88 – 881By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease

Enzyme and pathway databases

BioCyciBSUB:BSU04010-MONOMER.

Protein family/group databases

MEROPSiS26.005.

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase I U (EC:3.4.21.89)
Short name:
SPase I
Alternative name(s):
Leader peptidase I
Gene namesi
Name:sipU
Synonyms:ycsB
Ordered Locus Names:BSU04010
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1616CytoplasmicSequence analysisAdd
BLAST
Transmembranei17 – 3721HelicalSequence analysisAdd
BLAST
Topological domaini38 – 187150ExtracellularSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 187187Signal peptidase I UPRO_0000109501Add
BLAST

Proteomic databases

PaxDbiP42959.

Expressioni

Inductioni

Expressed constitutively.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100002268.

Structurei

3D structure databases

ProteinModelPortaliP42959.
SMRiP42959. Positions 33-185.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108ZX0. Bacteria.
COG0681. LUCA.
HOGENOMiHOG000003673.
InParanoidiP42959.
KOiK03100.
OMAiVPTHKLF.
PhylomeDBiP42959.

Family and domain databases

Gene3Di2.10.109.10. 2 hits.
InterProiIPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
[Graphical view]
PANTHERiPTHR12383. PTHR12383. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00727. LEADERPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00760. SPASE_I_2. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P42959-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAKTITLKK KRKIKTIVVL SIIMIAALIF TIRLVFYKPF LIEGSSMAPT
60 70 80 90 100
LKDSERILVD KAVKWTGGFH RGDIIVIHDK KSGRSFVKRL IGLPGDSIKM
110 120 130 140 150
KNDQLYINDK KVEEPYLKEY KQEVKESGVT LTGDFEVEVP SGKYFVMGDN
160 170 180
RLNSLDSRNG MGMPSEDDII GTESLVFYPF GEMRQAK
Length:187
Mass (Da):21,183
Last modified:November 1, 1995 - v1
Checksum:i31C48774CF6A849B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38161 Genomic DNA. Translation: BAA07353.1.
D50453 Genomic DNA. Translation: BAA09032.1.
AL009126 Genomic DNA. Translation: CAB12209.1.
PIRiI39890.
RefSeqiNP_388283.1. NC_000964.3.
WP_003234434.1. NZ_JNCM01000031.1.

Genome annotation databases

EnsemblBacteriaiCAB12209; CAB12209; BSU04010.
GeneIDi939966.
KEGGibsu:BSU04010.
PATRICi18972378. VBIBacSub10457_0417.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38161 Genomic DNA. Translation: BAA07353.1.
D50453 Genomic DNA. Translation: BAA09032.1.
AL009126 Genomic DNA. Translation: CAB12209.1.
PIRiI39890.
RefSeqiNP_388283.1. NC_000964.3.
WP_003234434.1. NZ_JNCM01000031.1.

3D structure databases

ProteinModelPortaliP42959.
SMRiP42959. Positions 33-185.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100002268.

Protein family/group databases

MEROPSiS26.005.

Proteomic databases

PaxDbiP42959.

Protocols and materials databases

DNASUi939966.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB12209; CAB12209; BSU04010.
GeneIDi939966.
KEGGibsu:BSU04010.
PATRICi18972378. VBIBacSub10457_0417.

Phylogenomic databases

eggNOGiENOG4108ZX0. Bacteria.
COG0681. LUCA.
HOGENOMiHOG000003673.
InParanoidiP42959.
KOiK03100.
OMAiVPTHKLF.
PhylomeDBiP42959.

Enzyme and pathway databases

BioCyciBSUB:BSU04010-MONOMER.

Family and domain databases

Gene3Di2.10.109.10. 2 hits.
InterProiIPR000223. Pept_S26A_signal_pept_1.
IPR019758. Pept_S26A_signal_pept_1_CS.
IPR019757. Pept_S26A_signal_pept_1_Lys-AS.
IPR019756. Pept_S26A_signal_pept_1_Ser-AS.
IPR028360. Peptidase_S24/S26_b-rbn.
IPR019759. Peptidase_S24_S26.
IPR015927. Peptidase_S24_S26A/B/C.
[Graphical view]
PANTHERiPTHR12383. PTHR12383. 1 hit.
PfamiPF00717. Peptidase_S24. 1 hit.
[Graphical view]
PRINTSiPR00727. LEADERPTASE.
SUPFAMiSSF51306. SSF51306. 1 hit.
TIGRFAMsiTIGR02227. sigpep_I_bact. 1 hit.
PROSITEiPS00501. SPASE_I_1. 1 hit.
PS00760. SPASE_I_2. 1 hit.
PS00761. SPASE_I_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLEPU_BACSU
AccessioniPrimary (citable) accession number: P42959
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: September 7, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

B.subtilis contains five chromosomal type I signal peptidases: SipS, SipT, SipU, SipV and SipW. They have different, but overlapping, substrate specificities and have different transcription patterns.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.