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Protein

Signal peptidase I U

Gene

sipU

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Miscellaneous

B.subtilis contains five chromosomal type I signal peptidases: SipS, SipT, SipU, SipV and SipW. They have different, but overlapping, substrate specificities and have different transcription patterns.

Catalytic activityi

Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei46By similarity1
Active sitei88By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease

Enzyme and pathway databases

BioCyciBSUB:BSU04010-MONOMER

Protein family/group databases

MEROPSiS26.005

Names & Taxonomyi

Protein namesi
Recommended name:
Signal peptidase I U (EC:3.4.21.89)
Short name:
SPase I
Alternative name(s):
Leader peptidase I
Gene namesi
Name:sipU
Synonyms:ycsB
Ordered Locus Names:BSU04010
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 16CytoplasmicSequence analysisAdd BLAST16
Transmembranei17 – 37HelicalSequence analysisAdd BLAST21
Topological domaini38 – 187ExtracellularSequence analysisAdd BLAST150

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001095011 – 187Signal peptidase I UAdd BLAST187

Proteomic databases

PaxDbiP42959
PRIDEiP42959

Expressioni

Inductioni

Expressed constitutively.

Interactioni

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100002268

Structurei

3D structure databases

ProteinModelPortaliP42959
SMRiP42959
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S26 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4108ZX0 Bacteria
COG0681 LUCA
HOGENOMiHOG000003673
InParanoidiP42959
KOiK03100
OMAiNIVGRYM
PhylomeDBiP42959

Family and domain databases

InterProiView protein in InterPro
IPR036286 LexA/Signal_pep-like_sf
IPR000223 Pept_S26A_signal_pept_1
IPR019758 Pept_S26A_signal_pept_1_CS
IPR019757 Pept_S26A_signal_pept_1_Lys-AS
IPR019756 Pept_S26A_signal_pept_1_Ser-AS
IPR015927 Peptidase_S24_S26A/B/C
PfamiView protein in Pfam
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00727 LEADERPTASE
SUPFAMiSSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR02227 sigpep_I_bact, 1 hit
PROSITEiView protein in PROSITE
PS00501 SPASE_I_1, 1 hit
PS00760 SPASE_I_2, 1 hit
PS00761 SPASE_I_3, 1 hit

Sequencei

Sequence statusi: Complete.

P42959-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAKTITLKK KRKIKTIVVL SIIMIAALIF TIRLVFYKPF LIEGSSMAPT
60 70 80 90 100
LKDSERILVD KAVKWTGGFH RGDIIVIHDK KSGRSFVKRL IGLPGDSIKM
110 120 130 140 150
KNDQLYINDK KVEEPYLKEY KQEVKESGVT LTGDFEVEVP SGKYFVMGDN
160 170 180
RLNSLDSRNG MGMPSEDDII GTESLVFYPF GEMRQAK
Length:187
Mass (Da):21,183
Last modified:November 1, 1995 - v1
Checksum:i31C48774CF6A849B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38161 Genomic DNA Translation: BAA07353.1
D50453 Genomic DNA Translation: BAA09032.1
AL009126 Genomic DNA Translation: CAB12209.1
PIRiI39890
RefSeqiNP_388283.1, NC_000964.3
WP_003234434.1, NZ_JNCM01000031.1

Genome annotation databases

EnsemblBacteriaiCAB12209; CAB12209; BSU04010
GeneIDi939966
KEGGibsu:BSU04010
PATRICifig|224308.179.peg.426

Similar proteinsi

Entry informationi

Entry nameiLEPU_BACSU
AccessioniPrimary (citable) accession number: P42959
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1995
Last sequence update: November 1, 1995
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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