Probable tartrate dehydrogenase/decarboxylase - Bacillus subtilis (strain 168)

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P42958 (TTUC_BACSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 97. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Probable tartrate dehydrogenase/decarboxylase
Short name=TDH
EC=1.1.1.93
EC=4.1.1.73

Alternative name(s):
D-malate dehydrogenase [decarboxylating]
EC=1.1.1.83

Gene names

Name:	ycsA
Ordered Locus Names:	BSU04000

Organism

Bacillus subtilis (strain 168) [Reference proteome] [HAMAP]

Taxonomic identifier

224308 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus ›

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity

Tartrate + NAD⁺ = oxaloglycolate + NADH.

Meso-tartrate + NAD⁺ = oxaloglycolate + NADH.

(R,R)-tartrate + NAD⁺ = oxaloglycolate + NADH.

(R,R)-tartrate = D-glycerate + CO₂.

(R)-malate + NAD⁺ = pyruvate + CO₂ + NADH.

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family.

Sequence caution

The sequence BAA07352.1 differs from that shown. Reason: Frameshift at several positions.

The sequence BAA09031.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Ligand	NAD
Molecular function	Lyase Oxidoreductase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular_function	D-malate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC NAD binding Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro tartrate decarboxylase activity Inferred from electronic annotation. Source: EC tartrate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 354

354

Probable tartrate dehydrogenase/decarboxylase

PRO_0000083820

Experimental info

Sequence conflict

241

N → K in BAA07352. Ref.1

Sequence conflict

241

N → K in BAA09031. Ref.2

Sequence conflict

256

G → E in BAA07352. Ref.1

Sequence conflict

256

G → E in BAA09031. Ref.2

Sequence conflict

263

S → P in BAA07352. Ref.1

Sequence conflict

263

S → P in BAA09031. Ref.2

Sequences

Sequence

Length

Mass (Da)

Tools

P42958 [UniParc].

Last modified July 28, 2009. Version 4.
Checksum: 816DC5A21FC23D14
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FASTA

354

38,728

        10         20         30         40         50         60 
MTMKQFEIAA IPGDGVGKEV VAAAEKVLHT AAEVHGGLSF SFTAFPWSCD YYLEHGKMMP 

        70         80         90        100        110        120 
EDGIHTLTQF EAVFLGAVGN PKLVPDHISL WGLLLKIRRE LELSINMRPA KQMAGITSPL 

       130        140        150        160        170        180 
LHPNDFDFVV IRENSEGEYS EVGGRIHRGD DEIAIQNAVF TRKATERVMR FAFELAKKRR 

       190        200        210        220        230        240 
SHVTSATKSN GIYHAMPFWD EVFQQTAADY SGIETSSQHI DALAAFFVTR PETFDVIVAS 

       250        260        270        280        290        300 
NLFGDILTDI SSSLMGSIGI APSANINPSG KYPSMFEPVH GSAPDIAGQG LANPIGQIWT 

       310        320        330        340        350 
AKLMLDHFGE EELGAKILDV MEQVTADGIK TRDIGGQSTT AEVTDEICSR LRKL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Determination of a 17,484 bp nucleotide sequence around the 39 degrees region of the Bacillus subtilis chromosome and similarity analysis of the products of putative ORFs." Akagawa E., Kurita K., Sugawara T., Nakamura K., Kasahara Y., Ogasawara N., Yamane K. Microbiology 141:3241-3245(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[2]	"The 25 degrees-36 degrees region of the Bacillus subtilis chromosome: determination of the sequence of a 146 kb segment and identification of 113 genes." Yamane K., Kumano M., Kurita K. Microbiology 142:3047-3056(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[3]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. Danchin A. Nature 390:249-256(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
[4]	"Detecting and analyzing DNA sequencing errors: toward a higher quality of the Bacillus subtilis genome sequence." Medigue C., Rose M., Viari A., Danchin A. Genome Res. 9:1116-1127(1999) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION.
[5]	"From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later." Barbe V., Cruveiller S., Kunst F., Lenoble P., Meurice G., Sekowska A., Vallenet D., Wang T., Moszer I., Medigue C., Danchin A. Microbiology 155:1758-1775(2009) [PubMed] [Europe PMC] [Abstract] Cited for: SEQUENCE REVISION TO 241; 256 AND 263.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D38161 Genomic DNA. Translation: BAA07352.1. Frameshift. D50453 Genomic DNA. Translation: BAA09031.1. Frameshift. AL009126 Genomic DNA. Translation: CAB12208.3.
PIR	A69765.
RefSeq	NP_388282.3. NC_000964.3.
3D structure databases
ProteinModelPortal	P42958.
SMR	P42958. Positions 5-354.
ModBase	Search...
Protein-protein interaction databases
STRING	224308.BSU04000.
Proteomic databases
PaxDb	P42958.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	CAB12208; CAB12208; BSU04000.
GeneID	938262.
KEGG	bsu:BSU04000.
PATRIC	18972376. VBIBacSub10457_0416.
Organism-specific databases
GenoList	BSU04000.
Phylogenomic databases
eggNOG	COG0473.
HOGENOM	HOG000021111.
KO	K07246.
ProtClustDB	PRK08194.
Enzyme and pathway databases
BioCyc	BSUB:BSU04000-MONOMER.
Family and domain databases
Gene3D	3.40.718.10. 1 hit.
InterPro	IPR019818. IsoCit/isopropylmalate_DH_CS. IPR001804. Isocitrate/isopropylmalate_DH. IPR024084. IsoPropMal-DH-like_dom. IPR011829. TTC_DH. [Graphical view]
PANTHER	PTHR11835. PTHR11835. 1 hit.
Pfam	PF00180. Iso_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR02089. TTC. 1 hit.
PROSITE	PS00470. IDH_IMDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TTUC_BACSU

Accession

Primary (citable) accession number: P42958
Secondary accession number(s): O31481

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	July 28, 2009
Last modified:	May 1, 2013
This is version 97 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program

Relevant documents

Bacillus subtilis

Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents