Reviewed, UniProtKB/Swiss-Prot P42958 (TTUC_BACSU)

Names and origin

Protein names

Recommended name:
    Probable tartrate dehydrogenase/decarboxylase
      Short name=TDH
    EC=1.1.1.93
    EC=4.1.1.73
Alternative name(s):
    D-malate dehydrogenase [decarboxylating]
    EC=1.1.1.83

Gene names

Name:	ycsA
Ordered Locus Names:	BSU04000

Organism

Bacillus subtilis [Complete proteome] [HAMAP]

Taxonomic identifier

1423 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Tartrate + NAD+ = oxaloglycolate + NADH. Meso-tartrate + NAD+ = oxaloglycolate + NADH. (R,R)-tartrate + NAD+ = oxaloglycolate + NADH. (R,R)-tartrate = D-glycerate + CO2. (R)-malate + NAD+ = pyruvate + CO2 + NADH.
Sequence similarities	Belongs to the isocitrate and isopropylmalate dehydrogenases family.
Sequence caution	The sequence BAA07352.1 differs from that shown. Reason: Frameshift at several positions. The sequence BAA09031.1 differs from that shown. Reason: Frameshift at several positions.

Ontologies

Keywords
Ligand	NAD
Molecular function	Lyase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	D-malate dehydrogenase (decarboxylating) activity Inferred from electronic annotation. Source: EC NAD or NADH binding Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: InterPro tartrate decarboxylase activity Inferred from electronic annotation. Source: EC tartrate dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Probable tartrate dehydrogenase/decarboxylase		PRO_0000083820
Experimental info
	Sequence conflict	143	1	G → V Ref.1
	Sequence conflict	143	1	G → V Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P42958-1 [UniParc]. Last modified August 4, 2003. Version 3. Checksum: A3BBCD9F2221E32F	FASTA	354	38,824
	10 20 30 40 50 60 MTMKQFEIAA IPGDGVGKEV VAAAEKVLHT AAEVHGGLSF SFTAFPWSCD YYLEHGKMMP 70 80 90 100 110 120 EDGIHTLTQF EAVFLGAVGN PKLVPDHISL WGLLLKIRRE LELSINMRPA KQMAGITSPL 130 140 150 160 170 180 LHPNDFDFVV IRENSEGEYS EVGGRIHRGD DEIAIQNAVF TRKATERVMR FAFELAKKRR 190 200 210 220 230 240 SHVTSATKSN GIYHAMPFWD EVFQQTAADY SGIETSSQHI DALAAFFVTR PETFDVIVAS 250 260 270 280 290 300 KLFGDILTDI SSSLMESIGI APPANINPSG KYPSMFEPVH GSAPDIAGQG LANPIGQIWT 310 320 330 340 350 AKLMLDHFGE EELGAKILDV MEQVTADGIK TRDIGGQSTT AEVTDEICSR LRKL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Determination of a 17,484 bp nucleotide sequence around the 39 degrees region of the Bacillus subtilis chromosome and similarity analysis of the products of putative ORFs." Akagawa E., Kurita K., Sugawara T., Nakamura K., Kasahara Y., Ogasawara N., Yamane K. Microbiology 141:3241-3245(1995) [PubMed: 8574415] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[2]	"The 25 degrees-36 degrees region of the Bacillus subtilis chromosome: determination of the sequence of a 146 kb segment and identification of 113 genes." Yamane K., Kumano M., Kurita K. Microbiology 142:3047-3056(1996) [PubMed: 8969502] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: 168.
[3]	"The complete genome sequence of the Gram-positive bacterium Bacillus subtilis." Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V., Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R., Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S., Bruschi C.V. , Caldwell B., Capuano V., Carter N.M., Choi S.-K., Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F., Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D., Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M., Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P., Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K., Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S., Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y., Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G., Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J., Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C., Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S., Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B., Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S., Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M., Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y., Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J., Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A., Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M., Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S., Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E., Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K., Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E., Yoshikawa H., Danchin A. Nature 390:249-256(1997) [PubMed: 9384377] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 168.
[4]	"Detecting and analyzing DNA sequencing errors: toward a higher quality of the Bacillus subtilis genome sequence." Medigue C., Rose M., Viari A., Danchin A. Genome Res. 9:1116-1127(1999) [PubMed: 10568751] [Abstract] Cited for: SEQUENCE REVISION.

Cross-references

Sequence databases
EMBLGenBankDDBJ	D38161 Genomic DNA. Translation: BAA07352.1. Frameshift. D50453 Genomic DNA. Translation: BAA09031.1. Frameshift. Z99106 Genomic DNA. Translation: CAB12208.2.
PIR	A69765.
RefSeq	NP_388282.2.
3D structure databases
HSSP	HSSP built from PDB template 1WAL based on UniProtKB P00351.
ModBase	Search...
Genome annotation databases
GeneID	938262.
GenomeReviews	Gene locus BSU04000 in contig AL009126_GR.
KEGG	bsu:BSU04000.
Organism-specific databases
SubtiList	BG11222. ycsA. [Micado]
CMR	Search...
Phylogenomic databases
HOGENOM	P42958.
OMA	P42958. YAQHGQM.
Enzyme and pathway databases
BioCyc	BSUB224308:BSU0401-MON.
BRENDA	1.1.1.83. 150. 1.1.1.93. 150. 4.1.1.73. 150.
Family and domain databases
InterPro	IPR019818. IsoCit/isopropylmalate_DH_CS. IPR001804. Isocitrate/isopropylmalate_DH. IPR011829. TTC_DH. [Graphical view]
Gene3D	G3DSA:3.40.718.10. IDH_IMDH. 1 hit.
PANTHER	PTHR11835. IDH_IMDH_dimeric. 1 hit. PTHR11835:SF8. TTC_DH. 1 hit.
Pfam	PF00180. Iso_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR02089. TTC. 1 hit.
PROSITE	PS00470. IDH_IMDH. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TTUC_BACSU

Accession

Primary (citable) accession number: P42958
Secondary accession number(s): O31481

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1995
Last sequence update:	August 4, 2003
Last modified:	June 16, 2009
This is version 64 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)